Purpose: To correlate retinal circulatory measurements using scanning laser fl uorescein angiography and flow velocities of retrobulbar vessels measured by mea ns of colour Doppler imaging. Methods: Fifteen patients w...Purpose: To correlate retinal circulatory measurements using scanning laser fl uorescein angiography and flow velocities of retrobulbar vessels measured by mea ns of colour Doppler imaging. Methods: Fifteen patients with normal pressure gla ucoma (NPG) and 15 healthy volunteers underwent colour Doppler imaging and fluor escein angiographic studies. Peak systolic velocities (PSVs), end-diastolic velocities (EDVs) and resistive indices (RIs) of the ophthalmic artery (OA) an d central retinal artery were obtained. In the fluorescein angiograms arterioven ous passage time (AVP) was quantified by means of digital dye dilution curve ana lysis. Results: Arteriovenous passage time was significantly prolonged in NPG pa tients compared to healthy subjects (P=0.0026). In the central retinal artery PS V (P=0.023) and EDV (P < 0.0001) were significantly decreased and RI was increas ed (P < 0.0001) in patients with NPG. The EDV of the central retinal artery show ed a significant correlation with AVP (EDV: r=-0.53, P=0.0023). The RI of the c entral retinal artery correlated significantly to AVP (RI: r= 0.63, P< 0.0001). The AVP did not correlate to EDV or PSV, nor to the RI measured in the ophthalmi c artery. Conclusion: Arteriovenous passage time, which represents blood flow in a vascular segment of artery, capillary bed and corresponding vein, was found t o be correlated to the EDV and the RI of the central retinal artery. The combina tion of different techniques allows further interpretation of ocular circulatory responses.展开更多
Aim:Ocular hemodynamics is of great interest in glaucoma,especially since vascular disturbances may play a pathogenetic role in disease development.To investigate the hemodynamic differences between normal pressure gl...Aim:Ocular hemodynamics is of great interest in glaucoma,especially since vascular disturbances may play a pathogenetic role in disease development.To investigate the hemodynamic differences between normal pressure glaucoma patients and normal volunteers,flow velocities of the retrobulbar vessels were measured by colour Doppler imaging.Method:15 patients with normal pressure glaucoma(NPG)and 15 healthy volunteers underwent colour Doppler imaging(CDI)of the retrobulbar vessels.The patients and the volunteers were especially gender and age-matched.Peak systolic velocities(PSV),end-diastolic velocities(EDV),and resistive indices(RI)of the ophthalmic artery and central retinal artery were obtained.Results:In NPG patients,PSV and EDV in the central retinal artery were significantly decreased,whereas RI was increased in central retinal artery and the ophthalmic artery.Conclusion:Colour Doppler imaging is a non-invasive technique that allows further estimation of the ocular circulatory status.Particularly in the group of patients with disturbed hemodynamics,like NPG patients,it was able to show a reduction of the retrobulbar hemodynamics.展开更多
文摘Purpose: To correlate retinal circulatory measurements using scanning laser fl uorescein angiography and flow velocities of retrobulbar vessels measured by mea ns of colour Doppler imaging. Methods: Fifteen patients with normal pressure gla ucoma (NPG) and 15 healthy volunteers underwent colour Doppler imaging and fluor escein angiographic studies. Peak systolic velocities (PSVs), end-diastolic velocities (EDVs) and resistive indices (RIs) of the ophthalmic artery (OA) an d central retinal artery were obtained. In the fluorescein angiograms arterioven ous passage time (AVP) was quantified by means of digital dye dilution curve ana lysis. Results: Arteriovenous passage time was significantly prolonged in NPG pa tients compared to healthy subjects (P=0.0026). In the central retinal artery PS V (P=0.023) and EDV (P < 0.0001) were significantly decreased and RI was increas ed (P < 0.0001) in patients with NPG. The EDV of the central retinal artery show ed a significant correlation with AVP (EDV: r=-0.53, P=0.0023). The RI of the c entral retinal artery correlated significantly to AVP (RI: r= 0.63, P< 0.0001). The AVP did not correlate to EDV or PSV, nor to the RI measured in the ophthalmi c artery. Conclusion: Arteriovenous passage time, which represents blood flow in a vascular segment of artery, capillary bed and corresponding vein, was found t o be correlated to the EDV and the RI of the central retinal artery. The combina tion of different techniques allows further interpretation of ocular circulatory responses.
文摘Aim:Ocular hemodynamics is of great interest in glaucoma,especially since vascular disturbances may play a pathogenetic role in disease development.To investigate the hemodynamic differences between normal pressure glaucoma patients and normal volunteers,flow velocities of the retrobulbar vessels were measured by colour Doppler imaging.Method:15 patients with normal pressure glaucoma(NPG)and 15 healthy volunteers underwent colour Doppler imaging(CDI)of the retrobulbar vessels.The patients and the volunteers were especially gender and age-matched.Peak systolic velocities(PSV),end-diastolic velocities(EDV),and resistive indices(RI)of the ophthalmic artery and central retinal artery were obtained.Results:In NPG patients,PSV and EDV in the central retinal artery were significantly decreased,whereas RI was increased in central retinal artery and the ophthalmic artery.Conclusion:Colour Doppler imaging is a non-invasive technique that allows further estimation of the ocular circulatory status.Particularly in the group of patients with disturbed hemodynamics,like NPG patients,it was able to show a reduction of the retrobulbar hemodynamics.
