We report on two female patientswho presentedwith painful recurrent palpable purpura,ulcers and necroses on the extremities. The results of all examinations and laboratory tests considered together suggested a diagnos...We report on two female patientswho presentedwith painful recurrent palpable purpura,ulcers and necroses on the extremities. The results of all examinations and laboratory tests considered together suggested a diagnosis of necrotizing leukocytoclastic vasculitis. Leukocytoclastic vasculitis is an inflammatory necrotizing condition of the superficial dermal vessels, presenting with variable clinical symptoms. In most cases it becomes manifest as palpable purpura,but hemorrhagic- necrotizing,bullous, nodular and urticarial presentations also occur. Common etiological factors include bacterial, viral or drug antigens, chronic infections (hepatitis B and C), non- Hodgkin lymphomas (monoclonal gammopathy, multiple myeloma), leukemia (hairy cell leukemia), and tumors (bronchial, breast, and gastric cancer) and also connective tissue disorders. In the course of the work- up, a plasmocytoma was discovered as the cause of the leukocytoclastic vasculitis, presenting in a similar way to livedo reticularis in one case and to pyoderma gangraenosum in the other.展开更多
Sinus histiocytosis with massive lymphadenopathy or Rosai- Dorfman disease i s a non-Langerhans cell histiocytosis of unknown etiolosy. The most characteri stic feature is lymphadenopathy, especially that of cervical ...Sinus histiocytosis with massive lymphadenopathy or Rosai- Dorfman disease i s a non-Langerhans cell histiocytosis of unknown etiolosy. The most characteri stic feature is lymphadenopathy, especially that of cervical lymph nodes. In app roximately 40% of patients there are extranodal manifestations of the disease. Skin is the most commonly affected organ (27% ). We report a 79- year-old f emale patient with purely cutaneous manifestations. This form of the disease is a very rare differential diagnosis in dermatology.展开更多
文摘We report on two female patientswho presentedwith painful recurrent palpable purpura,ulcers and necroses on the extremities. The results of all examinations and laboratory tests considered together suggested a diagnosis of necrotizing leukocytoclastic vasculitis. Leukocytoclastic vasculitis is an inflammatory necrotizing condition of the superficial dermal vessels, presenting with variable clinical symptoms. In most cases it becomes manifest as palpable purpura,but hemorrhagic- necrotizing,bullous, nodular and urticarial presentations also occur. Common etiological factors include bacterial, viral or drug antigens, chronic infections (hepatitis B and C), non- Hodgkin lymphomas (monoclonal gammopathy, multiple myeloma), leukemia (hairy cell leukemia), and tumors (bronchial, breast, and gastric cancer) and also connective tissue disorders. In the course of the work- up, a plasmocytoma was discovered as the cause of the leukocytoclastic vasculitis, presenting in a similar way to livedo reticularis in one case and to pyoderma gangraenosum in the other.
文摘Sinus histiocytosis with massive lymphadenopathy or Rosai- Dorfman disease i s a non-Langerhans cell histiocytosis of unknown etiolosy. The most characteri stic feature is lymphadenopathy, especially that of cervical lymph nodes. In app roximately 40% of patients there are extranodal manifestations of the disease. Skin is the most commonly affected organ (27% ). We report a 79- year-old f emale patient with purely cutaneous manifestations. This form of the disease is a very rare differential diagnosis in dermatology.
