Therapeutic effect of autologous concentrated growth factor on lower-extremity chronic refractory wounds:A case report

BACKGROUND Management of chronic refractory wounds is one of the toughest clinical challenges for surgeons.Because of poor blood supply,less tissue coverage,and easy exposure,the lower leg is a common site for chronic refractory wounds.The current therapeutic regimens often lead to prolonged hospital stay and higher healthcare costs.Concentrated growth factor(CGF)is a novel blood extract that contains various growth factors,platelets,and fibrins to promote wound healing process.However,there has been little research reported on the treatment of lower extremity wounds with CGF.CASE SUMMARY A 37-year-old man,without any past medical history,presented an ulcerated chronic wound on his right lower leg.The skin defect exhibited clear boundaries,with a size of 2.0 cm×3.5 cm.The depth of wound was up to the layer of deep fascia.Staphylococcus aureus was detected by bacterial culture.The final diagnosis was right lower extremity ulcers with infection.Cefathiamidine,silver sulfadiazine,and mupirocin cream were applied to control the infection.CGF gel was prepared from the patient’s blood sample,and was used to cover the wound after thorough debridement.The skin wound was successfully healed after three times of CGF treatment.CONCLUSION CGF displays an excellent wound healing promoting effect in patients with lowerextremity chronic refractory wounds.

The concept, key technologies and applications of temporal-spatial information infrastructure

Smart city is the development of digital city; as its main supporting technology, the digital city geo-spatial framework has to be upgraded to the temporal-spatial information infrastructure (TSII). first, this paper proposes the concept and basic framework of smart city and defines the concept of TSII - processes, integration, mining analysis, and share time-stamps geographic data - and the related policy, regulations and standards, technology, facilities, mechanism, and human resources. The framework has four components: the benchmark of time and space, temporal-spatial big data, the cloud service platform and the related supporting environment. Second, the temporal-spatial big data and cloud service platform are elaborated. finally, an application of TSII constructed by the Xicheng District Planning Bureau in Beijing is introduced, which provides a useful reference for the construction of smart city.

Graphics processing unit-based dynamic volume rendering for typhoons on a virtual globe

Typhoons are usually accompanied by strong winds,heavy rain,storm surges and other disastrous events,and they are the most severe weather phenomena in the western part of the North Pacific Ocean.Visualisation is a key technology for analysing and presenting climate simulations and observations together with related social and ecological data.Virtual globes are a logical platform for visualising such geospatial data via the Internet.To implement interactive visualisation of typhoon data within virtual globes,this study provides a 3D texture-mapping algorithm to render volume textures on a globe.In addition,a systematic framework is proposed in which a hierarchical octree-based multiresolution data structure is implemented to organise the large volume dataset,and a graphics processing unit-based dynamic interpolation approach is proposed to obtain a smooth effect.Finally,the structure is combined with a level of detail strategy to enable the rendering of dynamic volumetric data at an acceptable interactive frame rate.To demonstrate the capabilities of this framework,data for a simulated typhoon event were rendered in World Wind,an open-source virtual globe.The experimental results demonstrate that the application of the proposed strategies can result in an interactive visualisation performance that renders typhoon data on virtual globes.