Purpose: To evaluate (with three different electrophysiological methods) the r esidual retinal function in a selected group of patients with retinitis pigmento sa and remaining small central visual fields. Methods: Fo...Purpose: To evaluate (with three different electrophysiological methods) the r esidual retinal function in a selected group of patients with retinitis pigmento sa and remaining small central visual fields. Methods: Fourteen patients from se veral different genetic subgroups, who had been followed with visual acuity and visual field testing for periods up to 32 years, were examined. Ophthalmological examination included full-field electroretinography (ERG), multifocal electror etinography (mfERG) and multifocal visual evoked potential (mfVEP). Results: The ERGs were severely reduced in all patients. The mfERGs demonstrated the residua l central retinal function in five of the patients. The mfVEPs showed measurable amplitudes centrally in most of the patients. The follow-up examinations demon strated the slowly progressive course of the disease with preservation or only s light further loss of visual fields over a period of 7-32 years. Conclusion: Pa tients with retinitis pigmentosa may not always follow the typical natural cours e with progressive loss of visual fields, which may in some patients remain unaf fected over several decades. Multifocal ERG and mfVEP may be clinically useful f or evaluating remaining visual function in these patients.展开更多
Purpose: Clinical investigation of central retinal dysfunction in two cases of solar retinopathy. Methods: Two patients were examined for best corrected visua l acuity (VA), fundus inspection, visual fields, multifoca...Purpose: Clinical investigation of central retinal dysfunction in two cases of solar retinopathy. Methods: Two patients were examined for best corrected visua l acuity (VA), fundus inspection, visual fields, multifocal electroretinography (mfERG) with a stimulus pattern of 241 hexagons and, at follow-up, also with op tical coherence tomography (OCT). Results: At the initial examination, mfERG rev ealed central retinal dysfunction, which had improved by the time of follow-up. In Case 1, a foveal oedema regressed over time, although VA remained slightly r educed. In Case 2, OCT showed spots of increased reflectivity corresponding to t he patient’s symptoms. Conclusion: Central retinal dysfunction due to solar ret inopathy may improve over time. However, structural and functional changes may p ersist. This report illustrates that mfERG and OCT are useful tools for objectiv e documentation of the pathology in solar retinopathy.展开更多
文摘Purpose: To evaluate (with three different electrophysiological methods) the r esidual retinal function in a selected group of patients with retinitis pigmento sa and remaining small central visual fields. Methods: Fourteen patients from se veral different genetic subgroups, who had been followed with visual acuity and visual field testing for periods up to 32 years, were examined. Ophthalmological examination included full-field electroretinography (ERG), multifocal electror etinography (mfERG) and multifocal visual evoked potential (mfVEP). Results: The ERGs were severely reduced in all patients. The mfERGs demonstrated the residua l central retinal function in five of the patients. The mfVEPs showed measurable amplitudes centrally in most of the patients. The follow-up examinations demon strated the slowly progressive course of the disease with preservation or only s light further loss of visual fields over a period of 7-32 years. Conclusion: Pa tients with retinitis pigmentosa may not always follow the typical natural cours e with progressive loss of visual fields, which may in some patients remain unaf fected over several decades. Multifocal ERG and mfVEP may be clinically useful f or evaluating remaining visual function in these patients.
文摘Purpose: Clinical investigation of central retinal dysfunction in two cases of solar retinopathy. Methods: Two patients were examined for best corrected visua l acuity (VA), fundus inspection, visual fields, multifocal electroretinography (mfERG) with a stimulus pattern of 241 hexagons and, at follow-up, also with op tical coherence tomography (OCT). Results: At the initial examination, mfERG rev ealed central retinal dysfunction, which had improved by the time of follow-up. In Case 1, a foveal oedema regressed over time, although VA remained slightly r educed. In Case 2, OCT showed spots of increased reflectivity corresponding to t he patient’s symptoms. Conclusion: Central retinal dysfunction due to solar ret inopathy may improve over time. However, structural and functional changes may p ersist. This report illustrates that mfERG and OCT are useful tools for objectiv e documentation of the pathology in solar retinopathy.
