Objective:To determine if clinical use of two different doses of botulinum exotoxin A(BTX-A)injections to the forehead area result in wrinkle reduction and modifications of eyebrow position.Design:Prospective study.Se...Objective:To determine if clinical use of two different doses of botulinum exotoxin A(BTX-A)injections to the forehead area result in wrinkle reduction and modifications of eyebrow position.Design:Prospective study.Setting Private practice,Dermatologic Laser Centre,Marseille,France.Subjects:Twenty-four adult patients treated with BTX-A(Vistabel)-injections for forehead rhytides.Intervention:Of the 24 patients,12 received BTX-A injections of 5 U only and 12 received injections of 10 U into the forehead,with or without treatment of the lateral forehead.The eyebrow position,forehead height and number of forehead lines determine the number of injection points.Patients were evaluated before injection and every 2 months after treatment during next 8 months.Results:In the two groups of 12 patients,we found no significant change between the two doses.At each time after injections(every 2 months until 8 months),both groups showed a statistically significant improvement except at 8 months.Both groups exhibited the same results on standardized photos and on 3D skin profilometry.Conclusions:The two doses of BTX-A injections into the forehead gave the same results.The duration of the effect is similar along 8 months.This study emphasizes the role of low doses of BTX-A injections to obtain good clinical results without freezing aspect.展开更多
文摘Objective:To determine if clinical use of two different doses of botulinum exotoxin A(BTX-A)injections to the forehead area result in wrinkle reduction and modifications of eyebrow position.Design:Prospective study.Setting Private practice,Dermatologic Laser Centre,Marseille,France.Subjects:Twenty-four adult patients treated with BTX-A(Vistabel)-injections for forehead rhytides.Intervention:Of the 24 patients,12 received BTX-A injections of 5 U only and 12 received injections of 10 U into the forehead,with or without treatment of the lateral forehead.The eyebrow position,forehead height and number of forehead lines determine the number of injection points.Patients were evaluated before injection and every 2 months after treatment during next 8 months.Results:In the two groups of 12 patients,we found no significant change between the two doses.At each time after injections(every 2 months until 8 months),both groups showed a statistically significant improvement except at 8 months.Both groups exhibited the same results on standardized photos and on 3D skin profilometry.Conclusions:The two doses of BTX-A injections into the forehead gave the same results.The duration of the effect is similar along 8 months.This study emphasizes the role of low doses of BTX-A injections to obtain good clinical results without freezing aspect.
