Background: Research regarding long-term cognitive outcome following corona ry artery bypass graft (CABG) is inconsistent, which may be due in part to diffe rential genetic and environmental influences within most stu...Background: Research regarding long-term cognitive outcome following corona ry artery bypass graft (CABG) is inconsistent, which may be due in part to diffe rential genetic and environmental influences within most study samples. Methods: The authors examined the effect of CABG on cognitive status change scores in me mbers of the National Academy of Sciences-National Research Council Twins Regi stry of World War II veterans. Subjects were administered the modified Telephone Interview for Cognitive Status (TICS-m) at approximately 3-year intervals b etween 1990 and 2002 as part of an epidemiologic study of dementia. Results: Bas ed on co-twin control analyses using a repeated-measures analysis of varianc e matching twins discordant for CABG within the pair (n = 464 individuals) acros s three age categories (63 to 70, 71 to 73, 74 to 83), the authors found at foll ow-up that men who had CABG between ages 63 and 70 showed an increase in TICS -m scores and performed better than their co-twin who did not have the proce dure. No significant differences were found within twin pairs for the older two age groups following CABG surgery. This age effect was replicated when comparing individuals positive for CABG surgery with nonfamilial, age-and education-m atched controls who were negative for CABG. Conclusions: In this study of twin p airs who share many genetic and environmental risks for cerebrovascular problems , the results suggest that timing of the CABG procedure may be important to pred icting positive cognitive outcomes.展开更多
文摘Background: Research regarding long-term cognitive outcome following corona ry artery bypass graft (CABG) is inconsistent, which may be due in part to diffe rential genetic and environmental influences within most study samples. Methods: The authors examined the effect of CABG on cognitive status change scores in me mbers of the National Academy of Sciences-National Research Council Twins Regi stry of World War II veterans. Subjects were administered the modified Telephone Interview for Cognitive Status (TICS-m) at approximately 3-year intervals b etween 1990 and 2002 as part of an epidemiologic study of dementia. Results: Bas ed on co-twin control analyses using a repeated-measures analysis of varianc e matching twins discordant for CABG within the pair (n = 464 individuals) acros s three age categories (63 to 70, 71 to 73, 74 to 83), the authors found at foll ow-up that men who had CABG between ages 63 and 70 showed an increase in TICS -m scores and performed better than their co-twin who did not have the proce dure. No significant differences were found within twin pairs for the older two age groups following CABG surgery. This age effect was replicated when comparing individuals positive for CABG surgery with nonfamilial, age-and education-m atched controls who were negative for CABG. Conclusions: In this study of twin p airs who share many genetic and environmental risks for cerebrovascular problems , the results suggest that timing of the CABG procedure may be important to pred icting positive cognitive outcomes.
