Bone defects are encountered substantially in clinical practice,and bionic scaffolds represent a promising solution for repairing bone defects.However,it is difficult to fabricate scaffolds with bionic structures and ...Bone defects are encountered substantially in clinical practice,and bionic scaffolds represent a promising solution for repairing bone defects.However,it is difficult to fabricate scaffolds with bionic structures and reconstruct the microenvironment to fulfill the satisfying repair effects.In this review article,we first discuss various strategies for the design and construction of bionic scaffolds to promote bone defect repair,especially including the structural construction of the scaffold and the integration of bioactive substances together with the application of external stimuli.We then discuss the roles of artificial intelligence and medical imaging in aiding clinical treatment.Finally,we point out the challenges and future outlooks in developing multifunctional bone repair scaffolds,aiming to provide insights for improving bone regeneration efficacy and accelerating clinical translation.展开更多
基金State Key Laboratory of Organic-Inorganic Composites,Beijing University of Chemical Technology,Grant/Award Number:oic-202201004National Natural Science Foundation of China,Grant/Award Number:52221006Fundamental Research Funds for the Central Universities,Grant/Award Number:buctrc202312。
文摘Bone defects are encountered substantially in clinical practice,and bionic scaffolds represent a promising solution for repairing bone defects.However,it is difficult to fabricate scaffolds with bionic structures and reconstruct the microenvironment to fulfill the satisfying repair effects.In this review article,we first discuss various strategies for the design and construction of bionic scaffolds to promote bone defect repair,especially including the structural construction of the scaffold and the integration of bioactive substances together with the application of external stimuli.We then discuss the roles of artificial intelligence and medical imaging in aiding clinical treatment.Finally,we point out the challenges and future outlooks in developing multifunctional bone repair scaffolds,aiming to provide insights for improving bone regeneration efficacy and accelerating clinical translation.
