Aspirin has been marketed for just over 100 years and for, an evolving set of clinical indications, has been the world's first and most successful mass marketed pharmaceutical compound. However, by 1937 it was cle...Aspirin has been marketed for just over 100 years and for, an evolving set of clinical indications, has been the world's first and most successful mass marketed pharmaceutical compound. However, by 1937 it was clear that aspirin could cause acute gastric erosions and chronic ulcers. Attempts to develop aspirin like compounds that would avoid of aspirin's topical toxicity did not result in avoidance of the same side effects. This is probably because aspirin and non-aspirin NSAIDs inhibit prostaglandin synthesis, a central component of both their therapeutic and toxic activity.展开更多
文摘Aspirin has been marketed for just over 100 years and for, an evolving set of clinical indications, has been the world's first and most successful mass marketed pharmaceutical compound. However, by 1937 it was clear that aspirin could cause acute gastric erosions and chronic ulcers. Attempts to develop aspirin like compounds that would avoid of aspirin's topical toxicity did not result in avoidance of the same side effects. This is probably because aspirin and non-aspirin NSAIDs inhibit prostaglandin synthesis, a central component of both their therapeutic and toxic activity.
