Surgery with adjuvant or neoadjuvant treatment vs surgery alone for resectable pancreatic cancer: A network meta-analysis

BACKGROUND Pancreatic cancer is one of the most common and lethal malignancies worldwide. The common treatment options for resectable pancreatic cancer include surgery alone, neoadjuvant chemotherapy (CT), neoadjuvant chemoradiotherapy (CRT), adjuvant CT, and adjuvant CRT. However, the optimal treatment is still controversial. AIM To identify the most effective approach for pancreatic cancer using network meta-analysis. METHODS Eligible studies were searched from PubMed, MEDLINE, EMBASE, Cochrane database, and Google scholar. We searched and included randomized controlled trials reporting on neoadjuvant and adjuvant therapies. For direct comparisons, standard pairwise meta-analysis was performed using the inverse variance DerSimonian-Laird random-effects model. For indirect comparisons, Bayesian network meta-analysis was used to combine direct and indirect evidence. We used relative hazard ratios (HRs) to estimate death difference of different treatments, and relative odds ratios (ORs) for toxic effects. Treatment effects were ranked based on their efficacy for improving survival or reducing toxicity using rankogram. The quality of evidence of estimates from direct comparison and network meta-analysis was evaluated following the GRADE approach. RESULTS We included 13 high quality trials with 1591 participants in this network metaanalysis. Compared with surgery alone [pooled HR = 0.7, 95% confidence interval (CI): 0.62-0.79] and surgery with adjuvant CRT (pooled HR = 0.6, 95%CI: 0.54-0.72), surgery with adjuvant CT had a higher rate of overall survival. In contrast, standard pairwise meta-analysis showed a statistically significant survival advantage of surgery with adjuvant CT compared with surgery alone (pooled HR = 0.75, 95%CI: 0.63-0.89;P < 0.001). Rankogram showed that surgery with adjuvant CT was most likely to rank the best in terms of overall survival (probability: 94.2%), followed by surgery alone (probability: 5.8%). No significant differences in overall toxicity or haematological toxicity were found between all the therapies. High quality evidence supported surgery with adjuvant CT over surgery alone for increasing overall survival. Moderate quality evidence supported surgery with adjuvant CT over surgery with adjuvant CRT for increasing overall survival. CONCLUSION Surgery with adjuvant CT prolongs overall survival compared with surgery alone and surgery with adjuvant CRT, suggesting surgery with adjuvant CT is the optimal treatment for resectable pancreatic cancer.

Simple and Efficient Cultivation Technology for the Peanut under the Standardization Mode of Single-seed Sowing

Single-seed sowing is a new,simple and efficient cultivation mode for peanut that realized from cultivation of healthy individual and construction of high-yielding population. The cultivation mode has the obvious advantages in uniform seedling,strong sprouting,seed saving and cost saving,thus it is considered as one of the effective ways for high-yield and high-efficient peanut cultivation in China in the future.Through integrating with other high-efficiency and simple cultivation measures,the single-seed sowing technology system has made conforming to China's national standardization cultivations of peanut and the technology was already applied in the main producing areas of peanut and gained the significant efficiency and abroad application prospects. Based on many years of researches in single-seed sowing technology,high-efficiency fertilization and scientific chemical control in the research team,by combining with the latest research results in plant protection and machinery,this paper described the key points and matters needing attentions from variety selection,planting mode,rational fertilization,planting specifications and field management.

关于伪满时期日本在东北地区建筑防寒保温措施的研究——以《满洲建筑杂志》为研究对象

伪满洲国时期,日本为了长期殖民,在中国东北地区开展了广泛的建设活动。受地域特征影响,这个时期日本所修建的建筑并不同于其国内的建筑风格,尤其是在防寒保温措施方面,有了新的研究与发展。对于这些,《满洲建筑杂志》里的诸多文章都有详细的描述。本文运用关键词分析法,对《满洲建筑杂志》中的相关文章进行整理分析,进而探究伪满时期日本在东北地区关于建筑防寒措施的应用及主要关注点。

Noncyclic nonadiabatic holonomic quantum gates via shortcuts to adiabaticity

High-fidelity quantum gates are essential for large-scale quantum computation.However,any quantum manipulation will inevitably affected by noises,systematic errors and decoherence effects,which lead to infidelity of a target quantum task.Therefore,implementing high-fidelity,robust and fast quantum gates is highly desired.Here,we propose a fast and robust scheme to construct high-fidelity holonomic quantum gates for universal quantum computation based on resonant interaction of three-level quantum systems via shortcuts to adiabaticity.In our proposal,the target Hamiltonian to induce noncyclic non-Abelian geometric phases can be inversely engineered with less evolution time and demanding experimentally,leading to high-fidelity quantum gates in a simple setup.Besides,our scheme is readily realizable in physical system currently pursued for implementation of quantum computation.Therefore,our proposal represents a promising way towards fault-tolerant geometric quantum computation.

Distribution characteristics and its controlling factor of lacustrine high-quality source rocks in the Bozhong sag,Bohai Bay Basin

Distribution of Paleogene lacustrine high-quality source rocks in the Bozhong sag in Bohai Bay Basin is analyzed through data of geochemistry,geology and well logging,and its differences under the control of climate and tectonics is also well discussed.Distribution characteristics of the high-quality source rocks developed in the saline environment controlled by the climate are quite different from that developed in the rapid subsidence environment controlled by tectonics.The high-quality source rocks in Member 1 of Shahejie Formation developed in the saline environment account for 81.9%of total subsag area,and are distributed widely and extensively.The high-quality source rocks in Member 3 of Shahejie Formation and Member 3 of Dongying Formation is developed in the tectonic subsidence environment,and horizontally,the subsag subsidence rates has a positive correlation with the area proportion of the high-quality source rocks in the sag;vertically,the reduction-oxidation interface of the lake controls the enrichment of highquality source rocks.Controlled by the saline environment and rapid subsidence environment,the highquality source rocks in the Bozhong sag and adjacent areas have three types of development condition:the saline water,the tectonic subsidence,and joint control of the saline water and the tectonic subsidence.The humid climate and low subsidence rate are not favorable for development of high-quality source rocks.