To improve the encapsulation efficiency and minimize particle agglomeration of liposomes, rapid expansion from supercritical to surfactant solution（RESSS） was applied to self-assembly of liposomes entrapping hinesol...To improve the encapsulation efficiency and minimize particle agglomeration of liposomes, rapid expansion from supercritical to surfactant solution（RESSS） was applied to self-assembly of liposomes entrapping hinesol in supercritical carbon dioxide（SC-CO2） medium. In the process, the solution of liposomal materials and hinesol dissolved in the mixture of SC-CO2/ethanol was sprayed into a surfactant solution. The surfactant provided stabilization for liposomes by preventing bubbles overflowing and liposomes agglomeration during the spraying process. The encapsulating performance and particle size distribution of liposomes could be controlled by changing expansion processing conditions. When the solution was sprayed into a 5.0% Poloxamer 188 solution at a flow rate of 2 L/min, the entrapment efficiency and average particle size of liposomes were found to be 88.26% and 124 nm, respectively, which came to the standards of Chinese pharmacopoeia. The results show RESSS process provides an innovative method for formation of liposomes incorporating valid compositions extracted from the Chinese traditional medicines in SC-CO2 medium.展开更多
The magnetic interface forward and inversion method is realized using the Taylor series expansion to linearize the Fourier transform of the exponential function. With a large expansion step and unbounded neighborhood,...The magnetic interface forward and inversion method is realized using the Taylor series expansion to linearize the Fourier transform of the exponential function. With a large expansion step and unbounded neighborhood, the Taylor series is not convergent, and therefore, this paper presents the magnetic interface forward and inversion method based on Pade approximation instead of the Taylor series expansion. Compared with the Taylor series, Pade＇s expansion＇s convergence is more stable and its approximation more accurate. Model tests show the validity of the magnetic forward modeling and inversion of Pade approximation proposed in the paper, and when this inversion method is applied to the measured data of the Matagami area in Canada, a stable and reasonable distribution of underground interface is obtained.展开更多
基金Supported by the National Natural Science Foundation of China(No.20606013)the Produce-learn-research Project of Shenzhen Scinence and Technology Program(No.2008342)the Fundamental Research Project of Shenzhen Science and Technology, China(No.JC200903120089A)
文摘To improve the encapsulation efficiency and minimize particle agglomeration of liposomes, rapid expansion from supercritical to surfactant solution（RESSS） was applied to self-assembly of liposomes entrapping hinesol in supercritical carbon dioxide（SC-CO2） medium. In the process, the solution of liposomal materials and hinesol dissolved in the mixture of SC-CO2/ethanol was sprayed into a surfactant solution. The surfactant provided stabilization for liposomes by preventing bubbles overflowing and liposomes agglomeration during the spraying process. The encapsulating performance and particle size distribution of liposomes could be controlled by changing expansion processing conditions. When the solution was sprayed into a 5.0% Poloxamer 188 solution at a flow rate of 2 L/min, the entrapment efficiency and average particle size of liposomes were found to be 88.26% and 124 nm, respectively, which came to the standards of Chinese pharmacopoeia. The results show RESSS process provides an innovative method for formation of liposomes incorporating valid compositions extracted from the Chinese traditional medicines in SC-CO2 medium.
基金supported by Sino Probe-09-01-Integrated geophysical data processing and integrated system for moving platform(No.201311192)Graduate innovation fund of Jilin University(No.2015025)
文摘The magnetic interface forward and inversion method is realized using the Taylor series expansion to linearize the Fourier transform of the exponential function. With a large expansion step and unbounded neighborhood, the Taylor series is not convergent, and therefore, this paper presents the magnetic interface forward and inversion method based on Pade approximation instead of the Taylor series expansion. Compared with the Taylor series, Pade＇s expansion＇s convergence is more stable and its approximation more accurate. Model tests show the validity of the magnetic forward modeling and inversion of Pade approximation proposed in the paper, and when this inversion method is applied to the measured data of the Matagami area in Canada, a stable and reasonable distribution of underground interface is obtained.
