Qinghai Lake is the largest saline lake in China.The change in the lake volume is an indicator of the variation in water resources and their response to climate change on the Qinghai-Tibetan Plateau(QTP)in China.The p...Qinghai Lake is the largest saline lake in China.The change in the lake volume is an indicator of the variation in water resources and their response to climate change on the Qinghai-Tibetan Plateau(QTP)in China.The present study quantitatively evaluated the effects of climate change and land use/cover change(LUCC)on the lake volume of the Qinghai Lake in China from 1958 to 2018,which is crucial for water resources management in the Qinghai Lake Basin.To explore the effects of climate change and LUCC on the Qinghai Lake volume,we analyzed the lake level observation data and multi-period land use/land cover(LULC)data by using an improved lake volume estimation method and Integrated Valuation of Ecosystem Services and Trade-offs(InVEST)model.Our results showed that the lake level decreased at the rate of 0.08 m/a from 1958 to 2004 and increased at the rate of 0.16 m/a from 2004 to 2018.The lake volume decreased by 105.40×10^(8) m^(3) from 1958 to 2004,with the rate of 2.24×10^(8) m^(3)/a,whereas it increased by 74.02×10^(8) m^(3) from 2004 to 2018,with the rate of 4.66×10^(8) m^(3)/a.Further,the climate of the Qinghai Lake Basin changed from warm-dry to warm-humid.From 1958 to 2018,the increase in precipitation and the decrease in evaporation controlled the change of the lake volume,which were the main climatic factors affecting the lake volume change.From 1977 to 2018,the measured water yield showed an"increase-decrease-increase"fluctuation in the Qinghai Lake Basin.The effects of climate change and LUCC on the measured water yield were obviously different.From 1977 to 2018,the contribution rate of LUCC was -0.76% and that of climate change was 100.76%;the corresponding rates were 8.57% and 91.43% from 1977 to 2004,respectively,and -4.25% and 104.25% from 2004 to 2018,respectively.Quantitative analysis of the effects and contribution rates of climate change and LUCC on the Qinghai Lake volume revealed the scientific significance of climate change and LUCC,as well as their individual and combined effects in the Qinghai Lake Basin and on the QTP.This study can contribute to the water resources management and regional sustainable development of the Qinghai Lake Basin.展开更多
以前期制备的Lactobacillus plantarum JLAU103胞外多糖(exopolysaccharide,EPS)为原料,将其按不同比例与鱼明胶(fish gelatin,FG)混合添加到低脂酸奶中,研究其对低脂酸奶品质特性的改善作用。结果表明:添加0.1%(m/m)EPS和0.6%(m/m)FG...以前期制备的Lactobacillus plantarum JLAU103胞外多糖(exopolysaccharide,EPS)为原料,将其按不同比例与鱼明胶(fish gelatin,FG)混合添加到低脂酸奶中,研究其对低脂酸奶品质特性的改善作用。结果表明:添加0.1%(m/m)EPS和0.6%(m/m)FG可提高低脂酸奶的持水力和pH值,降低滴定酸度,黏度趋于正常酸奶;使低脂酸奶的蛋白网状结构空隙变小,结构更加紧密。与低脂酸奶相比,0.6%FG+0.1%EPS组低脂酸奶的活菌数得到显著提升(P<0.05),达到8.40×10^(8)CFU/mL;特征挥发性风味物质如双乙酰、2-壬酮、2,3-戊二酮等含量明显增多,感官评分较高,且质构得到显著改善。流变学结果表明,添加EPS减小了低脂酸奶的触变环面积,增强了稳定性和总应变,使低脂酸奶形成更牢固的凝胶网络。因此,L.plantarum JLAU103 EPS与FG联合使用能够明显改善低脂酸奶的品质,具有很好的应用前景。展开更多
目的 富含半胱氨酸的酸性分泌蛋白(secreted protein acidic and rich in cysteine, SPARC),也称为骨粘连蛋白(osteonectin)及基底膜-40(BM-40),是一种与细胞分泌有关的小分子糖蛋白。在多种恶性肿瘤中发现SPARC发挥着促进肿瘤侵袭与转...目的 富含半胱氨酸的酸性分泌蛋白(secreted protein acidic and rich in cysteine, SPARC),也称为骨粘连蛋白(osteonectin)及基底膜-40(BM-40),是一种与细胞分泌有关的小分子糖蛋白。在多种恶性肿瘤中发现SPARC发挥着促进肿瘤侵袭与转移的作用,且与肿瘤患者预后不佳有关。目前SPARC在非小细胞肺癌(non-small-cell lung cancer,NSCLC)中的预后作用仍有争议,故本研究采用meta分析的方法评估SPARC在NSCLC患者中的表达水平及与预后的关系。方法 本研究通过对PubMed、Web of Science、EMBASE、Cochrane Library、中国知网(CNKI)、万方数据库进行全面检索,收集纳入研究SPARC表达水平与NSCLC患者预后关系的文献及相关数据,采用Review Manager 5.4软件进行数据分析,计算危险比(hazard ratio,HR)及95%置信区间(CI)以评估SPARC表达与NSCLC患者总生存期(overall survival, OS)的关系。结果 总共纳入5项研究,共计430例患者,对这些研究进行异质性检验(I2=31%,P=0.21),采用固定效应模型进行数据合并的HR值为1.77,95%可信区间为1.41~2.21,表明SPARC高水平表达与NSCLC患者较差的OS相关。针对SPARC是否有甲基化进行了亚组分析,结果显示在无甲基化的各研究中无异质性(I2=0%,P=0.89),合并的HR值为1.97,95%CI为1.40-2.79,有甲基化的各研究中有明显的异质性(I2=80%,P=0.03),合并的HR值为1.63,95%CI为1.21-2.19,表明SPARC的预后意义因是否有甲基化而改变。结论 SPARC高表达是非小细胞肺癌患者预后不良的一个指标,可作为评估非小细胞肺癌患者预后的潜在生物标记物。展开更多
目的观察肝豆灵片联合推拿手法治疗痰瘀互结型肝豆状核变性(WD)肌张力障碍的临床疗效。方法选取于2021年9月-2023年2月安徽中医药大学第一附属医院脑病科住院治疗的肌张力障碍的痰瘀互结型WD患者40例,随机分为对照组和观察组,每组各20...目的观察肝豆灵片联合推拿手法治疗痰瘀互结型肝豆状核变性(WD)肌张力障碍的临床疗效。方法选取于2021年9月-2023年2月安徽中医药大学第一附属医院脑病科住院治疗的肌张力障碍的痰瘀互结型WD患者40例,随机分为对照组和观察组,每组各20例。对照组采用二巯丙磺酸钠祛铜联合推拿手法治疗,观察组在对照组的基础上加用肝豆灵片治疗,8 d 1个疗程,共治疗4个疗程。治疗前后采用日常生活能力量表(ADL)、改良Ashworth肌张力分级评分、中医证候积分、有效率评价两组治疗效果。结果治疗后两组ADL量表评分均高于治疗前(P<0.01),改良Ashworth肌张力分级评分、中医证候积分均低于治疗前(P<0.01),观察组治疗后ADL量表评分高于对照组(P<0.01),Ashworth肌张力分级评分低于对照组(P<0.05),中医证候分低于对照组(P<0.01),观察组临床疗效高于对照组,差异无统计学意义(P>0.05)。结论肝豆灵片联合推拿手法可有效改善痰瘀互结型WD患者肌张力障碍,提高患者的生活质量,为临床治疗带来新思路。展开更多
Cucumber is an important vegetable worldwide,and powdery mildew(PM)is a common and serious disease of cucumbers.Breeding disease-resistant cucumber varieties is the most advantageous strategy to control this disease.I...Cucumber is an important vegetable worldwide,and powdery mildew(PM)is a common and serious disease of cucumbers.Breeding disease-resistant cucumber varieties is the most advantageous strategy to control this disease.In recent years,exploration and identification of cucumber PM resistance genes have achieved great advancement,and many genes have been cloned and verified using different methods.However,the resistance mechanism of cucumber PM is still unclear,and many ambiguities need to be elucidated urgently.In this review,we summarized the research advances in PM resistance in cucumbers,including genetic analysis,quantitative trait locus mapping,map-based cloning,transcriptomics,mlo-mediated PM resistance,and mining of noncoding RNAs involved in resistance.Finally,the research directions and the problems that need to be solved in the future were discussed.展开更多
基金funded by the Strategic Priority Research Program of the Chinese Academy of Sciences(XDA20100101)the National Key Research and Development Program of China(2019YFC0507404)the Gansu Province Science Foundation for Youth,China(20JR5RA543).
文摘Qinghai Lake is the largest saline lake in China.The change in the lake volume is an indicator of the variation in water resources and their response to climate change on the Qinghai-Tibetan Plateau(QTP)in China.The present study quantitatively evaluated the effects of climate change and land use/cover change(LUCC)on the lake volume of the Qinghai Lake in China from 1958 to 2018,which is crucial for water resources management in the Qinghai Lake Basin.To explore the effects of climate change and LUCC on the Qinghai Lake volume,we analyzed the lake level observation data and multi-period land use/land cover(LULC)data by using an improved lake volume estimation method and Integrated Valuation of Ecosystem Services and Trade-offs(InVEST)model.Our results showed that the lake level decreased at the rate of 0.08 m/a from 1958 to 2004 and increased at the rate of 0.16 m/a from 2004 to 2018.The lake volume decreased by 105.40×10^(8) m^(3) from 1958 to 2004,with the rate of 2.24×10^(8) m^(3)/a,whereas it increased by 74.02×10^(8) m^(3) from 2004 to 2018,with the rate of 4.66×10^(8) m^(3)/a.Further,the climate of the Qinghai Lake Basin changed from warm-dry to warm-humid.From 1958 to 2018,the increase in precipitation and the decrease in evaporation controlled the change of the lake volume,which were the main climatic factors affecting the lake volume change.From 1977 to 2018,the measured water yield showed an"increase-decrease-increase"fluctuation in the Qinghai Lake Basin.The effects of climate change and LUCC on the measured water yield were obviously different.From 1977 to 2018,the contribution rate of LUCC was -0.76% and that of climate change was 100.76%;the corresponding rates were 8.57% and 91.43% from 1977 to 2004,respectively,and -4.25% and 104.25% from 2004 to 2018,respectively.Quantitative analysis of the effects and contribution rates of climate change and LUCC on the Qinghai Lake volume revealed the scientific significance of climate change and LUCC,as well as their individual and combined effects in the Qinghai Lake Basin and on the QTP.This study can contribute to the water resources management and regional sustainable development of the Qinghai Lake Basin.
文摘目的观察肝豆灵片联合推拿手法治疗痰瘀互结型肝豆状核变性(WD)肌张力障碍的临床疗效。方法选取于2021年9月-2023年2月安徽中医药大学第一附属医院脑病科住院治疗的肌张力障碍的痰瘀互结型WD患者40例,随机分为对照组和观察组,每组各20例。对照组采用二巯丙磺酸钠祛铜联合推拿手法治疗,观察组在对照组的基础上加用肝豆灵片治疗,8 d 1个疗程,共治疗4个疗程。治疗前后采用日常生活能力量表(ADL)、改良Ashworth肌张力分级评分、中医证候积分、有效率评价两组治疗效果。结果治疗后两组ADL量表评分均高于治疗前(P<0.01),改良Ashworth肌张力分级评分、中医证候积分均低于治疗前(P<0.01),观察组治疗后ADL量表评分高于对照组(P<0.01),Ashworth肌张力分级评分低于对照组(P<0.05),中医证候分低于对照组(P<0.01),观察组临床疗效高于对照组,差异无统计学意义(P>0.05)。结论肝豆灵片联合推拿手法可有效改善痰瘀互结型WD患者肌张力障碍,提高患者的生活质量,为临床治疗带来新思路。
基金supported by the National Natural Science Foundation of China(Grant No.31701915)Zhejiang Province Public Welfare Technology Application Research Project(Grant No.LGN19C150007).
文摘Cucumber is an important vegetable worldwide,and powdery mildew(PM)is a common and serious disease of cucumbers.Breeding disease-resistant cucumber varieties is the most advantageous strategy to control this disease.In recent years,exploration and identification of cucumber PM resistance genes have achieved great advancement,and many genes have been cloned and verified using different methods.However,the resistance mechanism of cucumber PM is still unclear,and many ambiguities need to be elucidated urgently.In this review,we summarized the research advances in PM resistance in cucumbers,including genetic analysis,quantitative trait locus mapping,map-based cloning,transcriptomics,mlo-mediated PM resistance,and mining of noncoding RNAs involved in resistance.Finally,the research directions and the problems that need to be solved in the future were discussed.
