[目的]掌握鄂尔多斯市女性高危型人乳头瘤病毒(high-risk human papillomavirus,hrHPV)感染情况和宫颈癌及癌前病变检出情况,并探讨宫颈癌及癌前病变的危险因素。[方法]数据来源于鄂尔多斯市2016―2020年开展的宫颈癌筛查项目。分析35~6...[目的]掌握鄂尔多斯市女性高危型人乳头瘤病毒(high-risk human papillomavirus,hrHPV)感染情况和宫颈癌及癌前病变检出情况,并探讨宫颈癌及癌前病变的危险因素。[方法]数据来源于鄂尔多斯市2016―2020年开展的宫颈癌筛查项目。分析35~64岁女性的hrHPV感染率和宫颈癌及癌前病变检出率情况。同时以825例宫颈上皮内瘤样病变2级以上(CIN2+)为病例组,按照年龄不超过2岁从同旗区同年参与筛查未被诊断为CIN2+的女性中选取825例对照,分析宫颈癌及癌前病变的危险因素。[结果]研究纳入187 863名女性进行分析,hrHPV感染率为12.81%,hrHPV感染率随年龄增大而增加(线性趋势χ2=155.787,P<0.001)。宫颈癌检出率为37.79/10万,宫颈癌癌前病变检出率为401.36/10万,早诊率为93.45%,宫颈癌癌前病变和宫颈癌检出率分别在40~44岁和60~64岁年龄组最高,不同年龄组间差异有统计学意义(P值均<0.001)。影响因素分析结果显示hrHPV感染为宫颈癌及癌前病变发生的危险因素(OR=374.442,95%CI:90.718~1 545.534),而受教育程度高(OR=0.251,95%CI:0.092~0.683)为保护因素。[结论]鄂尔多斯市宫颈癌癌前病变、宫颈癌检出率及早诊率较高,显示出鄂尔多斯宫颈癌筛查工作成效显著。未来开展工作时,应格外注重40~44岁女性的筛查,以实现早诊早治的目的;积极鼓励适龄女性及早接种HPV疫苗;加强对女性,特别是低文化程度以及老年女性宫颈癌相关知识的宣传教育,提升其健康意识,促使其主动参与宫颈癌筛查。展开更多
Background Standardized screening tools for Parkinson syndrome have not been developed for non-westem populations. This study aimed to validate the Copiah County questionnaire （CCQ） as a screening instrument in a Ch...Background Standardized screening tools for Parkinson syndrome have not been developed for non-westem populations. This study aimed to validate the Copiah County questionnaire （CCQ） as a screening instrument in a Chinese rural population. Methods All participants of a previously reported prevalent study were interviewed using CCQ. The participants who answered yes to at least one item on CCQ were defined as positive. The Parkinson＇s disease （PD） diagnosis was established using United Kingdom Parkinson＇s disease Brain Bank Clinical diagnosis criteria （UKPDBBC） and served as a gold standard to determine the sensitivity, specificity, and positive and negative predictive values （PPV, NPV） for the questionnaire. Results Among 16 130 participants, 2872 （17.8%） were screened positive for CCQ and 13 258 negative （82.2%）. Among the 697 participants diagnosed as having Parkinson syndrome, 605 were positive for CCQ, and 92 were negative, leading to a sensitivity of 86.8%. Out of the 15 433 non-Parkinson syndrome participants, 13 166 were negative to CCQ, giving a specificity of 85.3%. Among the 2872 participants screened positive, 605 were diagnosed with Parkinson syndrome, and their PPV was 21.1%. For the 13 258 participants screened negative on CCQ, 92 were diagnosed with Parkinson syndrome and 13 166 did not have Parkinson syndrome, leading to a NPV of 99.3%. Conclusions CCQ appeared to have satisfactory statistical parameters to serve as a screening instrument for Parkinson syndrome in this rural Chinese population. Further studies may prove the utility of this short questionnaire in Parkinson syndrome screening among Chinese populations including those residing in rural areas.展开更多
文摘[目的]掌握鄂尔多斯市女性高危型人乳头瘤病毒(high-risk human papillomavirus,hrHPV)感染情况和宫颈癌及癌前病变检出情况,并探讨宫颈癌及癌前病变的危险因素。[方法]数据来源于鄂尔多斯市2016―2020年开展的宫颈癌筛查项目。分析35~64岁女性的hrHPV感染率和宫颈癌及癌前病变检出率情况。同时以825例宫颈上皮内瘤样病变2级以上(CIN2+)为病例组,按照年龄不超过2岁从同旗区同年参与筛查未被诊断为CIN2+的女性中选取825例对照,分析宫颈癌及癌前病变的危险因素。[结果]研究纳入187 863名女性进行分析,hrHPV感染率为12.81%,hrHPV感染率随年龄增大而增加(线性趋势χ2=155.787,P<0.001)。宫颈癌检出率为37.79/10万,宫颈癌癌前病变检出率为401.36/10万,早诊率为93.45%,宫颈癌癌前病变和宫颈癌检出率分别在40~44岁和60~64岁年龄组最高,不同年龄组间差异有统计学意义(P值均<0.001)。影响因素分析结果显示hrHPV感染为宫颈癌及癌前病变发生的危险因素(OR=374.442,95%CI:90.718~1 545.534),而受教育程度高(OR=0.251,95%CI:0.092~0.683)为保护因素。[结论]鄂尔多斯市宫颈癌癌前病变、宫颈癌检出率及早诊率较高,显示出鄂尔多斯宫颈癌筛查工作成效显著。未来开展工作时,应格外注重40~44岁女性的筛查,以实现早诊早治的目的;积极鼓励适龄女性及早接种HPV疫苗;加强对女性,特别是低文化程度以及老年女性宫颈癌相关知识的宣传教育,提升其健康意识,促使其主动参与宫颈癌筛查。
文摘Background Standardized screening tools for Parkinson syndrome have not been developed for non-westem populations. This study aimed to validate the Copiah County questionnaire （CCQ） as a screening instrument in a Chinese rural population. Methods All participants of a previously reported prevalent study were interviewed using CCQ. The participants who answered yes to at least one item on CCQ were defined as positive. The Parkinson＇s disease （PD） diagnosis was established using United Kingdom Parkinson＇s disease Brain Bank Clinical diagnosis criteria （UKPDBBC） and served as a gold standard to determine the sensitivity, specificity, and positive and negative predictive values （PPV, NPV） for the questionnaire. Results Among 16 130 participants, 2872 （17.8%） were screened positive for CCQ and 13 258 negative （82.2%）. Among the 697 participants diagnosed as having Parkinson syndrome, 605 were positive for CCQ, and 92 were negative, leading to a sensitivity of 86.8%. Out of the 15 433 non-Parkinson syndrome participants, 13 166 were negative to CCQ, giving a specificity of 85.3%. Among the 2872 participants screened positive, 605 were diagnosed with Parkinson syndrome, and their PPV was 21.1%. For the 13 258 participants screened negative on CCQ, 92 were diagnosed with Parkinson syndrome and 13 166 did not have Parkinson syndrome, leading to a NPV of 99.3%. Conclusions CCQ appeared to have satisfactory statistical parameters to serve as a screening instrument for Parkinson syndrome in this rural Chinese population. Further studies may prove the utility of this short questionnaire in Parkinson syndrome screening among Chinese populations including those residing in rural areas.
