目的探讨自拟冰砂止痛酊外用辅助阿片类药物治疗癌性疼痛的临床疗效。方法采用随机数字表法将120例中重度癌性疼痛患者分为对照组和研究组各60例。在常规治疗基础上,研究组予自拟冰砂止痛酊,对照组予安慰剂,均每6 h 1次,涂擦痛处。2组...目的探讨自拟冰砂止痛酊外用辅助阿片类药物治疗癌性疼痛的临床疗效。方法采用随机数字表法将120例中重度癌性疼痛患者分为对照组和研究组各60例。在常规治疗基础上,研究组予自拟冰砂止痛酊,对照组予安慰剂,均每6 h 1次,涂擦痛处。2组疗程均14 d。观察2组临床疗效,比较2组疼痛数字评分法(NRS)评分、匹兹堡睡眠质量指数(PSQI)、焦虑自评量表(SAS)评分、抑郁自评量表(SDS)评分、癌症患者生活质量问卷评分,监测2组不良反应。结果研究组总有效率为90.0%(54/60),对照组为75.0%(45/60),2组比较差异有统计学意义(P<0.05)。与本组治疗前比较,2组治疗7、14 d NRS、PSQI、SAS、SDS评分明显下降(P<0.05);2组治疗同一时点比较,研究组治疗7、14 d NRS、PSQI、SAS、SDS评分明显低于对照组(P<0.05)。与本组治疗前比较,2组治疗后总体生命质量、躯体功能、角色功能、认知功能、情感功能、社会功能评分明显升高(P<0.05);研究组治疗后上述评分明显高于对照组(P<0.05)。2组不良反应比较差异无统计学意义(P>0.05)。结论自拟冰砂止痛酊外用辅助阿片类药物治疗癌性疼痛具有较好的镇痛效果,可改善患者焦虑、抑郁情绪及生活质量。展开更多
Rotational energy is a type of common energy source that can be harvested for supplying low-powered electronic devices.This paper proposes and investigates a novel cam-like dielectric elastomer generator(CDEG)for high...Rotational energy is a type of common energy source that can be harvested for supplying low-powered electronic devices.This paper proposes and investigates a novel cam-like dielectric elastomer generator(CDEG)for high-performance rotational energy harvesting.A mushroom-head clamp is designed to form a type of advanced conical dielectric elastomer membranes(DEMs).Moreover,a type of multi-protrusion cam mechanism is designed in the CDEG to effectively convert any external rotational excitation into a linear reciprocating motion,which can be further converted into electricity through the DEMs.First,the operating principle of the system under external rotational excitation is analyzed theoretically by deducing the deformation condition of the DEMs and the electrical output of the system.Second,the prototype is fabricated,and the rotational-to-linear motion conversion rule of its cam-like mechanism and the DEM capacitance calculation approach are validated.The experimental results show that adequate charging time and discharging time of the DEMs,which can be realized through the proposed cam-like mechanisms,are beneficial to the energy harvesting(EH)performance of the system.Third,with the validated theoretical model,numerical simulations are conducted to further study the system dynamics and the influences of important system parameters on the EH performance to provide a guideline for system improvement.Finally,the genetic algorithm is adopted to obtain the optimal system parameters and the corresponding electrical output of the proposed CDEG,demonstrating its superior output power at ultralow rotational frequencies compared with other typical rotational energy harvesters in the literature.展开更多
文摘目的探讨自拟冰砂止痛酊外用辅助阿片类药物治疗癌性疼痛的临床疗效。方法采用随机数字表法将120例中重度癌性疼痛患者分为对照组和研究组各60例。在常规治疗基础上,研究组予自拟冰砂止痛酊,对照组予安慰剂,均每6 h 1次,涂擦痛处。2组疗程均14 d。观察2组临床疗效,比较2组疼痛数字评分法(NRS)评分、匹兹堡睡眠质量指数(PSQI)、焦虑自评量表(SAS)评分、抑郁自评量表(SDS)评分、癌症患者生活质量问卷评分,监测2组不良反应。结果研究组总有效率为90.0%(54/60),对照组为75.0%(45/60),2组比较差异有统计学意义(P<0.05)。与本组治疗前比较,2组治疗7、14 d NRS、PSQI、SAS、SDS评分明显下降(P<0.05);2组治疗同一时点比较,研究组治疗7、14 d NRS、PSQI、SAS、SDS评分明显低于对照组(P<0.05)。与本组治疗前比较,2组治疗后总体生命质量、躯体功能、角色功能、认知功能、情感功能、社会功能评分明显升高(P<0.05);研究组治疗后上述评分明显高于对照组(P<0.05)。2组不良反应比较差异无统计学意义(P>0.05)。结论自拟冰砂止痛酊外用辅助阿片类药物治疗癌性疼痛具有较好的镇痛效果,可改善患者焦虑、抑郁情绪及生活质量。
基金supported by the National Natural Science Foundation of China(Grant Nos.52205114,51905349,U2013603)Guangdong Basic and Applied Basic Research Foundation(Grant Nos.2022A1515010126,2023A1515012921,2020A1515011509)+1 种基金Excellent Science and Technology Creative Talent Training Program of Shenzhen,China(Grant No.RCBS20221008093252089)Shenzhen Natural Science Fund(the Stable Support Plan Program 20220809181431001)。
文摘Rotational energy is a type of common energy source that can be harvested for supplying low-powered electronic devices.This paper proposes and investigates a novel cam-like dielectric elastomer generator(CDEG)for high-performance rotational energy harvesting.A mushroom-head clamp is designed to form a type of advanced conical dielectric elastomer membranes(DEMs).Moreover,a type of multi-protrusion cam mechanism is designed in the CDEG to effectively convert any external rotational excitation into a linear reciprocating motion,which can be further converted into electricity through the DEMs.First,the operating principle of the system under external rotational excitation is analyzed theoretically by deducing the deformation condition of the DEMs and the electrical output of the system.Second,the prototype is fabricated,and the rotational-to-linear motion conversion rule of its cam-like mechanism and the DEM capacitance calculation approach are validated.The experimental results show that adequate charging time and discharging time of the DEMs,which can be realized through the proposed cam-like mechanisms,are beneficial to the energy harvesting(EH)performance of the system.Third,with the validated theoretical model,numerical simulations are conducted to further study the system dynamics and the influences of important system parameters on the EH performance to provide a guideline for system improvement.Finally,the genetic algorithm is adopted to obtain the optimal system parameters and the corresponding electrical output of the proposed CDEG,demonstrating its superior output power at ultralow rotational frequencies compared with other typical rotational energy harvesters in the literature.
