Pjridine has been generally synthesized by aldehydes and ammonia in a turbulent fluidized-bed reactor. In this paper, a novel riser reactor was proposed for pyridine synthesis. Experiment result showed that the yield ...Pjridine has been generally synthesized by aldehydes and ammonia in a turbulent fluidized-bed reactor. In this paper, a novel riser reactor was proposed for pyridine synthesis. Experiment result showed that the yield of pyridine and 3-picoline decreased, but the selectivity of pyridine over 3-picoline increased compared to turbulent fluidized-bed reactor. Based on experimental data, a modified kinetic model was used for the determination of optimal operating condition for riser reactor. The optimal operating condition of riser reactor given by this modified model was as follows： The reaction temperature of 755 K, catalyst to feedstock ratio （CTFR） of 87, residence timeof3.8sandinitialacetaldehydesconcentrationof0.0029mol.L-1 （acetaldehydes to formaldehydes ratio by mole （ATFR） of 0.65 and ammonia to aldehydes ratio by mole （ATAR） of 0.9, water contention of 63wt% （formaldehyde solution））.展开更多
Objective: To explore the demographic and disease-related factors associated with acupuncture response in patients with chronic tension-type headache(CTTH). Methods: Using data from the randomized clinical trial(218 c...Objective: To explore the demographic and disease-related factors associated with acupuncture response in patients with chronic tension-type headache(CTTH). Methods: Using data from the randomized clinical trial(218 cases) consisting of 4 weeks of baseline assessment, 8 weeks of treatment, and 24 weeks of follow-up, participants were regrouped into responders(at least a 50% reduction in monthly headache days at week 16 compared with baseline) and non-responders. Twenty-three demographic and disease-related factors associated with acupuncture response in 183 participants were analyzed by multivariable logistic regression. Results: One hundred and nineteen(65.0%) participants were classified as responders. Four factors were significantly independently associated with acupuncture response, including treatment assignment, headache intensity at baseline, and 2 domains [general health(GH) and social functioning(SF)] from the 36-Item Short Form Health Survey quality of life questionnaire. Treatment assignment was associated with nonresponse: participants receiving true acupuncture were 3-time more likely to achieve a CTTH response than those receiving superficial acupuncture [odds ratio(OR) 0.322, 95% confidence interval(CI) 0.162 to 0.625, P=0.001]. Compared with patients with mild-intensity headache, patients with moderate-intensity headache were twice as likely to respond to acupuncture(OR 2.001, 95% CI 1.020 to 4.011, P=0.046). The likelihood of non-response increased by 4.5% with each unit increase in the GH grade(OR 0.955, 95% CI 0.917 to 0.993, P=0.024) while decreased by 3.8% with each unit increase in the SF grade(OR 1.038, 95% CI 1.009 to 1.069, P=0.011). Conclusions: Greater headache intensity, lower GH score, and higher SF score were associated with better acupuncture responses in CTTH patients. These 3 factors require independent validation as predictors of acupuncture effectiveness in CTTH.展开更多
目的了解湖南省首例猪链球菌14型菌株的生物学性状及病原学特征。方法采集患者的关节液接种到血琼脂平板,进行猪链球菌的分离培养,通过镜检、生化和血清凝集试验确认后,用聚合酶链反应(PCR)检测猪链球菌种特异性基因(16 S rRNA)、2型荚...目的了解湖南省首例猪链球菌14型菌株的生物学性状及病原学特征。方法采集患者的关节液接种到血琼脂平板,进行猪链球菌的分离培养,通过镜检、生化和血清凝集试验确认后,用聚合酶链反应(PCR)检测猪链球菌种特异性基因(16 S rRNA)、2型荚膜多糖基因(cps2 J)、14型荚膜多糖基因(cps14 J)以及相关毒力基因:溶菌酶释放相关蛋白(mrp)、溶血素(sly)、纤粘连蛋白结合蛋白(fbps)、胞外因子(ef)、谷氨酸脱氢酶(gdh)、毒力相关序列orf2基因(orf2)和甘油醛一3一磷酸脱氢酶的编码基因(gapdh)。结果患者的关节液中分离到猪链球菌14型菌株,种特异性基因16 S rRNA阳性,荚膜多糖基因cps2 J阴性、cps14 J阳性,毒力基因mrp阴性,其余sly、fbps、ef、gdh、orf2、gapdh均为阳性。结论湖南省已经出现了猪链球菌14型的流行,并携带多种毒力基因,需密切关注其流行趋势。展开更多
基金Supported by the National Basic Research Program of China(973 Program,2012CB215000)
文摘Pjridine has been generally synthesized by aldehydes and ammonia in a turbulent fluidized-bed reactor. In this paper, a novel riser reactor was proposed for pyridine synthesis. Experiment result showed that the yield of pyridine and 3-picoline decreased, but the selectivity of pyridine over 3-picoline increased compared to turbulent fluidized-bed reactor. Based on experimental data, a modified kinetic model was used for the determination of optimal operating condition for riser reactor. The optimal operating condition of riser reactor given by this modified model was as follows： The reaction temperature of 755 K, catalyst to feedstock ratio （CTFR） of 87, residence timeof3.8sandinitialacetaldehydesconcentrationof0.0029mol.L-1 （acetaldehydes to formaldehydes ratio by mole （ATFR） of 0.65 and ammonia to aldehydes ratio by mole （ATAR） of 0.9, water contention of 63wt% （formaldehyde solution））.
基金Supported by the International Cooperation Program of Science and Technology Department of Sichuan Province,China(No.2016HH0007)。
文摘Objective: To explore the demographic and disease-related factors associated with acupuncture response in patients with chronic tension-type headache(CTTH). Methods: Using data from the randomized clinical trial(218 cases) consisting of 4 weeks of baseline assessment, 8 weeks of treatment, and 24 weeks of follow-up, participants were regrouped into responders(at least a 50% reduction in monthly headache days at week 16 compared with baseline) and non-responders. Twenty-three demographic and disease-related factors associated with acupuncture response in 183 participants were analyzed by multivariable logistic regression. Results: One hundred and nineteen(65.0%) participants were classified as responders. Four factors were significantly independently associated with acupuncture response, including treatment assignment, headache intensity at baseline, and 2 domains [general health(GH) and social functioning(SF)] from the 36-Item Short Form Health Survey quality of life questionnaire. Treatment assignment was associated with nonresponse: participants receiving true acupuncture were 3-time more likely to achieve a CTTH response than those receiving superficial acupuncture [odds ratio(OR) 0.322, 95% confidence interval(CI) 0.162 to 0.625, P=0.001]. Compared with patients with mild-intensity headache, patients with moderate-intensity headache were twice as likely to respond to acupuncture(OR 2.001, 95% CI 1.020 to 4.011, P=0.046). The likelihood of non-response increased by 4.5% with each unit increase in the GH grade(OR 0.955, 95% CI 0.917 to 0.993, P=0.024) while decreased by 3.8% with each unit increase in the SF grade(OR 1.038, 95% CI 1.009 to 1.069, P=0.011). Conclusions: Greater headache intensity, lower GH score, and higher SF score were associated with better acupuncture responses in CTTH patients. These 3 factors require independent validation as predictors of acupuncture effectiveness in CTTH.
文摘目的了解湖南省首例猪链球菌14型菌株的生物学性状及病原学特征。方法采集患者的关节液接种到血琼脂平板,进行猪链球菌的分离培养,通过镜检、生化和血清凝集试验确认后,用聚合酶链反应(PCR)检测猪链球菌种特异性基因(16 S rRNA)、2型荚膜多糖基因(cps2 J)、14型荚膜多糖基因(cps14 J)以及相关毒力基因:溶菌酶释放相关蛋白(mrp)、溶血素(sly)、纤粘连蛋白结合蛋白(fbps)、胞外因子(ef)、谷氨酸脱氢酶(gdh)、毒力相关序列orf2基因(orf2)和甘油醛一3一磷酸脱氢酶的编码基因(gapdh)。结果患者的关节液中分离到猪链球菌14型菌株,种特异性基因16 S rRNA阳性,荚膜多糖基因cps2 J阴性、cps14 J阳性,毒力基因mrp阴性,其余sly、fbps、ef、gdh、orf2、gapdh均为阳性。结论湖南省已经出现了猪链球菌14型的流行,并携带多种毒力基因,需密切关注其流行趋势。
