目的:比较Ⅲ-Ⅳ期卵巢癌(International Federation of Gynecology and Obstetrics,FIGO)新辅助化疗(neoadjuvant chemotherapy,NACT)联合间隔减瘤手术与初始肿瘤细胞减灭术(primary debulking surgery,PDS)联合化疗两种治疗模式有效性...目的:比较Ⅲ-Ⅳ期卵巢癌(International Federation of Gynecology and Obstetrics,FIGO)新辅助化疗(neoadjuvant chemotherapy,NACT)联合间隔减瘤手术与初始肿瘤细胞减灭术(primary debulking surgery,PDS)联合化疗两种治疗模式有效性及安全性差异。方法:计算机检索Pubmed、Cochrane Library、Embase、Web of Science、中国生物医学文献数据库、万方数据库和中国知网等数据库,查找NACT对比PDS治疗Ⅲ-Ⅳ期卵巢癌随机对照研究相关文献,应用Review Manager 5.3软件进行统计分析。结果:纳入4项研究,共计1631例患者。NACT组与PDS组总生存期(HR=0.95,95%CI为0.84~1.07,P=0.38)和无进展生存期相似(HR=0.97,95%CI为0.88~1.08,P=0.61);NACT组肿瘤完整切除率较PDS组提高(RR=2.47,95%CI为1.50~4.05,P=0.0004)。在不良反应和安全性方面,NACT组患者≥3级静脉血栓发生率(RR=0.25,95%CI为0.10~0.62,P=0.003)、≥3级感染发生率(RR=0.30,95%CI为0.16~0.56,P=0.0002)和围手术期死亡率(RR=0.17,95%CI为0.06~0.48,P=0.0009)均降低。结论:在Ⅲ-Ⅳ期卵巢癌治疗中,两种治疗模式生存获益相当,但新辅助化疗联合间隔减瘤手术可以提高肿瘤完整切除率,具有更好的安全性。新辅助化疗联合间隔减瘤手术可作为Ⅲ-Ⅳ期卵巢癌患者一种推荐治疗方式。展开更多
目的:研究小核糖体核蛋白B(small nuclear ribonucleoprotein polypeptides B and B1,SNRPB)在乳腺癌中的表达及临床意义。方法:运用Oncomine数据库搜索乳腺癌与SNRPB基因相关的数据,通过Kaplan-Meier Plotter数据库分析SNRPB基因与乳...目的:研究小核糖体核蛋白B(small nuclear ribonucleoprotein polypeptides B and B1,SNRPB)在乳腺癌中的表达及临床意义。方法:运用Oncomine数据库搜索乳腺癌与SNRPB基因相关的数据,通过Kaplan-Meier Plotter数据库分析SNRPB基因与乳腺癌患者预后的关系。结果:Oncomine数据库中SNRPB基因癌组织/正常组织表达量分析结果共有414个,在癌组织中显著高表达109个,低表达3个。其中13个分析结果显示SNRPB在乳腺癌组织(包括6个侵袭性乳腺癌分析结果)中显著高表达,低表达的分析结果为1个。运用Kaplan-Meier Plotter数据库分析结果显示,高表达SNRPB的乳腺癌患者其总体生存率(OS)、无复发生存率(PFS)、无远处转移生存率(DMFS)显著低于低表达SNRPB的乳腺癌患者(P<0.05)。结论:SNRPB基因在乳腺癌中高表达,可以作为有效的生物标志物预测乳腺癌患者转移的发生及判断预后,可为乳腺癌的靶向治疗提供依据。展开更多
MgO- Mg2TiO4 composite was prepared by adding chemically pure TiO2（0,1%,2%,5% and 10%,in mass,the same hereinafter） to light-burned magnesia（particle size 〈0.045 mm）,ball milling,dry pressing,and reaction sinteri...MgO- Mg2TiO4 composite was prepared by adding chemically pure TiO2（0,1%,2%,5% and 10%,in mass,the same hereinafter） to light-burned magnesia（particle size 〈0.045 mm）,ball milling,dry pressing,and reaction sintering at 1 400,1 500 and 1 600 ℃ fo3 h,respectively. Apparent porosity,bulk density and corrosion resistance to AlF3- Na3AlF6- K3AlF6 were in vestigated. Phase composition and microstructure wer analyzed. The results show that：（1） MgO- Mg2TiO4 composite can be synthesized by reaction sintering; with TiO2 addition increasing from 0 to 5%,the specimen i denser obviously accompanying with more Mg2TiO4 form ing and MgO grains growing; the specimen with 10%TiO2obtains a slightly lower density than that with 5%TiO2due to larger volume expansion resulting from th formation of more Mg2TiO4;（2）with TiO2 addition in creasing from 0 to 5%,corrosion resistance to AlF3-Na3AlF6- K3AlF6 of the specimens improves gradually owing to the density increase and the Mg2TiO4 possessing good chemical stability distributing along periclas grains; compared with the specimen with 5% TiO2,tha with 10% TiO2 owns a little worse corrosion resistanc because of the lower density.展开更多
文摘目的:比较Ⅲ-Ⅳ期卵巢癌(International Federation of Gynecology and Obstetrics,FIGO)新辅助化疗(neoadjuvant chemotherapy,NACT)联合间隔减瘤手术与初始肿瘤细胞减灭术(primary debulking surgery,PDS)联合化疗两种治疗模式有效性及安全性差异。方法:计算机检索Pubmed、Cochrane Library、Embase、Web of Science、中国生物医学文献数据库、万方数据库和中国知网等数据库,查找NACT对比PDS治疗Ⅲ-Ⅳ期卵巢癌随机对照研究相关文献,应用Review Manager 5.3软件进行统计分析。结果:纳入4项研究,共计1631例患者。NACT组与PDS组总生存期(HR=0.95,95%CI为0.84~1.07,P=0.38)和无进展生存期相似(HR=0.97,95%CI为0.88~1.08,P=0.61);NACT组肿瘤完整切除率较PDS组提高(RR=2.47,95%CI为1.50~4.05,P=0.0004)。在不良反应和安全性方面,NACT组患者≥3级静脉血栓发生率(RR=0.25,95%CI为0.10~0.62,P=0.003)、≥3级感染发生率(RR=0.30,95%CI为0.16~0.56,P=0.0002)和围手术期死亡率(RR=0.17,95%CI为0.06~0.48,P=0.0009)均降低。结论:在Ⅲ-Ⅳ期卵巢癌治疗中,两种治疗模式生存获益相当,但新辅助化疗联合间隔减瘤手术可以提高肿瘤完整切除率,具有更好的安全性。新辅助化疗联合间隔减瘤手术可作为Ⅲ-Ⅳ期卵巢癌患者一种推荐治疗方式。
文摘目的:研究小核糖体核蛋白B(small nuclear ribonucleoprotein polypeptides B and B1,SNRPB)在乳腺癌中的表达及临床意义。方法:运用Oncomine数据库搜索乳腺癌与SNRPB基因相关的数据,通过Kaplan-Meier Plotter数据库分析SNRPB基因与乳腺癌患者预后的关系。结果:Oncomine数据库中SNRPB基因癌组织/正常组织表达量分析结果共有414个,在癌组织中显著高表达109个,低表达3个。其中13个分析结果显示SNRPB在乳腺癌组织(包括6个侵袭性乳腺癌分析结果)中显著高表达,低表达的分析结果为1个。运用Kaplan-Meier Plotter数据库分析结果显示,高表达SNRPB的乳腺癌患者其总体生存率(OS)、无复发生存率(PFS)、无远处转移生存率(DMFS)显著低于低表达SNRPB的乳腺癌患者(P<0.05)。结论:SNRPB基因在乳腺癌中高表达,可以作为有效的生物标志物预测乳腺癌患者转移的发生及判断预后,可为乳腺癌的靶向治疗提供依据。
文摘MgO- Mg2TiO4 composite was prepared by adding chemically pure TiO2（0,1%,2%,5% and 10%,in mass,the same hereinafter） to light-burned magnesia（particle size 〈0.045 mm）,ball milling,dry pressing,and reaction sintering at 1 400,1 500 and 1 600 ℃ fo3 h,respectively. Apparent porosity,bulk density and corrosion resistance to AlF3- Na3AlF6- K3AlF6 were in vestigated. Phase composition and microstructure wer analyzed. The results show that：（1） MgO- Mg2TiO4 composite can be synthesized by reaction sintering; with TiO2 addition increasing from 0 to 5%,the specimen i denser obviously accompanying with more Mg2TiO4 form ing and MgO grains growing; the specimen with 10%TiO2obtains a slightly lower density than that with 5%TiO2due to larger volume expansion resulting from th formation of more Mg2TiO4;（2）with TiO2 addition in creasing from 0 to 5%,corrosion resistance to AlF3-Na3AlF6- K3AlF6 of the specimens improves gradually owing to the density increase and the Mg2TiO4 possessing good chemical stability distributing along periclas grains; compared with the specimen with 5% TiO2,tha with 10% TiO2 owns a little worse corrosion resistanc because of the lower density.
