随着腹腔镜技术和设备的发展,微创技术在外科手术中的应用愈加广泛,腹腔镜全胃切除术(laparoscopic total gastrectomy,LTG)也得到了广泛开展。已有众多回顾性和队列研究结果显示,LTG与开腹全胃切除术比较,其具有创伤小、术后恢复快等优...随着腹腔镜技术和设备的发展,微创技术在外科手术中的应用愈加广泛,腹腔镜全胃切除术(laparoscopic total gastrectomy,LTG)也得到了广泛开展。已有众多回顾性和队列研究结果显示,LTG与开腹全胃切除术比较,其具有创伤小、术后恢复快等优势,且在安全性和近、远期疗效方面并不劣于开腹手术,但尚缺乏高级别循证依据。目前我国及日韩等胃癌高发国家正在进行多项前瞻性的多中心临床研究,以论证LTG的安全性及可行性,并评估其远期疗效。展开更多
Since first described in 1982,intraductal papillary mucinous neoplasm(IPMN)has been the preferred term to describe the proliferation of the pancreatic ductal epithelium.It is totally different from pancreatic carcinom...Since first described in 1982,intraductal papillary mucinous neoplasm(IPMN)has been the preferred term to describe the proliferation of the pancreatic ductal epithelium.It is totally different from pancreatic carcinoma in epi demiology,histology,pathology and prognosis.According to the site of involvement,IPMNs are classified into three categories,i.e.main duct type,branch duct type,and combined type.Most branch duct IPMNs are benign,whereas the other two types are often malignant.A large branch duct IPMN and marked dilation of the main pancreatic duct indicate the presence of adenoma at least.The additional existence of large mural nodules increases the possibility of malignancy in all types.The prognosis is more favorable after complete resection of benign and non-invasive malignant IPMNs.Malignant IPMNs that become more aggressive after parenchymal invasion necessitate adequate lymph node dissection.On the other hand,asymptomatic branch duct IPMNs without mural nodules can be observed without the need for resection for a considerable period of time.Our review addresses available data,current understanding,controversy,and future directions about IPMNs.展开更多
The natural history and clinical manifestation of resected intraductal papillary mucinous neoplasm(IPMN)of the pancreas were elucidated,and based on this,a retrospective pancreatic database was reviewed to identify pa...The natural history and clinical manifestation of resected intraductal papillary mucinous neoplasm(IPMN)of the pancreas were elucidated,and based on this,a retrospective pancreatic database was reviewed to identify patients with IPMN who were surgically managed in our department from 1999 to June 2006.Pathologic rereview of each case was performed,and the clinico-pathologic features were examined.Student’s T test and x2 analysis were used to identify factors associated with malignancy.Fifty-one patients were identified.There were 33 males and 18 females.One patient’s pancreas was unresectable,two patients underwent a total pancreatectomy,42 patients had a pancreatecoduodenectomy and five patients had distal pancreatectomy.Main-duct type carcinoma was identified in 24 patients;branch-duct type in 15 patients,and mixed type in 12 patients.Invasive carcinoma was present in 35 patients.Weight loss and jaundice occurred more commonly in the invasive group.The average serum CA19-9 level was significantly higher in the invasive group(1542μ vs 94.5μ).The average diameter of the pancreatic duct was also wider in the invasive group(8.7 mm vs 4.3 mm).Significant predictors of malignant IPMNs included weight loss,jaundice,a high level of serum CA19-9,a large pancreatic duct and main-duct type carcinoma.展开更多
文摘随着腹腔镜技术和设备的发展,微创技术在外科手术中的应用愈加广泛,腹腔镜全胃切除术(laparoscopic total gastrectomy,LTG)也得到了广泛开展。已有众多回顾性和队列研究结果显示,LTG与开腹全胃切除术比较,其具有创伤小、术后恢复快等优势,且在安全性和近、远期疗效方面并不劣于开腹手术,但尚缺乏高级别循证依据。目前我国及日韩等胃癌高发国家正在进行多项前瞻性的多中心临床研究,以论证LTG的安全性及可行性,并评估其远期疗效。
文摘Since first described in 1982,intraductal papillary mucinous neoplasm(IPMN)has been the preferred term to describe the proliferation of the pancreatic ductal epithelium.It is totally different from pancreatic carcinoma in epi demiology,histology,pathology and prognosis.According to the site of involvement,IPMNs are classified into three categories,i.e.main duct type,branch duct type,and combined type.Most branch duct IPMNs are benign,whereas the other two types are often malignant.A large branch duct IPMN and marked dilation of the main pancreatic duct indicate the presence of adenoma at least.The additional existence of large mural nodules increases the possibility of malignancy in all types.The prognosis is more favorable after complete resection of benign and non-invasive malignant IPMNs.Malignant IPMNs that become more aggressive after parenchymal invasion necessitate adequate lymph node dissection.On the other hand,asymptomatic branch duct IPMNs without mural nodules can be observed without the need for resection for a considerable period of time.Our review addresses available data,current understanding,controversy,and future directions about IPMNs.
文摘The natural history and clinical manifestation of resected intraductal papillary mucinous neoplasm(IPMN)of the pancreas were elucidated,and based on this,a retrospective pancreatic database was reviewed to identify patients with IPMN who were surgically managed in our department from 1999 to June 2006.Pathologic rereview of each case was performed,and the clinico-pathologic features were examined.Student’s T test and x2 analysis were used to identify factors associated with malignancy.Fifty-one patients were identified.There were 33 males and 18 females.One patient’s pancreas was unresectable,two patients underwent a total pancreatectomy,42 patients had a pancreatecoduodenectomy and five patients had distal pancreatectomy.Main-duct type carcinoma was identified in 24 patients;branch-duct type in 15 patients,and mixed type in 12 patients.Invasive carcinoma was present in 35 patients.Weight loss and jaundice occurred more commonly in the invasive group.The average serum CA19-9 level was significantly higher in the invasive group(1542μ vs 94.5μ).The average diameter of the pancreatic duct was also wider in the invasive group(8.7 mm vs 4.3 mm).Significant predictors of malignant IPMNs included weight loss,jaundice,a high level of serum CA19-9,a large pancreatic duct and main-duct type carcinoma.
