目的优选巴戟天酒炙工艺,并比较炮制前后对环磷酰胺所致生精障碍雄性小鼠生殖氧化应激的影响。方法采用L16(4^(5))正交试验设计,以蔗糖、1-蔗果三糖、耐斯糖、1F-果呋喃糖基耐斯糖4种寡糖总含量为评价指标,结合方差分析和熵权逼近理想...目的优选巴戟天酒炙工艺,并比较炮制前后对环磷酰胺所致生精障碍雄性小鼠生殖氧化应激的影响。方法采用L16(4^(5))正交试验设计,以蔗糖、1-蔗果三糖、耐斯糖、1F-果呋喃糖基耐斯糖4种寡糖总含量为评价指标,结合方差分析和熵权逼近理想解排序法(technique for order of preference by similarity to ideal solution,TOPSIS)筛选酒炙巴戟天的工艺参数,并比较巴戟天酒炙前后对环磷酰胺所致生精障碍雄性小鼠生殖氧化应激的影响。结果酒炙巴戟天最佳炮制工艺参数:100 g饮片加黄酒20 mL,密闭闷润2 h,炒制温度60℃,炒制时间7 min,于50℃干燥1 h。药效实验结果表明,巴戟天酒炙后总寡糖对模型小鼠生殖氧化应激作用明显优于生品总寡糖(P<0.05)。结论首次运用熵权TOPSIS法优选巴戟天酒炙工艺,结果简便、准确、可行;药效实验结果为巴戟天酒炙的合理性提供科学依据。展开更多
Background Epicardial adipose tissue(EAT)is a unique visceral adipose tissue that is located between the myocardium and the visceral layer of the pericardium.Physiologically,EAT can produce heat and protect the heart....Background Epicardial adipose tissue(EAT)is a unique visceral adipose tissue that is located between the myocardium and the visceral layer of the pericardium.Physiologically,EAT can produce heat and protect the heart.Under pathological conditions,EAT is involved in the development of diastolic heart failure(DHF)by secreting a variety of pro-inflammatory cytokines.More and more studies have shown that EAT plays an important role in the inflammatory mechanism and myocardial remodeling of DHF.Exercise,weight loss and drug therapy can significantly reduce the thickness/volume of EAT and its functional disorder.In recent years,research on EAT and DHF has made new progress.This article reviewed the mechanism and treatment of EAT in the development of DHF.展开更多
文摘目的优选巴戟天酒炙工艺,并比较炮制前后对环磷酰胺所致生精障碍雄性小鼠生殖氧化应激的影响。方法采用L16(4^(5))正交试验设计,以蔗糖、1-蔗果三糖、耐斯糖、1F-果呋喃糖基耐斯糖4种寡糖总含量为评价指标,结合方差分析和熵权逼近理想解排序法(technique for order of preference by similarity to ideal solution,TOPSIS)筛选酒炙巴戟天的工艺参数,并比较巴戟天酒炙前后对环磷酰胺所致生精障碍雄性小鼠生殖氧化应激的影响。结果酒炙巴戟天最佳炮制工艺参数:100 g饮片加黄酒20 mL,密闭闷润2 h,炒制温度60℃,炒制时间7 min,于50℃干燥1 h。药效实验结果表明,巴戟天酒炙后总寡糖对模型小鼠生殖氧化应激作用明显优于生品总寡糖(P<0.05)。结论首次运用熵权TOPSIS法优选巴戟天酒炙工艺,结果简便、准确、可行;药效实验结果为巴戟天酒炙的合理性提供科学依据。
基金supported by the Jining City Science and Technology Key Research and Development Program(No.2018SMNS006)the 2018 Shandong Province professional degree graduate case teaching project(No.SDYAL18100)。
文摘Background Epicardial adipose tissue(EAT)is a unique visceral adipose tissue that is located between the myocardium and the visceral layer of the pericardium.Physiologically,EAT can produce heat and protect the heart.Under pathological conditions,EAT is involved in the development of diastolic heart failure(DHF)by secreting a variety of pro-inflammatory cytokines.More and more studies have shown that EAT plays an important role in the inflammatory mechanism and myocardial remodeling of DHF.Exercise,weight loss and drug therapy can significantly reduce the thickness/volume of EAT and its functional disorder.In recent years,research on EAT and DHF has made new progress.This article reviewed the mechanism and treatment of EAT in the development of DHF.
