Microendoscopes are vital for disease detection and clinical diagnosis. The essential issue for microendoscopes is to achieve minimally invasive and high-resolution observations of soft tissue structures inside deep b...Microendoscopes are vital for disease detection and clinical diagnosis. The essential issue for microendoscopes is to achieve minimally invasive and high-resolution observations of soft tissue structures inside deep body cavities.Obviously, the microscope objective is a must with the capabilities of both high lateral resolution in a wide field of view(FOV) and miniaturization in size. Here, we propose a meta-objective, i.e., microscope objective based on cascaded metalenses. The two metalenses, with the optical diameters of 400 μm and 180 μm, respectively, are mounted on both sides of a 500-μm-thick silica film. Sub-micrometer lateral resolution reaches as high as 775 nm in such a naked meta-objective, with monochromatic aberration correction in a 125 μm full FOV and near diffraction limit imaging. Combined with a fiber bundle microscope system, the single cell contour of biological tissue(e.g., water lily leaf) can be clearly observed, compared to the indistinguishable features in other conventional lens-based fiber bundle systems, such as plano–convex and gradient refractive index(GRIN) cases.展开更多
基金National Natural Science Foundation of China(62035016,61775243,61805288,61905291)National Key Research and Development Program of China(2019YFB2203502)+3 种基金Guangdong Basic and Applied Basic Research Foundation(2018B030308005,2020A1515010626)Guangzhou ScienceTechnology and Innovation Commission(201804020029)Fundamental Research Funds for the Central Universities。
文摘Microendoscopes are vital for disease detection and clinical diagnosis. The essential issue for microendoscopes is to achieve minimally invasive and high-resolution observations of soft tissue structures inside deep body cavities.Obviously, the microscope objective is a must with the capabilities of both high lateral resolution in a wide field of view(FOV) and miniaturization in size. Here, we propose a meta-objective, i.e., microscope objective based on cascaded metalenses. The two metalenses, with the optical diameters of 400 μm and 180 μm, respectively, are mounted on both sides of a 500-μm-thick silica film. Sub-micrometer lateral resolution reaches as high as 775 nm in such a naked meta-objective, with monochromatic aberration correction in a 125 μm full FOV and near diffraction limit imaging. Combined with a fiber bundle microscope system, the single cell contour of biological tissue(e.g., water lily leaf) can be clearly observed, compared to the indistinguishable features in other conventional lens-based fiber bundle systems, such as plano–convex and gradient refractive index(GRIN) cases.
