Objective: To explore brain activations associated with electroacupuncture simulation at Tongli(HT 5) and its comparison with brain activations during picture-naming task. Methods: Twenty healthy subjects were enr...Objective: To explore brain activations associated with electroacupuncture simulation at Tongli(HT 5) and its comparison with brain activations during picture-naming task. Methods: Twenty healthy subjects were enrolled in this study. Half of them received electroacupuncture stimulation at HT 5(ACUP group) and the other half of them received stimulation at a nonmeridian sham acupoint(SHAM group). All subjects performed picture-naming task. Each subject finished two runs of functional magnetic resonance imaging examinations in one session and picture-naming task was performed before electroacupuncture stimulation. Subjective brain activations were obtained using generalized linear model and inter-group analyses were performed after that. Results: The electroacupuncture stimulation at HT 5 induced significant brain activations in both the anterior and posterior language regions, including the left inferior frontal gyrus, which was in consistent with activations induced during picture-naming task. Group analysis showed a tendency of increased activation of ACUP group in left inferior frontal gyrus compared with SHAM group(P〈0.05 FDR corrected). Conclusions: Electroacupuncture treatment at the acupoint HT 5 has modulation effect on typical language-implicated brain regions in healthy subjects, which provides supporting evidence for beneficial effects of needling at HT 5 for recovery of language function in aphasia.展开更多
基金Supported by the Hundred Talents Program of Chinese Academy of Sciences(No.Y14408)Shenzhen Science and Technology Program(No.JC201005270293A,JC201104220257A and 201101017)National Natural Science Foundation of China(No.81471738)
文摘Objective: To explore brain activations associated with electroacupuncture simulation at Tongli(HT 5) and its comparison with brain activations during picture-naming task. Methods: Twenty healthy subjects were enrolled in this study. Half of them received electroacupuncture stimulation at HT 5(ACUP group) and the other half of them received stimulation at a nonmeridian sham acupoint(SHAM group). All subjects performed picture-naming task. Each subject finished two runs of functional magnetic resonance imaging examinations in one session and picture-naming task was performed before electroacupuncture stimulation. Subjective brain activations were obtained using generalized linear model and inter-group analyses were performed after that. Results: The electroacupuncture stimulation at HT 5 induced significant brain activations in both the anterior and posterior language regions, including the left inferior frontal gyrus, which was in consistent with activations induced during picture-naming task. Group analysis showed a tendency of increased activation of ACUP group in left inferior frontal gyrus compared with SHAM group(P〈0.05 FDR corrected). Conclusions: Electroacupuncture treatment at the acupoint HT 5 has modulation effect on typical language-implicated brain regions in healthy subjects, which provides supporting evidence for beneficial effects of needling at HT 5 for recovery of language function in aphasia.