背景:近年来,控释靶向纳米粒子在恶性肿瘤化疗方面得到越来越广泛的应用。目的:综述控释靶向纳米粒子在骨肿瘤治疗方面的应用及其发展前景。方法:以"Nanoparticles,controlled drug release,bone tumor or osteosarcoma or Ewing s...背景:近年来,控释靶向纳米粒子在恶性肿瘤化疗方面得到越来越广泛的应用。目的:综述控释靶向纳米粒子在骨肿瘤治疗方面的应用及其发展前景。方法:以"Nanoparticles,controlled drug release,bone tumor or osteosarcoma or Ewing sarcoma"为关键词,检索Pub Med、Web of Science、NCBI数据库中近十年来关于纳米控释靶向粒子在骨肿瘤治疗方面应用的最新进展。结果与结论:骨肿瘤是一种具有较高发病率和死亡率的恶性肿瘤,严重威胁人类的健康。与传统化疗药物相比,纳米粒子具有控制释放,联合、协同治疗,跨越生物屏障,靶向治疗,增强肿瘤积累,延长循环时间等优势。控释靶向纳米粒子能针对骨肿瘤复杂的微环境实现靶向、精密调控,从而解决传统化疗所具有的不良反应和耐药性等问题。如何在保证载药率的同时提高纳米药物在肿瘤部位渗透效率、减少系统毒性、实现纳米药物治疗的多功能性是最终的研究目标。相信控释靶向纳米粒子以其固有的优势配合其智能、协同的载药方式,必将在这一交叉学科发挥更大的作用。展开更多
[Abstract] Objective： To report the technique of reconstruction of large skin and soft tissue defects in the upper extremity using pedicled latissimus dorsi myocu- taneous flaps. Methods： Six patients with large sk...[Abstract] Objective： To report the technique of reconstruction of large skin and soft tissue defects in the upper extremity using pedicled latissimus dorsi myocu- taneous flaps. Methods： Six patients with large skin and soft tissue defects were included in this report. There were 5 trauma patients and the rest one needed to receive plastic surgery for his extremity scar. All wounds were in the upper extremity. The sizes of defects ranged from 15 cmx6 cm to 30 cmx 18 cm. Pedicled latissimus dorsi myocutaneous flaps were designed according to the defect area and raised with part of latissi- mus dorsi. The thoracodorsal artery and its perforators were carefully protected during surgery. Results： All flaps healed primarily without flap congestion, margin necrosis or infection. The skin donor sites either received split-thickness skin graft （3 cases, mostly from the anterior thigh） or was closed primarily （3 cases） and had minimal morbidity. Follow-up of 6-12 months showed that the contour of flap was aesthetic and the func- tion of limb was excellent. Conclusion： Our experience indicates that the pedicled latissimus dorsi myocutaneous flap is favorable for recon- struction of large skin and soft tissue defects in the upper extremity展开更多
文摘背景:近年来,控释靶向纳米粒子在恶性肿瘤化疗方面得到越来越广泛的应用。目的:综述控释靶向纳米粒子在骨肿瘤治疗方面的应用及其发展前景。方法:以"Nanoparticles,controlled drug release,bone tumor or osteosarcoma or Ewing sarcoma"为关键词,检索Pub Med、Web of Science、NCBI数据库中近十年来关于纳米控释靶向粒子在骨肿瘤治疗方面应用的最新进展。结果与结论:骨肿瘤是一种具有较高发病率和死亡率的恶性肿瘤,严重威胁人类的健康。与传统化疗药物相比,纳米粒子具有控制释放,联合、协同治疗,跨越生物屏障,靶向治疗,增强肿瘤积累,延长循环时间等优势。控释靶向纳米粒子能针对骨肿瘤复杂的微环境实现靶向、精密调控,从而解决传统化疗所具有的不良反应和耐药性等问题。如何在保证载药率的同时提高纳米药物在肿瘤部位渗透效率、减少系统毒性、实现纳米药物治疗的多功能性是最终的研究目标。相信控释靶向纳米粒子以其固有的优势配合其智能、协同的载药方式,必将在这一交叉学科发挥更大的作用。
文摘[Abstract] Objective： To report the technique of reconstruction of large skin and soft tissue defects in the upper extremity using pedicled latissimus dorsi myocu- taneous flaps. Methods： Six patients with large skin and soft tissue defects were included in this report. There were 5 trauma patients and the rest one needed to receive plastic surgery for his extremity scar. All wounds were in the upper extremity. The sizes of defects ranged from 15 cmx6 cm to 30 cmx 18 cm. Pedicled latissimus dorsi myocutaneous flaps were designed according to the defect area and raised with part of latissi- mus dorsi. The thoracodorsal artery and its perforators were carefully protected during surgery. Results： All flaps healed primarily without flap congestion, margin necrosis or infection. The skin donor sites either received split-thickness skin graft （3 cases, mostly from the anterior thigh） or was closed primarily （3 cases） and had minimal morbidity. Follow-up of 6-12 months showed that the contour of flap was aesthetic and the func- tion of limb was excellent. Conclusion： Our experience indicates that the pedicled latissimus dorsi myocutaneous flap is favorable for recon- struction of large skin and soft tissue defects in the upper extremity
