High-energy-density rechargeable lithium batteries are being pursued by researchers because of their revolutionary potential nature.Current advanced practical lithium-ion batteries have an energy density of around300 ...High-energy-density rechargeable lithium batteries are being pursued by researchers because of their revolutionary potential nature.Current advanced practical lithium-ion batteries have an energy density of around300 W·h·kg^(-1).Continuing to increase the energy density of batteries to a higher level could lead to a major explosion development in some fields,such as electric aviation.Here,we have manufactured practical pouch-type rechargeable lithium batteries with both a gravimetric energy density of 711.3 W·h·kg^(-1)and a volumetric energy density of 1653.65 W·h·L^(-1).This is achieved through the use of high-performance battery materials including high-capacity lithium-rich manganese-based cathode and thin lithium metal anode with high specific energy,combined with extremely advanced process technologies such as high-loading electrode preparation and lean electrolyte injection.In this battery material system,the structural stability of cathode material in a widened charge/discharge voltage range and the deposition/dissolution behavior of interfacial modified thin lithium electrode are studied.展开更多
The morphological changes of deep-water channels have an important influence on the distributions of channel sand reservoirs,so it is important to explore the morphological change process of deep-water channel for the...The morphological changes of deep-water channels have an important influence on the distributions of channel sand reservoirs,so it is important to explore the morphological change process of deep-water channel for the exploration and development of deep-water oil and gas.Based on a typical sinuous Quaternary channel(Channel I)in the Taranaki Basin,New Zealand,a variety of seismic interpretation techniques were applied to quantitatively characterize the morphological characteristics of the Channel I,and the relationships between the quantitative parameters and the morphological changes of the Channel I,as well as the controlling factors affecting those morphological changes,were discussed.The results are as follows:(1)in the quantitative analysis,six parameters were selected:the channel depth,width,sinuosity,and aspect ratio(width/depth),the channel swing amplitude(λ)and the channel bend frequency(ω);(2)according to the quantitative morphological parameters of the channel(mainly including three parameters such as channel sinuosity,ωandλ),the Channel I was divided into three types:the low-sinuous channel(LSC),the high-sinuous channel(HSC),the moderate-sinuous channel(MSC).U-shaped channel cross-sections developed in the LSC,V-shaped channel cross-sections developed in the HSC,including inclined-V and symmetric-V cross-sections,and dish-shaped channel cross-sections developed in the MSC;(3)the morphological characteristics of the LSC and MSC were related to their widths and depths,while the morphology of the HSC was greatly affected by the channel width,a change in depth did not affect the HSC morphology;(4)the morphological changes of the Channel I were controlled mainly by the slope gradient,the restricted capacity of the channel and the differential in fluid properties.展开更多
Deep-water channel systems are important petroleum reservoirs,and many have been discovered worldwide.Understanding deep-water channel sedimentary elements and evolution is helpful for deep-sea petroleum exploration a...Deep-water channel systems are important petroleum reservoirs,and many have been discovered worldwide.Understanding deep-water channel sedimentary elements and evolution is helpful for deep-sea petroleum exploration and development.Based on high-resolution 3D seismic data,the Miocene channel system in the deep-water Taranaki Basin,New Zealand,was analyzed by using seismic interpretation techniques such as interlayer attribute extraction and strata slicing.The channel system was divided into five composite channels(CC-I to CC-V)according to four secondary level channel boundaries,and sedimentary elements such as channels,slump deposits,inner levees,mass transport deposits,and hemipelagic drape deposits were identified in the channel system.The morphological characteristics of several composite channels exhibited stark variances,and the overall morphology of the composite channels changed from relatively straight to highly sinuous to relatively straight.The evolution of the composite channels involved a gradual and repeated process of erosion and filling,and the composite channels could be divided into three evolutionary stages:initial erosion-filling,later erosion-filling(multistage),and channel abandonment.The middle Miocene channel system may have formed as a consequence of combined regional tectonic activity and global climatic change,and its intricate morphological alterations may have been influenced by the channel's ability to self-regulate and gravity flow properties.When studying the sedimentary evolution of a large-scale deep-water channel system in the Taranaki Basin during the Oligocene-Miocene,which transitioned from a passive margin to plate convergence,it can be understood how tectonic activity affected the channel and can also provide a theoretical reference for the evolution of the deepwater channels in areas with similar tectonic conversion environments around the world.展开更多
BACKGROUND:Several observational studies have shown an association between homocysteine(Hcy)levels and chronic obstructive pulmonary disease(COPD),but causal relationships are not clear.Our study aimed to explore the ...BACKGROUND:Several observational studies have shown an association between homocysteine(Hcy)levels and chronic obstructive pulmonary disease(COPD),but causal relationships are not clear.Our study aimed to explore the causal relationship between plasma Hcy and COPD by two-sample Mendelian randomization(MR).METHODS:A two-sample MR study was performed to infer the causal link.Genetically predicted plasma Hcy was selected as an instrumental variable(Ⅳ)from published genome-wide association study(GWAS)meta-analyses.COPD with different etiologies was extracted as outcome variables from other GWAS meta-analyses.The main MR analysis was performed using the inversevariance weighted(IVW)method.Additional analyses were further performed using Cochran’s Q-test and MR-Egger regression to evaluate the heterogeneity or horizontal pleiotropy of our findings.RESULTS:MR analysis showed no significant association between plasma Hcy and COPD.The results of the groups were consistent with the sensitivity analysis and repeated analysis,without heterogeneity or horizontal pleiotropy.The IVW results showed COPD hospital admissions(odds ratio[OR]1.06,95%confidence interval[CI]0.91-1.24,P=0.42),asthma/COPD(OR 0.97,95%CI0.89-1.06,P=0.55),COPD-related chronic infection(OR 1.50,95%CI 0.57-3.99,P=0.41),COPDI asthma/interstitial lung disease(ILD)-related pneumonia or pneumonia-derived septicemia(OR 0.93,95%CI 0.86-1.02,P=0.13),and COPD-related respiratory insufficiency(OR 1.00,95%CI 0.7-1.44,P=0.99).CONCLUSION:There is no direct causal relationship between plasma Hcy and COPD in our study.As Hcy is known to have deleterious effects on endothelial function and vascular homeostasis,further studies are needed to investigate whether additional factors mediate the association between Hcy and COPD.展开更多
目的建立预测Ⅰ~Ⅲ期结直肠癌病人神经/脉管浸润(perineural or lymphovascular invasion,PNI/LVI)的列线图预测模型,验证和预测其效能。方法回顾性分析2017年1月至2022年9月徐州医科大学附属医院行结直肠癌根治术治疗的结直肠癌病人68...目的建立预测Ⅰ~Ⅲ期结直肠癌病人神经/脉管浸润(perineural or lymphovascular invasion,PNI/LVI)的列线图预测模型,验证和预测其效能。方法回顾性分析2017年1月至2022年9月徐州医科大学附属医院行结直肠癌根治术治疗的结直肠癌病人684例的临床病理资料,利用R软件采用随机数种子的方式将上述资料按7∶3分成训练组(479例)和验证组(205例)。通过单因素相关分析,把P<0.1的参数纳入到多因素logistic回归分析,筛选影响结直肠恶性肿瘤PNI/LVI的危险因素,建立列线图模型。通过受试者操作特征曲线(ROC曲线)评估风险模型的预测价值,然后通过一致性指数、校准曲线和临床决策曲线分析(DCA)评估预测模型识别、校准和临床实用性方面的有效性。结果糖尿病、肿瘤长径、组织学分级、癌结节、T分期、N分期、血小板计数/淋巴细胞计数(PLR)、血小板计数×中性粒细胞计数/淋巴细胞(SII)、纤维蛋白原(g/L)/前白蛋白(g/L)(FPR)、癌胚抗原(CEA)、糖类抗原(CA)199在单因素分析中P<0.1。而多因素分析结果表明,CA199、T分期和N分期与Ⅰ~Ⅲ期结直肠癌病人PNI/LVI的发生独立相关因素。训练组和验证组的一致性指数分别为0.88[95%CI:(0.85,0.91)]和0.84[95%CI:(0.78,0.89)],同样校准曲线和DCA表明该模型具有良好的准确度和临床实用性。结论以CA199、T分期和N分期为基础建立的列线图模型有助于预测Ⅰ~Ⅲ期结直肠癌病人的PNI/LVI风险,该风险评价模型在临床上具有较好的预测效果。展开更多
We present an approach to classify medical text at a sentence level automatically.Given the inherent complexity of medical text classification,we employ adapters based on pre-trained language models to extract informa...We present an approach to classify medical text at a sentence level automatically.Given the inherent complexity of medical text classification,we employ adapters based on pre-trained language models to extract information from medical text,facilitating more accurate classification while minimizing the number of trainable parameters.Extensive experiments conducted on various datasets demonstrate the effectiveness of our approach.展开更多
In rice–wheat rotation systems, crop straw is usually retained in the field at land preparation in every, or every other, season. We conducted a 3-year-6-season experiment in the middle–lower Yangtze River Valley to...In rice–wheat rotation systems, crop straw is usually retained in the field at land preparation in every, or every other, season. We conducted a 3-year-6-season experiment in the middle–lower Yangtze River Valley to compare the grain qualities of rice under straw retained after single or double seasons per year. Four treatments were designed as: both wheat and rice straw retained(WR), only rice straw retained(R), only wheat straw retained(W), and no straw retained(CK). The varieties were Yangmai 16 wheat and Wuyunjing 23 japonica rice. The results showed contrasting effects of W and R on rice quality. Amylopectin content, peak viscosity, cool viscosity, and breakdown viscosity of rice grain were significantly increased in W compared to the CK, whereas gelatinization temperature,setback viscosity, and protein content significantly decreased. In addition, the effect of WR on rice grain quality was similar to that of W, although soil fertility was enhanced in WR due to straw being retained in two cycles. The differences in protein and starch contents among the treatments might result from soil nitrogen supply. These results indicate that wheat straw retained in the field is more important for high rice quality than rice straw return, and straw from both seasons is recommended for positive effects on soil fertility.展开更多
The effects of tungsten W doping and coating on the electrochemical performance of LiCoO2 cathode are compara- tively studied in this work. The amount of modification component is as low as 0.1 wt% and 0.3 wt% respect...The effects of tungsten W doping and coating on the electrochemical performance of LiCoO2 cathode are compara- tively studied in this work. The amount of modification component is as low as 0.1 wt% and 0.3 wt% respectively. After 100 cycles between 3.0 V-4.6 V, 0.1 wt% W doping provides an optimized capacity retention of 72.3%. However, W coating deteriorates battery performance with capacity retention of 47.8%, even lower than bare LiCoO2 of 55.7%. These different electrochemical performances can be attributed to the surface aggregation of W between doping and coating methods. W substitution is proved to be a promising method to develop high voltage cathodes. Practical performance relies on detailed synthesis method.展开更多
The missile autopilot for an interceptor with tail fins and pulse thrusters is designed via the θ-D approach. The nonlin- ear dynamic model of the pitch and yaw motion of the missile is transformed into a linear-like...The missile autopilot for an interceptor with tail fins and pulse thrusters is designed via the θ-D approach. The nonlin- ear dynamic model of the pitch and yaw motion of the missile is transformed into a linear-like structure with state-dependent coef- ficient (SDC) matrices. Based on the linear-like structure, a θ-D feedback controller is designed to steer the missile to track refer- ence acceleration commands. A sufficient condition that ensures the asymptotic stability of the tracking system is given based on Lyapunov's theorem. Numerical results show that the proposed autopilot achieves good tracking performance and the closed-loop tracking system is asymptotically stable.展开更多
High chemical reactivity, large volume changes, and uncontrollable lithium dendrite growth have always been the key problems of lithium metal anodes.Coating has been demonstrated as an effective strategy to protect th...High chemical reactivity, large volume changes, and uncontrollable lithium dendrite growth have always been the key problems of lithium metal anodes.Coating has been demonstrated as an effective strategy to protect the lithium metal.In this work, the effects of polyacrylonitrile(PAN)-based coatings on electrodeposited lithium have been studied.Our results show that a PAN coating layer provides uniform and dendrite-free lithium deposition as well as better cycling performance with carbonate electrolyte.Notably, heat treatment of the PAN coating layer promotes the formation of larger deposit particle size and higher coulombic efficiency(85%).The compact coating layer of heat-treated PAN with a large Young modulus(82.7 GPa) may provide stable protection for the active lithium.Improved homogeneity of morphology and mechanical properties of heat-treated PAN contribute to the larger deposit particles.This work provides new feasibility to optimize the polymer coating through rational modification of polymers.展开更多
BACKGROUND:Paraquat(PQ)-induced acute lung injury(ALI)and pulmonary fi brosis are common diseases with high mortality but without eff ective antidotes in emergency medicine.Our previous study has proved that arctigeni...BACKGROUND:Paraquat(PQ)-induced acute lung injury(ALI)and pulmonary fi brosis are common diseases with high mortality but without eff ective antidotes in emergency medicine.Our previous study has proved that arctigenin suppressed pulmonary fibrosis induced by PQ.We wondered whether arctigenin could also have a protective eff ect on PQ-induced ALI.METHODS:A PQ-induced A549 cell injury model was used,and the effect of arctigenin was determined by a cell counting kit-8(CCK-8)cell viability assay.In addition,terminal deoxynucleotidyl transferase(TdT)-mediated dUTP nick-end labelling(TUNEL)staining assays and mitochondrial membrane potential assays were performed to evaluate the level of cell apoptosis.The generation of reactive oxygen species(ROS)was refl ected by dihydroethidium(DHE)staining and a 2’,7’-dichlorodihy drofluorescein diacetate(DCFH-DA)assay.Moreover,immunoblotting studies were used to assess the expression of mitogen-activated protein kinases(MAPKs)and p38 MAPK.RESULTS:Arctigenin attenuated PQ-induced inhibition of A549 cell viability in a dose-dependent manner.Arctigenin also significantly reduced PQ-induced A549 cell apoptosis,as refl ected by the TUNEL assay and mitochondrial membrane potential assay,which may result from suppressed ROS/p38 MAPK signaling because we found that arctigenin dramatically suppressed ROS generation and p38 MAPK phosphorylation.CONCLUSION:Arctigenin could attenuate PQ-induced lung epithelial A549 cell injury in vitro by suppressing ROS/p38 MAPK-mediated cell apoptosis,and arctigenin might be considered a potential candidate drug for PQ-induced ALI.展开更多
Hedgehogs in the genus Mesechinus (Family Erinaceidae), which include two currently recognized species ( M. dauuricus and M. hughi), are distributed from northeast Mongolia to the upper Amur Basin in Russia and ad...Hedgehogs in the genus Mesechinus (Family Erinaceidae), which include two currently recognized species ( M. dauuricus and M. hughi), are distributed from northeast Mongolia to the upper Amur Basin in Russia and adjacent areas in northeast and northern China. In recent years, a population of Mesechinus hedgehogs was discovered from Mt. Gaoligong, southwestern Yunnan, China, far from the known distribution range of the genus. Furthermore, these hedgehogs are the only known population to be distributed at elevations higher than 2 100 m and in sympatry with gymnures. To evaluate the taxonomic status of these hedgehogs, we examined specimens representing Mesechinus taxa in China and further conducted morphometric and karyotypic analyses. Our results supported the existence of four species in China. Specifically, we identified the hedgehogs from Mt. Gaoligong as a new species, Mesechinus wangi sp. nov., and recognized M. miodon, previously considered as a synonym of either M. dauuricus or M. hughi as a distinct species. Interestingly, we observed a supernumerary M4 on all specimens of Mesechinus wangi sp. nov., which is an extremely rare event in the evolution of mammalian dentition.展开更多
针对智能装备系统直线与旋转两自由度驱动需求,提出定子励磁型混合磁路直线旋转永磁(statorexcitedhybrid magnetic circuit linear and rotary permanent magnet,SEHMCLRPM)电机,采用轴向和径向双凸极齿结构,轴向直线运动与径向旋转运...针对智能装备系统直线与旋转两自由度驱动需求,提出定子励磁型混合磁路直线旋转永磁(statorexcitedhybrid magnetic circuit linear and rotary permanent magnet,SEHMCLRPM)电机,采用轴向和径向双凸极齿结构,轴向直线运动与径向旋转运动磁场共用定、转子磁路。永磁体设置在定子上,动子上既无绕组也无永磁体,动子结构简单坚固,重量轻,具有转矩惯量比高、动态响应速度快、可靠性高等特点;定子同时设置有直线与旋转两套绕组,直线和旋转运动控制独立,降低两自由度驱动控制的复杂度。分析该类电机的运行原理和结构特点,探讨混合磁路特征,构建该类SEHMC-LRPM电机的解耦等效磁路模型,实现该类电机的磁路设计。在此基础上,基于3D有限元方法分析混合磁路与两自由度耦合磁场,揭示两自由度磁场与电机磁场分布、空载和负载特性的关系。最后,加工制造样机,并进行实验研究,验证该电机结构的有效性和理论分析的正确性。展开更多
Objective:To observe the effects of platelet-rich plasma(PRP)on in vitro proliferation and migration of fibroblasts from human chronic refractory wound granulation tissue.Methods:Fibroblasts were separated from human ...Objective:To observe the effects of platelet-rich plasma(PRP)on in vitro proliferation and migration of fibroblasts from human chronic refractory wound granulation tissue.Methods:Fibroblasts were separated from human chronic refractory wound granulation tissue and then were identified.The obtained fibroblasts were divided into fetal bovine serum(FBS)group,hydrogel group and PRP group,and the three groups were cultured with culture mediums containing FBS,hydrogel and PRP respectively,in order to observe the growth of fibroblasts.The wound scratch assay was used to observe the migration of fibroblasts.Results:PRP group had more fibroblasts than FBS group and hydrogel group since Day 5 of culture,and exhibited greater fibroblast scratch migration area than FBS group on 48 h and 72 h of wound scratch assay(all p<.05).Conclusions:Compared with FBS,human fibroblasts cultured by PRP can more effectively promote the proliferation and migration of fibroblasts.展开更多
We experimentally demonstrate the quantum anti-Zeno effect in a two-level system based on a single trapped ion ^(40)Ca~+. In the large detuning regime, we show that the transfer from the ground state to the excited...We experimentally demonstrate the quantum anti-Zeno effect in a two-level system based on a single trapped ion ^(40)Ca~+. In the large detuning regime, we show that the transfer from the ground state to the excited state can be remarkably enhanced by the inserted projection measurements. The inserted measurements in our experiment are realized by the electron shelving technique. Compared to the ideal projection measurement, which makes the quantum state collapse instantaneously, a practical electron shelving process needs a finite time duration. The minimum time for this collapse process is shown to be inversely proportional to the square of the coupling strength between the measurement laser and the system.展开更多
基金supported by the National Key Research and Development Program of China (Grant No.2021YFB2500300)the National Natural Science Foundation of China (Grant No.22239003)+1 种基金the CAS Project for Young Scientists in Basic Research(Grant No.YSBR-058)the Strategic Research and Consulting Project of the Chinese Academy of Engineering(Grant No.2022-XZ-15)。
文摘High-energy-density rechargeable lithium batteries are being pursued by researchers because of their revolutionary potential nature.Current advanced practical lithium-ion batteries have an energy density of around300 W·h·kg^(-1).Continuing to increase the energy density of batteries to a higher level could lead to a major explosion development in some fields,such as electric aviation.Here,we have manufactured practical pouch-type rechargeable lithium batteries with both a gravimetric energy density of 711.3 W·h·kg^(-1)and a volumetric energy density of 1653.65 W·h·L^(-1).This is achieved through the use of high-performance battery materials including high-capacity lithium-rich manganese-based cathode and thin lithium metal anode with high specific energy,combined with extremely advanced process technologies such as high-loading electrode preparation and lean electrolyte injection.In this battery material system,the structural stability of cathode material in a widened charge/discharge voltage range and the deposition/dissolution behavior of interfacial modified thin lithium electrode are studied.
基金The National Natural Science Foundation of China under contract Nos 42077410,41872112 and 42002031the Key Scientific Research Projects in University of Henan Province under contract No.18A170007.
文摘The morphological changes of deep-water channels have an important influence on the distributions of channel sand reservoirs,so it is important to explore the morphological change process of deep-water channel for the exploration and development of deep-water oil and gas.Based on a typical sinuous Quaternary channel(Channel I)in the Taranaki Basin,New Zealand,a variety of seismic interpretation techniques were applied to quantitatively characterize the morphological characteristics of the Channel I,and the relationships between the quantitative parameters and the morphological changes of the Channel I,as well as the controlling factors affecting those morphological changes,were discussed.The results are as follows:(1)in the quantitative analysis,six parameters were selected:the channel depth,width,sinuosity,and aspect ratio(width/depth),the channel swing amplitude(λ)and the channel bend frequency(ω);(2)according to the quantitative morphological parameters of the channel(mainly including three parameters such as channel sinuosity,ωandλ),the Channel I was divided into three types:the low-sinuous channel(LSC),the high-sinuous channel(HSC),the moderate-sinuous channel(MSC).U-shaped channel cross-sections developed in the LSC,V-shaped channel cross-sections developed in the HSC,including inclined-V and symmetric-V cross-sections,and dish-shaped channel cross-sections developed in the MSC;(3)the morphological characteristics of the LSC and MSC were related to their widths and depths,while the morphology of the HSC was greatly affected by the channel width,a change in depth did not affect the HSC morphology;(4)the morphological changes of the Channel I were controlled mainly by the slope gradient,the restricted capacity of the channel and the differential in fluid properties.
基金The National Natural Science Foundation of China under contract Nos 42077410 and 41872112。
文摘Deep-water channel systems are important petroleum reservoirs,and many have been discovered worldwide.Understanding deep-water channel sedimentary elements and evolution is helpful for deep-sea petroleum exploration and development.Based on high-resolution 3D seismic data,the Miocene channel system in the deep-water Taranaki Basin,New Zealand,was analyzed by using seismic interpretation techniques such as interlayer attribute extraction and strata slicing.The channel system was divided into five composite channels(CC-I to CC-V)according to four secondary level channel boundaries,and sedimentary elements such as channels,slump deposits,inner levees,mass transport deposits,and hemipelagic drape deposits were identified in the channel system.The morphological characteristics of several composite channels exhibited stark variances,and the overall morphology of the composite channels changed from relatively straight to highly sinuous to relatively straight.The evolution of the composite channels involved a gradual and repeated process of erosion and filling,and the composite channels could be divided into three evolutionary stages:initial erosion-filling,later erosion-filling(multistage),and channel abandonment.The middle Miocene channel system may have formed as a consequence of combined regional tectonic activity and global climatic change,and its intricate morphological alterations may have been influenced by the channel's ability to self-regulate and gravity flow properties.When studying the sedimentary evolution of a large-scale deep-water channel system in the Taranaki Basin during the Oligocene-Miocene,which transitioned from a passive margin to plate convergence,it can be understood how tectonic activity affected the channel and can also provide a theoretical reference for the evolution of the deepwater channels in areas with similar tectonic conversion environments around the world.
基金supported by grants from Hainan Provincial Natural Science Foundation of China(821RC557,2019RC232)National Natural Science Foundation of China(81871611,82160647)+1 种基金Finance Science and Technology Program of Sichuan Province(2022YFS0602)Hainan Clinical Medical Research Center Project(LCYX202310)。
文摘BACKGROUND:Several observational studies have shown an association between homocysteine(Hcy)levels and chronic obstructive pulmonary disease(COPD),but causal relationships are not clear.Our study aimed to explore the causal relationship between plasma Hcy and COPD by two-sample Mendelian randomization(MR).METHODS:A two-sample MR study was performed to infer the causal link.Genetically predicted plasma Hcy was selected as an instrumental variable(Ⅳ)from published genome-wide association study(GWAS)meta-analyses.COPD with different etiologies was extracted as outcome variables from other GWAS meta-analyses.The main MR analysis was performed using the inversevariance weighted(IVW)method.Additional analyses were further performed using Cochran’s Q-test and MR-Egger regression to evaluate the heterogeneity or horizontal pleiotropy of our findings.RESULTS:MR analysis showed no significant association between plasma Hcy and COPD.The results of the groups were consistent with the sensitivity analysis and repeated analysis,without heterogeneity or horizontal pleiotropy.The IVW results showed COPD hospital admissions(odds ratio[OR]1.06,95%confidence interval[CI]0.91-1.24,P=0.42),asthma/COPD(OR 0.97,95%CI0.89-1.06,P=0.55),COPD-related chronic infection(OR 1.50,95%CI 0.57-3.99,P=0.41),COPDI asthma/interstitial lung disease(ILD)-related pneumonia or pneumonia-derived septicemia(OR 0.93,95%CI 0.86-1.02,P=0.13),and COPD-related respiratory insufficiency(OR 1.00,95%CI 0.7-1.44,P=0.99).CONCLUSION:There is no direct causal relationship between plasma Hcy and COPD in our study.As Hcy is known to have deleterious effects on endothelial function and vascular homeostasis,further studies are needed to investigate whether additional factors mediate the association between Hcy and COPD.
文摘目的建立预测Ⅰ~Ⅲ期结直肠癌病人神经/脉管浸润(perineural or lymphovascular invasion,PNI/LVI)的列线图预测模型,验证和预测其效能。方法回顾性分析2017年1月至2022年9月徐州医科大学附属医院行结直肠癌根治术治疗的结直肠癌病人684例的临床病理资料,利用R软件采用随机数种子的方式将上述资料按7∶3分成训练组(479例)和验证组(205例)。通过单因素相关分析,把P<0.1的参数纳入到多因素logistic回归分析,筛选影响结直肠恶性肿瘤PNI/LVI的危险因素,建立列线图模型。通过受试者操作特征曲线(ROC曲线)评估风险模型的预测价值,然后通过一致性指数、校准曲线和临床决策曲线分析(DCA)评估预测模型识别、校准和临床实用性方面的有效性。结果糖尿病、肿瘤长径、组织学分级、癌结节、T分期、N分期、血小板计数/淋巴细胞计数(PLR)、血小板计数×中性粒细胞计数/淋巴细胞(SII)、纤维蛋白原(g/L)/前白蛋白(g/L)(FPR)、癌胚抗原(CEA)、糖类抗原(CA)199在单因素分析中P<0.1。而多因素分析结果表明,CA199、T分期和N分期与Ⅰ~Ⅲ期结直肠癌病人PNI/LVI的发生独立相关因素。训练组和验证组的一致性指数分别为0.88[95%CI:(0.85,0.91)]和0.84[95%CI:(0.78,0.89)],同样校准曲线和DCA表明该模型具有良好的准确度和临床实用性。结论以CA199、T分期和N分期为基础建立的列线图模型有助于预测Ⅰ~Ⅲ期结直肠癌病人的PNI/LVI风险,该风险评价模型在临床上具有较好的预测效果。
文摘We present an approach to classify medical text at a sentence level automatically.Given the inherent complexity of medical text classification,we employ adapters based on pre-trained language models to extract information from medical text,facilitating more accurate classification while minimizing the number of trainable parameters.Extensive experiments conducted on various datasets demonstrate the effectiveness of our approach.
基金financial supported by the National Key Technology R&D Program of China (2012BAD04B08, 2011BAD16B14)
文摘In rice–wheat rotation systems, crop straw is usually retained in the field at land preparation in every, or every other, season. We conducted a 3-year-6-season experiment in the middle–lower Yangtze River Valley to compare the grain qualities of rice under straw retained after single or double seasons per year. Four treatments were designed as: both wheat and rice straw retained(WR), only rice straw retained(R), only wheat straw retained(W), and no straw retained(CK). The varieties were Yangmai 16 wheat and Wuyunjing 23 japonica rice. The results showed contrasting effects of W and R on rice quality. Amylopectin content, peak viscosity, cool viscosity, and breakdown viscosity of rice grain were significantly increased in W compared to the CK, whereas gelatinization temperature,setback viscosity, and protein content significantly decreased. In addition, the effect of WR on rice grain quality was similar to that of W, although soil fertility was enhanced in WR due to straw being retained in two cycles. The differences in protein and starch contents among the treatments might result from soil nitrogen supply. These results indicate that wheat straw retained in the field is more important for high rice quality than rice straw return, and straw from both seasons is recommended for positive effects on soil fertility.
基金Project supported by the National Key Rerearch and Development Program of China(Grant No.2017YFB0102004)the National Natural Science Foundation of China(Grant No.51502334)+1 种基金the Fund from Beijing Municipal Science&Technology Commission,China(Grant No.D171100005517001)the Thousand Talent Program for Outstanding Young Scientists,China
文摘The effects of tungsten W doping and coating on the electrochemical performance of LiCoO2 cathode are compara- tively studied in this work. The amount of modification component is as low as 0.1 wt% and 0.3 wt% respectively. After 100 cycles between 3.0 V-4.6 V, 0.1 wt% W doping provides an optimized capacity retention of 72.3%. However, W coating deteriorates battery performance with capacity retention of 47.8%, even lower than bare LiCoO2 of 55.7%. These different electrochemical performances can be attributed to the surface aggregation of W between doping and coating methods. W substitution is proved to be a promising method to develop high voltage cathodes. Practical performance relies on detailed synthesis method.
基金supported by the National Natural Science Foundation of China(61174203)the Aeronautical Science Foundation of China(20110177002)
文摘The missile autopilot for an interceptor with tail fins and pulse thrusters is designed via the θ-D approach. The nonlin- ear dynamic model of the pitch and yaw motion of the missile is transformed into a linear-like structure with state-dependent coef- ficient (SDC) matrices. Based on the linear-like structure, a θ-D feedback controller is designed to steer the missile to track refer- ence acceleration commands. A sufficient condition that ensures the asymptotic stability of the tracking system is given based on Lyapunov's theorem. Numerical results show that the proposed autopilot achieves good tracking performance and the closed-loop tracking system is asymptotically stable.
基金Project supported by the National Natural Science Foundation of China(Grant Nos.51822211 and 51802342)the State Grid Technology Project,China(Grant No.DG71-17-010)
文摘High chemical reactivity, large volume changes, and uncontrollable lithium dendrite growth have always been the key problems of lithium metal anodes.Coating has been demonstrated as an effective strategy to protect the lithium metal.In this work, the effects of polyacrylonitrile(PAN)-based coatings on electrodeposited lithium have been studied.Our results show that a PAN coating layer provides uniform and dendrite-free lithium deposition as well as better cycling performance with carbonate electrolyte.Notably, heat treatment of the PAN coating layer promotes the formation of larger deposit particle size and higher coulombic efficiency(85%).The compact coating layer of heat-treated PAN with a large Young modulus(82.7 GPa) may provide stable protection for the active lithium.Improved homogeneity of morphology and mechanical properties of heat-treated PAN contribute to the larger deposit particles.This work provides new feasibility to optimize the polymer coating through rational modification of polymers.
基金This work was supported by the National Natural Science Foundation of China(82172182 and 82102311)Social Development Projects of Jiangsu Province(BE2017720)+2 种基金Natural Science Foundation of Jiangsu Province(BK20190247)Science Foundation of Jiangsu Health Commission(H2018039)Jiangsu Postdoctoral Research Foundation(2018K048A and 2020Z193).
文摘BACKGROUND:Paraquat(PQ)-induced acute lung injury(ALI)and pulmonary fi brosis are common diseases with high mortality but without eff ective antidotes in emergency medicine.Our previous study has proved that arctigenin suppressed pulmonary fibrosis induced by PQ.We wondered whether arctigenin could also have a protective eff ect on PQ-induced ALI.METHODS:A PQ-induced A549 cell injury model was used,and the effect of arctigenin was determined by a cell counting kit-8(CCK-8)cell viability assay.In addition,terminal deoxynucleotidyl transferase(TdT)-mediated dUTP nick-end labelling(TUNEL)staining assays and mitochondrial membrane potential assays were performed to evaluate the level of cell apoptosis.The generation of reactive oxygen species(ROS)was refl ected by dihydroethidium(DHE)staining and a 2’,7’-dichlorodihy drofluorescein diacetate(DCFH-DA)assay.Moreover,immunoblotting studies were used to assess the expression of mitogen-activated protein kinases(MAPKs)and p38 MAPK.RESULTS:Arctigenin attenuated PQ-induced inhibition of A549 cell viability in a dose-dependent manner.Arctigenin also significantly reduced PQ-induced A549 cell apoptosis,as refl ected by the TUNEL assay and mitochondrial membrane potential assay,which may result from suppressed ROS/p38 MAPK signaling because we found that arctigenin dramatically suppressed ROS generation and p38 MAPK phosphorylation.CONCLUSION:Arctigenin could attenuate PQ-induced lung epithelial A549 cell injury in vitro by suppressing ROS/p38 MAPK-mediated cell apoptosis,and arctigenin might be considered a potential candidate drug for PQ-induced ALI.
基金supported by the National Key Research and Development Program of China(2017YFC0505200)Fundamental Research Funds for NIES in 2017(GYZX170308)+1 种基金Biodiversity Conservation Program by MEP of ChinaK.H. was supported by a JSPS Postdoctoral Fellowship for Overseas Researchers(P16092)
文摘Hedgehogs in the genus Mesechinus (Family Erinaceidae), which include two currently recognized species ( M. dauuricus and M. hughi), are distributed from northeast Mongolia to the upper Amur Basin in Russia and adjacent areas in northeast and northern China. In recent years, a population of Mesechinus hedgehogs was discovered from Mt. Gaoligong, southwestern Yunnan, China, far from the known distribution range of the genus. Furthermore, these hedgehogs are the only known population to be distributed at elevations higher than 2 100 m and in sympatry with gymnures. To evaluate the taxonomic status of these hedgehogs, we examined specimens representing Mesechinus taxa in China and further conducted morphometric and karyotypic analyses. Our results supported the existence of four species in China. Specifically, we identified the hedgehogs from Mt. Gaoligong as a new species, Mesechinus wangi sp. nov., and recognized M. miodon, previously considered as a synonym of either M. dauuricus or M. hughi as a distinct species. Interestingly, we observed a supernumerary M4 on all specimens of Mesechinus wangi sp. nov., which is an extremely rare event in the evolution of mammalian dentition.
文摘针对智能装备系统直线与旋转两自由度驱动需求,提出定子励磁型混合磁路直线旋转永磁(statorexcitedhybrid magnetic circuit linear and rotary permanent magnet,SEHMCLRPM)电机,采用轴向和径向双凸极齿结构,轴向直线运动与径向旋转运动磁场共用定、转子磁路。永磁体设置在定子上,动子上既无绕组也无永磁体,动子结构简单坚固,重量轻,具有转矩惯量比高、动态响应速度快、可靠性高等特点;定子同时设置有直线与旋转两套绕组,直线和旋转运动控制独立,降低两自由度驱动控制的复杂度。分析该类电机的运行原理和结构特点,探讨混合磁路特征,构建该类SEHMC-LRPM电机的解耦等效磁路模型,实现该类电机的磁路设计。在此基础上,基于3D有限元方法分析混合磁路与两自由度耦合磁场,揭示两自由度磁场与电机磁场分布、空载和负载特性的关系。最后,加工制造样机,并进行实验研究,验证该电机结构的有效性和理论分析的正确性。
文摘Objective:To observe the effects of platelet-rich plasma(PRP)on in vitro proliferation and migration of fibroblasts from human chronic refractory wound granulation tissue.Methods:Fibroblasts were separated from human chronic refractory wound granulation tissue and then were identified.The obtained fibroblasts were divided into fetal bovine serum(FBS)group,hydrogel group and PRP group,and the three groups were cultured with culture mediums containing FBS,hydrogel and PRP respectively,in order to observe the growth of fibroblasts.The wound scratch assay was used to observe the migration of fibroblasts.Results:PRP group had more fibroblasts than FBS group and hydrogel group since Day 5 of culture,and exhibited greater fibroblast scratch migration area than FBS group on 48 h and 72 h of wound scratch assay(all p<.05).Conclusions:Compared with FBS,human fibroblasts cultured by PRP can more effectively promote the proliferation and migration of fibroblasts.
基金Project supported by the National Basic Research Program of China(Grant No.2016YFA0301903)the National Natural Science Foundation of China(Grant Nos.11174370,11304387,61632021,11305262,11574398,and N 61205108)the Research Plan Project of National University of Defense Technology,China(Grant No.ZK16-03-04)
文摘We experimentally demonstrate the quantum anti-Zeno effect in a two-level system based on a single trapped ion ^(40)Ca~+. In the large detuning regime, we show that the transfer from the ground state to the excited state can be remarkably enhanced by the inserted projection measurements. The inserted measurements in our experiment are realized by the electron shelving technique. Compared to the ideal projection measurement, which makes the quantum state collapse instantaneously, a practical electron shelving process needs a finite time duration. The minimum time for this collapse process is shown to be inversely proportional to the square of the coupling strength between the measurement laser and the system.