Advances of embedded resistive random access memory in industrial manufacturing and its potential applications

Embedded memory,which heavily relies on the manufacturing process,has been widely adopted in various industrial applications.As the field of embedded memory continues to evolve,innovative strategies are emerging to enhance performance.Among them,resistive random access memory(RRAM)has gained significant attention due to its numerousadvantages over traditional memory devices,including high speed(<1 ns),high density(4 F^(2)·n^(-1)),high scalability(~nm),and low power consumption(~pJ).This review focuses on the recent progress of embedded RRAM in industrial manufacturing and its potentialapplications.It provides a brief introduction to the concepts and advantages of RRAM,discusses the key factors that impact its industrial manufacturing,and presents the commercial progress driven by cutting-edge nanotechnology,which has been pursued by manysemiconductor giants.Additionally,it highlights the adoption of embedded RRAM in emerging applications within the realm of the Internet of Things and future intelligent computing,with a particular emphasis on its role in neuromorphic computing.Finally,the review discusses thecurrent challenges and provides insights into the prospects of embedded RRAM in the era of big data and artificial intelligence.

碳纳米管对复合材料耐湿热老化过程的健康监测

基于电阻法和声发射方法对三相复合材料在湿热环境中的老化过程进行了健康监测,试件的电阻变化率与吸湿率之间呈现接近线性的关系,这为基于电阻法对材料提供健康监测打下了基础。比较了不同碳纳米管含量时声发射和电阻法对健康监测的效果后发现,当碳纳米管含量在0.2%和0.5%时,声发射相比电阻法来说,其变化幅度更接近于材料力学性能的变化幅度;而当碳纳米管含量为1%和2%时,相较于声发射法,电阻法则更加适合用于健康监测。

Localization Method for the Pointing Observation with the Collimated Telescopes of Insight-HXMT

An accurate target source position is sometimes useful for the pointing observation with the collimated telescopes of the Hard X-ray Modulation Telescope(Insight-HXMT),which is determined by the reliability of the instrumental response.Insight-HXMT has the unique design that all three main payloads(LE,ME and HE)consist of detector groups with three fields of views(FOVs)whose orientations differ by 60°.As the point-spread functions are different at different positions in the FOV coordinates,the count rate ratios between the detector groups depend on the position of an X-ray source in the FOVs.Based on the multi-FOV design,we develop a localization method for an X-ray source in the pointing observation of Insight-HXMT.The accuracy of the method is investigated with the pointing observations of the Crab with different exposures.We find that the statistical error decreases with the exposure,and the systematic error is dominant for the exposure>128 s.With the exposure of1024 s,the total error is 0°.015 for the Crab.This method can effectively distinguish the Rapid Burster H 1730–333and Slow Burster GX 354–0,which are only 0°.5 apart and can both contribute to bursts in the light curve obtained by Insight-HXMT.We also apply the pointing observation localization method to locate the X-ray counterpart of FRB 200428 with high precision.The located position is consistent with SGR J1935+2154 within 1σuncertainty of 10′,which provides important evidence that fast radio bursts can originate from magnetars.

Electrostatic Complexes of Nano-Montmorillonite/Ethyl Lauroyl Arginate Stabilized Sunflower Oil Pickering Emulsions

Compared with traditional surfactant-stabilised emulsions, Pickering emulsions, stabilised by clay nanoparticles, have the advantages of strong interface stability, strong versatility, and low toxicity. Moreover, they have excellent application potential in the fields of food and medicine. In this study, a food-grade Pickering emulsion stabiliser was prepared by physically adsorbing the cationic surfactant ethyl lauroyl arginate (LAE) on the surface of nano-montmorillonite (NMMT). Different LAE/NMMT combinations were assessed for their capacity to stabilise an oil-in-water emulsion at a low solid concentration (0.5%, w/v). The controllability of the droplet diameter and stability of the Pickering emulsions can be realised by changing the content of LAE. Scanning electron microscopy (SEM), and laser confocal microscopy (CLSM) confirmed the successful preparation of sunflower oil Pickering emulsion droplets stabilised by LAE/NMMT (0.0075%/1%). Additionally, the LAE/NMMT studied in this work could be used as a highly effective antibacterial surfactant with inorganic nanoparticles to efficiently stabilise Pickering emulsions, thus expanding the potential of preparing edible Pickering emulsion formulae.

Tissue array for Tp53,C-myc,CCND1 gene over-expression in different tumors

AIM:To rapidly detect molecular alterations in different malignancies and investigate the possible role of Tp53,C-myc,and CCND1 genes in development of tumors in human organs and their adjacent normal tissues,as well as the possible relation between well-and poorly-differentiated tumors.METHODS:A tissue array consisting of seven different tumors was generated.The tissue array included 120 points of esophagus,120 points of stomach,80 points of rectum,60 points of thyroid gland,100 points of mammary gland,80 points of liver,and 80 points of colon.Expressions of Tp53,C-myc,and CCND1 were determined by RNA in situ hybridization.3' terminal digoxin-labeled anti-sense single stranded oligonucleotide and locked nucleic acid modifying probe were used.RESULTS:The expression level of Tp53 gene was higher in six different carcinoma tissue samples than in paracancerous tissue samples with the exception in colon carcinoma tissue samples(P < 0.05).The expression level of CCND1 gene was significantly different in different carcinoma tissue samples with the exception in esophagus and colon carcinoma tissue samples.The expression level of C-myc gene was different in esophagus carcinoma tissue samples(c2 = 18.495,P = 0.000),stomach carcinoma tissue samples(c2 = 23.750,P = 0.000),and thyroid gland tissue samples(c2 = 10.999,P = 0.004).The intensity of signals was also different in different carcinoma tissue samples and paracancerous tissue samples.CONCLUSION:Over-expression of the Tp53,CCND1,and C-myc genes appears to play a role in development of human cancer by regulating the expression of mRNA.Tp53,CCND1 and C-myc genes are significantly correlated with the development of different carcinomas.

高韧性尼龙6-聚氧化乙烯醚复合材料制备及复合形式对合成及结构性能影响

分别通过物理分散和化学嵌段形式将柔性端氨基聚氧化乙烯醚(PEA)引入尼龙6(PA6)体系制备了PA6/PEA共混物和PA6-b-PEA共聚物。研究发现,PEA的引入使得聚合反应活性降低,活化能增大,共聚体系中PEA-TDI大分子引发剂的长链效应和位阻效应对聚合反应的延缓作用更明显。当复合材料中PEA含量相同时,共混体系的结晶性能优于共聚体系,而当嵌段的PEA含量较高时,共聚体系形成少量γ晶。随PEA含量增加,PA6-PEA复合材料的弹性平台和应变硬化现象愈加明显。嵌段的柔性PEA链段使共聚分子链排列不再规整,分子链运动能力大幅提升,从而使PA6-b-PEA共聚物具有高抗冲击性,其冲击断面产生大形变和"毛发"结构,呈现韧性断裂特征。

Evaluation Indicator System of Low-carbon Landscape in Residential Areas: A Case Study of Garden Plant Landscape

Garden plant landscape is one of the main contents of low-carbon landscape design in residential areas. From the basic theory of garden plant landscaping, we put forth five principles and ideas concerning the building of evaluation indicator system of garden plant landscape, to establish the indicator system with ecological quality, recreational function and aesthetic effect as three layers. According to the characteristics of evaluation system, we use qualitative and quantitative integration method, coupled with analytic hierarchy process (AHP) and expert consulting method, to determine the weight of various factors. And we use fuzzy comprehensive evaluation method to test this indicator system, so as to provide a theoretical basis for the research on evaluation indicator system of low-carbon landscape.

Study of ATP borate ester effects on cell sensitization to radiation emitted by a nuclear reactor

Adenosine triphosphate(ATP)borate ester as a new boron agent for boron neutron capture therapy was tested.It was synthesized via a dehydration reaction induced by heating adenosine triphosphate disodium with boric acid.Next,ATP borate ester pretreatments were assessed to study their effects on cell sensitization from exposure to thermal neutron irradiation emitted by a nuclear reactor.Using cell viability assays(CCK8),survival rates of A549 cells pretreated with or without boroncontaining agents,including ATP borate ester and 4-dihydroxyborylphenylalanine(BPA),were measured.One week after feeding an ATP borate ester solution to tumorbearing nude mice,elemental B content values of tumor muscle and blood were measured using inductively coupled plasma mass spectrometry(ICP-MS).Meanwhile,other tumor tissue samples were placed in a culture medium,subjected to a 3-min neutron irradiation exposure,and then fixed in formalin 24 h later for the terminaldeoxynucleotidyl transferase(TDT)-mediated d UTP nick end labeling(TUNEL)immunohistochemical staining analysis.Results showed that A549 cell irradiation sensitization(irradiation dose of 0.33 Gy)varied with pretreatment.Sensitization values of the ATP borate ester pretreatment group were 1.3–14.1 with boron agent concentrations of 0.3–4.5 mM.Within 1.1–3.4 mM,ATP borate ester showed significantly higher sensitization values than BPA.Meanwhile,TUNEL results demonstrated that apoptosis rates of tumor tissue cells exposed to irradiation after ATP borate ester pretreatment significantly exceeded the corresponding rates for BPA-pretreated cells.In animal experiments,although the distribution ratio of ATP borate ester(tumor tissue/normal muscle,T/N)of 1.2 was not significantly different compared with that of BPA(1.3),the total ATP borate ester concentration in the tumor tissue(0.79±0.05μg/g)significantly exceeded that of BPA(0.58±0.05μg/g).Thus,compared with BPA,the greater enrichment of ATP borate ester in tumor tissues permits preferential targeting toward tumor cells for radiation sensitization.Therefore,ATP borate ester is superior to BPA for use in boron neutron capture therapy.

GRB 190530A:From Precursor,Prompt Emission to Afterglow all Originated from Synchrotron Radiation

GRB 190530A was jointly observed by the High Energy X-ray Telescope of the Hard X-ray Modulation Telescope(Insight-HXMT/HE)and the Ground-Based Wide-Angle Camera network(GWAC-N)with the extremely large field of view.After triggered by Insight-HXMT/HE and Fermi/GBM,we observed the optical emission of GRB 190530A,using the 30 cm telescope of GWAC(GWAC-F30)to search and locate its position.Subsequent observation of the late afterglow of GRB 190530A was made with the 2.16 m telescope at Xinglong Observatory.In this paper,we make a detailed exploration of the origin of GRB 190530A.In the prompt emission,a“double-tracking”pattern is presented both for the low-energy spectral indexαand the peak energy Epin the Band function with Insight-HXMT/HE and Fermi/GBM data;the results of GRB 190530A are consistent with the Amati and Yonetoku correlations;the spectral lag(τ)versus energy(E)can be estimated withτ=-3.0±0.06+(0.17±0.03)logE.The synchrotron radiation can account for the origin of GRB190530A prompt emission behaviors.Theαand Epof the precursor are essentially the same as that of the main prompt emission,implying that they have the same origin.For the afterglow,it can be described with the external forward shock model in ISM circumburst medium.In summary,from precursor,prompt emission to afterglow of GRB 190530A all originated from synchrotron radiation.

Malnutrition and Quality of Life in Chinese Cancer Patients: a Clinical Study of 23,994 Subjects

Background Malnutrition is common in patients with cancer,and can negatively impact their quality of life(QoL)and even survival.However,there is currently no large data available on the prevalence of malnutrition in Chinese cancer patients.This study evaluated the prevalence of malnutrition and the QoL of Chinese patients with locoregional,recurrent or metastatic cancer.Methods We conducted a nationwide observational,multi-center,hospital-based cross-sectional study within the Chinese Society of Nutritional Oncology(CSNO)Network.All of the patients were diagnosed with one of the following 18 different types of malignant tumors:lung cancer,gastric cancer,liver cancer,colorectal cancer,breast cancer,esophageal cancer,cervical cancer,endometrial cancer,nasopharyngeal carcinoma,malignant lymphoma,leukemia,pancreatic cancer,ovarian cancer,prostate cancer,bladder cancer,brain cancer,biliary tract malignant tumors or gastrointestinal stromal tumors.These patients were enrolled from 72 hospitals located in different regions of China.The patients’nutritional status was evaluated based on the body mass index(BMI),loss of bodyweight,laboratory measurements and patient generated-subjective global assessment(PG-SGA)scores.The cancer patients’physical status and QoL were assessed by the Karnofsky Performance Status(KPS)questionnaire and the European Organization for Research and Treatment of Cancer(EORTC)QLQ-C30 questionnaire,respectively.Results From December 2013 to April 2016,23,994 patients hospitalized for cancer treatment(such as surgery,chemotherapy or radiotherapy)were enrolled in the study.The patients included 12,494(52.9%)males and 11,124(47.1%)females.The mean age was 55.8±13.7 years.The proportions of patients in cancer stagesⅠ,Ⅱ,Ⅲ,Ⅳand uncertain were 11.5%,20.3%,27.5%,30.2%and 10.5%,respectively.Among the 23,994 inpatients,the proportions of patients who were underweight(BMI<18.5 kg/m2),normal(18.5 kg/m2<BMI<24 kg/m2),overweight(24 kg/m2≤BMI<28 kg/m2)and obese(BMI≥28 kg/m2)were 9.3%,59.9%,26.1%and 4.7%,respectively.A total of 18.3%(4,101/22,424)of patients had lost 5%or more of their bodyweight within the past month and 19.6%(2,463/12,538)of patients had lost 10%or more of their bodyweight within the past 6 months.According to the PG-SGA scores,26.6%of the patients were severely malnourished(score≥9),31.3%were moderately malnourished(scores 4~8).A total of 22.2%of patients had a serum albumin level lower than 35g/L.Only 8.6%(2056/23,991)of the patients had severe KPS scores(≤60).The patients with these severe KPS scores were most frequently among those with cancers of the brain(19.7%),prostate(18.0%),pancreas(15.5%)and bladder(15.0%).Based on the QLQ-C30 score,11.6%of patients had a poor QoL.The PG-SGA score and global QoL were correlated(r=-0.593,P<0.001).Conclusion The prevalence of malnutrition in patients with cancer is relatively high,and is related to a poorer QoL.The present findings should be kept in mind when assessing cancer patients,because addressing the patient’s problems in nutritional status would be expected to improve both the clinical outcomes and QoL in cancer patients with malnutrition.

Validity of the Chinese Version of the Patient-Generated Subjective Global Assessment (PG-SGA) in Lung Cancer Patients

The prevalence of malnutrition is high among oncology patients in China. Although the Patient- Generated Subjective Global Assessment (PG-SGA) is widely recognized as an important nutritional assessment tool, it has not been validated for Chinese cancer patients. The purpose of this study was to conduct an analysis of nutrition screening and assessment data to validate the Chinese version of the PG-SGA in Chinese patients with lung cancer. This was an observational, cross-sectional study of 2,000 consecutive adult patients with lung cancer treated at several tertiary hospitals in China. Anthropometric and patient descriptive data were collected. The PG-SGA generated a score for the nutritional risk and a global rating for the nutritional status. The internal consistency, external consistency, and construct validity were evaluated, and a known-groups comparison and principal component analyses were conducted to evaluate the reliability and validity of the PG-SGA. The known-groups comparison demonstrated the ability of the PG-SGA to differentiate lung cancer patients of different nutritional and body mass index (BMI) groups. A confirmatory factor analysis supported the original four-factor structure of the PG-SGA. In terms of the internal and external consistency, the PG-SGA demonstrated intra-class correlation coefficients (ICC) up to 0.987. Alternative form validity was also demonstrated between Box 4 of the PG-SGA and the Karnofsky Performance Status score, with excellent external consistency (r = 0.972, P < 0.001). The construct validity was supported, and selected questionnaire dimensions were evident in the principal component analysis. Significant Spearman correlations (P < 0.001) were demonstrated. The Chinese version of the PG-SGA demonstrated significant reliability and sufficient exploratory properties to support its validity. It seems to be a valid tool that can be used to access the nutritional status of Chinese lung cancer patients. The validity of the PG-SGA in Chinese cancer patients warrants further investigation in other cancer types.

Extension Protocol for the Investigation on Nutrition Status and Clinical Outcome of Patients with Common Cancers in China(INSCOC)Study:2021 update

Background Malnutrition is common in patients with cancer,and this adversely affects the survival and quality of life of patients.Chinese Society for Nutritional Oncology issued a multi-center,large-scale,long-term follow-up prospective study,the Investigation on Nutrition Status and Clinical Outcome of Patients with Common Cancers in China(INSCOC study)since 2013.This is an extension to the previous 2013-2020 study protocol.This study still sought to:①address the prognostic impact of nutritional factors and quality of life on cancer patient survival;②describe the overall and cancer-specific incidence and/or distribution of malnutrition and different measurements of patient quality of life.Methods and study design This is an observational,multi-centered,hospital-based prospective cohort study.Data collection will be performed at baseline(within 48 hours after patient admission),during the hospital stay and 30 days after hospital admission.Follow-up will be conducted for 1-20 years after enrollment.The primary outcome will be the all-cause mortality/overall survival,and secondary outcomes will be the length of hospital stay and costs of hospitalization.Study factors will include demographic characteristics,tumor characteristics,information about chronic diseases,hematological measurements(e.g.,red blood cell count,total lymphocyte counts,hemoglobin,albumin,prealbumin,creatinine,C-reactive protein,IL-6),anthropometric measurements(e.g.,height,weight,arm circumference,arm muscle circumference,triceps skinfold thickness,and waist circumference),body composition parameters,PG-SGA scores,quality of life(as indicated by the QLQ-C30 questionnaire),muscle mass(as indicated by the calf circumference),muscle strength(as indicated by the handgrip strength),muscle function(as indicated by the six-meter walking speed test)and physical status assessments(as indicated by the Karnofsky Performance Status scores).This clinical study protocol was approved by local Ethics Committees of all the participating hospitals.Written informed consent is required for each subject included.Discussion This multi-center,large-scale,long-term follow up prospective study will help improve the diagnosis of malnutrition in cancer patients and identify the risk factors associated with adverse clinical outcomes.The anticipated results of this study will highlight the need for a truly scientific appraisal of nutrition therapy in Chinese oncology populations,and finally help treat the potentially reversible elements of malnutrition in cancer patients to improve their clinical outcomes in the future.

Validity of the Chinese Version of the Patient-Generated Subjective Global Assessment (PG-SGA) in Gastric Cancer Patients

Purpose Malnutrition is severe among gastric cancer patients in China. While the Patient-Generated Subjective Global Assessment (PG-SGA) is a widely used nutritional assessment tool, the validation for Chinese patients with gastric cancer has not been performed yet. The aim of this research is to validate the Chinese version of the PGSGA in Chinese gastric cancer patients by conducting analyses of nutrition screening and assessment data. Methods Two thousand consecutive adult patients with gastric cancer were included in this observational, cross-sectional study in several tertiary hospitals in China. A survey was made among those patients, which included several questionnaires and some anthropometric parameters. We calculated the parameters to validate the use of PG-SGA categorizing the nutritional status of gastric cancer patients. Then we performed statistical analysis to evaluate the internal consistency, external consistency, and construct validity. Results This study verified the ability of the PG-SGA to differentiate gastric cancer patients into different nutritional groups. The confirmatory factor analysis verified the original four-factor structure of the PG-SGA. The internal and external consistency was measured by a concordance analysis which showed an intraclass correlation coefficients (ICC) of 0.987. The correlations of the Box 4 score with the Karnofsky performance status score demonstrated alternative form validity with good external consistency (Pearson, r = 0.643, P < 0.001). All three anthropometric dimensions of the PG-SGA were supported by principal component analysis. Spearman correlations (P < 0.001) were significant in the majority of tests. Conclusion The Chinese version of the PG-SGA is a valid tool to access the patients’ nutritional status for Chinese gastric patients.

Timing analysis of the black hole candidate EXO 1846–031 with Insight-HXMT monitoring

We present the observational results from a detailed timing analysis of the black hole candidate EXO 1846-031 during its outburst in 2019 with the observations of Insight-HXMT,NICER and MAXI.This outburst can be classified roughly into four different states.Type-C quasi-periodic oscillations(QPOs)observed by NICER(about 0.1-6 Hz)and Insight-HXMT(about 0.7-8 Hz)are also reported in this work.Meanwhile,we study various physical quantities related to QPO frequency.The QPO rms-frequency relationship in the energy band 1-10 keV indicates that there is a turning pointing in frequency around2 Hz,which is similar to that of GRS 1915+105.A possible hypothesis for the relationship above may be related to the inclination of the source,which may require a high inclination to explain it.The relationships between QPO frequency and QPO rms,hardness,total fractional rms and count rate have also been found in other transient sources,which can indicate that the origin of type-C QPOs is non-thermal.

Lifetime measurements in 138Nd

Lifetimes of the 2_(1)^(+),4_(1)^(+),7_(2)^(-),10_(2)^(+),12_(2)^(+),and 14_(1)^(+) states in 138 Nd populated via the 123 Sb(19 F,4n)138 Nd fusion–evaporation reaction were measured with the recoil distance Doppler shift technique in combination with the differential decay curve method.The B(E2;2_(1)^(+)→0_(1)^(+))value fit well with the systematic trend in the Nd isotope chain and Grodzins rule,which proved that 138Nd is a transitional nucleus.

Analysis of Style of Rockery Building and Stone Stacking Technique in the Royal Garden of the Song Dynasty: A Case Study of Genyue Royal Garden

Rockery building and stone stacking is a technique commonly used in building of classical gardens.Its emergence allows the fairy thought of"one pond and three mountains"to be reflected in different classical gardens.In the Northern Song Dynasty,the style of rockery building and stone stacking in the royal garden was an artistic climax in the history of the garden,and the technique of rockery building and stone stacking in Genyue Royal Garden was considered as the beginning of specialization.Through sorting out the records of the royal gardens in the Song Dynasty,this paper summarized the content of studying the royal gardens of the Song Dynasty,and systematically sorted out the development history of the techniques and styles of the royal gardens of the Song Dynasty and applied them into construction of some gardens.

Value of Horizontal Inscribed Boards in Jiuxia Village from the Perspective of Farming-reading Culture

Horizontal inscribed boards are the main form for working people to long for and pursue a better life,and are an important carrier of traditional culture. From the perspectives of sociology,architecture and ecological folklore,this article analyzes the intrinsic relationships between people’s values,neighborhoods,customs and horizontal inscribed boards,and interprets the decorative value,human value and modern value of horizontal inscribed boards through preliminarily studying the cultural connotation of horizontal inscribed boards in Jiuxia Village.

The Inspiration of Poetic and Picturesque Literati Garden to Chinese Modern Gardening

Literati garden in Chinese classical garden has its own characteristics,and literature,philosophy and aesthetic values contained in literati garden have a profound impact on the gardening of later generations.Literati garden embodies the aesthetic orientation of Chinese people’s love of poetry and painting,pays attention to the creation of poetic atmosphere and creates an emotional space,making that viewers appreciate the beauty of blending feelings and scenery.In this paper,the characteristics of the literati garden in Chinese classical garden are summarized,and its gardening essence is excavated,and its enlightenment to the modern Chinese garden is explored.

Evaluation and Renovation Strategy of Buildings in Mountainous Towns from the Perspectives of Nature and Culture

In recent years,as a new growth point of China's economic development,small towns are under construction in full swing[1].But with the rapid expansion,many problems that the city scholars and builders think about have emerged.The problems in the construction of small towns are mainly reflected in the over development of capital,insufficient understanding on culture,deviation of construction strategies,etc.In many small towns,there is an imbalance between the volume and color of buildings,the architectural form is single[2],and the expression of local culture is insufficient.From the perspectives of nature and culture,the architecture of Ciping Town,a mountainous town,is evaluated.In view of the problems found,this paper puts forward its thinking on the buildings in this type of small towns,so as to provide some reference for the development of architecture in this type of small towns.

Comprehensive Evaluation of New Fresh Edible Sweet-glutinous Maize Varieties Based on Entropy Weight Method

In this study,the entropy weight method was used to comprehensively evaluate the eight sweet-glutinous maize varieties in the regional trials in Shanxi Province in 2016. The results showed that the order of the performance of comprehensive traits of the tested varieties was Heitiannuo 631,Heitiannuo No. 2,Cainuo No. 5,Xinnuo 8601,FYN 1601,Xinnuo 8608,Jindannuo 41,Caitiannuo 1958( from good to poor). Among them,Heitiannuo 631,Heitiannuo No. 2 and Cainuo No. 5 are excellent varieties,and the rest are good varieties.