During the period of reconstruction after Yushu Earthquake,a large number of sea-level or low land workers ascended there and worked at altitudes between 3 750 m and 4 878 m which is a hypoxic environment. To investig...During the period of reconstruction after Yushu Earthquake,a large number of sea-level or low land workers ascended there and worked at altitudes between 3 750 m and 4 878 m which is a hypoxic environment. To investigate the sleep quality at that altitude,we performed two full polysomnographies (PSGs) in 10 volunteers,who were healthy male workers,aged 31±6.6,born and living at sea level,without experience of pre-altitude exposure. The assessment of subjective sleep quality was performed twice in each volunteer. The first investigations were carried out at sea level in Jinan city (p B =760 torr,1 torr=133.322 4 Pa). The second studies were performed at an altitude of 3 750 m (p B =416 torr) in Yushu Jiegu in the same 10 workers after they lived and worked at that altitude for 5 months. At sea level,workers presented a normal sleep structure and a higher oxygenation during sleep. However,as compared to sea-level sleep,at 3 750 m,workers had a shorter total sleep time (TST) (p<0.001),a longer stage 1 non-rapid eye movement (nREM) sleep (p<0.05) and a shorter 3+4 nREM and rapid eye movement (REM) sleep (p<0.05) with a severe sleep hypoxemia (p<0.01). Our data suggested that sea-level workers revealed a disturbed sleep and a bad sleep quality with a significant sleep hypoxemia at altitude of 3 750 m. Strengthening the prevention and treatment are thereby sorely necessary.展开更多
基金"973"National Key Basic Research and Develvpment Program(No.2012CB518202)Project of Qinghai Development of Science and Technology(No.2011-N-150)
文摘During the period of reconstruction after Yushu Earthquake,a large number of sea-level or low land workers ascended there and worked at altitudes between 3 750 m and 4 878 m which is a hypoxic environment. To investigate the sleep quality at that altitude,we performed two full polysomnographies (PSGs) in 10 volunteers,who were healthy male workers,aged 31±6.6,born and living at sea level,without experience of pre-altitude exposure. The assessment of subjective sleep quality was performed twice in each volunteer. The first investigations were carried out at sea level in Jinan city (p B =760 torr,1 torr=133.322 4 Pa). The second studies were performed at an altitude of 3 750 m (p B =416 torr) in Yushu Jiegu in the same 10 workers after they lived and worked at that altitude for 5 months. At sea level,workers presented a normal sleep structure and a higher oxygenation during sleep. However,as compared to sea-level sleep,at 3 750 m,workers had a shorter total sleep time (TST) (p<0.001),a longer stage 1 non-rapid eye movement (nREM) sleep (p<0.05) and a shorter 3+4 nREM and rapid eye movement (REM) sleep (p<0.05) with a severe sleep hypoxemia (p<0.01). Our data suggested that sea-level workers revealed a disturbed sleep and a bad sleep quality with a significant sleep hypoxemia at altitude of 3 750 m. Strengthening the prevention and treatment are thereby sorely necessary.
