An outbreak of coronavirus disease 2019(COVID-19)has spread globally,with over 500 million cases and 6 million deaths to date.COVID-19 is associated with a systemic inflammatory response and abnormalities of the extra...An outbreak of coronavirus disease 2019(COVID-19)has spread globally,with over 500 million cases and 6 million deaths to date.COVID-19 is associated with a systemic inflammatory response and abnormalities of the extracellular matrix(ECM),which is also involved in inflammatory storms.Upon viral infection,ECM proteins are involved in the recruitment of inflammatory cells and interference with target organ metabolism,including in the lungs.Additionally,serum biomarkers of ECM turnover are associated with the severity of COVID-19 and may serve as potential targets.Consequently,understanding the expression and function of ECM,particularly of the lung,during severe acute respiratory syndrome of the coronavirus 2 infection would provide valuable insights into the mechanisms of COVID-19 progression.In this review,we summarize the current findings on ECM,such as hyaluronic acid,matrix metalloproteinases,and collagen,which are linked to the severity and inflammation of COVID-19.Some drugs targeting the extracellular surface have been effective.In the future,these ECM findings could provide novel perspectives on the pathogenesis and treatment of COVID-19.展开更多
基金Supported by the Key Program of the Natural Science Foundation of Ningbo,No.202003N4019Ningbo City COVID-19 Epidemic Prevention and Control Project,No.202002N7033+1 种基金Zhejiang Provincial Natural Science Foundation of China,No.Y23H190011Zhejiang Medical and Health Science and Technology Project,No.2019KY154。
文摘An outbreak of coronavirus disease 2019(COVID-19)has spread globally,with over 500 million cases and 6 million deaths to date.COVID-19 is associated with a systemic inflammatory response and abnormalities of the extracellular matrix(ECM),which is also involved in inflammatory storms.Upon viral infection,ECM proteins are involved in the recruitment of inflammatory cells and interference with target organ metabolism,including in the lungs.Additionally,serum biomarkers of ECM turnover are associated with the severity of COVID-19 and may serve as potential targets.Consequently,understanding the expression and function of ECM,particularly of the lung,during severe acute respiratory syndrome of the coronavirus 2 infection would provide valuable insights into the mechanisms of COVID-19 progression.In this review,we summarize the current findings on ECM,such as hyaluronic acid,matrix metalloproteinases,and collagen,which are linked to the severity and inflammation of COVID-19.Some drugs targeting the extracellular surface have been effective.In the future,these ECM findings could provide novel perspectives on the pathogenesis and treatment of COVID-19.
