BACKGROUND Renal pelvis sarcomatoid carcinoma(RPSC)is a rare and aggressive malignancy whose diagnosis is difficult because radiological imaging results can lead to misclassification as a more common type of renal tum...BACKGROUND Renal pelvis sarcomatoid carcinoma(RPSC)is a rare and aggressive malignancy whose diagnosis is difficult because radiological imaging results can lead to misclassification as a more common type of renal tumor.In addition,clinical management of patients with RPSC is difficult because of the limited efficacy of available treatments.In this study,we present a comprehensive description of a patient who presented with RPSC and a simultaneous renal vein tumor thrombus.CASE SUMMARY During April,2020,a 64-year-old female presented with an isolated episode of hematuria accompanied by abdominal pain.Computed tomography(CT)and magnetic resonance imaging(MRI)showed a lesion in the right renal pelvis.We therefore performed a radical nephrectomy of the right kidney.The subsequent histopathological and immunological results verified the diagnosis of RPSC.Despite administration of 6 cycles of a gemcitabine-cisplatin regimen,the patient's condition progressively deteriorated,and she died about 15 mo after the nephrectomy.CONCLUSION We performed a comprehensive analysis of a patient with RPSC that included CT,MRI,immunohistochemistry,and genetic testing.The insights from our detailed analysis of this patient and our concomitant review of the literature may assist clinicians in their diagnosis and treatment of RPSC.展开更多
We investigate the extinction coefficients of the surface atmospheric aerosol over the Large High Altitude Air Shower Observatory (LHAASO), located at the Haizi Mountain, Daocheng County, China. To this end, we utiliz...We investigate the extinction coefficients of the surface atmospheric aerosol over the Large High Altitude Air Shower Observatory (LHAASO), located at the Haizi Mountain, Daocheng County, China. To this end, we utilize the Longtin model, Mie scattering theory, and experimental data obtained by the Cloud-Aerosol Lidar and Infrared Pathfinder Satellite Observation (CALIPSO). Our theoretical calculations show that the total extinction coefficients of the atmospheric aerosol at the wavelength of 200–500 nm are inversely proportional to the laser wavelength, and influenced by the wind speed. From July 2015 to October 2016, the extinction coefficient of the surface atmospheric aerosols at 532 nm wavelength reached 0.04 km^-1 with no wind, while it increased to 0.1 km^-1 with gusts. In this period, the extinction coefficients of the surface atmospheric aerosol at 532 nm wavelength, obtained by the CALIPSO, change from 0.01 to 0.07 km^-1, which is less than the values obtained the theoretical calculation and larger than the average of Tibetan Plateau in 2006-2016. These calculations and experimental evidence provide important arguments to the model of atmospheric aerosol to be applied in the calibration of LHAASO. Our results suggest that the extinction coefficients over LHAASO require further study, including research on the size distribution, shape, concentration of aerosols particles, wind dependence, relative humidity dependence, etc.展开更多
基金Science and Technology Development Program of Jilin Province,No.2020122256JC and No.20200201602JC.
文摘BACKGROUND Renal pelvis sarcomatoid carcinoma(RPSC)is a rare and aggressive malignancy whose diagnosis is difficult because radiological imaging results can lead to misclassification as a more common type of renal tumor.In addition,clinical management of patients with RPSC is difficult because of the limited efficacy of available treatments.In this study,we present a comprehensive description of a patient who presented with RPSC and a simultaneous renal vein tumor thrombus.CASE SUMMARY During April,2020,a 64-year-old female presented with an isolated episode of hematuria accompanied by abdominal pain.Computed tomography(CT)and magnetic resonance imaging(MRI)showed a lesion in the right renal pelvis.We therefore performed a radical nephrectomy of the right kidney.The subsequent histopathological and immunological results verified the diagnosis of RPSC.Despite administration of 6 cycles of a gemcitabine-cisplatin regimen,the patient's condition progressively deteriorated,and she died about 15 mo after the nephrectomy.CONCLUSION We performed a comprehensive analysis of a patient with RPSC that included CT,MRI,immunohistochemistry,and genetic testing.The insights from our detailed analysis of this patient and our concomitant review of the literature may assist clinicians in their diagnosis and treatment of RPSC.
基金Supported by National Natural Science Foundation of China(11503021,11205126,11847307)Key Projects of Cooperation between Provincial Colleges and Schools of Science and Technology Plan from Sichuan Province(2017JZ0034)National Key Research and Development Program Projects(2018YFA0404201)
文摘We investigate the extinction coefficients of the surface atmospheric aerosol over the Large High Altitude Air Shower Observatory (LHAASO), located at the Haizi Mountain, Daocheng County, China. To this end, we utilize the Longtin model, Mie scattering theory, and experimental data obtained by the Cloud-Aerosol Lidar and Infrared Pathfinder Satellite Observation (CALIPSO). Our theoretical calculations show that the total extinction coefficients of the atmospheric aerosol at the wavelength of 200–500 nm are inversely proportional to the laser wavelength, and influenced by the wind speed. From July 2015 to October 2016, the extinction coefficient of the surface atmospheric aerosols at 532 nm wavelength reached 0.04 km^-1 with no wind, while it increased to 0.1 km^-1 with gusts. In this period, the extinction coefficients of the surface atmospheric aerosol at 532 nm wavelength, obtained by the CALIPSO, change from 0.01 to 0.07 km^-1, which is less than the values obtained the theoretical calculation and larger than the average of Tibetan Plateau in 2006-2016. These calculations and experimental evidence provide important arguments to the model of atmospheric aerosol to be applied in the calibration of LHAASO. Our results suggest that the extinction coefficients over LHAASO require further study, including research on the size distribution, shape, concentration of aerosols particles, wind dependence, relative humidity dependence, etc.