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Great efficacy of sulfachloropyrazine-sodium against acute murine toxoplasmosis 被引量:1
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作者 Yan-Bo Zeng Shun-Hai Zhu +7 位作者 Hui Dong Hong-Yu Han Lian-Lian Jiang Quan Wang Jun Cheng qi-ping zhao Wei-Jiao Ma Bing Huang 《Asian Pacific Journal of Tropical Biomedicine》 SCIE CAS 2012年第1期70-75,共6页
Objective:To identify more effective and less toxic drugs to treat animal toxoplasmosis.Methods:Efficucy of seven kinds of sulfonamides against Toxoplasma gondii(T.gondii)in an acute murine model was evaluated.The mic... Objective:To identify more effective and less toxic drugs to treat animal toxoplasmosis.Methods:Efficucy of seven kinds of sulfonamides against Toxoplasma gondii(T.gondii)in an acute murine model was evaluated.The mice used throughout the study were randomly assigned to many groups(10 mice each),which either remained uninfected or were infected intraperitoneally with lachyzoites of T.gondii(strains RH and CN).All groups were then treated with different sulfonamides and the optimal treatment protocol was determined candidates.Sulfadiazine-sodium(SD)was used for comparison.Results:The oplimal therapy involved gavaging mice twice per day with 250 mg/kg bw of sulfachloropyrazine-sodium(SPZ)for five days.Using this protocol,the average survival time and the time-point of 50%fatalities were prolonged significantly compared with SD treatment.Treatment with SFZ protected 40%of mice from death,and the heart and kidney tissue of these animals was parasite-free,as determined by nestedPCK.SPZ showed excellent therapeutic effects in the treatment of T.gondii in an acute murine model and is therefore a promising drug candidate for the treatment and prevention of T.gondii in animals.Conclusions:It can be concluded that the effective drug sulfachloropyrazine may be the new therapeutic options against animal toxoplasmosis. 展开更多
关键词 TOXOPLASMOSIS SULFONAMIDES Sulfachloropyrazine-sodium EFFICACY Therapy Toxoplasma GONDII MURINE Therapeutic effect
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Graphene-gold Nanoparticle Composite Film Modified Electrode for Determination of Trace Mercury in Environmental Water
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作者 Xue-mei Wang Shou-guo Wu +2 位作者 Hao Liu Lei Zhou qi-ping zhao 《Chinese Journal of Chemical Physics》 SCIE CAS CSCD 2013年第5期590-596,I0004,共8页
The graphene-gold nanoparticles composite film modified glassy carbon electrode (EG- AuNPs/GCE) was prepared by one-step coelectrodeposition and employed for determination of trace mercury in environmental water wit... The graphene-gold nanoparticles composite film modified glassy carbon electrode (EG- AuNPs/GCE) was prepared by one-step coelectrodeposition and employed for determination of trace mercury in environmental water with differential pulse stripping voltammetry. Such a nanostructured composite film combined with the advantages of gold nanoparticles and graphene, can greatly promote the electron-transfer process and increase accumulation abil-ity for Hg(Ⅱ), leading to a remarkably improved sensitivity. The linear calibration curve ranged from 0.2 μg/L to 30 μg/L for Hg(Ⅱ) and the detection limit (S/N=3) was found to be 0.03 μg/L at a deposition time of 300 s. Moreover, the stablity of the as-prepared electrode and interferences from other substances were evaluated. The modified electrode was successfully applied to the direct detection of Hg(Ⅱ) in real water samples. 展开更多
关键词 Graphene-gold nanoparticle composite membrane Chemically modified elec-trode MERCURY Stripping voltammetry
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