溃疡性结肠炎中医内外合治的思路与方法

中医认为溃疡性结肠炎的关键病机是脾虚为本,湿热为标,治疗须温清消补敛并施。从中医整体与局部相结合的观念出发,采用内外合治的治疗思路,即外治遵循苦寒消滞的治疗原则,以中药凉血止痢、清热利湿的“七碳方”直肠滴入保留灌肠;内治遵循温补培本的治疗原则,以口服中药“耄耋汤”健脾补肾、清热利湿。

Implementing geostatistical analysis to study spatio-temporal distribution patterns of swimming crabs(Portunus trituberculatus)

This study attempted to compare the performance of local polynomial interpolation,inverse distance weighted interpolation,and ordinary kriging in studying distribution patterns of swimming crabs.Cross-validation was used to select the optimum method to get distribution results,and kriging was used for making spatial variability analysis.Data were collected from 87 sampling stations in November of 2015(autumn)and February(winter),May(spring)and August(summer)of 2016.Results indicate that swimming crabs widely distributed in autumn and summer:in the summer,they were more spatially independent,and resources in each sampling station varied a lot;in the winter and spring,the abundance of crabs was much lower,but the individual crab size was bigger,and they showed the patchy and more concentrative distribution pattern,which means they were more spatially dependent.Distribution patterns were in accordance with ecological migration features of swimming crabs,which were affected by the changing marine environment.This study could infer that it is applicable to study crab fishery or even other crustacean species using geostatistical analysis.It not only helps practitioners have a better understanding of how swimming crabs migrate from season to season,but also assists researchers in carrying out a more comprehensive assessment of the fishery.Therefore,it may facilitate advancing the implementation in the pilot quota management program of swimming crabs in northern Zhejiang fishing grounds.

The state-of-the-arts of the study on grid interconnection between Iberian Peninsula and West Maghreb region

With the change of energy structure in Europe and the trend of diversification of energy supply, the interconnection of the power grid in the Mediterranean region has gradually become a hotspot in European energy research. This paper introduces the power supply, load demand, power grid construction and the present situation of multinational interregional interconnection in the Iberian Peninsula of the Tour of Mediterranean in Europe(Portugal and Spain) and the Western Maghreb countries(Morocco and Algeria). And the driving force and influence factors of regional power grid interconnection are also analyzed. According to the MEDGRID project aimed at realizing the Mediterranean power grid interconnection, this paper presents the interconnection schemes of the Iberian Peninsula and the Western Maghreb. Furthermore, the subsequent technical problems need to be solved are also expounded.

Dynamic frequency response from electric vehicles in the Great Britain power system

With the large penetration of renewable energy,fulfilling the balance between electricity demand and supply is a challenge to the modern power system.According to the UK government,the wind power penetration will reach 30%by the year 2020.The role of electric vehicles(EVs)contributing to frequency response was investigated.A dynamic frequency control strategy which considers the comfort level of vehicle owners was developed for EVs to regulate their power consumption according to the deviation of system frequency.A simulation model of a population of EVs equipped with such controlwas implemented inMatlab/Simulink platform.In this paper,a simplified Great Britain power system model is used to study the contribution of EVs to dynamic frequency control.The case study showed that using EVs as a demand response resource can greatly reduce the frequency deviations.And the rapid response from EVs can help reduce the operation cost of conventional generators.

Perovskite/GaAs-nanowire hybrid structure photodetectors with ultrafast multiband response enhancement by band engineering

We developed a hybrid structure photodetector combining one-dimensional(1D)inorganic GaAs nanowires and two-dimensional(2D)organic perovskite materials,which can achieve various performance enhancements using a relatively simple structure.Via the optical absorption enhancement of perovskite and the type-II energy band structure formed by the heterostructure,the responsivity and detectivity of the photodetector from ultraviolet(UV)to visible(Vis)wavelengths are significantly enhanced,reaching 75 A/W and 1.49×10^(11)Jones,respectively.The response time of the photodetector was significantly decreased by 3 orders,from 785 ms to 0.5 ms,and the dark current was further reduced to 237 fA.A photodetector was prepared with enhanced responsivity and ultrafast response time in the multiband region from the UV to Vis wavelength.To the best of our knowledge,this is the first time to combine inorganicⅢ-ⅤGaAs nanomaterials with organic perovskite materials,which verifies the effective combination of inorganic and organic materials in a mixed dimension.The excellent photoelectric performance of the perovskite/GaAs-nanowire hybrid structure photodetector makes it a potential candidate material for a wide range of photoelectric applications such as multiband photodetection.

Distinct roles of two SEC scaffold proteins,AFF1 and AFF4,in regulating RNA polymerase Ⅱ transcription elongation

The super elongation complex(SEC)containing positive transcription elongation factor b plays a critical role in regulating transcription elongation.AFF1 and AFF4,two members of the AF4/FMR2 family,act as central scaffold proteins of SEC and are associated with various human diseases.However,their precise roles in transcriptional control remain unclear.Here,we investigate differences in the genomic distribution patterns of AFF1 and AFF4 around transcription start sites(TSSs).AFF1 mainly binds upstream of the TSS,while AFF4 is enriched downstream of the TSS.Notably,disruption of AFF4 results in slow elongation and early termination in a subset of AFF4-bound active genes,whereas AFF1 deletion leads to fast elongation and transcriptional readthrough in the same subset of genes.Additionally,AFF1 knockdown increases AFF4 levels at chromatin,and vice versa.In summary,these findings demonstrate that AFF1 and AFF4 function antagonistically to regulate RNA polymerase Ⅱ transcription.