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LAPLACE TRANSFORMS FOR ANALYTIC FUNCTIONS IN TUBULAR DOMAINS
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作者 Guantie DENG qian fu Hui CAO 《Acta Mathematica Scientia》 SCIE CSCD 2021年第6期1938-1948,共11页
Assume that 0<p<∞ and that B is a connected nonempty open set in R^(n),and that A^(p)(B)is the vector space of all holomorphic functions F in the tubular domains R^(n)+iB such that for any compact set K⊂B,‖ y... Assume that 0<p<∞ and that B is a connected nonempty open set in R^(n),and that A^(p)(B)is the vector space of all holomorphic functions F in the tubular domains R^(n)+iB such that for any compact set K⊂B,‖ y →‖x →F(x+iy)‖Lp(R^(n))‖ L(K)<∞,so A^(p)(B)is a Frechet space with the Heine-Borel property,its topology is induced by a complete invariant metric,is not locally bounded,and hence is not normal.Furthermore,if 1≤p≤2,then the element F of A^(p)(B)can be written as a Laplace transform of some function f∈L(R^(n)). 展开更多
关键词 Laplace transforms Fourier transform tubular domain regular cone
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基于GWAS和WGCNA分析挖掘玉米花期相关候选基因 被引量:1
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作者 钱甫 张占琴 +3 位作者 陈树宾 丁永福 桑志勤 李卫华 《作物学报》 CAS CSCD 北大核心 2023年第12期3261-3276,共16页
花期是玉米重要性状之一,解析玉米花期的遗传基础,挖掘玉米花期关键基因,对于选育广适玉米品种具有重要意义。在580份玉米自交系构成的自然群体中,3年种植测定散粉期、吐丝期和散粉吐丝间隔期等3个花期性状,利用分布全基因组的31,826个S... 花期是玉米重要性状之一,解析玉米花期的遗传基础,挖掘玉米花期关键基因,对于选育广适玉米品种具有重要意义。在580份玉米自交系构成的自然群体中,3年种植测定散粉期、吐丝期和散粉吐丝间隔期等3个花期性状,利用分布全基因组的31,826个SNPs(single nucleotide polymorphisms)标记进行全基因组关联分析(genome wide association study,GWAS),结合自交系B73的14个不同发育阶段的转录组数据进行权重基因共表达网络分析(weighted gene co-expression network analysis,WGCNA),挑选与玉米开花相关的组织特异性模块和关键基因。GWAS在多环境(2个环境以上)下共定位标记14个,挖掘到潜在候选基因10个,WGCNA挖掘到花期潜在候选基因17个,2种方法共同挖掘到候选基因3个。Zm00001d052180编码一个MADS-box转录因子19,Zm00001d016814编码NAC转录因子133,Zm00001d048082编码MADS-box转录因子8,这些基因主要参与调节花序生长发育。研究结果为解析玉米花期遗传基础及分子机制提供参考。 展开更多
关键词 玉米 花期性状 GWAS WGCNA 候选基因
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舌下含服粉尘螨滴剂对变应性鼻炎合并分泌性中耳炎患儿的临床疗效
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作者 雷盛钦 钱复 +2 位作者 胡水婷 吴琳琳 张素华 《中国医学创新》 CAS 2021年第14期23-27,共5页
目的:探讨舌下含服粉尘螨滴剂对变应性鼻炎合并分泌性中耳炎患儿的临床疗效。方法:选择本院2017年1月-2019年1月70例变应性鼻炎合并分泌性中耳炎患儿,随机分为治疗组和对照组,每组35例。对照组给予常规治疗,治疗组在对照组基础上给予舌... 目的:探讨舌下含服粉尘螨滴剂对变应性鼻炎合并分泌性中耳炎患儿的临床疗效。方法:选择本院2017年1月-2019年1月70例变应性鼻炎合并分泌性中耳炎患儿,随机分为治疗组和对照组,每组35例。对照组给予常规治疗,治疗组在对照组基础上给予舌下含服粉尘螨滴剂治疗。比较两组的疗效、不良反应及治疗前和治疗12个月后的VAS评分、听力情况。结果:治疗组总有效率高于对照组,差异有统计学意义(P<0.05)。两组治疗前VAS评分、听力情况比较,差异均无统计学意义(P>0.05);治疗12个月后,治疗组VAS评分、听力情况均优于对照组,差异均有统计学意义(P<0.05)。两组治疗过程均未出现不良反应。结论:舌下含服粉尘螨滴剂对变应性鼻炎合并分泌性中耳炎患儿安全有效,患儿的临床症状、听力改善显著。 展开更多
关键词 舌下含服 粉尘螨滴剂 变应性鼻炎 分泌性中耳炎
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Effect of operating parameters on the performance of thermally regenerative ammonia-based battery for low-temperature waste heat recovery 被引量:2
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作者 Yu Shi Liang Zhang +4 位作者 Jun Li qian fu Xun Zhu qiang Liao Yongsheng Zhang 《Chinese Journal of Chemical Engineering》 SCIE EI CAS CSCD 2021年第4期335-340,共6页
This study investigated the important factors that affect the operating parameters of thermally regenerative ammoniabased batteries(TRABs),including the metal electrode type,membrane type,electrode surface area,electr... This study investigated the important factors that affect the operating parameters of thermally regenerative ammoniabased batteries(TRABs),including the metal electrode type,membrane type,electrode surface area,electrode distance,electrolyte concentration,and ammonia concentration.The experimental results showed that the maximum power density of TRABs with a Cu electrode was 40.0 W·m^(2),which was considerably higher than that with Ni(0.34 W·m^(2))and Co(0.14 W·m^(2))electrodes.TRABs with an anion exchange membrane had a 28.6%higher maximum power density than those with a cation exchange membrane.An increased electrode surface resulted in an increased maximum power but a decreased maximum power density.Within a certain range,TRAB performance was enhanced with decreased electrode distance and increased electrolyte concentration.An increased ammonia concentration resulted in enhanced ammonia transfer and improved the TRAB performance. 展开更多
关键词 Electrochemistry Thermally regenerative ammonia-based BATTERY Recovery Renewable energy
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城市副中心剧院项目施工运输组织部署与降本增效问题探讨 被引量:1
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作者 何海琦 付玉玺 +2 位作者 钱甫 董俊海 吴良良 《建筑技术》 2022年第8期1101-1103,共3页
以城市副中心剧院项目为例,从生产和成本两个方面对歌剧院等具有裙房和楼中楼特点的复杂结构形式建筑进行分析。探究类似工程水平和垂直运输设备选型布置思路和成本控制方法。总结期间所遇到的问题和经验,达到为具有相似特点的工程提供... 以城市副中心剧院项目为例,从生产和成本两个方面对歌剧院等具有裙房和楼中楼特点的复杂结构形式建筑进行分析。探究类似工程水平和垂直运输设备选型布置思路和成本控制方法。总结期间所遇到的问题和经验,达到为具有相似特点的工程提供参考和借鉴、降本增效的目的。 展开更多
关键词 剧院 水平和垂直运输 降本增效 成本控制
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平行承发包模式下施工总承包方的管理和控制 被引量:1
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作者 钱甫 付玉玺 +2 位作者 孙佳 李兵 吴良良 《建筑技术》 2022年第8期1098-1100,共3页
针对现阶段平行承发包模式下的施工总承包单位和平行分包单位关系,以城市副中心剧院项目为研究对象。探讨平行分包模式的合理性、适用性和适用条件。分析该模式下的管理难点和问题,提出施工总承包单位的风险规避和管控措施,从而为未来... 针对现阶段平行承发包模式下的施工总承包单位和平行分包单位关系,以城市副中心剧院项目为研究对象。探讨平行分包模式的合理性、适用性和适用条件。分析该模式下的管理难点和问题,提出施工总承包单位的风险规避和管控措施,从而为未来工作开展提供经验和指导。 展开更多
关键词 平行承发包模式 FIDIC合同文本 管理难点 风险规避
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Super-resolution filtered ghost imaging with compressed sensing
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作者 Shao-Ying Meng Wei-Wei Shi +4 位作者 Jie Ji Jun-Jie Tao qian fu Xi-Hao Chen Ling-An Wu 《Chinese Physics B》 SCIE EI CAS CSCD 2020年第12期119-124,共6页
A filtered ghost imaging(GI)protocol is proposed that enables the Rayleigh diffraction limit to be exceeded in an intensity correlation system;a super-resolution reconstructed image is achieved by low-pass filtering o... A filtered ghost imaging(GI)protocol is proposed that enables the Rayleigh diffraction limit to be exceeded in an intensity correlation system;a super-resolution reconstructed image is achieved by low-pass filtering of the measured intensities.In a lensless GI experiment performed with spatial bandpass filtering,the spatial resolution can exceed the Rayleigh diffraction bound by more than a factor of 10.The resolution depends on the bandwidth of the filter,and the relationship between the two is investigated and discussed.In combination with compressed sensing programming,not only high resolution can be maintained but also image quality can be improved,while a much lower sampling number is sufficient. 展开更多
关键词 ghost imaging bandpass filtering compressed sensing super resolution
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玉米株高和穗位高的全基因组关联分析 被引量:1
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作者 钱甫 张占琴 +2 位作者 陈树宾 桑志勤 李卫华 《玉米科学》 CAS CSCD 北大核心 2024年第1期65-73,81,共10页
以580份遗传多样性丰富的玉米自交系为关联群体,利用分布于全基因组的31826个单核苷酸多态性(Single Nucleotide Polymorphisms,SNPs)分别对株高和穗位高性状3年表型值及BLUE(Best Linear Unbiased Esti⁃mate)值进行全基因组关联分析。... 以580份遗传多样性丰富的玉米自交系为关联群体,利用分布于全基因组的31826个单核苷酸多态性(Single Nucleotide Polymorphisms,SNPs)分别对株高和穗位高性状3年表型值及BLUE(Best Linear Unbiased Esti⁃mate)值进行全基因组关联分析。结果表明,4个环境下共检测到58个显著性SNPs,共定位的SNPs有6个,其中3个与株高显著关联,4个与穗位高显著关联。在共定位显著标记440 kb范围内,共检测到76个关联基因,其中66个有基因描述,53个基因在GO(Gene Ontology)富集分析中得到分类,可归类到20类生物过程、10类分子功能以及8类细胞组成。综合基因功能注释和GO富集分析结果,预测了7个可能与株高和穗位高性状有关的候选基因。 展开更多
关键词 玉米 株高 穗位高 全基因组关联分析
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Hierarchical vectorization for facial images
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作者 qian fu Linlin Liu +1 位作者 Fei Hou Ying He 《Computational Visual Media》 SCIE EI CSCD 2024年第1期97-118,共22页
The explosive growth of social media means portrait editing and retouching are in high demand.While portraits are commonly captured and stored as raster images,editing raster images is non-trivial and requires the use... The explosive growth of social media means portrait editing and retouching are in high demand.While portraits are commonly captured and stored as raster images,editing raster images is non-trivial and requires the user to be highly skilled.Aiming at developing intuitive and easy-to-use portrait editing tools,we propose a novel vectorization method that can automatically convert raster images into a 3-tier hierarchical representation.The base layer consists of a set of sparse diffusion curves(DCs)which characterize salient geometric features and low-frequency colors,providing a means for semantic color transfer and facial expression editing.The middle level encodes specular highlights and shadows as large,editable Poisson regions(PRs)and allows the user to directly adjust illumination by tuning the strength and changing the shapes of PRs.The top level contains two types of pixel-sized PRs for high-frequency residuals and fine details such as pimples and pigmentation.We train a deep generative model that can produce high-frequency residuals automatically.Thanks to the inherent meaning in vector primitives,editing portraits becomes easy and intuitive.In particular,our method supports color transfer,facial expression editing,highlight and shadow editing,and automatic retouching.To quantitatively evaluate the results,we extend the commonly used FLIP metric(which measures color and feature differences between two images)to consider illumination.The new metric,illumination-sensitive FLIP,can effectively capture salient changes in color transfer results,and is more consistent with human perception than FLIP and other quality measures for portrait images.We evaluate our method on the FFHQR dataset and show it to be effective for common portrait editing tasks,such as retouching,light editing,color transfer,and expression editing. 展开更多
关键词 face editing VECTORIZATION Poisson editing color transfer illumination editing expression editing
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Outcomes in pediatric recipients of single kidney transplantation from pediatric donors with acute kidney injury:A single-center pilot study
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作者 qiang Zhang Yanxu Chen +10 位作者 Haiyue Yu Jun Li Chenglin Wu Sizhe Long Pengan Li qian fu Huanxi Zhang Xiaojun Su Bowen Xu Longshan Liu Changxi Wang 《Chinese Medical Journal》 SCIE CAS CSCD 2024年第12期1489-1491,共3页
To the Editor:The shortage of deceased donor(DD)kidneys for transplantation remains a persistent concern.Despite the potential reversibility of acute kidney injury(AKI)lesions,kidneys from pediatric donors with AKI ar... To the Editor:The shortage of deceased donor(DD)kidneys for transplantation remains a persistent concern.Despite the potential reversibility of acute kidney injury(AKI)lesions,kidneys from pediatric donors with AKI are often underutilized,especially in the context of pediatric transplantation.By implementing single kidney transplantation(SKT)from pediatric donors to pediatric recipients(PTP),we can optimize the utilization of available kidneys and increase the number of pediatric recipients. 展开更多
关键词 PEDIATRIC KIDNEY ACUTE
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浅析某型电源输出异常的几点思考
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作者 钱富 崔忞慜 王军阳 《船舶标准化与质量》 2024年第3期57-60,共4页
运用装备质量问题技术归零的方法,对某型电源输出异常故障从电源的工作原理入手,首先通过失效分析确定故障模式;然后进行过程梳理,对其中可疑的因素进行筛选和验证,分析可能故障点,以确定质量问题的关键来源;最后经故障确认和试验验证,... 运用装备质量问题技术归零的方法,对某型电源输出异常故障从电源的工作原理入手,首先通过失效分析确定故障模式;然后进行过程梳理,对其中可疑的因素进行筛选和验证,分析可能故障点,以确定质量问题的关键来源;最后经故障确认和试验验证,成功找到故障点,并进一步提出有效的解决措施来排除故障。通过不断实践总结,探讨了如何按照GJB/Z 194-2021《装备质量问题归零实施指南》快速有效地开展质量问题技术归零工作,以确保产品不带隐患交付、不带风险随船出航,为后续类似故障分析提供了思路。 展开更多
关键词 装备质量 质量问题 技术归零 电源输出
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Graphene oxide modified membrane for alleviated ammonia crossover and improved electricity generation in thermally regenerative batteries 被引量:2
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作者 Yongsheng Zhang Yu Shi +4 位作者 Liang Zhang Jun Li qian fu Xun Zhu qiang Liao 《Chinese Chemical Letters》 SCIE CAS CSCD 2023年第2期485-488,共4页
Thermally regenerative batteries(TRBs) are promising for harvesting low-grade waste heat into electrical power. However, the ammonia crossover from anode to cathode causes self-discharge and then leads to the decay of... Thermally regenerative batteries(TRBs) are promising for harvesting low-grade waste heat into electrical power. However, the ammonia crossover from anode to cathode causes self-discharge and then leads to the decay of capacity. To alleviate the ammonia crossover and improve electricity generation, a stable graphene oxide(GO) modified anion exchange membrane(AEM) was proposed. Compared with the original AEM, the GO modified AEM with a 39.5% lower ammonia permeability induces a 24.3% higher maximal power output and 20.2% higher energy density in TRBs. Together with the visualization result,it was demonstrated the ammonia crossover was effectively alleviated by GO modifying the AEM not at a cost of the reduced battery performance, indicating the promising application in future TRBs. 展开更多
关键词 Thermally regenerative batteries Ammonia crossover Surface modification Graphene oxide Electrophoretic deposition
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耳鼻咽喉疾病患儿多药耐药菌感染现状及影响因素 被引量:2
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作者 雷盛钦 胡水婷 +2 位作者 黄小燕 钱复 吴琳琳 《中华医院感染学杂志》 CAS CSCD 北大核心 2020年第21期3351-3354,共4页
目的调查分析耳鼻咽喉疾病患儿多药耐药菌(MDROs)感染现状及影响因素。方法回顾性分析2015年9月-2019年9月江西省九江市妇幼保健院耳鼻喉科收治的206例耳鼻咽喉疾病患儿临床资料,采集患儿标本(包含耳内、鼻、咽喉等处分泌物)行病原菌检... 目的调查分析耳鼻咽喉疾病患儿多药耐药菌(MDROs)感染现状及影响因素。方法回顾性分析2015年9月-2019年9月江西省九江市妇幼保健院耳鼻喉科收治的206例耳鼻咽喉疾病患儿临床资料,采集患儿标本(包含耳内、鼻、咽喉等处分泌物)行病原菌检测和药敏试验,依据是否出现MDROs感染分为MDROs感染组、非MDROs感染组,分析206例患儿MDROs感染现状和病原菌分布情况及MDROs感染的影响因素。结果共分离病原菌186株,48例患儿检出MDROs(共50株),MDROs感染率26.88%(50/186)。2015年-2019年耳鼻咽喉疾病患儿MDROs感染率逐年递增。患儿MDROs感染病原菌以产超广谱β内酰胺酶肠杆菌科细菌(30.00%)、泛耐药铜绿假单胞菌(28.00%)、耐甲氧西林金黄色葡萄球菌(26.00%)较为常见。MDROs感染组病程>5年、出现急性感染期频次≥3次/年、抗菌药物使用种类≥3种占比高于非MDROs感染组(P<0.05)。病程、出现急性感染期频次、抗菌药物使用种类、不规律用药次数为耳鼻咽喉疾病患儿MDROs感染的高危因素(P<0.05)。结论耳鼻咽喉疾病患儿MDROs感染风险高,临床需加强对病程长、急性感染期频次高患儿的重视,而规范使用抗菌药物、提高规律用药积极性,对降低MDROs感染风险有重要临床意义。 展开更多
关键词 耳鼻咽喉 小儿 多药耐药菌 感染现状 分布 危险因素
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可再生合成燃料研究进展 被引量:5
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作者 夏奡 陈蓉 +3 位作者 付乾 朱贤青 朱恂 廖强 《科学通报》 EI CAS CSCD 北大核心 2020年第18期1814-1823,共10页
能源是支撑人类文明和发展的源泉,自古以来人类社会的每一次重要进步都伴随着能源利用效率的不断提升.然而,化石燃料的过度开采和利用不仅造成了能源危机,而且还导致了温室气体、颗粒物等污染物过量排放所引发的严重环境问题.如何获得... 能源是支撑人类文明和发展的源泉,自古以来人类社会的每一次重要进步都伴随着能源利用效率的不断提升.然而,化石燃料的过度开采和利用不仅造成了能源危机,而且还导致了温室气体、颗粒物等污染物过量排放所引发的严重环境问题.如何获得可再生的洁净燃料是人类社会可持续发展面临的重要挑战.19世纪中叶,人类已经开展了制备可再生合成燃料方面的探索,发现利用厌氧微生物可以转化生物质制取富含甲烷的燃气.历经160余年的发展,已经形成了多条直接或间接的可再生合成燃料制备途径.本文围绕可再生燃料的电化学合成、光催化转化、热化学转化、微生物转化四种主要合成路线,综述了利用可再生能源转化二氧化碳制备甲烷、醇醚燃料、烷烃柴油、航空燃油等合成燃料的发展历程、重要进展及挑战,为未来的燃料可持续供给提供新思路. 展开更多
关键词 可再生能源 燃料 光催化 电化学合成 热化学转化 微生物转化
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A piezoelectric tracked vehicle with potential application to planetary exploration 被引量:3
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作者 JIN JiaMei qian fu +2 位作者 YANG Ying ZHANG JianHui ZHU KongJun 《Chinese Science Bulletin》 SCIE CAS 2012年第11期1339-1342,共4页
A piezoelectric driving method for rover vehicles is proposed in this paper. Employing this method, a tracked vehicle driven by friction forces from a frame mounted with piezoelectric elements was developed. The vehic... A piezoelectric driving method for rover vehicles is proposed in this paper. Employing this method, a tracked vehicle driven by friction forces from a frame mounted with piezoelectric elements was developed. The vehicle is designed with no driver sprocket, no idler-wheel and no supporting bogie wheels, and the vehicle thus requires no lubrication and has potential application in planetary exploration. The frame consists of a pair of piezoelectric transducers. Each transducer comprises four annular parts jointed by beams adhered with piezoelectric ceramics. The tracks are set to the outer surface of the annular parts by means of track tension. Traveling rotating waves are generated by piezoelectric transducers in the annular parts, which generate microscopic elliptical motions at the interface of the tracks. The microscopic elliptical motions from the piezoelectric transducers drive the track vehicle to move. Finite elements analysis was carried out to verify the operation principle using commercial software ANSYS. Piezoelectric transducers were fabricated, assembled and tested to validate the concepts of the proposed rover vehicle and confirm the simulation results. A prototype vehicle with mass of 0.57 kg moves at a speed of 4.3 mm/s at a driving voltage of 250 V and operating frequency of 65.53 kHz. 展开更多
关键词 履带车辆 压电元件 应用 ANSYS有限元分析 压电换能器 索具 行星 驱动链轮
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Hemodynamics in Transplant Renal Artery Stenosis and its Alteration after Stent Implantation Based on a Patient-specific Computational Fluid Dynamics Model 被引量:3
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作者 Hong-Yang Wang Long-Shan Liu +6 位作者 Hai-Ming Cao Jun Li Rong-Hai Deng qian fu Huan-Xi Zhang Ji-Guang Fei Chang-Xi Wang 《Chinese Medical Journal》 SCIE CAS CSCD 2017年第1期23-31,共9页
Background: Accumulating studies on computational fluid dynamics (CFD) support the involvement of hemodynamic factors in artery stenosis. Based on a patient-specific CFD model, the present study aimed to investigat... Background: Accumulating studies on computational fluid dynamics (CFD) support the involvement of hemodynamic factors in artery stenosis. Based on a patient-specific CFD model, the present study aimed to investigate the hemodynamic characteristics of transplant renal artery stenosis (TRAS) and its alteration after stent treatment. Methods: Computed tomography angiography (CTA) data of kidney transplant recipients in a single transplant center from April 2013 to November 2014 were reviewed. The three-dimensional geometry of transplant renal artery (TRA) was reconstructed from the qualified CTA images and categorized into three groups: the normal, stenotic, and stented groups. Hemodynamic parameters including pressure distribution, velocity, wall shear stress (WSS), and mass flow rate (MFR) were extracted. The data of hemodynamic parameters were expressed as median (interquartile range), and Mann-Whitney U-test was used for analysis. Results: Totally, 6 normal, 12 stenotic, and 6 stented TRAs were included in the analysis. TRAS presented nonuniform pressure distribution, adverse pressure gradient across stenosis throat, flow vortex, and a separation zone at downstream stenosis. Stenotic arteries had higher maximal velocity and maximal WSS (2.94 [2.14, 3.30] vs. 1.06 /0.89, 1.15] m/s, 256.5 [149.8, 349.4] vs. 41.7 [37.8, 45.3] Pa at end diastole, P - 0.001 ; 3.25 [2.67, 3.56] vs. 1.65 [ 1.18, 1.72] m/s, 281.3 [ 184.3,364.7] vs. 65.8 [61.2, 71.9] Pa at peak systole, P - 0.001 ) and lower minimal WSS and MFRs (0.07 [0.03, 0.13] vs. 0.52 [0.45, 0.67] Pa, 1.5 [1.0, 3.0] vs. 11.0 [8.0, 11.3] g/s at end diastole, P = 0.001 ; 0.08 [0.03, 0.19] vs. 0.70 [0.60, 0.81] Pa, 2.0 [1.3, 3.3] vs. 16.5 [13.0, 20.3] g/s at peak systole, P 0.001) as compared to normal arteries. Stent implantation ameliorated all the alterations of the above hemodynamic factors except low WSS. Conclusions: Hemodynamic factors were significantly changed in severe TRAS. Stent implantation can restore or ameliorate deleterious change of hemodynamic factors except low WSS at stent regions. 展开更多
关键词 HEMODYNAMICS Kidney Transplantation Patient-specific Modeling Renal Artery Obstruction
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Whole-exome sequencing identified compound heterozygous variants in MMKS in a Chinese pedigree with Bardet-Biedl syndrome 被引量:2
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作者 Zhan Qi Ying Shen +6 位作者 qian fu Wei Li Wei Yang Wenshan Xu Ping Chu Yaxin Zhang Hui Wang 《Science China(Life Sciences)》 SCIE CAS CSCD 2017年第7期739-745,共7页
Bardet-Biedl syndrome(BBS) is a genetically heterogeneous disorder characterized by retinal dystrophy, polydactyly, obesity,developmental delay, and renal defects. At least 21 candidate BBS-associated genes(BBS1-19, N... Bardet-Biedl syndrome(BBS) is a genetically heterogeneous disorder characterized by retinal dystrophy, polydactyly, obesity,developmental delay, and renal defects. At least 21 candidate BBS-associated genes(BBS1-19, NPHP1, and IFT172) have previously been identified, and all of them play important roles in ciliary function. Here, we collected a BBS pedigree with four members and performed whole-exome sequencing on the proband. The variants were analyzed and evaluated to confirm their pathogenicity. We found compound heterozygous variants(c.1192C>T, p.Q398* and c.1175C>T, p.T392M) in MKKS in both the siblings, and these were likely to be pathogenic variants. We also found a missense variant(c.2029G>C, p.E677Q) in NPHP1 and a missense variant(c.2470C>T, p.R824C) in BBS9 in the proband only, which are variants of uncertain significance. The compound heterozygous variants were probably responsible for the BBS phenotype in this Chinese pedigree and the missense mutations in NPHP1 and BBS9 might contribute to the mutation load. 展开更多
关键词 Bardet-Biedl syndrome MKKS BBS6 NPHP1 whole-exome sequencing
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Pore-scale lattice Boltzmann simulation of flow and mass transfer in bioreactor with an immobilized granule for biohydrogen production
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作者 qiang Liao Yan-Xia Yang +2 位作者 Xun Zhu Rong Chen qian fu 《Science Bulletin》 SCIE EI CAS CSCD 2017年第1期22-30,共9页
The photo bioreaction combined with flow and mass transfer is simulated with pore-scale lattice Boltzmann (LB) method, which is the scenario of a bioreactor filled with a porous granule immobilized photosynthetic ba... The photo bioreaction combined with flow and mass transfer is simulated with pore-scale lattice Boltzmann (LB) method, which is the scenario of a bioreactor filled with a porous granule immobilized photosynthetic bacteria cells for hydrogen production. The quartet structure generation set (QSGS) is used to generate porous structure of the immobilized granule. The effects of porosity of the immobilized granule on flow and concentration fields as well as the hydrogen production performance are investi- gated. Higher porosity facilitates the substrate solution smoothly flowing through the porous granule with increasing velocity, and thus results in higher product concentration inside the immobilized gran- ule. Additionally, the substrate consumption efficiency increases, while hydrogen yield slightly decreases with increasing porosity, and they tend to stable for the porosity larger than 0.5. Furthermore, the LB numerical results have a good agreement with the experimental results. It is demonstrated that the pore-scale LB simulation method coupling with QSGS is available to simulate the photo hydrogen produc- tion in the hioreactor with porous immobilized granules. 展开更多
关键词 Lattice Boltzmann method Pore scale Immobilized granule Photo biohydrogen production
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Applying artificial neural network to predict the viscosity of microalgae slurry in hydrothermal hydrolysis process
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作者 Hao Chen qian fu +2 位作者 qiang Liao Xun Zhu Akeel Shah 《Energy and AI》 2021年第2期181-187,共7页
Estimation of the viscosity of microalgae slurry is the premise for the design of industrial reactors in microalgal biofuel production.To accurately predict the viscosity of microalgae slurry(Chlorella pyrenoidosa),an... Estimation of the viscosity of microalgae slurry is the premise for the design of industrial reactors in microalgal biofuel production.To accurately predict the viscosity of microalgae slurry(Chlorella pyrenoidosa),an artificial neural network(ANN)model is designed in this study.In the ANN model,the mass fraction of microalgal cell,shear rate,temperature,and retention time during the hydrothermal hydrolysis process are used as the input variables,and the viscosity of microalgae slurry is obtained as the output variable.Comparisons show that the ANN model is in excellent agreement with the experimental data.The mean square error(MSE),Mean Absolute Error(MAE),and goodness of fit(R 2)are 0.725,0.484 and 0.991,respectively.The results provide a proof-of-concept for using ANN models to estimate the viscosity of microalgae slurry.In particular,the developed ANN model can accurately predict the viscosity of microalgae slurry in a hydrothermal hydrolysis process,which cannot be accurately predicted by a standard curve fitting method. 展开更多
关键词 Artificial neural network Viscosity prediction Microalgae slurry Hydrothermal hydrolysis process Curve fitting
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