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Efficient Multi-Authority Attribute-Based Searchable Encryption Scheme with Blockchain Assistance for Cloud-Edge Coordination
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作者 Peng Liu qian he +2 位作者 Baokang Zhao Biao Guo Zhongyi Zhai 《Computers, Materials & Continua》 SCIE EI 2023年第9期3325-3343,共19页
Cloud storage and edge computing are utilized to address the storage and computational challenges arising from the exponential data growth in IoT.However,data privacy is potentially risky when data is outsourced to cl... Cloud storage and edge computing are utilized to address the storage and computational challenges arising from the exponential data growth in IoT.However,data privacy is potentially risky when data is outsourced to cloud servers or edge services.While data encryption ensures data confidentiality,it can impede data sharing and retrieval.Attribute-based searchable encryption(ABSE)is proposed as an effective technique for enhancing data security and privacy.Nevertheless,ABSE has its limitations,such as single attribute authorization failure,privacy leakage during the search process,and high decryption overhead.This paper presents a novel approach called the blockchain-assisted efficientmulti-authority attribute-based searchable encryption scheme(BEM-ABSE)for cloudedge collaboration scenarios to address these issues.BEM-ABSE leverages a consortium blockchain to replace the central authentication center for global public parameter management.It incorporates smart contracts to facilitate reliable and fair ciphertext keyword search and decryption result verification.To minimize the computing burden on resource-constrained devices,BEM-ABSE adopts an online/offline hybrid mechanism during the encryption process and a verifiable edge-assisted decryption mechanism.This ensures both low computation cost and reliable ciphertext.Security analysis conducted under the random oracle model demonstrates that BEM-ABSE is resistant to indistinguishable chosen keyword attacks(IND-CKA)and indistinguishable chosen plaintext attacks(INDCPA).Theoretical analysis and simulation results confirm that BEM-ABSE significantly improves computational efficiency compared to existing solutions. 展开更多
关键词 Attribute-based encryption search encryption blockchain multi-authority cloud-edge
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Direct evidence for efficient scattering of suprathermal electrons by whistler mode waves in the Martian magnetosphere
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作者 Tong Li Si Liu +8 位作者 Chang Yang FuLiang Xiao HongMing Yang Sai Zhang ZhongLei Gao qian he QingHua Zhou QiWu Yang YiHua he 《Earth and Planetary Physics》 CAS CSCD 2023年第6期607-614,共8页
Whistler mode waves are critical emissions in magnetized plasmas that usually influence the electron dynamics in a planetary magnetosphere.In this paper,we present a unique event in the Martian magnetosphere in which ... Whistler mode waves are critical emissions in magnetized plasmas that usually influence the electron dynamics in a planetary magnetosphere.In this paper,we present a unique event in the Martian magnetosphere in which enhanced whistler mode waves(~10^(−11) V^(2)/m^(2)/Hz)with frequency of 0.1 f_(ce)-0.5 f_(ce) occurred,based on MAVEN data,exactly corresponding to a significant decrease of suprathermal electron fluxes.The diffusion coefficients are calculated by using the observed electric field wave spectra.The pitch angle diffusion coefficient can approach 10^(−2) s^(−1),which is much larger,by~100 times,than the momentum diffusion coefficient,indicating that pitch angle scattering dominates the whistler-electron resonance process.The current results can successfully explain the dropout of the suprathermal electrons in this event.This study provides direct evidence for whistler-driven electron losses in the Martian magnetosphere. 展开更多
关键词 whistler mode waves diffusion coefficients electron scattering Martian magnetosphere
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存算一体技术研究现状 被引量:1
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作者 李嘉宁 姚鹏 +5 位作者 揭路 唐建石 伍冬 高滨 钱鹤 吴华强 《电子学报》 EI CAS CSCD 北大核心 2024年第4期1103-1117,共15页
冯诺依曼计算机体系结构面临着“存储墙”的瓶颈,阻碍AI(Artificial Intelligence)计算性能提升.存算一体硬件结构打破了“存储墙”的限制,大大提升了AI计算的性能.目前存算一体计算方案已在多种存储介质上得到实现,根据计算信号类型,... 冯诺依曼计算机体系结构面临着“存储墙”的瓶颈,阻碍AI(Artificial Intelligence)计算性能提升.存算一体硬件结构打破了“存储墙”的限制,大大提升了AI计算的性能.目前存算一体计算方案已在多种存储介质上得到实现,根据计算信号类型,可以将存算一体计算方案分成数字存算一体方案和模拟存算一体方案.存算一体硬件结构使得AI计算的性能取得巨大提升,然而进一步发展仍面临重大挑战.本文对不同信号域的存算一体方案的进行了对比分析,指出了每一种方案的主要优缺点,也指明了存算一体技术面临的挑战.我们认为,随着工艺集成、器件、电路、架构,软件工具链的跨层次协同研究发展,存算一体技术将在边缘端和云端,为AI计算提供更加强大和高效的算力. 展开更多
关键词 人工智能 存算一体 存储介质 计算信号类型 评价指标
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以社会共治促进预制菜产业健康发展的策略研究 被引量:1
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作者 张一鸣 王志波 +4 位作者 贾俊杰 郭亚辉 钱和 常巧英 姚卫蓉 《粮油食品科技》 CAS CSCD 北大核心 2024年第5期237-244,共8页
首先解读了预制菜的最新定义和范围,梳理了国外预制食品产业发展的历史和经验,从中汲取了其对于我国预制菜发展的启示和教训。随后分析了国内预制菜产业发展面临的问题及优势,展望了预制菜产业的未来发展趋势,发现预制菜产业的健康发展... 首先解读了预制菜的最新定义和范围,梳理了国外预制食品产业发展的历史和经验,从中汲取了其对于我国预制菜发展的启示和教训。随后分析了国内预制菜产业发展面临的问题及优势,展望了预制菜产业的未来发展趋势,发现预制菜产业的健康发展不仅仅需要依靠政府推动,还离不开市场的自发行为、群众对预制菜的科学认知以及社会媒体的正确引导。由此,紧跟预制菜前沿动态,立足于国内预制菜产业的实际发展状况,提出了以社会共治促进预制菜产业健康发展的策略,为我国预制菜产业高质量发展提供了思路和参考。 展开更多
关键词 预制菜 最新定义 社会共治 高质量发展
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米线加工过程中浸泡法脱镉的响应面优化及对大米品质的影响
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作者 殷杰 杨晓童 +4 位作者 郭亚辉 成玉梁 于航 钱和 姚卫蓉 《食品与发酵工业》 CAS CSCD 北大核心 2024年第13期182-189,共8页
该文通过测定米线传统工艺中镉含量的变化确定了浸泡环节具有脱镉效果,在此基础上利用三因素三水平的响应面优化确定了最佳的浸泡脱镉条件:浸泡温度39℃、浸泡时间36 h、料液比1∶3.8(g∶mL),脱镉率可达(39.51±3.07)%。而后利用扫... 该文通过测定米线传统工艺中镉含量的变化确定了浸泡环节具有脱镉效果,在此基础上利用三因素三水平的响应面优化确定了最佳的浸泡脱镉条件:浸泡温度39℃、浸泡时间36 h、料液比1∶3.8(g∶mL),脱镉率可达(39.51±3.07)%。而后利用扫描电镜与光谱学对浸泡脱镉前后大米内各组分的变化进行对比,证明浸泡可使大米变得松散,降低蛋白质、淀粉、脂肪含量,改变大米蛋白结构,增加直链淀粉含量。同时质构分析表明该方法可赋予其独特的口感,具有一定的应用价值。 展开更多
关键词 米线 浸泡法 脱镉率 品质 响应面法
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肿瘤病理完全缓解的手术指征及治疗决策探讨
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作者 史文松 胡玉缀 +5 位作者 常国涛 钱河 宋银森 杨玉伦 李向楠 郑慧禹 《医学与哲学》 北大核心 2024年第21期69-72,F0003,共5页
肿瘤新辅助治疗后病理完全缓解患者肿瘤组织内无残留癌细胞,预后较好,但术前评估无法精准判断,需依赖术后病理证实。这就引发了评估为临床完全缓解的患者手术适应证及临床决策的讨论。对于达到临床完全缓解的患者,并非都能实现病理完全... 肿瘤新辅助治疗后病理完全缓解患者肿瘤组织内无残留癌细胞,预后较好,但术前评估无法精准判断,需依赖术后病理证实。这就引发了评估为临床完全缓解的患者手术适应证及临床决策的讨论。对于达到临床完全缓解的患者,并非都能实现病理完全缓解,存在复发风险。“观察等待”策略是偏保守的管理方法,需客观对待癌症治疗中的“确定性”,包容其“不确定性”,如新辅助治疗后经评估为临床完全缓解,在不影响患者生活质量的同时,综合考虑病情及患者意愿,医患共同决策下制定“观察等待”策略可作为一种可选方案。 展开更多
关键词 新辅助治疗 病理完全缓解 手术适应证 医患共同决策
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Functional prediction of tomato PLATZ family members and functional verification of Sl PLATZ17
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作者 Min Xu Zhao Gao +8 位作者 Dalong Li Chen Zhang Yuqi Zhang qian he Yingbin Qi he Zhang Jingbin Jiang Xiangyang Xu Tingting Zhao 《Journal of Integrative Agriculture》 SCIE CSCD 2024年第1期141-154,共14页
PLATZ is a novel zinc finger DNA-binding protein that plays an important role in regulating plant growth and development and resisting abiotic stress.However,there has been very little research on the function of this... PLATZ is a novel zinc finger DNA-binding protein that plays an important role in regulating plant growth and development and resisting abiotic stress.However,there has been very little research on the function of this family gene in tomatoes,which limits its application in germplasm resource improvement.Therefore,the PLATZ gene family was identified and analyzed in tomato,and its roles were predicted and verified to provide a basis for in-depth research on SlPLATZ gene function.In this study,the PLATZ family members of tomato were identified in the whole genome,and 19 SlPLATZ genes were obtained.Functional prediction was conducted based on gene and promoter structure analysis and RNA-seq-based expression pattern analysis.SlPLATZ genes that responded significantly under different abiotic stresses or were significantly differentially expressed among multiple tissues were screened as functional gene resources.SlPLATZ17 was selected for functional verification by experiment-based analysis.The results showed that the downregulation of SlPLATZ17 gene expression reduced the drought and salt tolerance of tomato plants.Tomato plants overexpressing SlPLATZ17 had larger flower sizes and long,thin petals,adjacent petals were not connected at the base,and the stamen circumference was smaller.This study contributes to understanding the functions of the SlPLATZ family in tomato and provides a reference for functional gene screening. 展开更多
关键词 TOMATO PLATZ family abiotic stresses plant development
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A large language model-powered literature review for high-angle annular dark field imaging
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作者 Wenhao Yuan Cheng Peng qian he 《Chinese Physics B》 SCIE EI CAS CSCD 2024年第9期76-81,共6页
High-angle annular dark field(HAADF)imaging in scanning transmission electron microscopy(STEM)has become an indispensable tool in materials science due to its ability to offer sub-°A resolution and provide chemic... High-angle annular dark field(HAADF)imaging in scanning transmission electron microscopy(STEM)has become an indispensable tool in materials science due to its ability to offer sub-°A resolution and provide chemical information through Z-contrast.This study leverages large language models(LLMs)to conduct a comprehensive bibliometric analysis of a large amount of HAADF-related literature(more than 41000 papers).By using LLMs,specifically ChatGPT,we were able to extract detailed information on applications,sample preparation methods,instruments used,and study conclusions.The findings highlight the capability of LLMs to provide a new perspective into HAADF imaging,underscoring its increasingly important role in materials science.Moreover,the rich information extracted from these publications can be harnessed to develop AI models that enhance the automation and intelligence of electron microscopes. 展开更多
关键词 large language models high-angle annular dark field imaging deep learning
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Three-dimensional-arterial spin labeling perfusion correlation with diabetes-associated cognitive dysfunction and vascular endothelial growth factor in type 2 diabetes mellitus rat 被引量:5
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作者 Ju-Wei Shao Jin-De Wang +6 位作者 qian he Ying Yang Ying-Ying Zou Wei Su Shu-Tian Xiang Jian-Bo Li Jing Fang 《World Journal of Diabetes》 SCIE 2021年第4期499-513,共15页
BACKGROUND Type 2 diabetes mellitus(T2DM) has been strongly associated with an increased risk of developing cognitive dysfunction and dementia.The mechanisms of diabetes-associated cognitive dysfunction(DACD) have not... BACKGROUND Type 2 diabetes mellitus(T2DM) has been strongly associated with an increased risk of developing cognitive dysfunction and dementia.The mechanisms of diabetes-associated cognitive dysfunction(DACD) have not been fully elucidated to date.Some studies proved lower cerebral blood flow(CBF) in the hippocampus was associated with poor executive function and memory in T2DM.Increasing evidence showed that diabetes leads to abnormal vascular endothelial growth factor(VEGF) expression and CBF changes in humans and animal models.In this study,we hypothesized that DACD was correlated with CBF alteration as measured by three-dimensional(3D) arterial spin labeling(3D-ASL) and VEGF expression in the hippocampus.AIM To assess the correlation between CBF(measured by 3D-ASL and VEGF expression) and DACD in a rat model of T2DM.METHODS Forty Sprague-Dawley male rats were divided into control and T2DM groups.The T2DM group was established by feeding rats a high-fat diet and glucose to induce impaired glucose tolerance and then injecting them with streptozotocin to induce T2DM.Cognitive function was assessed using the Morris water maze experiment.The CBF changes were measured by 3D-ASL magnetic resonance imaging.VEGF expression was determined using immunofluorescence.RESULTS The escape latency time significantly reduced 15 wk after streptozotocin injection in the T2DM group.The total distance traveled was longer in the T2DM group;also,the platform was crossed fewer times.The percentage of distance in the target zone significantly decreased.CBF decreased in the bilateral hippocampus in the T2DM group.No difference was found between the right CBF value and the left CBF value in the T2DM group.The VEGF expression level in the hippocampus was lower in the T2DM group and correlated with the CBF value.The escape latency negatively correlated with the CBF value.The number of rats crossing the platform positively correlated with the CBF value.CONCLUSION Low CBF in the hippocampus and decreased VEGF expression might be crucial in DACD.CBF measured by 3D-ASL might serve as a noninvasive imaging biomarker for cognitive impairment associated with T2DM. 展开更多
关键词 Diabetes-associated cognitive dysfunction Diabetes mellitus Type 2 Perfusion imaging Receptors Vascular endothelial growth factor Hippocampus Three-dimensional pseudo-continuous arterial spin labeling
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Factors influencing the diagnosis and treatment of chronic prostatitis among urologists in China 被引量:3
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作者 Long-Fei Liu Jin-Rui Yang +6 位作者 David A.Ginsberg Hui-Wen Xie Jian-Ming Rao Long Wang Zhuo Yin qian he Tu-Bao Yang 《Asian Journal of Andrology》 SCIE CAS CSCD 2008年第4期675-680,共6页
Aim. To identify the factors influencing diagnosis and treatment of chronic prostatitis (CP) among Chinese urologists. Methods: A sample of 656 urologists from 29 provinces of China were asked to complete a questio... Aim. To identify the factors influencing diagnosis and treatment of chronic prostatitis (CP) among Chinese urologists. Methods: A sample of 656 urologists from 29 provinces of China were asked to complete a questionnaire that explored attitudes towards CP as well as diagnosis and treatment patterns in the management of CP. Both univariate and multivariate logistic regression analysis schemes were used to determine the factors that influence the diagnosis and treatment of CP. Results: A total of 656 questionnaires were given out. All were returned and 410 of those were included in the final univariate and multivariate analysis. Multivariate logistic regression analysis indicated that belief of bacterial infection in the etiology of CP (odds ratio [OR], 2.544; 95% confidence interval [CI], 1.650-3.923; P 〈 0.001) was the most significant factor influencing the routine performance of bacterial culture test. Using the same model, the type of hospital (OR, 2.799; 95% CI, 1.719-4.559; P 〈 0.001) and the routine use of the 4- or the 2-glass test (OR, 3.194; 95% CI, 2.069-4.931; P 〈 0.001) were determined to be significant factors influencing the use of the National Institutes of Health (NIH) new classification system. According to the same model, belief of bacterial infection in the etiology of CP (OR, 3.415; 95% CI, 2.024-5.762; P 〈 0.001) and the routine use of bacterial culture test (OR, 2.261; 95% CI, 1.364-3.749; P 〈 0.01) were important factors influencing the routine prescription of antibiotics. Conclusion: Our findings suggest that attitudes towards CP, and the characteristics of individual urologists' practices may influence the diagnosis and treatment of CP among Chinese urologists. 展开更多
关键词 chronic prostatitis diagnosis THERAPY physicians' practice patterns cross-sectional studies multivariate analysis
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Thermodynamics and density functional theory study of potassium dichromate interaction with galena 被引量:3
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作者 Jian-Hua Chen Xian-Hao Long +1 位作者 Li-Hong Lan qian he 《International Journal of Minerals,Metallurgy and Materials》 SCIE EI CAS CSCD 2014年第10期947-954,共8页
The adsorption heat and reaction rate constant of potassium dichromate on the surface of galena were studied. The results indicate that potassium dichromate tends to adsorption on the galena surface. The reaction orde... The adsorption heat and reaction rate constant of potassium dichromate on the surface of galena were studied. The results indicate that potassium dichromate tends to adsorption on the galena surface. The reaction order is only 0.08385, suggesting that the concentration of potassium dichromate has little influence on its adsorption on the galena surface. In addition, the simulation of CrO2 4- adsorption on the PbS (100) surface in the absence and presence of O2 was carried out by density functional theory (DFT). The calculated results show that CrO2 4- species adsorb energetically at the Pb-S bond site, and the presence of O2 can enhance this adsorption. 展开更多
关键词 FLOTATION potassium dichromate GALENA ADSORPTION THERMODYNAMICS density functional theory
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Scale-up of biomass conversion using 1-ethyl-3-methylimidazolium acetate as the solvent 被引量:3
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作者 Ling Liang Jipeng Yan +4 位作者 qian he Tina Luong Todd R.Pray Blake A.Simmons Ning Sun 《Green Energy & Environment》 SCIE CSCD 2019年第4期432-438,共7页
This scale-up study demonstrated the feasibility of an ionic liquid(IL)pretreatment process at 40 kg scale,using the IL 1-ethyl-3-methylimidazolium acetate([C2C1Im][OAc])as the solvent.The pretreatment was followed by... This scale-up study demonstrated the feasibility of an ionic liquid(IL)pretreatment process at 40 kg scale,using the IL 1-ethyl-3-methylimidazolium acetate([C2C1Im][OAc])as the solvent.The pretreatment was followed by enzymatic hydrolysis through which the process efficiency for biomass conversion to monomeric sugars was determined.The results show that 43 wt%of switchgrass was dissolved in IL after 2 h of pretreatment at 160℃ with 15 wt%solid loading.A 120 h enzymatic hydrolysis of the pretreated switchgrass results in 96%glucan and 98%xylan conversion.[C2C1Im][OAc]pretreatment has been successfully scaled up to 40 kg with improved sugar titers and yields relative to bench scale(6 kg).The mass flow of the overall process was established and the major scale-up challenges of the process were identified. 展开更多
关键词 IONIC liquid 1-Ethyl-3-methylimidazolium ACETATE PRETREATMENT Scale up ENZYME
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High Permeability of Boron along the Transverse Direction of Wood under High-Voltage Electrostatic Field (HVEF) Treatment 被引量:1
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作者 Daiyuan Zhang qian he +8 位作者 Baocong Du Junbao Yu Xudong Zhu Dingyi Yang Shengcai Li Tianyi Zhan Liming Shen Zhiqiang Wang Xiaoning Lu 《Journal of Renewable Materials》 SCIE EI 2022年第3期721-734,共14页
Permeability of wood preservative is one of the most significant factors for protection of wood construction.Ani-sotropic flow permeability was involved in different directions of wood with higher flow resistance in t... Permeability of wood preservative is one of the most significant factors for protection of wood construction.Ani-sotropic flow permeability was involved in different directions of wood with higher flow resistance in the trans-verse and lower longitudinal directions.In this study,boron acid solution was brushed onto the tangential section of air-dried wood cubes and boron penetration along wood transverse direction was investigated under free dif-fusion,vacuum and HVEF treatments.Multi-scale boron distribution,FTIR measurement,leaching property,mechanical properties and fungistatic characteristic were investigated for free diffusion,vacuum and HVEF trea-ted samples respectively.The results revealed that boron exhibited high permeability along the transverse direc-tion with the penetration depth of≈35 mm for HVEF treated samples and≈1 mm for free diffusion and vacuum treated samples.For HVEF treated samples,no significant decrease of hardness,compression modulus of elasti-city and strength were found in the treated samples.Better fungistatic characteristic was showcased in HVEF trea-ted samples exposed to white rot fungi.Thus,HVEF treatment has a positive effect on boron permeability and the improvement of penetration depth of preservatives hence playing a significant role in wood protection and prolonging the service life of wood construction. 展开更多
关键词 Wood permeability boron distribution transverse direction HVEF treatment mechanical property fungistatic property
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Improving the Properties of Fast-Growing Chinese Fir by Vacuum Hot Pressing Treatment 被引量:1
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作者 Lu Hong Biqing Shu +3 位作者 qian he Zehui Ju Haiyang Zhang Xiaoning Lu 《Journal of Renewable Materials》 SCIE EI 2021年第1期49-59,共11页
Chinese fir was compressed by vacuum hot pressing and conventional hot pressing at different temperatures(180℃,200℃ and 220℃),respectively.The color parameters of the heat-compressed sample were measured,the relati... Chinese fir was compressed by vacuum hot pressing and conventional hot pressing at different temperatures(180℃,200℃ and 220℃),respectively.The color parameters of the heat-compressed sample were measured,the relative mechanical properties of the material were tested and changes in the chemistry of fir were investigated using Fourier transform infrared spectroscopy(FTIR)and Xray photoelectron spectroscopy(XPS).The results indicated that the color difference between compressed and untreated wood increased gradually with the increase of temperature.Compared with the conventional hot pressing treatment,the color difference(ΔE*)of the Chinese fir treated by vacuum hot pressing decreased by 43.73%,69.91%,and 77.17%,respectively.The mechanical properties(bending elastic modulus and bending strength)of Chinese fir treated by vacuum hot pressing were significantly improved.The 24-hour water absorption thickness expansion rate of fir treated by vacuum hot pressing is smaller than that of conventional hot pressing.It is implied that vacuum hot pressing treatment is an effective method to produce compressed wood,which can improve the mechanical properties and dimensional stability of wood,and reduce the influence of carbonization on wood color. 展开更多
关键词 Chinese fir vacuum hot pressing COLOR mechanical properties dimensional stability
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Steam Exploded Peanut Shell Fiber as the Filler in the Rigid Polyurethane Foams 被引量:1
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作者 Zehui Ju qian he +5 位作者 Tianyi Zhan Haiyang Zhang Lin Sun Lu Hong Xinyi Shi Xiaoning Lu 《Journal of Renewable Materials》 SCIE 2019年第11期1077-1091,共15页
In this study,steam exploded peanut shell fibers(SE-PSFs)were utilized to fabricate with rigid polyurethane foam(RPUF)in order to improve sound absorption performance and hydrothermal weather resistance.Optimized meth... In this study,steam exploded peanut shell fibers(SE-PSFs)were utilized to fabricate with rigid polyurethane foam(RPUF)in order to improve sound absorption performance and hydrothermal weather resistance.Optimized method of SE treatment,RPUF preparation and flame retardant treatment were selected to prepare SE-PSF/RPUF composites in this experiment.Physical and mechanical properties including density,water absorption capacity,thickness swelling rate,compressive strength,thermal conductivity and average sound absorption coefficient of SE-PSF/RPUF were investigated and compared with the control(PRUF).The results showed that the density,water absorption capacity,thickness swelling rate and thermal conductivity showed an increasing trend with the increase of SE-PSFs content.The strength of the composite material showed a downward trend with the increase of the SE-PSFs content.The average sound absorption coefficient of the SE-PSFs/RPUF compared with PRUF significant increased,and the average sound absorption coefficient of the SE-PSFs/RPUF with SE-PSFs 40%was 0.47.The study getted the best ratio of flame retardants for 10%EG and 3%DMMP.The oxygen index was 35.56 vol%. 展开更多
关键词 Steam explosion peanut shell fiber POLYURETHANE COMPOSITE flame retardant properties
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Prolonged stay of spontaneous intracranial hemorrhage patients in the emergency department is correlated with worse outcomes
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作者 qian he Rui Guo +3 位作者 Ke Zhang Chao You Yi Liu Zhi Zeng 《World Journal of Emergency Medicine》 SCIE CAS CSCD 2022年第3期222-225,共4页
Spontaneous intracerebral hemorrhage(ICH)represents the second most common type of stroke,with high mortality and disability rates.^([1,2])In 2010,there were approximately 5.3 million ICH cases,with 3 million deaths w... Spontaneous intracerebral hemorrhage(ICH)represents the second most common type of stroke,with high mortality and disability rates.^([1,2])In 2010,there were approximately 5.3 million ICH cases,with 3 million deaths worldwide.^([1])However,there is still no validated medical treatment for ICH,with the role of surgery remaining controversial.^([2,3])Cusack et al^([4])demonstrated that lowering blood pressure rapidly in hypertensive ICH patients may be safe and at least partially effective in inhibiting hematoma expansion. 展开更多
关键词 PATIENTS HYPERTENSIVE MORTALITY
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Curcumin in The Treatment of in Animals Myocardial ischemia reperfusion:A Systematic review and Meta-analysis
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作者 qian he Bin Meng +3 位作者 Hong-Yun Hu Gao-Jian Zhuang Qun Tang Xu Zhu 《Medical Data Mining》 2019年第2期66-75,共10页
Objective:The protective effects of curcumin on myocardial ischemia-reperfusion were systematically evaluated by analyzing the related literatures of curcumin and myocardial ischemia-reperfusion.Methods:The computer w... Objective:The protective effects of curcumin on myocardial ischemia-reperfusion were systematically evaluated by analyzing the related literatures of curcumin and myocardial ischemia-reperfusion.Methods:The computer was searched for Wanfang,VIP,China National Knowledge Infrastructure(CNKI),SinoMed,and Pubmed database to find animal experiments on curcumin treatment of myocardial ischemia-reperfusion.The retrieval time is from the establishment of the database to November 2018.Two researchers independently screened the literature based on inclusion and exclusion criteria,extracted the data,and assessed the risk of bias in the included studies.Meta analysis was performed using RevMan 5.3 software.Results:Finally,9 studies were included for analysis.Meta-analysis showed that the curcumin group can reduce LDH and MDA levels compared with the ischemiarreperfusion group(LDH:SMD=-4.75,95%CI[-6.56,-2.94],P<0.01,MDA:SMD=-2.27,95%CI[-3.07,-1.47],P<0.01),the difference was statistically significant(P<0.01).In the subgroup analysis of different doses of curcumin,different doses of curcumin(0.8,10,12.5,20,25,30,50 mg)were able to reduce LDH content compared with the ischemia-reperfusion group,and the differences were statistically significant.Different doses of curcumin(5,10,20,30,40mg)can reduce MDA content,and the difference is statistically significant;curcumin(0.8mg)group has no statistically significant effect on MDA content(SMD=-0.54,95%CI[-1.35,0.28],P=0.20).The relationship between the content of MDA and the dose of curcumin showed that compared with the curcumin(20 mg)group,the curcumin(40 mg)group could better reduce the MDA content,and the difference was statistically significant(P=0.03).Conclusion:Curcumin can reduce the content of LDH and MDA in myocardial ischemia-reperfusion,and has a protective effect on myocardium.Moreover,the ability to reduce the damage is related to the dose of curcumin.However,the sample of the included studies is limited,and this conclusion requires more high-quality experiments to verify. 展开更多
关键词 CURCUMIN MYOCARDIAL ISCHEMIA-REPERFUSION META-ANALYSIS ANIMAL experiment systematic review
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凹凸棒土作为食源性致病菌核酸提取材料的可行性研究 被引量:1
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作者 王莫凡 臧垚 +4 位作者 曹一康 郭亚辉 谢云飞 钱和 姚卫蓉 《食品安全质量检测学报》 CAS 北大核心 2023年第9期128-136,共9页
目的研究凹凸棒土作为一种低成本、高效的食源性致病菌核酸提取材料的可行性。方法利用X射线衍射(X-ray diffraction,XRD)、傅里叶变换红外光谱(Fourier transform infrared spectroscopy,FTIR)、Zeta电位分析、扫描电子显微镜(scanning... 目的研究凹凸棒土作为一种低成本、高效的食源性致病菌核酸提取材料的可行性。方法利用X射线衍射(X-ray diffraction,XRD)、傅里叶变换红外光谱(Fourier transform infrared spectroscopy,FTIR)、Zeta电位分析、扫描电子显微镜(scanning electron microscope,SEM)和比表面积及孔径分析(brunauer-emmett-teller,BET)对凹土样品进行表征,建立凹土样品对DNA吸附和解吸附的方法和体系,并进行条件优化。利用吸附动力学模型和吸附等温模型考察其对DNA的吸附作用,以金黄色葡萄球菌为核酸提取对象,考察核酸提取的得量、纯度与完整性。结果吸附体系中最适pH为5.0,Na+最适浓度为300 mmol/L,准一级动力学模型和Freundlich模型更好地模拟吸附结果,凹凸棒土对DNA饱和吸附量理论值达到18.8972 ng/μg,选取25 mmol/L三聚磷酸钠为解吸剂,解吸率可达95.80%±0.44%。将凹凸棒土应用于金黄色葡萄球菌核酸的提取可获得完整、得量为(4.74±0.20)μg的基因组DNA。结论凹凸棒土对DNA有较强的吸附效果,且选取合适的解吸剂DNA易洗脱。以凹凸棒土为核酸固相提取材料,有望实现食源性致病菌基因组DNA的低成本、高效提取。 展开更多
关键词 凹凸棒土 核酸提取 基因组DNA 吸附 食源性致病菌
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类超晶格结构:有序性传质赋予燃料电池高品质输出性能
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作者 王健 轩文辉 +7 位作者 何倩 蒋金霞 周圆圆 聂瑶 廖强 邵敏华 丁炜 魏子栋 《电化学》 CAS 北大核心 2023年第1期43-51,共9页
质子交换膜燃料电池(PEMFC)是一种强耦合、复杂非线性、动态的、多输入多输出的能量转换装置,不容易达到或保持理想的工作状态。在动态的PEMFC的工作状态下,其输出的电流和电压是振动的、不稳定的,会对负载的使用和寿命造成很大的影响,... 质子交换膜燃料电池(PEMFC)是一种强耦合、复杂非线性、动态的、多输入多输出的能量转换装置,不容易达到或保持理想的工作状态。在动态的PEMFC的工作状态下,其输出的电流和电压是振动的、不稳定的,会对负载的使用和寿命造成很大的影响,严重时亦可损坏负载。该波动的电流或电压输出不仅直接决定着发电系统的成本,而且影响着有效的能量转换效率及电子原件和设备的寿命。基于此,本工作针对燃料电池动态特性及动态排水空间受限导致其电流不规则波动,进而影响输出电能品质和燃料电池系统及其他电子元件的寿命和维护成本等问题,开发了一种外延生长的方法制备排水空间可调控的抗溺水电极,通过调控载体的成核位点密度,形成一种具有不同排水空间的类超晶体结构微米级铂基催化剂。该催化剂制备的电极不仅表现出极佳的抗溺水性,在极低的电流振幅(25 mA·cm^(-2))下持续稳定的输出高品质电能,同时提高了铂的利用率,使其组成的MEA比功率密度达到11.69 W·mg_(Pt)^(-1),表现出极高的应用潜力。 展开更多
关键词 传质 PtCo合金 电能品质 类超晶格 氧还原
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Intercross population study reveals that co-mutation of mitfa genes in two subgenomes induces red skin color in common carp(Cyprinus carpio wuyuanensis) 被引量:1
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作者 Bi-Jun Li Lin Chen +10 位作者 Meng-Zhen Yan Xiao-Qing Zou Yu-Lin Bai Ya-Guo Xue Zhou Jiang Bao-Hua Chen Cheng-Yu Li qian he Jian-Xin Feng Tao Zhou Peng Xu 《Zoological Research》 SCIE CAS CSCD 2023年第2期276-286,共11页
Common carp are among the oldest domesticated fish in the world.As such,there are many food and ornamental carp strains with abundant phenotypic variations due to natural and artificial selection.Hebao red carp(HB,Cyp... Common carp are among the oldest domesticated fish in the world.As such,there are many food and ornamental carp strains with abundant phenotypic variations due to natural and artificial selection.Hebao red carp(HB,Cyprinus carpio wuyuanensis),an indigenous strain in China,is renowned for its unique body morphology and reddish skin.To reveal the genetic basis underlying the distinct skin color of HB,we constructed an improved highfidelity(HiFi) HB genome with good contiguity,completeness,and correctness.Genome structure comparison was conducted between HB and a representative wild strain,Yellow River carp(YR,C.carpio haematopterus),to identify structural variants and genes under positive selection.Signatures of artificial selection during domestication were identified in HB and YR populations,while phenotype mapping was performed in a segregating population generated by HB×YR crosses.Body color in HB was associated with regions with fixed mutations.The simultaneous mutation and superposition of a pair of homologous genes(mitfa) in chromosomes A06 and B06 conferred the reddish color in domesticated HB.Transcriptome analysis of common carp with different alleles of the mitfa mutation confirmed that gene duplication can buffer the deleterious effects of mutation in allotetraploids.This study provides new insights into genotype-phenotype associations in allotetraploid species and lays a foundation for future breeding of common carp. 展开更多
关键词 Cyprinus carpio Artificial selection COLORATION mitfa Structural variant
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