Cloud storage and edge computing are utilized to address the storage and computational challenges arising from the exponential data growth in IoT.However,data privacy is potentially risky when data is outsourced to cl...Cloud storage and edge computing are utilized to address the storage and computational challenges arising from the exponential data growth in IoT.However,data privacy is potentially risky when data is outsourced to cloud servers or edge services.While data encryption ensures data confidentiality,it can impede data sharing and retrieval.Attribute-based searchable encryption(ABSE)is proposed as an effective technique for enhancing data security and privacy.Nevertheless,ABSE has its limitations,such as single attribute authorization failure,privacy leakage during the search process,and high decryption overhead.This paper presents a novel approach called the blockchain-assisted efficientmulti-authority attribute-based searchable encryption scheme(BEM-ABSE)for cloudedge collaboration scenarios to address these issues.BEM-ABSE leverages a consortium blockchain to replace the central authentication center for global public parameter management.It incorporates smart contracts to facilitate reliable and fair ciphertext keyword search and decryption result verification.To minimize the computing burden on resource-constrained devices,BEM-ABSE adopts an online/offline hybrid mechanism during the encryption process and a verifiable edge-assisted decryption mechanism.This ensures both low computation cost and reliable ciphertext.Security analysis conducted under the random oracle model demonstrates that BEM-ABSE is resistant to indistinguishable chosen keyword attacks(IND-CKA)and indistinguishable chosen plaintext attacks(INDCPA).Theoretical analysis and simulation results confirm that BEM-ABSE significantly improves computational efficiency compared to existing solutions.展开更多
Whistler mode waves are critical emissions in magnetized plasmas that usually influence the electron dynamics in a planetary magnetosphere.In this paper,we present a unique event in the Martian magnetosphere in which ...Whistler mode waves are critical emissions in magnetized plasmas that usually influence the electron dynamics in a planetary magnetosphere.In this paper,we present a unique event in the Martian magnetosphere in which enhanced whistler mode waves(~10^(−11) V^(2)/m^(2)/Hz)with frequency of 0.1 f_(ce)-0.5 f_(ce) occurred,based on MAVEN data,exactly corresponding to a significant decrease of suprathermal electron fluxes.The diffusion coefficients are calculated by using the observed electric field wave spectra.The pitch angle diffusion coefficient can approach 10^(−2) s^(−1),which is much larger,by~100 times,than the momentum diffusion coefficient,indicating that pitch angle scattering dominates the whistler-electron resonance process.The current results can successfully explain the dropout of the suprathermal electrons in this event.This study provides direct evidence for whistler-driven electron losses in the Martian magnetosphere.展开更多
PLATZ is a novel zinc finger DNA-binding protein that plays an important role in regulating plant growth and development and resisting abiotic stress.However,there has been very little research on the function of this...PLATZ is a novel zinc finger DNA-binding protein that plays an important role in regulating plant growth and development and resisting abiotic stress.However,there has been very little research on the function of this family gene in tomatoes,which limits its application in germplasm resource improvement.Therefore,the PLATZ gene family was identified and analyzed in tomato,and its roles were predicted and verified to provide a basis for in-depth research on SlPLATZ gene function.In this study,the PLATZ family members of tomato were identified in the whole genome,and 19 SlPLATZ genes were obtained.Functional prediction was conducted based on gene and promoter structure analysis and RNA-seq-based expression pattern analysis.SlPLATZ genes that responded significantly under different abiotic stresses or were significantly differentially expressed among multiple tissues were screened as functional gene resources.SlPLATZ17 was selected for functional verification by experiment-based analysis.The results showed that the downregulation of SlPLATZ17 gene expression reduced the drought and salt tolerance of tomato plants.Tomato plants overexpressing SlPLATZ17 had larger flower sizes and long,thin petals,adjacent petals were not connected at the base,and the stamen circumference was smaller.This study contributes to understanding the functions of the SlPLATZ family in tomato and provides a reference for functional gene screening.展开更多
High-angle annular dark field(HAADF)imaging in scanning transmission electron microscopy(STEM)has become an indispensable tool in materials science due to its ability to offer sub-°A resolution and provide chemic...High-angle annular dark field(HAADF)imaging in scanning transmission electron microscopy(STEM)has become an indispensable tool in materials science due to its ability to offer sub-°A resolution and provide chemical information through Z-contrast.This study leverages large language models(LLMs)to conduct a comprehensive bibliometric analysis of a large amount of HAADF-related literature(more than 41000 papers).By using LLMs,specifically ChatGPT,we were able to extract detailed information on applications,sample preparation methods,instruments used,and study conclusions.The findings highlight the capability of LLMs to provide a new perspective into HAADF imaging,underscoring its increasingly important role in materials science.Moreover,the rich information extracted from these publications can be harnessed to develop AI models that enhance the automation and intelligence of electron microscopes.展开更多
BACKGROUND Type 2 diabetes mellitus(T2DM) has been strongly associated with an increased risk of developing cognitive dysfunction and dementia.The mechanisms of diabetes-associated cognitive dysfunction(DACD) have not...BACKGROUND Type 2 diabetes mellitus(T2DM) has been strongly associated with an increased risk of developing cognitive dysfunction and dementia.The mechanisms of diabetes-associated cognitive dysfunction(DACD) have not been fully elucidated to date.Some studies proved lower cerebral blood flow(CBF) in the hippocampus was associated with poor executive function and memory in T2DM.Increasing evidence showed that diabetes leads to abnormal vascular endothelial growth factor(VEGF) expression and CBF changes in humans and animal models.In this study,we hypothesized that DACD was correlated with CBF alteration as measured by three-dimensional(3D) arterial spin labeling(3D-ASL) and VEGF expression in the hippocampus.AIM To assess the correlation between CBF(measured by 3D-ASL and VEGF expression) and DACD in a rat model of T2DM.METHODS Forty Sprague-Dawley male rats were divided into control and T2DM groups.The T2DM group was established by feeding rats a high-fat diet and glucose to induce impaired glucose tolerance and then injecting them with streptozotocin to induce T2DM.Cognitive function was assessed using the Morris water maze experiment.The CBF changes were measured by 3D-ASL magnetic resonance imaging.VEGF expression was determined using immunofluorescence.RESULTS The escape latency time significantly reduced 15 wk after streptozotocin injection in the T2DM group.The total distance traveled was longer in the T2DM group;also,the platform was crossed fewer times.The percentage of distance in the target zone significantly decreased.CBF decreased in the bilateral hippocampus in the T2DM group.No difference was found between the right CBF value and the left CBF value in the T2DM group.The VEGF expression level in the hippocampus was lower in the T2DM group and correlated with the CBF value.The escape latency negatively correlated with the CBF value.The number of rats crossing the platform positively correlated with the CBF value.CONCLUSION Low CBF in the hippocampus and decreased VEGF expression might be crucial in DACD.CBF measured by 3D-ASL might serve as a noninvasive imaging biomarker for cognitive impairment associated with T2DM.展开更多
Aim. To identify the factors influencing diagnosis and treatment of chronic prostatitis (CP) among Chinese urologists. Methods: A sample of 656 urologists from 29 provinces of China were asked to complete a questio...Aim. To identify the factors influencing diagnosis and treatment of chronic prostatitis (CP) among Chinese urologists. Methods: A sample of 656 urologists from 29 provinces of China were asked to complete a questionnaire that explored attitudes towards CP as well as diagnosis and treatment patterns in the management of CP. Both univariate and multivariate logistic regression analysis schemes were used to determine the factors that influence the diagnosis and treatment of CP. Results: A total of 656 questionnaires were given out. All were returned and 410 of those were included in the final univariate and multivariate analysis. Multivariate logistic regression analysis indicated that belief of bacterial infection in the etiology of CP (odds ratio [OR], 2.544; 95% confidence interval [CI], 1.650-3.923; P 〈 0.001) was the most significant factor influencing the routine performance of bacterial culture test. Using the same model, the type of hospital (OR, 2.799; 95% CI, 1.719-4.559; P 〈 0.001) and the routine use of the 4- or the 2-glass test (OR, 3.194; 95% CI, 2.069-4.931; P 〈 0.001) were determined to be significant factors influencing the use of the National Institutes of Health (NIH) new classification system. According to the same model, belief of bacterial infection in the etiology of CP (OR, 3.415; 95% CI, 2.024-5.762; P 〈 0.001) and the routine use of bacterial culture test (OR, 2.261; 95% CI, 1.364-3.749; P 〈 0.01) were important factors influencing the routine prescription of antibiotics. Conclusion: Our findings suggest that attitudes towards CP, and the characteristics of individual urologists' practices may influence the diagnosis and treatment of CP among Chinese urologists.展开更多
The adsorption heat and reaction rate constant of potassium dichromate on the surface of galena were studied. The results indicate that potassium dichromate tends to adsorption on the galena surface. The reaction orde...The adsorption heat and reaction rate constant of potassium dichromate on the surface of galena were studied. The results indicate that potassium dichromate tends to adsorption on the galena surface. The reaction order is only 0.08385, suggesting that the concentration of potassium dichromate has little influence on its adsorption on the galena surface. In addition, the simulation of CrO2 4- adsorption on the PbS (100) surface in the absence and presence of O2 was carried out by density functional theory (DFT). The calculated results show that CrO2 4- species adsorb energetically at the Pb-S bond site, and the presence of O2 can enhance this adsorption.展开更多
This scale-up study demonstrated the feasibility of an ionic liquid(IL)pretreatment process at 40 kg scale,using the IL 1-ethyl-3-methylimidazolium acetate([C2C1Im][OAc])as the solvent.The pretreatment was followed by...This scale-up study demonstrated the feasibility of an ionic liquid(IL)pretreatment process at 40 kg scale,using the IL 1-ethyl-3-methylimidazolium acetate([C2C1Im][OAc])as the solvent.The pretreatment was followed by enzymatic hydrolysis through which the process efficiency for biomass conversion to monomeric sugars was determined.The results show that 43 wt%of switchgrass was dissolved in IL after 2 h of pretreatment at 160℃ with 15 wt%solid loading.A 120 h enzymatic hydrolysis of the pretreated switchgrass results in 96%glucan and 98%xylan conversion.[C2C1Im][OAc]pretreatment has been successfully scaled up to 40 kg with improved sugar titers and yields relative to bench scale(6 kg).The mass flow of the overall process was established and the major scale-up challenges of the process were identified.展开更多
Permeability of wood preservative is one of the most significant factors for protection of wood construction.Ani-sotropic flow permeability was involved in different directions of wood with higher flow resistance in t...Permeability of wood preservative is one of the most significant factors for protection of wood construction.Ani-sotropic flow permeability was involved in different directions of wood with higher flow resistance in the trans-verse and lower longitudinal directions.In this study,boron acid solution was brushed onto the tangential section of air-dried wood cubes and boron penetration along wood transverse direction was investigated under free dif-fusion,vacuum and HVEF treatments.Multi-scale boron distribution,FTIR measurement,leaching property,mechanical properties and fungistatic characteristic were investigated for free diffusion,vacuum and HVEF trea-ted samples respectively.The results revealed that boron exhibited high permeability along the transverse direc-tion with the penetration depth of≈35 mm for HVEF treated samples and≈1 mm for free diffusion and vacuum treated samples.For HVEF treated samples,no significant decrease of hardness,compression modulus of elasti-city and strength were found in the treated samples.Better fungistatic characteristic was showcased in HVEF trea-ted samples exposed to white rot fungi.Thus,HVEF treatment has a positive effect on boron permeability and the improvement of penetration depth of preservatives hence playing a significant role in wood protection and prolonging the service life of wood construction.展开更多
Chinese fir was compressed by vacuum hot pressing and conventional hot pressing at different temperatures(180℃,200℃ and 220℃),respectively.The color parameters of the heat-compressed sample were measured,the relati...Chinese fir was compressed by vacuum hot pressing and conventional hot pressing at different temperatures(180℃,200℃ and 220℃),respectively.The color parameters of the heat-compressed sample were measured,the relative mechanical properties of the material were tested and changes in the chemistry of fir were investigated using Fourier transform infrared spectroscopy(FTIR)and Xray photoelectron spectroscopy(XPS).The results indicated that the color difference between compressed and untreated wood increased gradually with the increase of temperature.Compared with the conventional hot pressing treatment,the color difference(ΔE*)of the Chinese fir treated by vacuum hot pressing decreased by 43.73%,69.91%,and 77.17%,respectively.The mechanical properties(bending elastic modulus and bending strength)of Chinese fir treated by vacuum hot pressing were significantly improved.The 24-hour water absorption thickness expansion rate of fir treated by vacuum hot pressing is smaller than that of conventional hot pressing.It is implied that vacuum hot pressing treatment is an effective method to produce compressed wood,which can improve the mechanical properties and dimensional stability of wood,and reduce the influence of carbonization on wood color.展开更多
In this study,steam exploded peanut shell fibers(SE-PSFs)were utilized to fabricate with rigid polyurethane foam(RPUF)in order to improve sound absorption performance and hydrothermal weather resistance.Optimized meth...In this study,steam exploded peanut shell fibers(SE-PSFs)were utilized to fabricate with rigid polyurethane foam(RPUF)in order to improve sound absorption performance and hydrothermal weather resistance.Optimized method of SE treatment,RPUF preparation and flame retardant treatment were selected to prepare SE-PSF/RPUF composites in this experiment.Physical and mechanical properties including density,water absorption capacity,thickness swelling rate,compressive strength,thermal conductivity and average sound absorption coefficient of SE-PSF/RPUF were investigated and compared with the control(PRUF).The results showed that the density,water absorption capacity,thickness swelling rate and thermal conductivity showed an increasing trend with the increase of SE-PSFs content.The strength of the composite material showed a downward trend with the increase of the SE-PSFs content.The average sound absorption coefficient of the SE-PSFs/RPUF compared with PRUF significant increased,and the average sound absorption coefficient of the SE-PSFs/RPUF with SE-PSFs 40%was 0.47.The study getted the best ratio of flame retardants for 10%EG and 3%DMMP.The oxygen index was 35.56 vol%.展开更多
Spontaneous intracerebral hemorrhage(ICH)represents the second most common type of stroke,with high mortality and disability rates.^([1,2])In 2010,there were approximately 5.3 million ICH cases,with 3 million deaths w...Spontaneous intracerebral hemorrhage(ICH)represents the second most common type of stroke,with high mortality and disability rates.^([1,2])In 2010,there were approximately 5.3 million ICH cases,with 3 million deaths worldwide.^([1])However,there is still no validated medical treatment for ICH,with the role of surgery remaining controversial.^([2,3])Cusack et al^([4])demonstrated that lowering blood pressure rapidly in hypertensive ICH patients may be safe and at least partially effective in inhibiting hematoma expansion.展开更多
Objective:The protective effects of curcumin on myocardial ischemia-reperfusion were systematically evaluated by analyzing the related literatures of curcumin and myocardial ischemia-reperfusion.Methods:The computer w...Objective:The protective effects of curcumin on myocardial ischemia-reperfusion were systematically evaluated by analyzing the related literatures of curcumin and myocardial ischemia-reperfusion.Methods:The computer was searched for Wanfang,VIP,China National Knowledge Infrastructure(CNKI),SinoMed,and Pubmed database to find animal experiments on curcumin treatment of myocardial ischemia-reperfusion.The retrieval time is from the establishment of the database to November 2018.Two researchers independently screened the literature based on inclusion and exclusion criteria,extracted the data,and assessed the risk of bias in the included studies.Meta analysis was performed using RevMan 5.3 software.Results:Finally,9 studies were included for analysis.Meta-analysis showed that the curcumin group can reduce LDH and MDA levels compared with the ischemiarreperfusion group(LDH:SMD=-4.75,95%CI[-6.56,-2.94],P<0.01,MDA:SMD=-2.27,95%CI[-3.07,-1.47],P<0.01),the difference was statistically significant(P<0.01).In the subgroup analysis of different doses of curcumin,different doses of curcumin(0.8,10,12.5,20,25,30,50 mg)were able to reduce LDH content compared with the ischemia-reperfusion group,and the differences were statistically significant.Different doses of curcumin(5,10,20,30,40mg)can reduce MDA content,and the difference is statistically significant;curcumin(0.8mg)group has no statistically significant effect on MDA content(SMD=-0.54,95%CI[-1.35,0.28],P=0.20).The relationship between the content of MDA and the dose of curcumin showed that compared with the curcumin(20 mg)group,the curcumin(40 mg)group could better reduce the MDA content,and the difference was statistically significant(P=0.03).Conclusion:Curcumin can reduce the content of LDH and MDA in myocardial ischemia-reperfusion,and has a protective effect on myocardium.Moreover,the ability to reduce the damage is related to the dose of curcumin.However,the sample of the included studies is limited,and this conclusion requires more high-quality experiments to verify.展开更多
Common carp are among the oldest domesticated fish in the world.As such,there are many food and ornamental carp strains with abundant phenotypic variations due to natural and artificial selection.Hebao red carp(HB,Cyp...Common carp are among the oldest domesticated fish in the world.As such,there are many food and ornamental carp strains with abundant phenotypic variations due to natural and artificial selection.Hebao red carp(HB,Cyprinus carpio wuyuanensis),an indigenous strain in China,is renowned for its unique body morphology and reddish skin.To reveal the genetic basis underlying the distinct skin color of HB,we constructed an improved highfidelity(HiFi) HB genome with good contiguity,completeness,and correctness.Genome structure comparison was conducted between HB and a representative wild strain,Yellow River carp(YR,C.carpio haematopterus),to identify structural variants and genes under positive selection.Signatures of artificial selection during domestication were identified in HB and YR populations,while phenotype mapping was performed in a segregating population generated by HB×YR crosses.Body color in HB was associated with regions with fixed mutations.The simultaneous mutation and superposition of a pair of homologous genes(mitfa) in chromosomes A06 and B06 conferred the reddish color in domesticated HB.Transcriptome analysis of common carp with different alleles of the mitfa mutation confirmed that gene duplication can buffer the deleterious effects of mutation in allotetraploids.This study provides new insights into genotype-phenotype associations in allotetraploid species and lays a foundation for future breeding of common carp.展开更多
基金supported by the National Natural Science Foundation of China(Nos.62162018,61972412)the Natural Science Foundation of Guangxi(No.2019GXNSFGA245004)+1 种基金the Guilin Science and Technology Project(20210226-1)the Innovation Project of Guangxi Graduate Education(No.YCSW2022296).
文摘Cloud storage and edge computing are utilized to address the storage and computational challenges arising from the exponential data growth in IoT.However,data privacy is potentially risky when data is outsourced to cloud servers or edge services.While data encryption ensures data confidentiality,it can impede data sharing and retrieval.Attribute-based searchable encryption(ABSE)is proposed as an effective technique for enhancing data security and privacy.Nevertheless,ABSE has its limitations,such as single attribute authorization failure,privacy leakage during the search process,and high decryption overhead.This paper presents a novel approach called the blockchain-assisted efficientmulti-authority attribute-based searchable encryption scheme(BEM-ABSE)for cloudedge collaboration scenarios to address these issues.BEM-ABSE leverages a consortium blockchain to replace the central authentication center for global public parameter management.It incorporates smart contracts to facilitate reliable and fair ciphertext keyword search and decryption result verification.To minimize the computing burden on resource-constrained devices,BEM-ABSE adopts an online/offline hybrid mechanism during the encryption process and a verifiable edge-assisted decryption mechanism.This ensures both low computation cost and reliable ciphertext.Security analysis conducted under the random oracle model demonstrates that BEM-ABSE is resistant to indistinguishable chosen keyword attacks(IND-CKA)and indistinguishable chosen plaintext attacks(INDCPA).Theoretical analysis and simulation results confirm that BEM-ABSE significantly improves computational efficiency compared to existing solutions.
基金the National Natural Science Foundation of China grants 42230209, 42241136, 42374199, 42204171, 42274212the Natural Science Foundation of Hunan province Grant 2021JJ20010, 2023JJ20038
文摘Whistler mode waves are critical emissions in magnetized plasmas that usually influence the electron dynamics in a planetary magnetosphere.In this paper,we present a unique event in the Martian magnetosphere in which enhanced whistler mode waves(~10^(−11) V^(2)/m^(2)/Hz)with frequency of 0.1 f_(ce)-0.5 f_(ce) occurred,based on MAVEN data,exactly corresponding to a significant decrease of suprathermal electron fluxes.The diffusion coefficients are calculated by using the observed electric field wave spectra.The pitch angle diffusion coefficient can approach 10^(−2) s^(−1),which is much larger,by~100 times,than the momentum diffusion coefficient,indicating that pitch angle scattering dominates the whistler-electron resonance process.The current results can successfully explain the dropout of the suprathermal electrons in this event.This study provides direct evidence for whistler-driven electron losses in the Martian magnetosphere.
基金support from the National Natural Science Foundation of China(32102390 and 32072589)the China Agriculture Research System(CARS-23-A11)+1 种基金the Heilongjiang Provincial Natural Science Foundation of China(YQ2021C013)the Northeast Agricultural University Scholars Program(20XG28),China。
文摘PLATZ is a novel zinc finger DNA-binding protein that plays an important role in regulating plant growth and development and resisting abiotic stress.However,there has been very little research on the function of this family gene in tomatoes,which limits its application in germplasm resource improvement.Therefore,the PLATZ gene family was identified and analyzed in tomato,and its roles were predicted and verified to provide a basis for in-depth research on SlPLATZ gene function.In this study,the PLATZ family members of tomato were identified in the whole genome,and 19 SlPLATZ genes were obtained.Functional prediction was conducted based on gene and promoter structure analysis and RNA-seq-based expression pattern analysis.SlPLATZ genes that responded significantly under different abiotic stresses or were significantly differentially expressed among multiple tissues were screened as functional gene resources.SlPLATZ17 was selected for functional verification by experiment-based analysis.The results showed that the downregulation of SlPLATZ17 gene expression reduced the drought and salt tolerance of tomato plants.Tomato plants overexpressing SlPLATZ17 had larger flower sizes and long,thin petals,adjacent petals were not connected at the base,and the stamen circumference was smaller.This study contributes to understanding the functions of the SlPLATZ family in tomato and provides a reference for functional gene screening.
基金National Research Foundation(NRF)Singapore,under its NRF Fellowship(Grant No.NRFNRFF11-2019-0002).
文摘High-angle annular dark field(HAADF)imaging in scanning transmission electron microscopy(STEM)has become an indispensable tool in materials science due to its ability to offer sub-°A resolution and provide chemical information through Z-contrast.This study leverages large language models(LLMs)to conduct a comprehensive bibliometric analysis of a large amount of HAADF-related literature(more than 41000 papers).By using LLMs,specifically ChatGPT,we were able to extract detailed information on applications,sample preparation methods,instruments used,and study conclusions.The findings highlight the capability of LLMs to provide a new perspective into HAADF imaging,underscoring its increasingly important role in materials science.Moreover,the rich information extracted from these publications can be harnessed to develop AI models that enhance the automation and intelligence of electron microscopes.
基金Supported by The Endocrine Clinical Medical Center of Yunnan ProvinceNo.ZX20190202+2 种基金the Fund of the Diabetic Innovation Team in Yunnan Province,No.2019HC002the Special Joint Fund from Yunnan Provincial Department of Science and Technology and Kunming Medical University,Kunming,Yunnan,China,No.2018FE001(-267)the SKY Image Research Fund,China,No. Z-2014-07-2003-12。
文摘BACKGROUND Type 2 diabetes mellitus(T2DM) has been strongly associated with an increased risk of developing cognitive dysfunction and dementia.The mechanisms of diabetes-associated cognitive dysfunction(DACD) have not been fully elucidated to date.Some studies proved lower cerebral blood flow(CBF) in the hippocampus was associated with poor executive function and memory in T2DM.Increasing evidence showed that diabetes leads to abnormal vascular endothelial growth factor(VEGF) expression and CBF changes in humans and animal models.In this study,we hypothesized that DACD was correlated with CBF alteration as measured by three-dimensional(3D) arterial spin labeling(3D-ASL) and VEGF expression in the hippocampus.AIM To assess the correlation between CBF(measured by 3D-ASL and VEGF expression) and DACD in a rat model of T2DM.METHODS Forty Sprague-Dawley male rats were divided into control and T2DM groups.The T2DM group was established by feeding rats a high-fat diet and glucose to induce impaired glucose tolerance and then injecting them with streptozotocin to induce T2DM.Cognitive function was assessed using the Morris water maze experiment.The CBF changes were measured by 3D-ASL magnetic resonance imaging.VEGF expression was determined using immunofluorescence.RESULTS The escape latency time significantly reduced 15 wk after streptozotocin injection in the T2DM group.The total distance traveled was longer in the T2DM group;also,the platform was crossed fewer times.The percentage of distance in the target zone significantly decreased.CBF decreased in the bilateral hippocampus in the T2DM group.No difference was found between the right CBF value and the left CBF value in the T2DM group.The VEGF expression level in the hippocampus was lower in the T2DM group and correlated with the CBF value.The escape latency negatively correlated with the CBF value.The number of rats crossing the platform positively correlated with the CBF value.CONCLUSION Low CBF in the hippocampus and decreased VEGF expression might be crucial in DACD.CBF measured by 3D-ASL might serve as a noninvasive imaging biomarker for cognitive impairment associated with T2DM.
文摘Aim. To identify the factors influencing diagnosis and treatment of chronic prostatitis (CP) among Chinese urologists. Methods: A sample of 656 urologists from 29 provinces of China were asked to complete a questionnaire that explored attitudes towards CP as well as diagnosis and treatment patterns in the management of CP. Both univariate and multivariate logistic regression analysis schemes were used to determine the factors that influence the diagnosis and treatment of CP. Results: A total of 656 questionnaires were given out. All were returned and 410 of those were included in the final univariate and multivariate analysis. Multivariate logistic regression analysis indicated that belief of bacterial infection in the etiology of CP (odds ratio [OR], 2.544; 95% confidence interval [CI], 1.650-3.923; P 〈 0.001) was the most significant factor influencing the routine performance of bacterial culture test. Using the same model, the type of hospital (OR, 2.799; 95% CI, 1.719-4.559; P 〈 0.001) and the routine use of the 4- or the 2-glass test (OR, 3.194; 95% CI, 2.069-4.931; P 〈 0.001) were determined to be significant factors influencing the use of the National Institutes of Health (NIH) new classification system. According to the same model, belief of bacterial infection in the etiology of CP (OR, 3.415; 95% CI, 2.024-5.762; P 〈 0.001) and the routine use of bacterial culture test (OR, 2.261; 95% CI, 1.364-3.749; P 〈 0.01) were important factors influencing the routine prescription of antibiotics. Conclusion: Our findings suggest that attitudes towards CP, and the characteristics of individual urologists' practices may influence the diagnosis and treatment of CP among Chinese urologists.
基金financially supported by the National Natural Science Foundation of China(No.51164001)
文摘The adsorption heat and reaction rate constant of potassium dichromate on the surface of galena were studied. The results indicate that potassium dichromate tends to adsorption on the galena surface. The reaction order is only 0.08385, suggesting that the concentration of potassium dichromate has little influence on its adsorption on the galena surface. In addition, the simulation of CrO2 4- adsorption on the PbS (100) surface in the absence and presence of O2 was carried out by density functional theory (DFT). The calculated results show that CrO2 4- species adsorb energetically at the Pb-S bond site, and the presence of O2 can enhance this adsorption.
基金the funding support from The Bioenergy Technologies Office (BETO) within the US DOE’s Office of Energy Efficiency and Renewable Energythe funding support from the American Recovery and Reinvestment Actsupported by the US DOE’s Office of Science, Biological and Environmental Research program through contract DE-AC02-05CH11231 between Lawrence Berkeley National Laboratory and the U.S. Department of Energy
文摘This scale-up study demonstrated the feasibility of an ionic liquid(IL)pretreatment process at 40 kg scale,using the IL 1-ethyl-3-methylimidazolium acetate([C2C1Im][OAc])as the solvent.The pretreatment was followed by enzymatic hydrolysis through which the process efficiency for biomass conversion to monomeric sugars was determined.The results show that 43 wt%of switchgrass was dissolved in IL after 2 h of pretreatment at 160℃ with 15 wt%solid loading.A 120 h enzymatic hydrolysis of the pretreated switchgrass results in 96%glucan and 98%xylan conversion.[C2C1Im][OAc]pretreatment has been successfully scaled up to 40 kg with improved sugar titers and yields relative to bench scale(6 kg).The mass flow of the overall process was established and the major scale-up challenges of the process were identified.
基金The authors would like to express their sincere appreciation for the funding from the National Natural Science Foundation of China(Grant Nos.32071700 and 31901252)the National Key R&D Program of China(Grant No.2018YFD1101002)+1 种基金This study was also supported by the Natural Science Foundation of Jiangsu Province,China(Grant No.BK20180276)the Natural Science Foundation of the Jiangsu Higher Education Institutions of China(Grant Nos.18KJB220012 and 20KJB560010).
文摘Permeability of wood preservative is one of the most significant factors for protection of wood construction.Ani-sotropic flow permeability was involved in different directions of wood with higher flow resistance in the trans-verse and lower longitudinal directions.In this study,boron acid solution was brushed onto the tangential section of air-dried wood cubes and boron penetration along wood transverse direction was investigated under free dif-fusion,vacuum and HVEF treatments.Multi-scale boron distribution,FTIR measurement,leaching property,mechanical properties and fungistatic characteristic were investigated for free diffusion,vacuum and HVEF trea-ted samples respectively.The results revealed that boron exhibited high permeability along the transverse direc-tion with the penetration depth of≈35 mm for HVEF treated samples and≈1 mm for free diffusion and vacuum treated samples.For HVEF treated samples,no significant decrease of hardness,compression modulus of elasti-city and strength were found in the treated samples.Better fungistatic characteristic was showcased in HVEF trea-ted samples exposed to white rot fungi.Thus,HVEF treatment has a positive effect on boron permeability and the improvement of penetration depth of preservatives hence playing a significant role in wood protection and prolonging the service life of wood construction.
基金The Authors acknowledge funding support by the National Key R&D Program of China(2017YFC0703501)the Doctorate Fellowship Foundation of the Nanjing Forestry University and the China Double First Class University Plan.
文摘Chinese fir was compressed by vacuum hot pressing and conventional hot pressing at different temperatures(180℃,200℃ and 220℃),respectively.The color parameters of the heat-compressed sample were measured,the relative mechanical properties of the material were tested and changes in the chemistry of fir were investigated using Fourier transform infrared spectroscopy(FTIR)and Xray photoelectron spectroscopy(XPS).The results indicated that the color difference between compressed and untreated wood increased gradually with the increase of temperature.Compared with the conventional hot pressing treatment,the color difference(ΔE*)of the Chinese fir treated by vacuum hot pressing decreased by 43.73%,69.91%,and 77.17%,respectively.The mechanical properties(bending elastic modulus and bending strength)of Chinese fir treated by vacuum hot pressing were significantly improved.The 24-hour water absorption thickness expansion rate of fir treated by vacuum hot pressing is smaller than that of conventional hot pressing.It is implied that vacuum hot pressing treatment is an effective method to produce compressed wood,which can improve the mechanical properties and dimensional stability of wood,and reduce the influence of carbonization on wood color.
基金from the National Key R&D Program of China(2017YFC0703501)the National Natural and Science Foundation(Nos.BK20170926 and BK20150878)+2 种基金the Postgraduate Research&Practice Innovation Program of Jiangsu Province(KYCX18_0962)the Doctorate Fellowship Foundation of Nanjing Forestry University and the Priority Academic Program Development of Jiangsu Higher Education Institutions(PAPD)LERMAB is supported by the French National Research Agency through the Laboratory of Excellence ARBRE(ANR-12-LABXARBRE-01).
文摘In this study,steam exploded peanut shell fibers(SE-PSFs)were utilized to fabricate with rigid polyurethane foam(RPUF)in order to improve sound absorption performance and hydrothermal weather resistance.Optimized method of SE treatment,RPUF preparation and flame retardant treatment were selected to prepare SE-PSF/RPUF composites in this experiment.Physical and mechanical properties including density,water absorption capacity,thickness swelling rate,compressive strength,thermal conductivity and average sound absorption coefficient of SE-PSF/RPUF were investigated and compared with the control(PRUF).The results showed that the density,water absorption capacity,thickness swelling rate and thermal conductivity showed an increasing trend with the increase of SE-PSFs content.The strength of the composite material showed a downward trend with the increase of the SE-PSFs content.The average sound absorption coefficient of the SE-PSFs/RPUF compared with PRUF significant increased,and the average sound absorption coefficient of the SE-PSFs/RPUF with SE-PSFs 40%was 0.47.The study getted the best ratio of flame retardants for 10%EG and 3%DMMP.The oxygen index was 35.56 vol%.
基金supported by a grant from Sichuan Science and Technology Program,China(2019YFS0251).
文摘Spontaneous intracerebral hemorrhage(ICH)represents the second most common type of stroke,with high mortality and disability rates.^([1,2])In 2010,there were approximately 5.3 million ICH cases,with 3 million deaths worldwide.^([1])However,there is still no validated medical treatment for ICH,with the role of surgery remaining controversial.^([2,3])Cusack et al^([4])demonstrated that lowering blood pressure rapidly in hypertensive ICH patients may be safe and at least partially effective in inhibiting hematoma expansion.
文摘Objective:The protective effects of curcumin on myocardial ischemia-reperfusion were systematically evaluated by analyzing the related literatures of curcumin and myocardial ischemia-reperfusion.Methods:The computer was searched for Wanfang,VIP,China National Knowledge Infrastructure(CNKI),SinoMed,and Pubmed database to find animal experiments on curcumin treatment of myocardial ischemia-reperfusion.The retrieval time is from the establishment of the database to November 2018.Two researchers independently screened the literature based on inclusion and exclusion criteria,extracted the data,and assessed the risk of bias in the included studies.Meta analysis was performed using RevMan 5.3 software.Results:Finally,9 studies were included for analysis.Meta-analysis showed that the curcumin group can reduce LDH and MDA levels compared with the ischemiarreperfusion group(LDH:SMD=-4.75,95%CI[-6.56,-2.94],P<0.01,MDA:SMD=-2.27,95%CI[-3.07,-1.47],P<0.01),the difference was statistically significant(P<0.01).In the subgroup analysis of different doses of curcumin,different doses of curcumin(0.8,10,12.5,20,25,30,50 mg)were able to reduce LDH content compared with the ischemia-reperfusion group,and the differences were statistically significant.Different doses of curcumin(5,10,20,30,40mg)can reduce MDA content,and the difference is statistically significant;curcumin(0.8mg)group has no statistically significant effect on MDA content(SMD=-0.54,95%CI[-1.35,0.28],P=0.20).The relationship between the content of MDA and the dose of curcumin showed that compared with the curcumin(20 mg)group,the curcumin(40 mg)group could better reduce the MDA content,and the difference was statistically significant(P=0.03).Conclusion:Curcumin can reduce the content of LDH and MDA in myocardial ischemia-reperfusion,and has a protective effect on myocardium.Moreover,the ability to reduce the damage is related to the dose of curcumin.However,the sample of the included studies is limited,and this conclusion requires more high-quality experiments to verify.
基金financially supported by the National Key Research and Development Program of China (2020YFB1506001)the National Natural Science Foundation of China (Grant Nos. 51772037, 52021004, 22022502, 21761162015, 22179012, 22208034)+1 种基金the Program for the Top Young Innovative Talents of Chongqing (02200011130003)the graduate scientific research and innovation foundation of Chongqing (CYB20044)。
基金supported by the National Key R&D Program of China (2019YFE0119000)National Natural Science Foundation of China (31872561)+1 种基金National Science Fund for Distinguished Young Scholars (32225049)Alliance of International Science Organizations (ANSO-CR-PP-2021-03)。
文摘Common carp are among the oldest domesticated fish in the world.As such,there are many food and ornamental carp strains with abundant phenotypic variations due to natural and artificial selection.Hebao red carp(HB,Cyprinus carpio wuyuanensis),an indigenous strain in China,is renowned for its unique body morphology and reddish skin.To reveal the genetic basis underlying the distinct skin color of HB,we constructed an improved highfidelity(HiFi) HB genome with good contiguity,completeness,and correctness.Genome structure comparison was conducted between HB and a representative wild strain,Yellow River carp(YR,C.carpio haematopterus),to identify structural variants and genes under positive selection.Signatures of artificial selection during domestication were identified in HB and YR populations,while phenotype mapping was performed in a segregating population generated by HB×YR crosses.Body color in HB was associated with regions with fixed mutations.The simultaneous mutation and superposition of a pair of homologous genes(mitfa) in chromosomes A06 and B06 conferred the reddish color in domesticated HB.Transcriptome analysis of common carp with different alleles of the mitfa mutation confirmed that gene duplication can buffer the deleterious effects of mutation in allotetraploids.This study provides new insights into genotype-phenotype associations in allotetraploid species and lays a foundation for future breeding of common carp.