目的:系统评价亚洲人群在经皮冠状动脉介入(PCI)术前,负荷高剂量他汀类药物治疗急性冠脉综合征减少心血管事件的有效性。方法:应用计算机检索PubMed、EMBase、Cochrane图书馆公开发表的相关随机对照试验,对符合纳入标准的临床研究进行...目的:系统评价亚洲人群在经皮冠状动脉介入(PCI)术前,负荷高剂量他汀类药物治疗急性冠脉综合征减少心血管事件的有效性。方法:应用计算机检索PubMed、EMBase、Cochrane图书馆公开发表的相关随机对照试验,对符合纳入标准的临床研究进行资料提取。使用Cochrane系统评价员手册5.1.0进行质量评价,采用Rev Man 5.3统计软件进行荟萃(meta)分析。结果:最终纳入7项随机对照试验,共1381例入院前未服用他汀类药物的患者,其中试验组(负荷他汀组)689例,对照组692例。试验组的主要心脏不良事件(MACE)发生率显著低于对照组,差异有统计学意义(P<0.001)。同时,PCI术前负荷剂量对围手术期心肌梗死(PMI)发生率有影响,试验组的PMI发生率显著低于对照组,差异有统计学意义(P<0.001)。结论:对于亚洲的急性冠脉综合征患者,PCI术前给予负荷剂量他汀类药物能有效降低患者术后30d的心血管事件发生率。展开更多
Primary small cell carcinoma(SCC) is a group of aggressive neoplasms that mainly arise from the lung and digestive tract. Endometrial small cell carcinoma(ESCC) is extremely rare. To our knowledge, less than 90 ca...Primary small cell carcinoma(SCC) is a group of aggressive neoplasms that mainly arise from the lung and digestive tract. Endometrial small cell carcinoma(ESCC) is extremely rare. To our knowledge, less than 90 cases have been reported, and most of these reports were dedicated to describing the clinicopathologic or immunochemical features of ESCC. Herein, we present a new case of ESCC involving a 51-year-old woman and mainly focus on the magnetic resonance imaging(MRI) and positron emission tomography/computed tomography(PET/CT) findings. MRI showed that the uterus was significantly enlarged(11.6 cm × 11.1 cm × 14.4 cm), and a giant irregular mass(7.5 cm × 8.4 cm × 8.5 cm) was observed in the uterine cavity. The lesion demonstrated an extremely low apparent diffusion coefficient(ADC) value [(0.553±0.088)×10^–3 mm^2/s] and a high FDG uptake value(22.7). Multiple metastatic lymph nodes(LNs) were identified at different positions, with diameters ranging from 0.3 to 2.8 cm and a maximum standardized uptake value(SUV max) ranging from 6.9 to 19.3.展开更多
目的:根据治疗药物监测(therapeutic drug monitoring,TDM)工作的特点,探索一种针对药学本科生的医院药学TDM教学模式,以提升学生对TDM的理论认知及实践能力。方法:围绕医院药学TDM内容的教学大纲和培养目标,基于TDM工作实践,设计和应...目的:根据治疗药物监测(therapeutic drug monitoring,TDM)工作的特点,探索一种针对药学本科生的医院药学TDM教学模式,以提升学生对TDM的理论认知及实践能力。方法:围绕医院药学TDM内容的教学大纲和培养目标,基于TDM工作实践,设计和应用“微电影引导→课堂教学→现场教学”新教学模式。结果:TDM微电影具有引导作用,穿插丰富TDM实践案例的课堂教学提升了学生对TDM的认知,现场教学提升了学生的TDM实践能力。结论:“微电影引导→课堂教学→现场教学”是一种循序渐进的教学模式,适合药学本科生TDM教学,可在医院药学课程教学中推广及应用。展开更多
文摘目的:系统评价亚洲人群在经皮冠状动脉介入(PCI)术前,负荷高剂量他汀类药物治疗急性冠脉综合征减少心血管事件的有效性。方法:应用计算机检索PubMed、EMBase、Cochrane图书馆公开发表的相关随机对照试验,对符合纳入标准的临床研究进行资料提取。使用Cochrane系统评价员手册5.1.0进行质量评价,采用Rev Man 5.3统计软件进行荟萃(meta)分析。结果:最终纳入7项随机对照试验,共1381例入院前未服用他汀类药物的患者,其中试验组(负荷他汀组)689例,对照组692例。试验组的主要心脏不良事件(MACE)发生率显著低于对照组,差异有统计学意义(P<0.001)。同时,PCI术前负荷剂量对围手术期心肌梗死(PMI)发生率有影响,试验组的PMI发生率显著低于对照组,差异有统计学意义(P<0.001)。结论:对于亚洲的急性冠脉综合征患者,PCI术前给予负荷剂量他汀类药物能有效降低患者术后30d的心血管事件发生率。
文摘Primary small cell carcinoma(SCC) is a group of aggressive neoplasms that mainly arise from the lung and digestive tract. Endometrial small cell carcinoma(ESCC) is extremely rare. To our knowledge, less than 90 cases have been reported, and most of these reports were dedicated to describing the clinicopathologic or immunochemical features of ESCC. Herein, we present a new case of ESCC involving a 51-year-old woman and mainly focus on the magnetic resonance imaging(MRI) and positron emission tomography/computed tomography(PET/CT) findings. MRI showed that the uterus was significantly enlarged(11.6 cm × 11.1 cm × 14.4 cm), and a giant irregular mass(7.5 cm × 8.4 cm × 8.5 cm) was observed in the uterine cavity. The lesion demonstrated an extremely low apparent diffusion coefficient(ADC) value [(0.553±0.088)×10^–3 mm^2/s] and a high FDG uptake value(22.7). Multiple metastatic lymph nodes(LNs) were identified at different positions, with diameters ranging from 0.3 to 2.8 cm and a maximum standardized uptake value(SUV max) ranging from 6.9 to 19.3.
文摘目的:根据治疗药物监测(therapeutic drug monitoring,TDM)工作的特点,探索一种针对药学本科生的医院药学TDM教学模式,以提升学生对TDM的理论认知及实践能力。方法:围绕医院药学TDM内容的教学大纲和培养目标,基于TDM工作实践,设计和应用“微电影引导→课堂教学→现场教学”新教学模式。结果:TDM微电影具有引导作用,穿插丰富TDM实践案例的课堂教学提升了学生对TDM的认知,现场教学提升了学生的TDM实践能力。结论:“微电影引导→课堂教学→现场教学”是一种循序渐进的教学模式,适合药学本科生TDM教学,可在医院药学课程教学中推广及应用。