Research Progress on Integrated Chinese and Western Medicine Treatment of Tourette Syndrome in Children

Tourette syndrome is a common neuropsychiatric disorder that affects the physical and mental health of children.Early detection,diagnosis,and treatment are crucial to prevent serious impacts on the affected children,their families,and society.In recent years,there has been an increasing trend towards using a combination of methods in the clinical treatment of children with Tourette syndrome.This approach has achieved remarkable results,leading to a reduction in the rate of Tourette syndrome symptoms in children.In recent years,a combination of clinical methods has been used to treat children with Tourette syndrome,resulting in significant improvement in control rates.This article reviews the etiology of infantile Tourette syndrome and the progress made in Chinese and Western medicine treatments,providing a reference for further treatment of the condition.

Research Progress on Pulmonary Rehabilitation in Children with Bronchial Asthma

Bronchial asthma is a chronic respiratory disease that poses a significant threat to the physical and mental health of children globally.Currently,pulmonary rehabilitation is a non-pharmacological intervention that has shown promise in treating chronic respiratory diseases.However,most studies related to pulmonary rehabilitation only focus on chronic conditions such as chronic obstructive pulmonary disease(COPD),lung cancer,and bronchiectasis.Research on bronchial asthma in children is still in the preliminary stages.This article reviews the concept,basic content,and application mode of pulmonary rehabilitation,to provide reference for the clinical research of pulmonary rehabilitation in children with bronchial asthma,and to carry out multimodal pulmonary rehabilitation to improve the disease control level and quality of life of asthma in children.

Research Progress on the Relationship Between Dietary Inflammation Index and Geriatricrelated Diseases

Along with the acceleration of aging in our country and the increased prioritization on healthy living,the prevention and treatment of senile diseases have become a hot topic.The Dietary Inflammation Index(DII)is a new tool for assessing dietary inflammation.This article reviewed the research processes on the association between DII and age-related diseases such as osteoporosis,cognitive impairment,cardiovascular disease,cancer,and so on.It is expected that DII can provide guidance on the daily diet of older people,prevent and treat age-related diseases,and improve their quality of life.

Effect of Tuina-SET Sling Exercise Therapy on Analgesic Substances in Serum of Patients with Nonspecific Low Back Pain

[Objectives]This paper aimed to investigate the effect of Tuina combined with sling exercise therapy(SET)and psoas&abdominal training on serum 5-hydroxytryptamine(5-HT)andβ-endorphin(β-EP)levels in patients with nonspecific low back pain(NLBP).[Methods]Total 46 patients with NLBP who visited the Tuina Department of the First Affiliated Hospital of Hainan Medical University from August 2019 to May 2020 were randomly and evenly divided into control group and treatment group.On the basis of Tuina therapy,the patients in the control group and treatment group were treated with psoas&abdominal training and SET,respectively.After the treatment,the serum 5-HT andβ-EP levels of the patients were detected.[Results]The serum 5-HT andβ-EP levels in the treatment group were significantly improved compared with the control group(P<0.05).[Conclusions]The nerve&muscle reconstruction techniques of Tuina combined with SET or psoas&abdominal training can improve serum 5-HT andβ-EP levels in patients with NLBP.

Effects of Suoquan Yishen Formula on Mice with Diabetic Nephropathy (DN)

[Objectives]The purpose of this paper was to study the effects of Suoquan Yishen formula on mice with diabetic nephropathy(DN).[Methods]The mice were randomly divided into normal group,model group,irbesartan group,and high and low-dose Suoquan Yishen formula groups.The blood glucose level,BUN,Scr excretion and GSH activity and CAT activity were detected.[Results]The blood glucose levels of mice in the irbesartan group and high and low-dose Suoquan Yishen formula groups decreased.The BUN,PRO and Scr levels were higher and the GSH and CAT activity was lower in the model group compared with the normal group.After administration of Suoquan Yishen formula,the BUN,PRO and Scr levels of the DN mice decreased significantly,and the GSH and CAT activity increased significantly.[Conclusions]Suoquan Yishen formula can reduce blood glucose level,reduce PRO,BUN and Scr levels,and increase CAT and GSH activity in DN mice,thus protecting the ND mice.

Discussion on prevention and control of COVID-19 by non-drug methods in traditional Chinese medicine

COVID-19 has been discovered since December 2019 and has become a global pandemic recently,killing hundreds of thousands of people in 216 countries and regions around the world.COVID-19 has caused more than 4000 deaths in China,seriously affecting national health and national economy.Since the outbreak of COVID-19,National Health Commission of the People's Republic of China has used the method of sino-western medicine to prevent and control COVID-19,effectively curbed the spread of the epidemic.But the TCM methods in the scheme are all oral prescriptions,less involving non-drug methods.Therefore,I searched the COVID-19 control methods published in various parts of the country,this paper plans to discuss how to improve immunity from the perspective of non-drug methods such as moxibustion,diet therapy,self massage,physical exercise skills and traditional music,hoping can helps the susceptible populations,infected,discharged and medical staff in COVID-19 epidemic.

Future of targeted therapy for gastrointestinal cancer:Claudin 18.2

The treatment of gastrointestinal cancer has always been a crucial research area,and targeted therapy has been receiving increasing attention.At present,the effect of targeted therapy is unsatisfactory for gastric cancer.Thus,the discovery of new targets is crucial.Claudin 18.2(CLDN18.2),a member of the claudin family,belongs to the tight junction protein family that controls the flow of molecules between cell layers.CLDN18.2 expression has been discussed in many studies.In recent years,there have been many studies on targeted therapy with CLDN18.2-ideal monoclonal antibody 362.Furthermore,CLDN18.2-specific chimeric antigen receptor T therapy has been used for CLDN18.2-positive tumors,such as gastric and pancreatic cancers.Considerable research has been focused on CLDN18.2.CLDN18.2,a newly discovered marker for precise targeted therapy of gastric cancer,could offer new hope for the treatment of gastric cancer.

锆/铪氧簇中硫原子导向的金属-配体协同高效催化胺氧化反应

The performance applications(e.g.,photocatalysis)of zirconium(Zr)and hafnium(Hf)based complexes are greatly hindered by the limited development of their structures and the relatively inert metal reactivity.In this work,we constructed two ultrastable Zr/Hf-based clusters(Zr_(9)-TC4A and Hf_(9)-TC4A)using hydrophobic 4-tert-butylthiacalix[4]arene(H4TC4A)ligands,in which unsaturated coordinated sulfur(S)atoms on the TC4A^(4-)ligand can generate strong metal–ligand synergy with nearby active metal Zr/Hf sites.As a result,these two functionalized H4TC4A ligands modified Zr/Hf-oxo clusters,as catalysts for the amine oxidation reaction,exhibited excellent catalytic activity,achieving very high substrate conversion(>99%)and product selectivity(>90%).Combining comparative experiments and theoretical calculations,we found that these Zr/Hf-based cluster catalysts accomplish efficient amine oxidation reactions through synergistic effect between metals and ligands:(i)The photocatalytic benzylamine(BA)oxidation reaction was achieved by the synergistic effect of the dual active sites,in which,the naked S sites on the TC4A^(4-)ligand oxidize the BA by photogenerated hole and oxygen molecules are reduced by photogenerated electrons on the metal active sites;(ii)in the aniline oxidation reaction,aniline was adsorbed by the bare S sites on ligands to be closer to metal active sites and then oxidized by the oxygen-containing radicals activated by the metal sites,thus completing the catalytic reaction under the synergistic catalytic effect of the proximity metal–ligand.In this work,the Zr/Hf-based complexes applied in the oxidation of organic amines have been realized using active S atom-directed metal–ligand synergistic catalysis and have demonstrated very high reactivity.

Clinical application of free/total PSA ratio in the diagnosis of prostate cancer in men over 50 years of age with total PSA levels of 2.0-25.0 ng ml^(−1) in Western China

The goal of this study was to investigate the clinical application of free/total prostate-specific antigen(F/T PSA)ratio,considering the new broad serum total PSA(T-PSA)“gray zone”of 2.0–25.0 ng ml^(−1)in differential diagnosis of prostate cancer(PCa)and benign prostate diseases(BPD)in men over 50 years in Western China.A total of 1655 patients were included,528 with PCa and 1127 with BPD.Serum T-PSA,free PSA(F-PSA),and F/T PSA ratio were analyzed.Receiver operating characteristic curves were used to assess the efficiency of PSA and F/T PSA ratio.There were 47.4%of cancer patients with T-PSA of 2.0–25.0 ng ml^(−1).When T-PSA was 2.0–4.0 ng ml^(−1),4.0–10.0 ng ml^(−1),and 10.0–25.0 ng ml^(−1),the area under the curve(AUC)of F/T PSA ratio was 0.749,0.769,and 0.761,respectively.The best AUC of F/T PSA ratio was 0.811 when T-PSA was 2.0–25.0 ng ml^(−1),with a specificity of 0.732,a sensitivity of 0.788,and an optimal cutoff value of 15.5%.The AUC of F/T PSA ratio in different age groups(50–59 years,60–69 years,70–79 years,and≥80 years)was 0.767,0.806,0.815,and 0.833,respectively,and the best sensitivity(0.857)and specificity(0.802)were observed in patients over 80 years.The T-PSA trend was in accordance with the Gleason score,tumor node metastasis(TNM)stage,and American Joint Committee on Cancer prognosis group.Therefore,the F/T PSA ratio can facilitate the differential diagnosis of PCa and BPD in the broad T-PSA“gray zone”.Serum T-PSA can be a Gleason score and prognostic indicator.

Advances on topological materials

Topological materials refer to solid structures with topo-logically protected electronic states or other degrees of freedom.A prime example is a Chern insulator in which the occupied bands of states are organized with a non-trivial topology as characterized by a nonzero Chern in-teger,exhibiting gapless chiral excitations on the bound-aries,which are robust against scatterings.

Self-assembly of nanoparticles at solid-liquid interface for electrochemical capacitors

Self-assembly of nanoparticles at solid-liquid interface could be promising to realize the assembled functions for various applications,such as rechargeable batteries,supercapacitors,and electrocatalysis.This review summarizes the self-assembly of the nanoparticles at solid-liquid interface according to the different driving forces of assembly,including hydrophilic-hydrophobic interactions,solvophobic and electrostatic interaction.To be specific,the self-assembly can be divided into the following two types:surfactant-assisted self-assembly and direct self-assembly of Janus particles(inorganic and amphiphilic copolymer-inorganic Janus nanoparticles).Using the emulsion stabilized by nanoparticles as the template,the self-assembly constructed by the interaction of the nanostructure unit(including metal,metal oxide,and semiconductor,etc.)not only possesses the characteristic of nanostructure unit,but also exhibits the excellent assembly performance in electrochemistry aspect.The application of these assemblies in the area of electrochemical capacitors is presented.Finally,the current research progress and perspectives toward the self-assembly of nanoparticles at stabilized solid-liquid interface are proposed.

Attractive electron-electron interaction induced by geometric phase in a Bloch band

Attractive interaction between electrons(or neutral fermions)is responsible for superconductivity(or superfluidity).In condensed matter systems,attractive interaction is usually induced by the boson-exchange mechanism[1].Indeed,in the celebrated Bardeen-Cooper-Schreiffer(BCS)theory,electrons develop attractive interaction by exchanging phonons[2].Subsequent studies show that other collective excitations such as charge density waves[3]and spin fluctuations[4]can also induce attractive interaction.The bosonexchange mechanism,together with the concept of Cooperpair,is considered to be the cornerstone of the modern theory of superconductivity.

Danhong Injection Improves Elective Percutaneous Coronary Intervention in UA Patients with Blood Stasis Syndrome Revealed by Perioperative Metabolomics

Objective:To observe the effect of Danhong injection(DHI)on perioperative metabolomics of unstable angina pectoris(UA)with blood stasis syndrome.Materials and Methods:A prospective,randomized,controlled,and single-blind clinical trial was conducted.Sixty-one UA patients with traditional Chinese medicine blood stasis syndrome undergoing elective percutaneous coronary intervention(PCI)were randomly divided into the Danhong and control groups,and 10 healthy volunteers were included as baseline.The Danhong group received western medicine+DHI treatment,while the control group received western medicine+saline.Nontargeted metabolomics was used to analyze the serum metabolites of healthy volunteers in the Danhong and control groups before and 5 days after PCI.Results:Before treatment,there was no significant difference in serum metabolites between the Danhong and control groups,but there was a significant difference between the two groups and the healthy group.Differential metabolites were clustered mainly in glycerophospholipid,sphingolipid,purine,and amino acid groups,which were generated in their metabolic pathways.After 5 days of PCI,the profiles of serum metabolites were significantly closer between the Danhong-or control-treated groups and that of the healthy group.Furthermore,DHI treatment converted the serum metabolite profile more to that of the healthy group than the control treatment.Conclusion:The beneficial effect of DHI on patients with unstable angina is reflected at the level of serum metabolic biomarkers.