Dry eye and corneal sensitivity after small incision lenticule extraction and femtosecond laser-assisted in situ keratomileusis:a Meta-analysis

AIM：To assess the corneal sensitivity and the incidences of dry eye after small incision lenticule extraction（SMILE） and femtosecond laser-assisted in situ keratomileusis（FSLASIK）.METHODS：The Meta-analysis was performed using Rev Man 5.3.We searched on Pub Med from inception to March 2016.Summary weighted mean difference（WMD） and 95% confidence intervals（CIs） were used to analyze the datum.Random-effects or fixed-effects models were chosen up to between-study heterogeneity.The main outcomes were composed of the Ocular Surface Disease Index（OSDI） scores,tear film break-up time（TBUT）,Schirmer Test and corneal sensitivity.RESULTS：Eight eligible studies including 772 eyes（386 in SMILE group and 386 in FS-LASIK group） were identified.The parameters have no significiant difference heterogeneity between SMILE and FS-LASIK group preoperatively.There were significant differences between the two groups in OSDI scores at one and three months postoperatively,in TBUT at one and three months postoperatively,in corneal sensitivity at one week,about one month and three months postoperatively.However,there was no significant difference observed in Schirmer Test at the follow-up periods.CONCLUSION：Compare to FS-LASIK,dry eye and the corneal sensitivity recover better in the SMILE group,in first three months after the surgery.

Current progress in metabolomics of gestational diabetes mellitus

Gestational diabetes mellitus(GDM)is one of the most common metabolic disorders of pregnancy and can cause short-and long-term adverse effects in both pregnant women and their offspring.However,the etiology and pathogenesis of GDM are still unclear.As a metabolic disease,GDM is well suited to metabolomics study,which can monitor the changes in small molecular metabolites induced by maternal stimuli or perturbations in real time.The application of metabolomics in GDM can be used to discover diagnostic biomarkers,evaluate the prognosis of the disease,guide the application of diet or drugs,evaluate the curative effect,and explore the mechanism.This review provides comprehensive documentation of metabolomics research methods and techniques as well as the current progress in GDM research.We anticipate that the review will contribute to identifying gaps in the current knowledge or metabolomics technology,provide evidence-based information,and inform future research directions in GDM.