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干性年龄相关性黄斑变性药物治疗研究进展
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作者 周杰 陈倩茵 张静琳 《国际眼科杂志》 CAS 北大核心 2023年第11期1835-1839,共5页
年龄相关性黄斑变性(ARMD)是全球范围内引起不可逆性视觉损伤的主要原因之一,且随着人口老龄化的加剧,患者数量逐渐增多,其中约90%为干性ARMD。干性ARMD缺乏有效的治疗措施,近年来成为了研究热点,其中药物治疗是主要的治疗方式之一。目... 年龄相关性黄斑变性(ARMD)是全球范围内引起不可逆性视觉损伤的主要原因之一,且随着人口老龄化的加剧,患者数量逐渐增多,其中约90%为干性ARMD。干性ARMD缺乏有效的治疗措施,近年来成为了研究热点,其中药物治疗是主要的治疗方式之一。目前针对氧化损伤、炎症、血流障碍等ARMD致病因素,广泛开展了针对性的药物治疗,部分药物已被证实可减缓ARMD进展。本文总结了干性ARMD的药物治疗手段,包括抗氧化药物、补体类生物制剂、非甾体抗炎药和免疫抑制剂、血管扩张剂、神经保护药物及中药,对其作用机制及近年开展的临床研究进行综述,以期为干性ARMD的治疗与新药物的研发提供参考。 展开更多
关键词 干性年龄相关性黄斑变性 地图样萎缩 补体治疗 抗氧化治疗 药物治疗
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Air tamponade in retinal detachment surgery followed by ultra-widefield fundus imaging system 被引量:4
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作者 qian-yin chen Yun-Xia Tang +6 位作者 Yan-Qiong He Hui-Min Lin Ru-Long Gao Meng-Yuan Li Jin-Tong Hou Hong-Jie Ma Jing-Lin Zhang 《International Journal of Ophthalmology(English edition)》 SCIE CAS 2018年第7期1198-1203,共6页
AIM: To report the surgical result of pars plana vitrectomy(PPV) with air tamponade for rhegmatogenous retinal detachment(RRD) by ultra-widefield fundus imaging system. METHODS: Of 25 consecutive patients(25 e... AIM: To report the surgical result of pars plana vitrectomy(PPV) with air tamponade for rhegmatogenous retinal detachment(RRD) by ultra-widefield fundus imaging system. METHODS: Of 25 consecutive patients(25 eyes) with fresh primary RRD and causative retinal break and vitreous traction were presented. All the patients underwent PPV with air tamponade. Visual acuity(VA) was examined postoperatively and images were captured by ultrawidefield scanning laser ophthalmoscope system(Optos). RESULTS: Initial reattachment was achieved in 25 cases(100%). The air volume was 〉60% on the postoperative day(POD) 1. The ultra-widefield images showed that the retina was reattached in all air-filled eyes postoperatively. The retinal break and laser burns in the superior were detected in 22 of 25 eyes(88%). A missed retinal hole was found under intravitreal air bubble in 1 case(4%). The air volume was range from 40% to 60% on POD 3. A doublelayered image was seen in 25 of 25 eyes with intravitreal gas. Retinal breaks and laser burns around were seen in the intravitreal air. On POD 7, small bubble without effect was seen in 6 cases(24%) and bubble was completely disappeared in 4 cases(16%). Small oval bubble in the superior area was observed in 15 cases(60%). There were no missed and new retinal breaks and no retinal detachment in all cases on the POD 14 and 1 mo and last follow-up. Air disappeared completely on a mean of 9.84 d postoperatively. The mean final postoperative bestcorrected visual acuity(BCVA) was 0.35 log MAR. Mean final postoperative BCVA improved significantly relative to mean preoperative(P〈0.05). Final VA of 0.3 log MAR or better was seen in 13 eyes. CONCLUSION: PPV with air tamponade is an effective management for fresh RRD with superior retinal breaks. The ultra-widefield fundus imaging can detect postoperative retinal breaks in air-filled eyes. It would be a useful facility for follow-up after PPV with air tamponade. Facedown position and acquired visual rehabilitation may be shorten. 展开更多
关键词 rhegmatogenous retinal detachment air tamponade ultra-widefield fundus imaging system
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