BACKGROUND According to the latest report,colorectal cancer is still one of the most prevalent cancers,with the third highest incidence and mortality worldwide.Treatment of advanced rectal cancer with distant metastas...BACKGROUND According to the latest report,colorectal cancer is still one of the most prevalent cancers,with the third highest incidence and mortality worldwide.Treatment of advanced rectal cancer with distant metastases is usually unsatisfactory,especially for mismatch repair proficient(pMMR)rectal cancer,which leads to poor prognosis and recurrence.CASE SUMMARY We report a case of a pMMR rectal adenocarcinoma with metastases of multiple lymph nodes,including the left supraclavicular lymph node,before treatment in a 70-year-old man.He received full courses of chemoradiotherapy(CRT)followed by 4 cycles of programmed death 1 inhibitor Tislelizumab,and a pathologic complete response(pCR)was achieved,and the lesion of the left supraclavicular lymph node also disappeared.CONCLUSION pMMR advanced rectal cancer with preserved intact distant metastatic lymph nodes may benefit from full-course CRT combined with immunotherapy.展开更多
Carbon dioxide(CO_(2))electroreduction of products using renewable electricity sources is a promising avenue for chemical energy storage that is attracting increasing attention.Considerable effort has been focused on ...Carbon dioxide(CO_(2))electroreduction of products using renewable electricity sources is a promising avenue for chemical energy storage that is attracting increasing attention.Considerable effort has been focused on improving the activity and selectivity for CO_(2)electroreduction of C2+products,especially for ethanol.However,studies of this process’s underlying mechanism are still lacking.展开更多
基金Supported by National Natural Science Foundation of China,No.81870393.
文摘BACKGROUND According to the latest report,colorectal cancer is still one of the most prevalent cancers,with the third highest incidence and mortality worldwide.Treatment of advanced rectal cancer with distant metastases is usually unsatisfactory,especially for mismatch repair proficient(pMMR)rectal cancer,which leads to poor prognosis and recurrence.CASE SUMMARY We report a case of a pMMR rectal adenocarcinoma with metastases of multiple lymph nodes,including the left supraclavicular lymph node,before treatment in a 70-year-old man.He received full courses of chemoradiotherapy(CRT)followed by 4 cycles of programmed death 1 inhibitor Tislelizumab,and a pathologic complete response(pCR)was achieved,and the lesion of the left supraclavicular lymph node also disappeared.CONCLUSION pMMR advanced rectal cancer with preserved intact distant metastatic lymph nodes may benefit from full-course CRT combined with immunotherapy.
基金supported by grants from the National Natural Science Foundation of China(nos.22174165,21991151,21925404,21673081,21773315,and 21908253)the Key Project of Guangdong Natural Science Foundation(no.2018B030311002)+2 种基金the National Key Research and Development Program of China(nos.2016YFA0202604 and 2019YFA0705400)the Natural Science Foundation of Guangdong Province(no.2019A1515011117)the Guangdong Province Universities and Colleges Pearl River Scholar Funded Scheme(2017).
文摘Carbon dioxide(CO_(2))electroreduction of products using renewable electricity sources is a promising avenue for chemical energy storage that is attracting increasing attention.Considerable effort has been focused on improving the activity and selectivity for CO_(2)electroreduction of C2+products,especially for ethanol.However,studies of this process’s underlying mechanism are still lacking.
