Hepatocellular carcinoma(HCC) is a prevalent and highly malignant cancer throughout the world.Effective treatment of this disease is impeded by the high rate of metastasis, recurrence, and chemoresistance. Recent stud...Hepatocellular carcinoma(HCC) is a prevalent and highly malignant cancer throughout the world.Effective treatment of this disease is impeded by the high rate of metastasis, recurrence, and chemoresistance. Recent studies have revealed the close relationship between the malignant phenotype of HCC and cancer stem cells(CSCs). Therefore, CSC-targeted therapy is considered a promising strategy to eradicate HCC. Traditional Chinese medicine(TCM) can be effective in preventing recurrence and metastasis of some advanced HCC. A growing amount of literature has discovered that extracts or compounds derived from TCM exert an anti-CSC effect. This review introduces some formulas and chemical compounds derived from TCMs that have been reported to inhibit CSCs of HCC;these TCM-related drugs may help to provide an alternative approach to help manage cancers, especially for HCC which has a great potential of metastasis, recurrence, and chemoresistance.展开更多
基金supported by the National Natural Science Foundation of China (No. 81573894),which paid for planning and collection of literaturethe Budget Research Program of Shanghai Municipal Education Commission (No. 18LK027),which paid for writing and submitting the article for publication.
文摘Hepatocellular carcinoma(HCC) is a prevalent and highly malignant cancer throughout the world.Effective treatment of this disease is impeded by the high rate of metastasis, recurrence, and chemoresistance. Recent studies have revealed the close relationship between the malignant phenotype of HCC and cancer stem cells(CSCs). Therefore, CSC-targeted therapy is considered a promising strategy to eradicate HCC. Traditional Chinese medicine(TCM) can be effective in preventing recurrence and metastasis of some advanced HCC. A growing amount of literature has discovered that extracts or compounds derived from TCM exert an anti-CSC effect. This review introduces some formulas and chemical compounds derived from TCMs that have been reported to inhibit CSCs of HCC;these TCM-related drugs may help to provide an alternative approach to help manage cancers, especially for HCC which has a great potential of metastasis, recurrence, and chemoresistance.
