Cu−Fe alloys with different Fe contents were prepared by vacuum hot pressing.After hot rolling and aging treatment,the effects of Fe content on microstructure,mechanical properties and electrical conductivity of Cu−Fe...Cu−Fe alloys with different Fe contents were prepared by vacuum hot pressing.After hot rolling and aging treatment,the effects of Fe content on microstructure,mechanical properties and electrical conductivity of Cu−Fe alloys were studied.The results show that,when w(Fe)<60%,the dynamic recrystallization extent of both Cu phase and Fe phase increases.When w(Fe)≥60%,Cu phase is uniformly distributed into the Fe phase and the deformation of alloy is more uniform.With the increase of the Fe content,the tensile strength of Cu−5wt.%Fe alloy increases from 305 MPa to 736 MPa of Cu−70wt.%Fe alloy,the elongation decreases from 23%to 17%and the electrical conductivity decreases from 31%IACS to 19%IACS.These results provide a guidance for the composition and processing design of Cu−Fe alloys.展开更多
Objective:To explore the effect of sodium ferulate in combined with atorvastatin on the renal interstitial fibrosis and inflammatory cytokines in patients with diabetic nephropathy (DN). Methods: A total of 111 patien...Objective:To explore the effect of sodium ferulate in combined with atorvastatin on the renal interstitial fibrosis and inflammatory cytokines in patients with diabetic nephropathy (DN). Methods: A total of 111 patients with DN who were admitted in our hospital from January, 2016 to April, 2017 were included in the study and randomized into the observation group and the control 1 and 2 group with 37 cases in each group. The patients in the control group were given routine blood sugar reducing, blood pressure reducing, and high quality low protein diet. On the above basis, the patients in the control 2 group were orally administrated with atorvastatin before sleep (20 mg). On the basis of treatments in the control 1 group, the patients in the observation group were given sodium ferulate (0.3 g) + 0.9% NaCl (250 mL), ivdrip, 1 time/d, and administrated with atorvastatin before sleep (20 mg). The fasting peripheral venous blood before and after treatment in the three groups was collected. The glycse oxidase (GOD) method was used to detect FPG. ELISA was used to detect SCr, TGF-β, AngⅡ, CTGF, hs-CRP, TNF-α, and IL-6. RIA was used to detect BUN and 24hUAER. The strengthened chemiluminescence immunoassay was used to detect CⅣ and PCⅢ. MAP was recorded. Results: FPG, MAP, BUN, 24hUAER, and SCr after treatment in the control 2 group were significantly lower than those in the control 1 group. FPG, MAP, BUN, 24hUAER, and SCr after treatment in the observation group were significantly lower than those in the control 2 group. AngⅡ, TGF-β, CTGF, PCⅢ, and CⅣ after treatment in the control 2 group were significantly lower than those in the control 1 group. AngⅡ, TGF-β, CTGF, PCⅢ, and CⅣ after treatment in the observation group were significantly lower than those in the control 2 group. TNF-α, IL-6, and hs-CRP after treatments in the control 2 group were significantly lower than those in the control 1 group. TNF-α, IL-6, and hs-CRP after treatment in the observation group were significantly lower than those in the control 2 group.Conclusions:The sodium ferulate in combined with atorvastatin can effectively improve the renal function in patients with DN, alleviate the systemic inflammatory reaction, and delay the renal interstitial fibrosis speed.展开更多
基金sponsored by the National Key Research and Development Program of China(No.2020YFB0311102)the Ningbo“Science and Technology Innovation 2025”Major Project,China(No.2019B10087)+1 种基金the Project of State Key Laboratory of Powder Metallurgy at Central South UniversityYoung People Fund of Jiangxi Province,China(No.2018BAB216005)。
文摘采用Gleeble-3500热模拟试验机对在变形温度500~650℃和应变速率0.001~1 s^(-1)条件下的60NiTi合金进行热压缩变形,分析其热变形行为和显微组织,建立变形本构模型,绘制热加工图。结果表明,当压缩温度升高或应变速率降低时,峰值应力减小。合金的热变形激活能为327.89 k J/mol,热加工工艺参数为变形温度600~650℃和应变速率0.005~0.05 s^(-1)。当变形温度升高时,合金的再结晶程度增大;当应变速率增大时,位错密度和孪晶数量增大,Ni3Ti相易于聚集;Ni3Ti析出相有利于诱发合金基体的动态再结晶。动态回复、动态再结晶和孪生是60NiTi合金热变形的主要机制。
基金financial supports from the National Natural Science Foundation of China (No.51974375)Key Project of "Technology Innovation 2025",Ningbo,China(No.2018B10030)+2 种基金Technology Research Program of Shenzhen,China (No.JSGG20170824162647398)Project of State Key Laboratory of Powder Metallurgy,Central South University,ChinaYoung People Fund of Jiangxi province,China (No.2018BAB216005.
文摘Cu−Fe alloys with different Fe contents were prepared by vacuum hot pressing.After hot rolling and aging treatment,the effects of Fe content on microstructure,mechanical properties and electrical conductivity of Cu−Fe alloys were studied.The results show that,when w(Fe)<60%,the dynamic recrystallization extent of both Cu phase and Fe phase increases.When w(Fe)≥60%,Cu phase is uniformly distributed into the Fe phase and the deformation of alloy is more uniform.With the increase of the Fe content,the tensile strength of Cu−5wt.%Fe alloy increases from 305 MPa to 736 MPa of Cu−70wt.%Fe alloy,the elongation decreases from 23%to 17%and the electrical conductivity decreases from 31%IACS to 19%IACS.These results provide a guidance for the composition and processing design of Cu−Fe alloys.
文摘Objective:To explore the effect of sodium ferulate in combined with atorvastatin on the renal interstitial fibrosis and inflammatory cytokines in patients with diabetic nephropathy (DN). Methods: A total of 111 patients with DN who were admitted in our hospital from January, 2016 to April, 2017 were included in the study and randomized into the observation group and the control 1 and 2 group with 37 cases in each group. The patients in the control group were given routine blood sugar reducing, blood pressure reducing, and high quality low protein diet. On the above basis, the patients in the control 2 group were orally administrated with atorvastatin before sleep (20 mg). On the basis of treatments in the control 1 group, the patients in the observation group were given sodium ferulate (0.3 g) + 0.9% NaCl (250 mL), ivdrip, 1 time/d, and administrated with atorvastatin before sleep (20 mg). The fasting peripheral venous blood before and after treatment in the three groups was collected. The glycse oxidase (GOD) method was used to detect FPG. ELISA was used to detect SCr, TGF-β, AngⅡ, CTGF, hs-CRP, TNF-α, and IL-6. RIA was used to detect BUN and 24hUAER. The strengthened chemiluminescence immunoassay was used to detect CⅣ and PCⅢ. MAP was recorded. Results: FPG, MAP, BUN, 24hUAER, and SCr after treatment in the control 2 group were significantly lower than those in the control 1 group. FPG, MAP, BUN, 24hUAER, and SCr after treatment in the observation group were significantly lower than those in the control 2 group. AngⅡ, TGF-β, CTGF, PCⅢ, and CⅣ after treatment in the control 2 group were significantly lower than those in the control 1 group. AngⅡ, TGF-β, CTGF, PCⅢ, and CⅣ after treatment in the observation group were significantly lower than those in the control 2 group. TNF-α, IL-6, and hs-CRP after treatments in the control 2 group were significantly lower than those in the control 1 group. TNF-α, IL-6, and hs-CRP after treatment in the observation group were significantly lower than those in the control 2 group.Conclusions:The sodium ferulate in combined with atorvastatin can effectively improve the renal function in patients with DN, alleviate the systemic inflammatory reaction, and delay the renal interstitial fibrosis speed.
