E-commerce refers to a kind of business and trade activities, which are conducted under the situation that buyers and sellers do not meet each other by using a fast, easy and low-cost way. Along with the promotion and...E-commerce refers to a kind of business and trade activities, which are conducted under the situation that buyers and sellers do not meet each other by using a fast, easy and low-cost way. Along with the promotion and application of computer office automation, it is necessary for e-commerce module to develop towards automation, in which the core lies in making a good design for operation module. In this paper, the promotion of e-commerce in the information age is reviewed by the authors, the unique characteristics of e-commerce functional modules are analyzed, and also the most important point of the design of e-commerce automatic operation module is discussed. Hopefully, helps can be provided for relevant follow-up studies in the future.展开更多
Class II HDACs, such as HDAC4, are critical regulators of the immune response in various immune cells;however, its role in innate immunity remains largely unknown.Here, we report that the overexpression of HDAC4 suppr...Class II HDACs, such as HDAC4, are critical regulators of the immune response in various immune cells;however, its role in innate immunity remains largely unknown.Here, we report that the overexpression of HDAC4 suppresses the production of type I interferons triggered by pattern-recognition receptors (PRRs). HDAC4 repressed the translocation of transcription factor IRF3 to the nucleus, thereby decreasing IRF3-mediated IFN-β expression. In particular, we also determined that HDAC4 can be phosphorylated and simultaneously block the phosphorylation of IRF3 at Ser386 and Ser396 by TBK1 and IKKε, respectively, by interacting with the kinase domain of TBK1 and IKKε. Furthermore, IFN-β may stimulate the expression of HDAC4. Our findings suggest that HDAC4 acts as a regulator of PRR signaling and is a novel mechanism of negative feedback regulation for preventing an overreactive innate immune response.展开更多
The importance of silicon in modem electronic devices has led to considerable interest in exploring the unconventional electronic properties of Si-based materials for future applications in spintronics and quantum com...The importance of silicon in modem electronic devices has led to considerable interest in exploring the unconventional electronic properties of Si-based materials for future applications in spintronics and quantum computing. Here, using density functional theory, we present the results of a systematic study of the effect of strain on Si（lll） thin films whose surfaces are functionalized with iodine. Films with an odd number of layers under biaxial strain are found to undergo a phase transition from a normal insulator to a topological insulator and ultimately to a metal. The spin-orbit coupling-induced topologically nontrivial band gap at the F point is found to be as large as 0.50 eV, which not only surpasses that of other Si-based topological materials, it is also large enough for practical realization of quantum spin Hall states at room temperature. No such nontrivial states are found in films for such a strain-induced transition with an even number of layers. Mechanisms are illustrated by a tight-binding model composed of s, px, and py orbitals. Equally important, we predict that iodized silicene, when stretched and hole-doped, would be a phonon-mediated super- conductor with a critical temperature of 9.2 K. This coexistence of a topological insulator and a superconducting phase in a single material is unusual; it has the potential for applications in electronic circuits and for the realization of Majorana fermions in quantum computations.展开更多
文摘E-commerce refers to a kind of business and trade activities, which are conducted under the situation that buyers and sellers do not meet each other by using a fast, easy and low-cost way. Along with the promotion and application of computer office automation, it is necessary for e-commerce module to develop towards automation, in which the core lies in making a good design for operation module. In this paper, the promotion of e-commerce in the information age is reviewed by the authors, the unique characteristics of e-commerce functional modules are analyzed, and also the most important point of the design of e-commerce automatic operation module is discussed. Hopefully, helps can be provided for relevant follow-up studies in the future.
文摘Class II HDACs, such as HDAC4, are critical regulators of the immune response in various immune cells;however, its role in innate immunity remains largely unknown.Here, we report that the overexpression of HDAC4 suppresses the production of type I interferons triggered by pattern-recognition receptors (PRRs). HDAC4 repressed the translocation of transcription factor IRF3 to the nucleus, thereby decreasing IRF3-mediated IFN-β expression. In particular, we also determined that HDAC4 can be phosphorylated and simultaneously block the phosphorylation of IRF3 at Ser386 and Ser396 by TBK1 and IKKε, respectively, by interacting with the kinase domain of TBK1 and IKKε. Furthermore, IFN-β may stimulate the expression of HDAC4. Our findings suggest that HDAC4 acts as a regulator of PRR signaling and is a novel mechanism of negative feedback regulation for preventing an overreactive innate immune response.
文摘The importance of silicon in modem electronic devices has led to considerable interest in exploring the unconventional electronic properties of Si-based materials for future applications in spintronics and quantum computing. Here, using density functional theory, we present the results of a systematic study of the effect of strain on Si（lll） thin films whose surfaces are functionalized with iodine. Films with an odd number of layers under biaxial strain are found to undergo a phase transition from a normal insulator to a topological insulator and ultimately to a metal. The spin-orbit coupling-induced topologically nontrivial band gap at the F point is found to be as large as 0.50 eV, which not only surpasses that of other Si-based topological materials, it is also large enough for practical realization of quantum spin Hall states at room temperature. No such nontrivial states are found in films for such a strain-induced transition with an even number of layers. Mechanisms are illustrated by a tight-binding model composed of s, px, and py orbitals. Equally important, we predict that iodized silicene, when stretched and hole-doped, would be a phonon-mediated super- conductor with a critical temperature of 9.2 K. This coexistence of a topological insulator and a superconducting phase in a single material is unusual; it has the potential for applications in electronic circuits and for the realization of Majorana fermions in quantum computations.
