Except for the standard aortic valve replacement,no effective medical treatment is available to prevent or delay calcific aortic valve disease(CAVD)progression.Recently,macrophages and high-mobility group box 1(HMGB1)...Except for the standard aortic valve replacement,no effective medical treatment is available to prevent or delay calcific aortic valve disease(CAVD)progression.Recently,macrophages and high-mobility group box 1(HMGB1)are the most intriguing candidates in various inflammatory disorders.However,the association between serum HMGB1,CAVD,and macrophage polarization remains unclear.Therefore,we examined whether the level of serum HMGB1 is clinically associated with aortic valve calcification and whether HMGB1 treatment can promote macrophage differentiation toward M1 or M2 phenotype.This experimental study included 19 CAVD patients and 20 healthy controls whose serum HMGB1 levels were examined by ELISA assay.THP-1 macrophage polarization system was established to test the polarization capability of HMGB1 treatment.The results showed that serum levels of HMGB1 were significantly reduced in patients with CAVD.HMGB1 treatment promoted M2 macrophage polarization but not M1 phenotype with increased IL-10 expression and reduced inducible nitric oxide synthase(iNOS)expression.Our findings suggest that serum HMGB1 is negatively associated with the development of aortic valve calcification,and HMGB1 treatment may facilitate M2 macrophage polarization for reducing aortic valve calcification.展开更多
We proposed a method using latent regression Bayesian network (LRBN) toextract the shared speech feature for the input of end-to-end speech recognition model.The structure of LRBN is compact and its parameter learning...We proposed a method using latent regression Bayesian network (LRBN) toextract the shared speech feature for the input of end-to-end speech recognition model.The structure of LRBN is compact and its parameter learning is fast. Compared withConvolutional Neural Network, it has a simpler and understood structure and lessparameters to learn. Experimental results show that the advantage of hybridLRBN/Bidirectional Long Short-Term Memory-Connectionist Temporal Classificationarchitecture for Tibetan multi-dialect speech recognition, and demonstrate the LRBN ishelpful to differentiate among multiple language speech sets.展开更多
As one of Chinese minority languages,Tibetan speech recognition technology was not researched upon as extensively as Chinese and English were until recently.This,along with the relatively small Tibetan corpus,has resu...As one of Chinese minority languages,Tibetan speech recognition technology was not researched upon as extensively as Chinese and English were until recently.This,along with the relatively small Tibetan corpus,has resulted in an unsatisfying performance of Tibetan speech recognition based on an end-to-end model.This paper aims to achieve an accurate Tibetan speech recognition using a small amount of Tibetan training data.We demonstrate effective methods of Tibetan end-to-end speech recognition via cross-language transfer learning from three aspects:modeling unit selection,transfer learning method,and source language selection.Experimental results show that the Chinese-Tibetan multi-language learning method using multilanguage character set as the modeling unit yields the best performance on Tibetan Character Error Rate(CER)at 27.3%,which is reduced by 26.1%compared to the language-specific model.And our method also achieves the 2.2%higher accuracy using less amount of data compared with the method using Tibetan multi-dialect transfer learning under the same model structure and data set.展开更多
Background:Coronary artery ectasia(CAE)complicated with concomitant congenital coronary artery fistula(CCAF)is rare.This study characterizes the clinical characteristics of CAE combining CCAF,and reports a single-inst...Background:Coronary artery ectasia(CAE)complicated with concomitant congenital coronary artery fistula(CCAF)is rare.This study characterizes the clinical characteristics of CAE combining CCAF,and reports a single-institution experience with surgical correction of CAE combining CCAF.Methods:A total of 24 symptomatic patients(8 males,median 52.5 years old)who underwent surgical correction of CAE combining CCAF in this center were reviewed.Based on the size of ectatic segment,the CAE were classified as a giant CAE(>20 mm,n=14)and a non-giant CAE(≤20 mm,n=10).Individualized surgical approaches were chosen.The patients were followed up for a median of 3.8 years.Results:The overwhelming majority of CAEs were solitary,and only 4.2%of CAEs were associated with multiple lesions.CAEs were predominantly located in the right coronary artery with predilection to women more than to men(2:1).95.8%of patients with the CCAF had single fistula defect.The right atrium was the most frequent drainage site(33.3%)followed by the left ventricle(25.0%).Surgical mortality was 4.2%.All 22 follow-up patients survived with recovery from symptoms and New York Heart Association(NYHA)functional class I-II.In 10 patients with non-giant CAEs undergoing closure of fistula alone,favorable in-hospital outcomes were recorded,but residual fistula(one patient)and acute inferior wall myocardial infarction related to intracoronary thrombosis(one patient)were observed at follow-up.In 11 patients with giant CAEs undergoing aneurysm resection plus distal bypass grafting at the time of closure of fistula,favorable in-hospital outcomes and encouraging midterm results were recorded.Additionally,in 3 patients with giant CAEs undergoing closure of fistula plus aneurysmal plication,adverse events occurred,including surgical death related to rupture of the ectatic segment(one patient),perioperative myocardial infarction caused by acute thromboembolism(one patient),nonfatal inferior wall myocardial infarction related to intracoronary thrombosis(one patient)at follow-up.Conclusion:Individualized surgical approaches based on the size and the location of ectatic coronary artery as well as fistula should be offered to symptomatic patients with CAE combining CCAF.展开更多
Most present research into facial expression recognition focuses on the visible spectrum, which is sen- sitive to illumination change. In this paper, we focus on in- tegrating thermal infrared data with visible spectr...Most present research into facial expression recognition focuses on the visible spectrum, which is sen- sitive to illumination change. In this paper, we focus on in- tegrating thermal infrared data with visible spectrum images for spontaneous facial expression recognition. First, the ac- tive appearance model AAM parameters and three defined head motion features are extracted from visible spectrum im- ages, and several thermal statistical features are extracted from infrared (IR) images. Second, feature selection is per- formed using the F-test statistic. Third, Bayesian networks BNs and support vector machines SVMs are proposed for both decision-level and feature-level fusion. Experiments on the natural visible and infrared facial expression (NVIE) spontaneous database show the effectiveness of the proposed methods, and demonstrate thermal 1R images' supplementary role for visible facial expression recognition.展开更多
The Adaptive Dropped Hinge Flap(ADHF) is a novel trailing edge high-lift device characterized by the integration of downward deflection spoiler and simple hinge flap, with excellent aerodynamic and mechanism performan...The Adaptive Dropped Hinge Flap(ADHF) is a novel trailing edge high-lift device characterized by the integration of downward deflection spoiler and simple hinge flap, with excellent aerodynamic and mechanism performance. In this paper, aerodynamic optimization design of an ADHF high-lift system is conducted considering the mechanism performance. Shape and settings of both takeoff and landing configurations are optimized and analyzed, with considering the kinematic constraints of ADHF mechanism, and the desired optimization results were obtained after optimization. Sensitivity analysis proves the robustness of the optimal design. Comparison shows that the ADHF design has better comprehensive performance of both mechanism and aerodynamics than the conventional Fowler flap and simple hinge flap design.展开更多
Calciphylaxis is a rare disease characterized histologically by microvessel calcification and microthrombosis,with high mortality and no proven therapy.Here,we reported a severe uremic calciphylaxis patient with progr...Calciphylaxis is a rare disease characterized histologically by microvessel calcification and microthrombosis,with high mortality and no proven therapy.Here,we reported a severe uremic calciphylaxis patient with progressive skin ischemia,large areas of painful malodorous ulcers,and mummified legs.Because of the worsening symptoms and signs refractory to conventional therapies,treatment with human amnion-derived mesenchymal stem cells(hAMSCs)was approved.Preclinical release inspections of hAMSCs,efficacy,and safety assessment,including cytokine secretory ability,immunocompetence,tumorigenicity,and genetics analysis in vitro,were introduced.We further performed acute and long-term hAMSC toxicity evaluations in C57BL/6 mice and rats,abnormal immune response tests in C57BL/6 mice,and tumorigenicity tests in neonatal Balbc-nu nude mice.After the preclinical research,the patient was treated with hAMSCs by intravenous and local intramuscular injection and external supernatant application to the ulcers.When followed up to 15 months,the blood-based markers of bone and mineral metabolism improved,with skin soft tissue regeneration and a more favorable profile of peripheral blood mononuclear cells.Skin biopsy after 1-month treatment showed vascular regeneration with mature noncalcified vessels within the dermis,and 20 months later,the re-epithelialization restored the integrity of the damaged site.No infusion or local treatment-related adverse events occurred.Thus,this novel long-term intravenous combined with local treatment with hAMSCs warrants further investigation as a potential regenerative treatment for uremic calciphylaxis due to effects of inhibiting vascular calcification,stimulating angiogenesis and myogenesis,anti-inflammatory and immune modulation,multidifferentiation,re-epithelialization,and restoration of integrity.展开更多
For many supervised learning applications, addi- tional information, besides the labels, is often available dur- ing training, but not available during testing. Such additional information, referred to the privileged ...For many supervised learning applications, addi- tional information, besides the labels, is often available dur- ing training, but not available during testing. Such additional information, referred to the privileged information, can be exploited during training to construct a better classifier. In this paper, we propose a Bayesian network (BN) approach for learning with privileged information. We propose to in- corporate the privileged information through a three-node BN. We further mathematically evaluate different topologies of the three-node BN and identify those structures, through which the privileged information can benefit the classifica- tion. Experimental results on handwritten digit recognition, spontaneous versus posed expression recognition, and gender recognition demonstrate the effectiveness of our approach.展开更多
Facial expression and emotion recognition from thermal infrared images has attracted more and more attentions in recent years. However, the features adopted in current work are either temperature statistical parameter...Facial expression and emotion recognition from thermal infrared images has attracted more and more attentions in recent years. However, the features adopted in current work are either temperature statistical parameters extracted from the facial regions of interest or several hand-crafted features that are commonly used in visible spectrum. Till now there are no image features specially designed for thermal infrared images. In this paper, we propose using the deep Boltzmann machine to learn thermal features for emotion recognition from thermal infrared facial images. First, the face is located and normalized from the thermal infrared im- ages. Then, a deep Boltzmann machine model composed of two layers is trained. The parameters of the deep Boltzmann machine model are further fine-tuned for emotion recognition after pre-tralning of feature learning. Comparative experimental results on the NVIE database demonstrate that our approach outperforms other approaches using temperature statistic features or hand-crafted features borrowed from visible domain. The learned features from the forehead, eye, and mouth are more effective for discriminating valence dimension of emotion than other facial areas. In addition, our study shows that adding unlabeled data from other database during training can also improve feature learning performance.展开更多
It has recently become clear that several human lineages coexisted with Homo sapiens during the late Middle and Late Pleistocene.Here,we report an archaic human fossil that throws new light on debates concerning the d...It has recently become clear that several human lineages coexisted with Homo sapiens during the late Middle and Late Pleistocene.Here,we report an archaic human fossil that throws new light on debates concerning the diversification of the Homo genus and the origin of H.sapiens.The fossil was recovered in Harbin city in northeastern China,with a minimum uranium-series age of 146 ka.This cranium is one of the best preserved Middle Pleistocene human fossils.Its massive size,with a large cranial capacity(1,420 mL)falling in the range of modern humans,is combined with a mosaic of primitive and derived characters.It differs from all the other named Homo species by presenting a combination of features,such as long and low cranial vault,a wide and low face,large and almost square orbits,gently curved but massively developed supraorbital torus,flat and low cheekbones with a shallow canine fossa,and a shallow palate with thick alveolar bone supporting very large molars.The excellent preservation of the Harbin cranium advances our understanding of several less-complete late Middle Pleistocene fossils from China,which have been interpreted as local evolutionary intermediates between the earlier species Homo erectus and later H.sapiens.Phylogenetic analyses based on parsimony criteria and Bayesian tip-dating suggest that the Harbin cranium and some other Middle Pleistocene human fossils from China,such as those from Dali and Xiahe,form a third East Asian lineage,which is a part of the sister group of the H.sapiens lineage.Our analyses of such morphologically distinctive archaic human lineages from Asia,Europe,and Africa suggest that the diversification of the Homo genus may have had a much deeper timescale than previously presumed.Sympatric isolation of small populations combined with stochastic long-distance dispersals is the best fitting biogeographical model for interpreting the evolution of the Homo genus.展开更多
As one of the most complete archaic human fossils,the Harbin cranium provides critical evidence for studying the diversification of the Homo genus and the origin of Homo sapiens.However,the unsystematic recovery of th...As one of the most complete archaic human fossils,the Harbin cranium provides critical evidence for studying the diversification of the Homo genus and the origin of Homo sapiens.However,the unsystematic recovery of this cranium and a long and confused history since the discovery impede its accurate dating.Here,we carried out a series of geochemical analyses,including non-destructive X-ray fluorescence(XRF),rare earth elements(REE),and the Sr isotopes,to test the reported provenance of the Harbin cranium and get better stratigraphic constraints.The results show that the Harbin cranium has very similar XRF element distribution patterns,REE concentration patterns,and Sr isotopic compositions to those of the Middle Pleistocene-Holocene mammalian and human fossils recently recovered from the Harbin area.The sediments adhered in the nasal cavity of the Harbin cranium have a 87Sr/86Sr ratio of 0.711898,falling in the variation range measured in a core drilled near the Dongjiang Bridge,where the cranium was discovered during its reconstruction.The regional stratigraphic correlations indicate that the Harbin cranium was probably from the upper part of the Upper Huangshan Formation of the Harbin area,which has an optically stimulated luminescence dating constraint between 138 and 309 ka.U-series disequilibrium dating(n=10)directly on the cranium suggests that the cranium is older than 146 ka.The multiple lines of evidence from our experiments consistently support the theory that the Harbin cranium is from the late Middle Pleistocene of the Harbin area.Our study also shows that geochemical approaches can provide reliable evidence for locating and dating unsystematically recovered human fossils,and potentially can be applied to other human fossils without clear provenance and stratigraphy records.展开更多
In eastern Asia,several Middle-Late Pleistocene human fossils,such as the Dali,Jinniushan,Hualongdong,and Harbin crania,evidently resemble each other and are phylogenetically closer to H.sapiens than to H.neanderthale...In eastern Asia,several Middle-Late Pleistocene human fossils,such as the Dali,Jinniushan,Hualongdong,and Harbin crania,evidently resemble each other and are phylogenetically closer to H.sapiens than to H.neanderthalensis or other archaic humans.1 The Harbin cranium is the best preserved of this group.It shows a mosaic combination of plesiomorphic and apomorphic features.Here,we suggest that the Harbin skull should be recognized as a new species of Homo.展开更多
文摘Except for the standard aortic valve replacement,no effective medical treatment is available to prevent or delay calcific aortic valve disease(CAVD)progression.Recently,macrophages and high-mobility group box 1(HMGB1)are the most intriguing candidates in various inflammatory disorders.However,the association between serum HMGB1,CAVD,and macrophage polarization remains unclear.Therefore,we examined whether the level of serum HMGB1 is clinically associated with aortic valve calcification and whether HMGB1 treatment can promote macrophage differentiation toward M1 or M2 phenotype.This experimental study included 19 CAVD patients and 20 healthy controls whose serum HMGB1 levels were examined by ELISA assay.THP-1 macrophage polarization system was established to test the polarization capability of HMGB1 treatment.The results showed that serum levels of HMGB1 were significantly reduced in patients with CAVD.HMGB1 treatment promoted M2 macrophage polarization but not M1 phenotype with increased IL-10 expression and reduced inducible nitric oxide synthase(iNOS)expression.Our findings suggest that serum HMGB1 is negatively associated with the development of aortic valve calcification,and HMGB1 treatment may facilitate M2 macrophage polarization for reducing aortic valve calcification.
文摘We proposed a method using latent regression Bayesian network (LRBN) toextract the shared speech feature for the input of end-to-end speech recognition model.The structure of LRBN is compact and its parameter learning is fast. Compared withConvolutional Neural Network, it has a simpler and understood structure and lessparameters to learn. Experimental results show that the advantage of hybridLRBN/Bidirectional Long Short-Term Memory-Connectionist Temporal Classificationarchitecture for Tibetan multi-dialect speech recognition, and demonstrate the LRBN ishelpful to differentiate among multiple language speech sets.
基金This work was supported by three projects.Zhao Y received the Grant with Nos.61976236 and 2020MDJC06Bi X J received the Grant with No.20&ZD279.
文摘As one of Chinese minority languages,Tibetan speech recognition technology was not researched upon as extensively as Chinese and English were until recently.This,along with the relatively small Tibetan corpus,has resulted in an unsatisfying performance of Tibetan speech recognition based on an end-to-end model.This paper aims to achieve an accurate Tibetan speech recognition using a small amount of Tibetan training data.We demonstrate effective methods of Tibetan end-to-end speech recognition via cross-language transfer learning from three aspects:modeling unit selection,transfer learning method,and source language selection.Experimental results show that the Chinese-Tibetan multi-language learning method using multilanguage character set as the modeling unit yields the best performance on Tibetan Character Error Rate(CER)at 27.3%,which is reduced by 26.1%compared to the language-specific model.And our method also achieves the 2.2%higher accuracy using less amount of data compared with the method using Tibetan multi-dialect transfer learning under the same model structure and data set.
基金This study was supported by a grant from National Natural Science Foundation of China(No.81100140).
文摘Background:Coronary artery ectasia(CAE)complicated with concomitant congenital coronary artery fistula(CCAF)is rare.This study characterizes the clinical characteristics of CAE combining CCAF,and reports a single-institution experience with surgical correction of CAE combining CCAF.Methods:A total of 24 symptomatic patients(8 males,median 52.5 years old)who underwent surgical correction of CAE combining CCAF in this center were reviewed.Based on the size of ectatic segment,the CAE were classified as a giant CAE(>20 mm,n=14)and a non-giant CAE(≤20 mm,n=10).Individualized surgical approaches were chosen.The patients were followed up for a median of 3.8 years.Results:The overwhelming majority of CAEs were solitary,and only 4.2%of CAEs were associated with multiple lesions.CAEs were predominantly located in the right coronary artery with predilection to women more than to men(2:1).95.8%of patients with the CCAF had single fistula defect.The right atrium was the most frequent drainage site(33.3%)followed by the left ventricle(25.0%).Surgical mortality was 4.2%.All 22 follow-up patients survived with recovery from symptoms and New York Heart Association(NYHA)functional class I-II.In 10 patients with non-giant CAEs undergoing closure of fistula alone,favorable in-hospital outcomes were recorded,but residual fistula(one patient)and acute inferior wall myocardial infarction related to intracoronary thrombosis(one patient)were observed at follow-up.In 11 patients with giant CAEs undergoing aneurysm resection plus distal bypass grafting at the time of closure of fistula,favorable in-hospital outcomes and encouraging midterm results were recorded.Additionally,in 3 patients with giant CAEs undergoing closure of fistula plus aneurysmal plication,adverse events occurred,including surgical death related to rupture of the ectatic segment(one patient),perioperative myocardial infarction caused by acute thromboembolism(one patient),nonfatal inferior wall myocardial infarction related to intracoronary thrombosis(one patient)at follow-up.Conclusion:Individualized surgical approaches based on the size and the location of ectatic coronary artery as well as fistula should be offered to symptomatic patients with CAE combining CCAF.
文摘Most present research into facial expression recognition focuses on the visible spectrum, which is sen- sitive to illumination change. In this paper, we focus on in- tegrating thermal infrared data with visible spectrum images for spontaneous facial expression recognition. First, the ac- tive appearance model AAM parameters and three defined head motion features are extracted from visible spectrum im- ages, and several thermal statistical features are extracted from infrared (IR) images. Second, feature selection is per- formed using the F-test statistic. Third, Bayesian networks BNs and support vector machines SVMs are proposed for both decision-level and feature-level fusion. Experiments on the natural visible and infrared facial expression (NVIE) spontaneous database show the effectiveness of the proposed methods, and demonstrate thermal 1R images' supplementary role for visible facial expression recognition.
基金supported by the National Natural Science Foundation of China(Nos.11872230,91852108,91952302,92052203)the Aeronautical Science Foundation of China(No.2020Z006058002)。
文摘The Adaptive Dropped Hinge Flap(ADHF) is a novel trailing edge high-lift device characterized by the integration of downward deflection spoiler and simple hinge flap, with excellent aerodynamic and mechanism performance. In this paper, aerodynamic optimization design of an ADHF high-lift system is conducted considering the mechanism performance. Shape and settings of both takeoff and landing configurations are optimized and analyzed, with considering the kinematic constraints of ADHF mechanism, and the desired optimization results were obtained after optimization. Sensitivity analysis proves the robustness of the optimal design. Comparison shows that the ADHF design has better comprehensive performance of both mechanism and aerodynamics than the conventional Fowler flap and simple hinge flap design.
基金funded by the National Natural Science Foundation of China(81270408,81570666,81730041,and 81671447)the International Society of Nephrology(ISN)Clinical Research Program(18-01-0247)+7 种基金Construction Program of Jiangsu Provincial Clinical Research Center Support System(BL2014084)Jiangsu Province Key Medical Personnel Project(ZDRCA2016002)CKD Anemia Research Foundation from China International Medical Foundation(Z-2017-24-2037)Outstanding Young and Middle-Aged Talents Support Program of The First Affiliated Hospital of Nanjing Medical University(Jiangsu Province Hospital)the National Key Research and Development Program of China(2017YFC1001303)the Program of Jiangsu Province Clinical Medical Center(YXZXB2016001,BL2012009)the State Key Laboratory of Reproductive Medicine Program(SKLRM-GC201803)the Program of Jiangsu Commission of Health(H201605).
文摘Calciphylaxis is a rare disease characterized histologically by microvessel calcification and microthrombosis,with high mortality and no proven therapy.Here,we reported a severe uremic calciphylaxis patient with progressive skin ischemia,large areas of painful malodorous ulcers,and mummified legs.Because of the worsening symptoms and signs refractory to conventional therapies,treatment with human amnion-derived mesenchymal stem cells(hAMSCs)was approved.Preclinical release inspections of hAMSCs,efficacy,and safety assessment,including cytokine secretory ability,immunocompetence,tumorigenicity,and genetics analysis in vitro,were introduced.We further performed acute and long-term hAMSC toxicity evaluations in C57BL/6 mice and rats,abnormal immune response tests in C57BL/6 mice,and tumorigenicity tests in neonatal Balbc-nu nude mice.After the preclinical research,the patient was treated with hAMSCs by intravenous and local intramuscular injection and external supernatant application to the ulcers.When followed up to 15 months,the blood-based markers of bone and mineral metabolism improved,with skin soft tissue regeneration and a more favorable profile of peripheral blood mononuclear cells.Skin biopsy after 1-month treatment showed vascular regeneration with mature noncalcified vessels within the dermis,and 20 months later,the re-epithelialization restored the integrity of the damaged site.No infusion or local treatment-related adverse events occurred.Thus,this novel long-term intravenous combined with local treatment with hAMSCs warrants further investigation as a potential regenerative treatment for uremic calciphylaxis due to effects of inhibiting vascular calcification,stimulating angiogenesis and myogenesis,anti-inflammatory and immune modulation,multidifferentiation,re-epithelialization,and restoration of integrity.
基金This paper was supported by the National Natural Sci- ence Foundation of China (Gront Nos. 61175037, 6122831M), US Natural Science Foundation CNS-1205664, Special Innovation Project on Speech of Anhui Province (11010202192), Project from Anhui Science and Technol- ogy Agency (1106c0805008) and Youth Creative Project of University of Science and Technology of China.
文摘For many supervised learning applications, addi- tional information, besides the labels, is often available dur- ing training, but not available during testing. Such additional information, referred to the privileged information, can be exploited during training to construct a better classifier. In this paper, we propose a Bayesian network (BN) approach for learning with privileged information. We propose to in- corporate the privileged information through a three-node BN. We further mathematically evaluate different topologies of the three-node BN and identify those structures, through which the privileged information can benefit the classifica- tion. Experimental results on handwritten digit recognition, spontaneous versus posed expression recognition, and gender recognition demonstrate the effectiveness of our approach.
基金This paper was supported by the National Natural Science Foundation of China (Grant Nos. 61175037, 61228304), Special Innovation Project on Speech of Anhui Province (11010202192), Project from Anhui Science and Technology Agency (1106c0805008) and the Fundamental Research Funds for the Central Universities. We also acknowledge partial support from the US National Science Foundation (1205664).
文摘Facial expression and emotion recognition from thermal infrared images has attracted more and more attentions in recent years. However, the features adopted in current work are either temperature statistical parameters extracted from the facial regions of interest or several hand-crafted features that are commonly used in visible spectrum. Till now there are no image features specially designed for thermal infrared images. In this paper, we propose using the deep Boltzmann machine to learn thermal features for emotion recognition from thermal infrared facial images. First, the face is located and normalized from the thermal infrared im- ages. Then, a deep Boltzmann machine model composed of two layers is trained. The parameters of the deep Boltzmann machine model are further fine-tuned for emotion recognition after pre-tralning of feature learning. Comparative experimental results on the NVIE database demonstrate that our approach outperforms other approaches using temperature statistic features or hand-crafted features borrowed from visible domain. The learned features from the forehead, eye, and mouth are more effective for discriminating valence dimension of emotion than other facial areas. In addition, our study shows that adding unlabeled data from other database during training can also improve feature learning performance.
基金This project has been supported by the National Natural Science Foundation of China(41842039,41625005,41888101,41988101,41877430,41977380)the Strategic Priority Research Program of the Chinese Academy of Sciences(CAS)(XDB26030300,XDA20070203,XDA19050100)+3 种基金the People’s Government of Hebei Province(Z20177187)the China Geological Survey(DD20190601)the Science Foundation of Hebei GEO University(TS2017-001)the Second Tibetan Plateau Scientific Expedition and Research Program(2019QZKK0705).
文摘It has recently become clear that several human lineages coexisted with Homo sapiens during the late Middle and Late Pleistocene.Here,we report an archaic human fossil that throws new light on debates concerning the diversification of the Homo genus and the origin of H.sapiens.The fossil was recovered in Harbin city in northeastern China,with a minimum uranium-series age of 146 ka.This cranium is one of the best preserved Middle Pleistocene human fossils.Its massive size,with a large cranial capacity(1,420 mL)falling in the range of modern humans,is combined with a mosaic of primitive and derived characters.It differs from all the other named Homo species by presenting a combination of features,such as long and low cranial vault,a wide and low face,large and almost square orbits,gently curved but massively developed supraorbital torus,flat and low cheekbones with a shallow canine fossa,and a shallow palate with thick alveolar bone supporting very large molars.The excellent preservation of the Harbin cranium advances our understanding of several less-complete late Middle Pleistocene fossils from China,which have been interpreted as local evolutionary intermediates between the earlier species Homo erectus and later H.sapiens.Phylogenetic analyses based on parsimony criteria and Bayesian tip-dating suggest that the Harbin cranium and some other Middle Pleistocene human fossils from China,such as those from Dali and Xiahe,form a third East Asian lineage,which is a part of the sister group of the H.sapiens lineage.Our analyses of such morphologically distinctive archaic human lineages from Asia,Europe,and Africa suggest that the diversification of the Homo genus may have had a much deeper timescale than previously presumed.Sympatric isolation of small populations combined with stochastic long-distance dispersals is the best fitting biogeographical model for interpreting the evolution of the Homo genus.
基金This project has been supported by the National Natural Science Foundation of China(41977380,41877430,41842039,41625005,41888101,41988101)the Strategic Priority Research Program of Chinese Academy of Sciences(CAS XDB26030400,XDB26030300,XDA20070203,XDA19050100)+3 种基金the People’s Government of Hebei Province(Z20177187)the China Geological Survey(DD20190601)the Science Foundation of Hebei GEO University(TS2017-001)the Second Tibetan Plateau Scientific Expedition and Research Program(2019QZKK0705)。
文摘As one of the most complete archaic human fossils,the Harbin cranium provides critical evidence for studying the diversification of the Homo genus and the origin of Homo sapiens.However,the unsystematic recovery of this cranium and a long and confused history since the discovery impede its accurate dating.Here,we carried out a series of geochemical analyses,including non-destructive X-ray fluorescence(XRF),rare earth elements(REE),and the Sr isotopes,to test the reported provenance of the Harbin cranium and get better stratigraphic constraints.The results show that the Harbin cranium has very similar XRF element distribution patterns,REE concentration patterns,and Sr isotopic compositions to those of the Middle Pleistocene-Holocene mammalian and human fossils recently recovered from the Harbin area.The sediments adhered in the nasal cavity of the Harbin cranium have a 87Sr/86Sr ratio of 0.711898,falling in the variation range measured in a core drilled near the Dongjiang Bridge,where the cranium was discovered during its reconstruction.The regional stratigraphic correlations indicate that the Harbin cranium was probably from the upper part of the Upper Huangshan Formation of the Harbin area,which has an optically stimulated luminescence dating constraint between 138 and 309 ka.U-series disequilibrium dating(n=10)directly on the cranium suggests that the cranium is older than 146 ka.The multiple lines of evidence from our experiments consistently support the theory that the Harbin cranium is from the late Middle Pleistocene of the Harbin area.Our study also shows that geochemical approaches can provide reliable evidence for locating and dating unsystematically recovered human fossils,and potentially can be applied to other human fossils without clear provenance and stratigraphy records.
文摘In eastern Asia,several Middle-Late Pleistocene human fossils,such as the Dali,Jinniushan,Hualongdong,and Harbin crania,evidently resemble each other and are phylogenetically closer to H.sapiens than to H.neanderthalensis or other archaic humans.1 The Harbin cranium is the best preserved of this group.It shows a mosaic combination of plesiomorphic and apomorphic features.Here,we suggest that the Harbin skull should be recognized as a new species of Homo.