Dear Editor,The first mitotic division in zygotes is crucial for the beginning of the life cycle for the human.After fertilization,zygotes reactivate cell cycle,both paternal and maternal genomes replicate and reprogr...Dear Editor,The first mitotic division in zygotes is crucial for the beginning of the life cycle for the human.After fertilization,zygotes reactivate cell cycle,both paternal and maternal genomes replicate and reprogram to become totipotent.In the meantime,the male and female pronucleus move to the center of the zygote and merge.Then zygotes enter the metaphase,and sister chromatids separate into two daughter cells(Eckersley-Maslin et al.,2018;Reichmann et al.,2018).This is a sensitive time window and many perturbances may cause the first mitosis to fail.展开更多
基金This work was supported by the National Key R&D Program of China(Grant 2019YFA0110001,2017YFA0102802)the National Natural Science Foundation of China(Grant Nos.31970819,91740115,31771108 to JN,Grant No.32000610 to JG,82001516 to BC,and 82071724 to ZZ)+2 种基金Beijing Hospitals Authority Youth Programme QML20201401 to LLJG is supported by the Tsinghua-Peking Center for Life Sciences postdoctoral fellowshipTsinghua University SRT grant 2111S0057 and 2111T0626 to QL and JN.
文摘Dear Editor,The first mitotic division in zygotes is crucial for the beginning of the life cycle for the human.After fertilization,zygotes reactivate cell cycle,both paternal and maternal genomes replicate and reprogram to become totipotent.In the meantime,the male and female pronucleus move to the center of the zygote and merge.Then zygotes enter the metaphase,and sister chromatids separate into two daughter cells(Eckersley-Maslin et al.,2018;Reichmann et al.,2018).This is a sensitive time window and many perturbances may cause the first mitosis to fail.
