The wide pillars are generally popular due to the high productivity and efficiency in Northwest China.The distribution of lateral abutment pressure in coal pillars is important for mining safety.To reveal the effect o...The wide pillars are generally popular due to the high productivity and efficiency in Northwest China.The distribution of lateral abutment pressure in coal pillars is important for mining safety.To reveal the effect of the first mining on the lateral abutment pressure distribution and evolution in wide pillars,an in-situ experiment,theoretical analysis and numerical simulation were performed.First,the field monitoring of lateral abutment pressure was conducted from the perspective of time and space in the Chahasu Coal Mine,Huangling No.2 Coal Mine and Lingdong Coal Mine during the first mining.Based on the field monitoring stress,a theoretical model was proposed to reveal the lateral abutment pressure distribution.The methodology was demonstrated through a case study.Aiming at the distribution mechanism,a numerical experiment was conducted through the finite-discrete element method(FDEM).Last,field observations of borehole fractures were performed to further study the damage distribution.In addition,two types of lateral abutment pressure evolution with mining advance were discussed.Suggestions on the stress monitoring layout were proposed as well.The results could provide foundations for strata control and disaster prevention in wide pillars in underground coal mines.展开更多
Sn-based perovskite solar cells(PSCs)demonstrate a potential development in eco-friendly devices due to their hypotoxicity.However,poor stability and crystalline quality are still the challenges for achieving high-per...Sn-based perovskite solar cells(PSCs)demonstrate a potential development in eco-friendly devices due to their hypotoxicity.However,poor stability and crystalline quality are still the challenges for achieving high-performance and long-term operating devices.In this work,inspired by biological protein,nickelporphyrin(Ni-P)with electron cloud on conjugate ring is applied into Sn-based perovskite to prevent perovskite from being eroded.The synergistic effect of water and oxygen is broken in grain boundaries and surface so that the stability of PSCs can be improved obviously,despite there is hardly any barrier for water to erode.Simultaneously,the electron-rich molecules can passivate the defects of perovskite such as iodine vacancy.Moreover,the ester group in Ni-P molecule can bind with SnI;to form complex and then restrain nucleation.Combining with the template effect of 2D molecular,the crystallization of perovskite films is optimized.Therefore,the Sn-based PSCs with Ni-P achieve a stabilized power conversion efficiency(PCE)of 7.79%with negligible hysteresis in fexible devices,respectively.Moreover,the PSCs can maintain 80%of the pristine PCE after 300 h under air environment.展开更多
This paper proposes to use the power system simulation software CYME to plan, model and simulate for an actual distribution network for improving the reliability and efficiency, enhancing the efficiency and capacity, ...This paper proposes to use the power system simulation software CYME to plan, model and simulate for an actual distribution network for improving the reliability and efficiency, enhancing the efficiency and capacity, simulating the abnormal condition of distribution network, and presenting operation program of safe, reliable and having simulation record statements. The modeling simulation results show that the software module has lots of advantages including high accuracy, ideal reliability, powerful practicality in simulation and analysis of distribution network, it only need to create once model, the model can sufficiently satisfy multifarious types of simulation analysis required for the distribution network planning.展开更多
The method is based on that the waveform of the inrush distorts seriously, while the fault current nearly keeps sinusoid. The complicated signal can be decomposed into a finite intrinsic mode functions (IMF) by the EM...The method is based on that the waveform of the inrush distorts seriously, while the fault current nearly keeps sinusoid. The complicated signal can be decomposed into a finite intrinsic mode functions (IMF) by the EMD, then define and compute the projection area on X-axis of each IMF—, the specific gravity of SIMF—, and the maximum of —. We can get a new scheme of transformer-protection based on comparing the difference between inrush and fault current. Theoretical analysis show that the method can precisely discriminate inrush and fault current, fault clearance time is about 20ms. Moreover, it is convenient to achieve and hardly be affect by not-periodic component.展开更多
At present, the development of distribution network can’t meet the requirements of rapid economic development. The traditional single energy supply is difficult to meet the request, and distributed energy supply has ...At present, the development of distribution network can’t meet the requirements of rapid economic development. The traditional single energy supply is difficult to meet the request, and distributed energy supply has a lot of advantages compared to it, particularly it's close to the end users, and they have been developed well and applied widely in recent years. This paper summarizes the features and current development of the distributed energy supply, and mainly describes the grid-connection model of distributed energy supply. Base on the mathematic grid-connection model of distributed power sources with different generation principles as well as that energy storage, the treatment of these models in distribution network power flow analysis is also presented.展开更多
Energy and environmental problems are among the important factors restricting economic development. The development of green energy is an important measure to deal with energy and environmental problems, such as wind ...Energy and environmental problems are among the important factors restricting economic development. The development of green energy is an important measure to deal with energy and environmental problems, such as wind energy and photovoltaic. Energy Internet is an important mean to promote the transformation of the energy structure, improve energy efficiency and reduce pollution. In introduction, the energy Internet is put forward. Then the architecture and characteristics of energy Internet, such as integration, openness, intelligence and marketization of energy Internet are analyzed. Next, key technologies such as energy router, virtual power plant and network security technology are discussed. Finally, a few suggestions for the development of energy Internet are proposed, and hoped to promote the development of energy Internet.展开更多
Combining with the characteristics of China's energy and the strategy of sustainable development, analyzing the pros and cons which caused by the appearance of DG and their operation connecting to grid, this paper...Combining with the characteristics of China's energy and the strategy of sustainable development, analyzing the pros and cons which caused by the appearance of DG and their operation connecting to grid, this paper points out that the two sides can achieve win-win under a reasonable combination between DG and distribution system, so as to optimize the allocation of resources, improve the utilization ratio of resource, and obtain maximum social benefit, harmoniously promote the development of power industry, economy and environment. As a word, this paper puts forward a new model of distribution network planning including DG and brings in penalty factorto guide the investment and construction of DG. Last of all, this paper presents the adoption of the coordination development coefficients which is to evaluate the power planning.展开更多
Hyperactivation of the NLRP3 inflammasome has been implicated in the pathogenesis of numerous diseases.However,the precise molecular mechanisms that modulate the transcriptional regulation of NLRP3 remain largely unkn...Hyperactivation of the NLRP3 inflammasome has been implicated in the pathogenesis of numerous diseases.However,the precise molecular mechanisms that modulate the transcriptional regulation of NLRP3 remain largely unknown.In this study,we demonstrated that S-nitrosoglutathione reductase(GSNOR)deficiency in macrophages leads to significant increases in the Nlrp3 and Il-1βexpression levels and interleukin-1β(IL-1β)secretion in response to NLRP3 inflammasome stimulation.Furthermore,in vivo experiments utilizing Gsnor^(−/−)mice revealed increased disease severity in both lipopolysaccharide(LPS)-induced septic shock and dextran sodium sulfate(DSS)-induced colitis models.Additionally,we showed that both LPS-induced septic shock and DSS-induced colitis were ameliorated in Gsnor^(−/−)Nlrp3^(−/−)double-knockout(DKO)mice.Mechanistically,GSNOR deficiency increases the S-nitrosation of mitogen-activated protein kinase 14(MAPK14)at the Cys211 residue and augments MAPK14 kinase activity,thereby promoting Nlrp3 and Il-1βtranscription and stimulating NLRP3 inflammasome activity.Our findings suggested that GSNOR is a regulator of the NLRP3 inflammasome and that reducing the level of S-nitrosylated MAPK14 may constitute an effective strategy for alleviating diseases associated with NLRP3-mediated inflammation.展开更多
Dear Editor,Methamphetamine(METH)is the most prevalent addictive psychostimulant in China.METH use disorder(MUD)and its associated disorders constitute a significant burden to the affected individuals and their famili...Dear Editor,Methamphetamine(METH)is the most prevalent addictive psychostimulant in China.METH use disorder(MUD)and its associated disorders constitute a significant burden to the affected individuals and their families(Paulus and Stewart,2020).Neurotransmitter system aberrations,mitochondrial dysfunction,oxidative stress,and inflammasome activation have been involved in METH-induced neurotoxicity(Shin et al.,2018;Wang et al.,2015;Wei et al.,2020).展开更多
基金We gratefully acknowledge financial support from the National Natural Science Foundation of China(NSFC)(No.51704097)Science Foundation of Henan Polytechnic University(No.J2021–2)+1 种基金Key Research and Development Program of Henan Province,China(No.202102310244)“Science and Technology to Help the Economy 2020”Key Project(No.SQ2020YFF0426364).
文摘The wide pillars are generally popular due to the high productivity and efficiency in Northwest China.The distribution of lateral abutment pressure in coal pillars is important for mining safety.To reveal the effect of the first mining on the lateral abutment pressure distribution and evolution in wide pillars,an in-situ experiment,theoretical analysis and numerical simulation were performed.First,the field monitoring of lateral abutment pressure was conducted from the perspective of time and space in the Chahasu Coal Mine,Huangling No.2 Coal Mine and Lingdong Coal Mine during the first mining.Based on the field monitoring stress,a theoretical model was proposed to reveal the lateral abutment pressure distribution.The methodology was demonstrated through a case study.Aiming at the distribution mechanism,a numerical experiment was conducted through the finite-discrete element method(FDEM).Last,field observations of borehole fractures were performed to further study the damage distribution.In addition,two types of lateral abutment pressure evolution with mining advance were discussed.Suggestions on the stress monitoring layout were proposed as well.The results could provide foundations for strata control and disaster prevention in wide pillars in underground coal mines.
基金support from the National Natural Science Foundation of China(NSFC)(22005131,52173169 and 11564025)。
文摘Sn-based perovskite solar cells(PSCs)demonstrate a potential development in eco-friendly devices due to their hypotoxicity.However,poor stability and crystalline quality are still the challenges for achieving high-performance and long-term operating devices.In this work,inspired by biological protein,nickelporphyrin(Ni-P)with electron cloud on conjugate ring is applied into Sn-based perovskite to prevent perovskite from being eroded.The synergistic effect of water and oxygen is broken in grain boundaries and surface so that the stability of PSCs can be improved obviously,despite there is hardly any barrier for water to erode.Simultaneously,the electron-rich molecules can passivate the defects of perovskite such as iodine vacancy.Moreover,the ester group in Ni-P molecule can bind with SnI;to form complex and then restrain nucleation.Combining with the template effect of 2D molecular,the crystallization of perovskite films is optimized.Therefore,the Sn-based PSCs with Ni-P achieve a stabilized power conversion efficiency(PCE)of 7.79%with negligible hysteresis in fexible devices,respectively.Moreover,the PSCs can maintain 80%of the pristine PCE after 300 h under air environment.
文摘This paper proposes to use the power system simulation software CYME to plan, model and simulate for an actual distribution network for improving the reliability and efficiency, enhancing the efficiency and capacity, simulating the abnormal condition of distribution network, and presenting operation program of safe, reliable and having simulation record statements. The modeling simulation results show that the software module has lots of advantages including high accuracy, ideal reliability, powerful practicality in simulation and analysis of distribution network, it only need to create once model, the model can sufficiently satisfy multifarious types of simulation analysis required for the distribution network planning.
文摘The method is based on that the waveform of the inrush distorts seriously, while the fault current nearly keeps sinusoid. The complicated signal can be decomposed into a finite intrinsic mode functions (IMF) by the EMD, then define and compute the projection area on X-axis of each IMF—, the specific gravity of SIMF—, and the maximum of —. We can get a new scheme of transformer-protection based on comparing the difference between inrush and fault current. Theoretical analysis show that the method can precisely discriminate inrush and fault current, fault clearance time is about 20ms. Moreover, it is convenient to achieve and hardly be affect by not-periodic component.
文摘At present, the development of distribution network can’t meet the requirements of rapid economic development. The traditional single energy supply is difficult to meet the request, and distributed energy supply has a lot of advantages compared to it, particularly it's close to the end users, and they have been developed well and applied widely in recent years. This paper summarizes the features and current development of the distributed energy supply, and mainly describes the grid-connection model of distributed energy supply. Base on the mathematic grid-connection model of distributed power sources with different generation principles as well as that energy storage, the treatment of these models in distribution network power flow analysis is also presented.
文摘Energy and environmental problems are among the important factors restricting economic development. The development of green energy is an important measure to deal with energy and environmental problems, such as wind energy and photovoltaic. Energy Internet is an important mean to promote the transformation of the energy structure, improve energy efficiency and reduce pollution. In introduction, the energy Internet is put forward. Then the architecture and characteristics of energy Internet, such as integration, openness, intelligence and marketization of energy Internet are analyzed. Next, key technologies such as energy router, virtual power plant and network security technology are discussed. Finally, a few suggestions for the development of energy Internet are proposed, and hoped to promote the development of energy Internet.
文摘Combining with the characteristics of China's energy and the strategy of sustainable development, analyzing the pros and cons which caused by the appearance of DG and their operation connecting to grid, this paper points out that the two sides can achieve win-win under a reasonable combination between DG and distribution system, so as to optimize the allocation of resources, improve the utilization ratio of resource, and obtain maximum social benefit, harmoniously promote the development of power industry, economy and environment. As a word, this paper puts forward a new model of distribution network planning including DG and brings in penalty factorto guide the investment and construction of DG. Last of all, this paper presents the adoption of the coordination development coefficients which is to evaluate the power planning.
基金Yunnan Fundamental Research Project(202305AH340006)National Natural Science Foundation of China(32201018)+1 种基金Basic Research Program and Key Project of Yunnan Province(202301AW070013 and 202003AD150009)Youth Innovation Promotion Association(2023403).
文摘Hyperactivation of the NLRP3 inflammasome has been implicated in the pathogenesis of numerous diseases.However,the precise molecular mechanisms that modulate the transcriptional regulation of NLRP3 remain largely unknown.In this study,we demonstrated that S-nitrosoglutathione reductase(GSNOR)deficiency in macrophages leads to significant increases in the Nlrp3 and Il-1βexpression levels and interleukin-1β(IL-1β)secretion in response to NLRP3 inflammasome stimulation.Furthermore,in vivo experiments utilizing Gsnor^(−/−)mice revealed increased disease severity in both lipopolysaccharide(LPS)-induced septic shock and dextran sodium sulfate(DSS)-induced colitis models.Additionally,we showed that both LPS-induced septic shock and DSS-induced colitis were ameliorated in Gsnor^(−/−)Nlrp3^(−/−)double-knockout(DKO)mice.Mechanistically,GSNOR deficiency increases the S-nitrosation of mitogen-activated protein kinase 14(MAPK14)at the Cys211 residue and augments MAPK14 kinase activity,thereby promoting Nlrp3 and Il-1βtranscription and stimulating NLRP3 inflammasome activity.Our findings suggested that GSNOR is a regulator of the NLRP3 inflammasome and that reducing the level of S-nitrosylated MAPK14 may constitute an effective strategy for alleviating diseases associated with NLRP3-mediated inflammation.
基金supported by the Strategic Priority Research Program(B)of CAS(XDB02020003)the National Natural Science Foundation of China(31671050 and 31900695)+2 种基金the Bureau of Frontier Sciences and Education of CAS(QYZDJ-SSW-SMC005)the Youth Innovation Promotion Association,“Light of West China”Program of CASthe Applied Basic Research Foundation of Yunnan Province,Yunnan Department of Science and Technology(202001AT070103)。
文摘Dear Editor,Methamphetamine(METH)is the most prevalent addictive psychostimulant in China.METH use disorder(MUD)and its associated disorders constitute a significant burden to the affected individuals and their families(Paulus and Stewart,2020).Neurotransmitter system aberrations,mitochondrial dysfunction,oxidative stress,and inflammasome activation have been involved in METH-induced neurotoxicity(Shin et al.,2018;Wang et al.,2015;Wei et al.,2020).