Antiphospholipid syndrome(APS)is a systemic autoimmune disease characterized by thrombotic or obstetric events caused by persistent antiphospholipid antibodies(aPLs),namely lupus anticoagulant,anticardiolipin antibodi...Antiphospholipid syndrome(APS)is a systemic autoimmune disease characterized by thrombotic or obstetric events caused by persistent antiphospholipid antibodies(aPLs),namely lupus anticoagulant,anticardiolipin antibodies,or anti-β2 glycoprotein I(anti-β2GPI)antibodies.^([1])The main target antigen in APS isβ2GPI,through which aPL binds to the cell membrane and subsequently activates membrane receptors and down-stream signal transducers.This may activate natural killer(NK)cells,leading to obstetric complications.展开更多
基金the National Natural Science Foundation of China(No.81871292)the Key Research and Development(R&D)Projects of Shanxi Province(No.201803D31136)。
文摘Antiphospholipid syndrome(APS)is a systemic autoimmune disease characterized by thrombotic or obstetric events caused by persistent antiphospholipid antibodies(aPLs),namely lupus anticoagulant,anticardiolipin antibodies,or anti-β2 glycoprotein I(anti-β2GPI)antibodies.^([1])The main target antigen in APS isβ2GPI,through which aPL binds to the cell membrane and subsequently activates membrane receptors and down-stream signal transducers.This may activate natural killer(NK)cells,leading to obstetric complications.
