Objective Anthracycline chemotherapeutic agents have significant cardiotoxicity.The present study emphasized the effect of anthracycline chemotherapy drugs on left ventricular(LV)myocardial stiffness in breast cancer ...Objective Anthracycline chemotherapeutic agents have significant cardiotoxicity.The present study emphasized the effect of anthracycline chemotherapy drugs on left ventricular(LV)myocardial stiffness in breast cancer patients by measuring the intrinsic wave velocity propagation(IVP),and evaluating the potential clinical value of IVP in detecting early LV diastolic function impairment.Methods A total of 68 newly diagnosed breast cancer patients,who were treated with anthracycline-based chemotherapy,were analyzed.Transthoracic echocardiography was performed at baseline(T0),and after 1,2,3,4 and 8 chemotherapeutic cycles(T1,T2,T3,T4 and T5,respectively).Then,the IVP,LV strain parameters[global longitudinal strain(GLS),longitudinal peak strain rate at systole(LSRs),longitudinal peak strain rate at early diastole(LSRe),longitudinal peak strain rate at late diastole(LSRa),and the E/LSRe ratio],and conventional echocardiographic parameters were obtained and further analyzed.A relative reduction of>15%in GLS was considered a marker of early LV subclinical dysfunction.Results Compared to the T0 stage,IVP significantly increased at the T1 stage.However,there were no significant changes in GLS,LSRs,or LSRe between the T0 and T1 stages.These parameters significantly decreased from the T2 stage.LSRa started to significantly decrease at the T5 stage,and the E/LSRe ratio started to significantly increase at the T3 stage(all P<0.05).At the T0 stage,IVP(AUC=0.752,P<0.001)had a good predictive value for LV subclinical dysfunction after chemotherapy.Conclusions IVP is a potentially sensitive parameter for the early clinical assessment of anthracycline-related cardiac diastolic impairment.展开更多
The Wenchuan earthquake generated strong surface disturbances and triggered a large number of loose deposits, resulting in the disasterprone environment with special watershed hydrological characteristics. This paper ...The Wenchuan earthquake generated strong surface disturbances and triggered a large number of loose deposits, resulting in the disasterprone environment with special watershed hydrological characteristics. This paper was to propose a debris flow formation process and explore the permeability characteristics and critical hydrodynamic conditions of the loose deposits triggered by the earthquake. The Guo Juanyan gully(31°05′27″ N to 31°05′46″ N, 103°36′58″ E to 103°37′09″ E) in Du Jiangyan City, located in the meizoseismal areas of the Wenchuan earthquake, was chosen as the study area and the disaster-prone environment was analyzed. The formation process of the debris flow was first proposed using a stability analysis, and then, the permeability characteristics of loose deposits were determined via in situ permeability experiments. Finally, the critical 1 h rainfall was simulated through a distributed hydrological model and verified by field observations. The formation process of debris flow could be divided into three stages based on the relationship between the hydrodynamic force and loose deposit resistance. The critical 1 h rainfall amounts under three antecedent moisture conditions(I-dry, II-normal and III-wet) were 52 mm/h, 43 mm/h and 34 mm/h, respectively. This study proposed a debris flow formation process in the meizoseismal areas of the Wenchuan earthquake based on the stability analysis and defined the rainfall threshold for debris flow early warning at the local level, which is significant for debris flow mitigation and risk management.展开更多
A catastrophic landslide occurred at Hongao dumpsite in Guangming New District of Shenzhen, South China, on December 20, 2015. An estimated total volume of 2.73×106 m3 of construction spoils was mobilized during ...A catastrophic landslide occurred at Hongao dumpsite in Guangming New District of Shenzhen, South China, on December 20, 2015. An estimated total volume of 2.73×106 m3 of construction spoils was mobilized during this event. The landslide traveled a long distance on a low-relief terrain. The affected area was approximately 1100 m in length and 630 m in width. This landslide made 33 buildings destroyed, 73 people died and 4 people lost. Due to the special dumping history and other factors, soil in this landfill is of high initial water content. To identify the major factors that attribute to the long runout character, a two-phase flow model of Iverson and George was used to simulate the dynamics of this landslide. The influence of initial hydraulic permeability, initial dilatancy, and earth pressure coefficient was examined through numerical simulations. We found that pore pressure has the most significant effect on the dynamic characteristics of Shenzhen landslides. Average pore pressure ratio ofthe whole basal surface was used to evaluate the degree of liquefaction for the sliding material. The evolution and influence factors of this ratio were analyzed based on the computational results. An exponential function was proposed to fit the evolution curve of the average pore pressure ratio, which can be used as a reasonable and simplified evaluation of the pore pressure. This fitting function can be utilized to improve the single-phase flow model.展开更多
Zn（O,S）（zinc oxysulfide） is an important chalcogenide material recently reported to be potentially applied as electrode buffers in thin film solar cells. Both vacuum and solution approaches have enabled the fabric...Zn（O,S）（zinc oxysulfide） is an important chalcogenide material recently reported to be potentially applied as electrode buffers in thin film solar cells. Both vacuum and solution approaches have enabled the fabrication of Zn（O,S） films. However they either require extreme conditions and high energy consumption for synthesis, or suffer from lack of controllability mainly due to the thermodynamic and kinetic distinction between Zn O and Zn S during film growth. Here we demonstrated an effective electrodeposition route to obtain high-quality Zn（O,S） thin films in a controllable manner. Importantly, tartaric acid was employed as a secondary complexing agent in the electrolyte to improve the film morphology, as well as to adjust other key properties such as composition and absorption. To elucidate the vital role that tartaric acid played, thermodynamic and kinetic processes of electrodeposition was investigated and discussed in detail. The accumulative contribution has shed light on further exploit of Zn（O,S） with tunable properties and optimization of the corresponding electrodeposition process, for the application in thin film solar cells.展开更多
基金the Hubei Province Health and Famliy Planning Scientific Research Project(No.WJ2023M011)the Department of Finance of Hubei Province(No.3890750).
文摘Objective Anthracycline chemotherapeutic agents have significant cardiotoxicity.The present study emphasized the effect of anthracycline chemotherapy drugs on left ventricular(LV)myocardial stiffness in breast cancer patients by measuring the intrinsic wave velocity propagation(IVP),and evaluating the potential clinical value of IVP in detecting early LV diastolic function impairment.Methods A total of 68 newly diagnosed breast cancer patients,who were treated with anthracycline-based chemotherapy,were analyzed.Transthoracic echocardiography was performed at baseline(T0),and after 1,2,3,4 and 8 chemotherapeutic cycles(T1,T2,T3,T4 and T5,respectively).Then,the IVP,LV strain parameters[global longitudinal strain(GLS),longitudinal peak strain rate at systole(LSRs),longitudinal peak strain rate at early diastole(LSRe),longitudinal peak strain rate at late diastole(LSRa),and the E/LSRe ratio],and conventional echocardiographic parameters were obtained and further analyzed.A relative reduction of>15%in GLS was considered a marker of early LV subclinical dysfunction.Results Compared to the T0 stage,IVP significantly increased at the T1 stage.However,there were no significant changes in GLS,LSRs,or LSRe between the T0 and T1 stages.These parameters significantly decreased from the T2 stage.LSRa started to significantly decrease at the T5 stage,and the E/LSRe ratio started to significantly increase at the T3 stage(all P<0.05).At the T0 stage,IVP(AUC=0.752,P<0.001)had a good predictive value for LV subclinical dysfunction after chemotherapy.Conclusions IVP is a potentially sensitive parameter for the early clinical assessment of anthracycline-related cardiac diastolic impairment.
基金Financial support was provided by the international cooperation project of the Ministry of Science and Technology (Grant No.2013DFA21720)the Key Laboratory of Mountain Hazards and Earth Surface Processes independent project fundingthe National Natural Science Foundation (Grant No. 41372331)
文摘The Wenchuan earthquake generated strong surface disturbances and triggered a large number of loose deposits, resulting in the disasterprone environment with special watershed hydrological characteristics. This paper was to propose a debris flow formation process and explore the permeability characteristics and critical hydrodynamic conditions of the loose deposits triggered by the earthquake. The Guo Juanyan gully(31°05′27″ N to 31°05′46″ N, 103°36′58″ E to 103°37′09″ E) in Du Jiangyan City, located in the meizoseismal areas of the Wenchuan earthquake, was chosen as the study area and the disaster-prone environment was analyzed. The formation process of the debris flow was first proposed using a stability analysis, and then, the permeability characteristics of loose deposits were determined via in situ permeability experiments. Finally, the critical 1 h rainfall was simulated through a distributed hydrological model and verified by field observations. The formation process of debris flow could be divided into three stages based on the relationship between the hydrodynamic force and loose deposit resistance. The critical 1 h rainfall amounts under three antecedent moisture conditions(I-dry, II-normal and III-wet) were 52 mm/h, 43 mm/h and 34 mm/h, respectively. This study proposed a debris flow formation process in the meizoseismal areas of the Wenchuan earthquake based on the stability analysis and defined the rainfall threshold for debris flow early warning at the local level, which is significant for debris flow mitigation and risk management.
基金supported by the National Key R&D Program of China(Grant Nos.2017YFC1502502,2017YFC1502506)National Nature Science Foundation of China(Grant Nos.41672318,51679229,41372331)+1 种基金135 Strategic Program of the Institute of Mountain Hazards and Environment,CAS(Grant No.SDS-135-1701)supported by Youth Innovation Promotion Association of the Chinese Academy of Sciences(2018405)
文摘A catastrophic landslide occurred at Hongao dumpsite in Guangming New District of Shenzhen, South China, on December 20, 2015. An estimated total volume of 2.73×106 m3 of construction spoils was mobilized during this event. The landslide traveled a long distance on a low-relief terrain. The affected area was approximately 1100 m in length and 630 m in width. This landslide made 33 buildings destroyed, 73 people died and 4 people lost. Due to the special dumping history and other factors, soil in this landfill is of high initial water content. To identify the major factors that attribute to the long runout character, a two-phase flow model of Iverson and George was used to simulate the dynamics of this landslide. The influence of initial hydraulic permeability, initial dilatancy, and earth pressure coefficient was examined through numerical simulations. We found that pore pressure has the most significant effect on the dynamic characteristics of Shenzhen landslides. Average pore pressure ratio ofthe whole basal surface was used to evaluate the degree of liquefaction for the sliding material. The evolution and influence factors of this ratio were analyzed based on the computational results. An exponential function was proposed to fit the evolution curve of the average pore pressure ratio, which can be used as a reasonable and simplified evaluation of the pore pressure. This fitting function can be utilized to improve the single-phase flow model.
基金funding support from the National Natural Science Foundation of China(21371016)funding support from Young Talent Thousand Program
文摘Zn（O,S）（zinc oxysulfide） is an important chalcogenide material recently reported to be potentially applied as electrode buffers in thin film solar cells. Both vacuum and solution approaches have enabled the fabrication of Zn（O,S） films. However they either require extreme conditions and high energy consumption for synthesis, or suffer from lack of controllability mainly due to the thermodynamic and kinetic distinction between Zn O and Zn S during film growth. Here we demonstrated an effective electrodeposition route to obtain high-quality Zn（O,S） thin films in a controllable manner. Importantly, tartaric acid was employed as a secondary complexing agent in the electrolyte to improve the film morphology, as well as to adjust other key properties such as composition and absorption. To elucidate the vital role that tartaric acid played, thermodynamic and kinetic processes of electrodeposition was investigated and discussed in detail. The accumulative contribution has shed light on further exploit of Zn（O,S） with tunable properties and optimization of the corresponding electrodeposition process, for the application in thin film solar cells.
