Evaluation of the general conditions and inflammatory response of antibiotics combined with fat-soluble vitamin therapy for pediatric pneumonia

Objective: To evaluate the general conditions and inflammatory response of antibiotics combined with fat-soluble vitamin therapy for pediatric pneumonia. Methods: A total of 350 children with pneumonia who were treated in our hospital between January 2014 and January 2017 were collected and divided into control group and observation group according to the random number table, 175 cases in each group. Control group received azithromycin therapy, and observation group received azithromycin combined with fat-soluble vitamin therapy. The differences in the systemic and inflammatory responses before and after treatment were compared between the two groups of patients. Results: Before treatment, differences in blood routine index levels as well as serum contents of oxidative stress indexes and inflammatory factors were not statistically significant between two groups of patients. After treatment, white blood cell count, neutrophil ratio as well as serum CRP, PCT, IL-6 and TNF-α contents of both groups were lower than those before treatment while lymphocyte ratio as well as serum IgA, IgG and IgM contents were higher than those before treatment, and white blood cell count, neutrophil ratio as well as serum CRP, PCT, IL-6 and TNF-α contents of observation group after treatment were lower than those of control group while lymphocyte ratio as well as serum IgA, IgG and IgM contents was higher than those of control group. Conclusion:Antibiotics combined with fat-soluble vitamin therapy for pediatric pneumonia can effectively optimize the patient's general conditions and reduce the inflammatory response.

Effect of azithromycin combined with licorzinc therapy on inflammatory response and immune response in children with mycoplasma pneumonia

Objective:To study the effect of azithromycin combined with licorzinc therapy on inflammatory response and immune response in children with mycoplasma pneumonia. Methods:A total of 150 children with mycoplasma pneumonia who were treated in our hospital between January 2014 and January 2017 were collected and divided into control group and observation group according to the random number table, with 75 cases in each group. Control group received azithromycin therapy, while observation group received azithromycin combined with licorzinc therapy. The therapies were given for the patients in both groups lasted for 14 d. The differences in serum levels of inflammatory factors, Th17/Treg cytokines and immunoglobulin were compared between the two groups before and after treatment.Results: Before treatment, differences in serum levels of inflammatory factors, Th17/Treg cytokines and immunoglobulin were not statistically significant between two groups of patients. After treatment, serum inflammatory factors IL-6, IL-12, IL-13 and MCP-4 levels of observation group were significantly lower than those of control group;serum Th17/Treg cytokines IL-17 and IL-25 levels were significantly lower than those of control group while IL-10 and IL-35 levels were significantly higher than those of control group;serum immunoglobulin IgA, IgG and IgM levels were significantly higher than those of control group.Conclusions: Azithromycin combined with licorzinc therapy can effectively reduce the systemic inflammatory response and optimize the immune function in children with mycoplasma pneumonia.

Correlation of serum NSE and S100β levels with inflammatory response and immune response in children with hand-foot-mouth disease complicated by encephalitis

Objective:To study the correlation of serum NSE and S100β levels with inflammatory response and immune response in children with hand-foot-mouth disease (HFMD) complicated by encephalitis.Methods:Children who were diagnosed with hand-foot-mouth disease in Yulin Third Hospital between May 2015 and February 2017 were selected, children who were combined with central nervous system were selected as severe group, and children who were not combined with central nervous system were selected as mild group;children who received physical examination during the same period were selected as the control group. Serum was collected to determine the contents of NSE, S100β and inflammatory response mediators, and peripheral blood was collected to determine the contents of T cell subsets and NK cells.Results: Serum NSE and S100β levels of severe group and mild group were significantly higher than those of control group, and serum NSE and S100β levels of severe group were significantly higher than those of mild group;serum TNF-α, IL-6, IL-10, IL-17 and PCT levels as well as peripheral blood HLA-DR+CD4+, HLA-DR+CD8+, CD38+CD4+ and CD38+CD8+ levels of severe group and mild group were significantly higher than those of control group while peripheral blood CD3+T cell, CD4+T cell, CD8+T cell and NK cell levels were significantly lower than those of control group;serum TNF-α, IL-6, IL-10, IL-17 and PCT levels as well as peripheral blood HLA-DR+CD4+, HLA-DR+CD8+, CD38+CD4+ and CD38+CD8+ levels of severe group were significantly higher than those of mild group and positively correlated with NSE and S100β levels while peripheral blood CD3+T cell, CD4+T cell, CD8+T cell and NK cell levels were significantly lower than those of mild group and negatively correlated with NSE and S100β levels.Conclusion: The increase of serum NSE and S100β levels in children with HFMD complicated by encephalitis is closely related to inflammatory response activation and immune response disorder.