Effect of Kang Ai injection + conventional chemotherapy on tumor markers, apoptotic molecules and immune response in patients with advanced NSCLC

Objective: To study the effects of Kang Ai injection + conventional chemotherapy on tumor markers, apoptotic molecules and immune response in patients with advanced non-small cell lung cancer (NSCLC). Methods: Patients diagnosed as advanced NSCLC in our hospital during March 2015 - October 2017 were randomly divided into the experimental group receiving Kang Ai injection + conventional chemotherapy and the control group receiving conventional chemotherapy. The contents of tumor markers, apoptotic molecules and immunologic cytokines in serum and the contents of immune cells in peripheral blood were determined before and after chemotherapy. Results: after chemotherapy, the content of CEA, CYFRA21-1, SCC-Ag, GDF15 and Livin in the serum of the two groups decreased significantly, and the content of PDCD5, P53 and Bax increased significantly, and the content of CEA, CYFRA21-1, SCC-Ag, GDF15, Livin in the serum of the experimental group were lower than those of the control group, and the content of PDCD5, P53 and Bax were higher than those of the control group;the content of CD3+ and CD4+ cells in peripheral blood and the content of IFN-γ, IL-2 in serum of control group significantly decreased, whereas the content of CD8+ cells in peripheral blood and the content of IL-4, IL-5 in serum significantly increased after chemotherapy;while the content of CD3+ and CD4+ cells in peripheral blood and the content of IFN-γ, IL-2 in serum of experimental group significantly increased, whereas the content of CD8+ cells in peripheral blood and the content of IL-4, IL-5 in serum significantly decreased after chemotherapy. Conclusion: Kang Ai injection + conventional chemotherapy in the treatment of advanced NSCLC can more significantly decrease the serum tumor markers, regulate the secretion of apoptotic molecules and anti-tumor immune response than conventional chemotherapy.

Effects of folic acid and vitamin therapy on Hcy metabolism, endothelial injury and placental blood perfusion of preeclampsia patients

Objective: To study the effects of folic acid and vitamin therapy on Hcy metabolism, endothelial injury and placental blood perfusion in preeclampsia. Methods: Preeclampsia patients in our hospital during May 2014-March 2017 were randomly divided into observation group receiving folic acid, vitamin and conventional treatment, the control group receiving conventional treatment;before and after 2 weeks treatment, serum Hcy metabolism index and endothelial injury index were determined;after delivery, contents of oxidative stress index and apoptosis index in placenta were determined. Results: Two weeks after treatment, serum Hcy, ET-1, sEng, sFlt-1 contents of observation group were significantly lower than the control group;VEGF, PLGF, folic acid and VitB12 contents were significantly higher than the control group;after delivery, MDA, AOPP, 8-OHdG, Fas, FasL, Bax, Caspase-3 contents in placenta of observation group patients were significantly lower than the control group;SOD, GSH-Px, XIAP and Survivin in placenta were significantly higher than control group. Conclusion:The treatment of preeclampsia by folic acid and vitamins can improve the metabolism of Hcy, alleviate the injury of the endothelial cells and increase the blood flow perfusion of the placenta.