Ferroptosis,a completely new form of regulated cell death,is mainly caused by an imbalance between oxidative damage and reductive protection and has shown great anti-cancer potential.However,existing small-molecule fe...Ferroptosis,a completely new form of regulated cell death,is mainly caused by an imbalance between oxidative damage and reductive protection and has shown great anti-cancer potential.However,existing small-molecule ferroptosis inducers have various limitations,such as poor water solubility,drug resistance and low targeting ability,hindering their clinical applications.Nanotechnology provides new opportunities for ferroptosis-driven tumor therapy.Especially,stimuli-responsive nanomaterials stand out among others and have been widely researched because of their unique spatiotemporal control advantages.Therefore,it’s necessary to summarize the application of those stimuli-responsive nanomaterials in ferroptosis.Here,we describe the physiological feature of ferroptosis and illustrate the current challenges to induce ferroptosis for cancer therapy.Then,nanomaterials that induce ferroptosis are classified and elaborated according to the external and internal stimuli.Finally,the future perspectives in the field are proposed.We hope this review facilitates paving the way for the design of intelligent nano-ferroptosis inducers.展开更多
基金supported by the Program for International S&T Cooperation Projects(2021YFE0112600)the National Natural Science Foundation of China(32000983,22027810)+4 种基金the National Key R&D Program of China(2021YFA1200900)the Strategic Priority Research Program of the Chinese Academy of Sciences(XDB36000000)the CAS Key Research Program for Frontier Sciences(ZDBS-LY-SLH039)the CAMS Innovation Fund for Medical Sciences(CIFMS 2019-I2M-5-018)the Research and Development Project in Key Areas of Guangdong Province(2019B090917011).
文摘Ferroptosis,a completely new form of regulated cell death,is mainly caused by an imbalance between oxidative damage and reductive protection and has shown great anti-cancer potential.However,existing small-molecule ferroptosis inducers have various limitations,such as poor water solubility,drug resistance and low targeting ability,hindering their clinical applications.Nanotechnology provides new opportunities for ferroptosis-driven tumor therapy.Especially,stimuli-responsive nanomaterials stand out among others and have been widely researched because of their unique spatiotemporal control advantages.Therefore,it’s necessary to summarize the application of those stimuli-responsive nanomaterials in ferroptosis.Here,we describe the physiological feature of ferroptosis and illustrate the current challenges to induce ferroptosis for cancer therapy.Then,nanomaterials that induce ferroptosis are classified and elaborated according to the external and internal stimuli.Finally,the future perspectives in the field are proposed.We hope this review facilitates paving the way for the design of intelligent nano-ferroptosis inducers.
