[Objectives]To explore the mechanism of Pinelliae Rhizoma in the treatment of insomnia.[Methods]Using the Traditional Chinese Medicine Systems Pharmacology(TCMSP)database,the effective components of Pinelliae Rhizoma ...[Objectives]To explore the mechanism of Pinelliae Rhizoma in the treatment of insomnia.[Methods]Using the Traditional Chinese Medicine Systems Pharmacology(TCMSP)database,the effective components of Pinelliae Rhizoma were explored,to predict its targets,and screen out the targets of insomnia through GeneCards,OMIM and other databases.With the aid of Cytoscape software,a"component-target-pathway-disease"network for the treatment of insomnia by Pinelliae Rhizoma was built.Then,a target protein-related interaction network was created through the String database,and biological function annotation and pathway analysis of key targets were performed.[Results]The 13 active components of Pinelliae Rhizoma take action in the treatment of insomnia by intervening 33 targets,59 GO biological processes,and 10 main biological pathways.[Conclusions]The active components of Pinelliae Rhizoma may treat insomnia by such pharmacological effect as regulating G protein-coupled amine receptor activity,adrenergic receptor activity,catecholamine binding,and neurotransmitter receptor activity.展开更多
Localized surface plasmon resonance(LSPR)effects of nanoscale plasmonic metals/semiconductor composites have been extensively applied into visible light photocatalysis.However,Pt nanoparticles(NPs)with the visible LSP...Localized surface plasmon resonance(LSPR)effects of nanoscale plasmonic metals/semiconductor composites have been extensively applied into visible light photocatalysis.However,Pt nanoparticles(NPs)with the visible LSPR absorption maxima have rarely been used as a photosensitizer to facilitate photocatalytic reactions,especially the photocatalytic overall water splitting(POWS)reaction,presumably because they feature weak light absorption.Herein,we present that the increased plasmonic absorption and local field enhancement can be achieved in the wide visible range by exploiting the simulated and experimental expressions of Pt nanocuboctahedra and Pt cuboctahedra-WO_(3)nanohybrids(Pt-WO3).First,monodisperse Pt cuboctahedra with different sizes,a hierarchical WO_(3)nanoarchitecture composed of radially patterned WO_(3)nanopillars,and Pt-WO_(3)were systematically synthesized.Subsequently,visible plasmonic Pt-WO_(3)photocatalysts were employed in the POWS tests and exhibited the significant activity enhancement in the visible light region.The apparent quantum efficiency(AQE)of greater than 7%within the range of visible light has been achieved for the optimal Pt-WO3.展开更多
Spinal cord injury(SCI)often results in an inhibitory environment at the injury site.In our previous studies,transplantation of a scaffold combined with stem cells was proven to induce neural regeneration in animal mo...Spinal cord injury(SCI)often results in an inhibitory environment at the injury site.In our previous studies,transplantation of a scaffold combined with stem cells was proven to induce neural regeneration in animal models of complete SCI.Based on these preclinical studies,collagen scaffolds loaded with the patients’own bone marrow mononuclear cells or human umbilical cord mesenchymal stem cells were transplanted into SCI patients.Fifteen patients with acute complete SCI and 51 patients with chronic complete SCI were enrolled and followed up for 2 to 5 years.No serious adverse events related to functional scaffold transplantation were observed.Among the patients with acute SCI,five patients achieved expansion of their sensory positions and six patients recovered sensation in the bowel or bladder.Additionally,four patients regained voluntary walking ability accompanied by reconnection of neural signal transduction.Among patients with chronic SCI,16 patients achieved expansion of their sensation level and 30 patients experienced enhanced reflexive defecation sensation or increased skin sweating below the injury site.Nearly half of the patients with chronic cervical SCI developed enhanced finger activity.These long-term follow-up results suggest that functional scaffold transplantation may represent a feasible treatment for patients with complete SCI.展开更多
基金Major Special Project for Medical Care and Health of Science and Technology Program of Zhongshan City,Guangdong Province(2019B1016).
文摘[Objectives]To explore the mechanism of Pinelliae Rhizoma in the treatment of insomnia.[Methods]Using the Traditional Chinese Medicine Systems Pharmacology(TCMSP)database,the effective components of Pinelliae Rhizoma were explored,to predict its targets,and screen out the targets of insomnia through GeneCards,OMIM and other databases.With the aid of Cytoscape software,a"component-target-pathway-disease"network for the treatment of insomnia by Pinelliae Rhizoma was built.Then,a target protein-related interaction network was created through the String database,and biological function annotation and pathway analysis of key targets were performed.[Results]The 13 active components of Pinelliae Rhizoma take action in the treatment of insomnia by intervening 33 targets,59 GO biological processes,and 10 main biological pathways.[Conclusions]The active components of Pinelliae Rhizoma may treat insomnia by such pharmacological effect as regulating G protein-coupled amine receptor activity,adrenergic receptor activity,catecholamine binding,and neurotransmitter receptor activity.
基金supported by the Six Talent Peaks Project in Jiangsu Province(No.JNHB-043)the Research Fund of State Key Laboratory of Materials-Oriented Chemical Engineering(No.ZK201713).
文摘Localized surface plasmon resonance(LSPR)effects of nanoscale plasmonic metals/semiconductor composites have been extensively applied into visible light photocatalysis.However,Pt nanoparticles(NPs)with the visible LSPR absorption maxima have rarely been used as a photosensitizer to facilitate photocatalytic reactions,especially the photocatalytic overall water splitting(POWS)reaction,presumably because they feature weak light absorption.Herein,we present that the increased plasmonic absorption and local field enhancement can be achieved in the wide visible range by exploiting the simulated and experimental expressions of Pt nanocuboctahedra and Pt cuboctahedra-WO_(3)nanohybrids(Pt-WO3).First,monodisperse Pt cuboctahedra with different sizes,a hierarchical WO_(3)nanoarchitecture composed of radially patterned WO_(3)nanopillars,and Pt-WO_(3)were systematically synthesized.Subsequently,visible plasmonic Pt-WO_(3)photocatalysts were employed in the POWS tests and exhibited the significant activity enhancement in the visible light region.The apparent quantum efficiency(AQE)of greater than 7%within the range of visible light has been achieved for the optimal Pt-WO3.
基金supported by grants from the National Natural Science Foundation of China(81891000)the National Key Research and Development Program of China(2016YFC1101504 and2016YFC1101505)。
文摘Spinal cord injury(SCI)often results in an inhibitory environment at the injury site.In our previous studies,transplantation of a scaffold combined with stem cells was proven to induce neural regeneration in animal models of complete SCI.Based on these preclinical studies,collagen scaffolds loaded with the patients’own bone marrow mononuclear cells or human umbilical cord mesenchymal stem cells were transplanted into SCI patients.Fifteen patients with acute complete SCI and 51 patients with chronic complete SCI were enrolled and followed up for 2 to 5 years.No serious adverse events related to functional scaffold transplantation were observed.Among the patients with acute SCI,five patients achieved expansion of their sensory positions and six patients recovered sensation in the bowel or bladder.Additionally,four patients regained voluntary walking ability accompanied by reconnection of neural signal transduction.Among patients with chronic SCI,16 patients achieved expansion of their sensation level and 30 patients experienced enhanced reflexive defecation sensation or increased skin sweating below the injury site.Nearly half of the patients with chronic cervical SCI developed enhanced finger activity.These long-term follow-up results suggest that functional scaffold transplantation may represent a feasible treatment for patients with complete SCI.
