Heuristic optimization methods provide a robust and efficient approach to solving complex optimization problems.This paper presents a hybrid optimization technique combining two heuristic optimization methods,artifici...Heuristic optimization methods provide a robust and efficient approach to solving complex optimization problems.This paper presents a hybrid optimization technique combining two heuristic optimization methods,artificial immune system（AIS） and particle swarm optimization（PSO）,together in searching for the global optima of nonlinear functions.The proposed algorithm,namely hybrid anti-prematuration optimization method,contains four significant operators,i.e.swarm operator,cloning operator,suppression operator,and receptor editing operator.The swarm operator is inspired by the particle swarm intelligence,and the clone operator,suppression operator,and receptor editing operator are gleaned by the artificial immune system.The simulation results of three representative nonlinear test functions demonstrate the superiority of the hybrid optimization algorithm over the conventional methods with regard to both the solution quality and convergence rate.It is also employed to cope with a real-world optimization problem.展开更多
The basic characteristics of China ESD program is:The dual attribute of the definition of ESD;A new interpretation of the subject-oriented education theory from the perspective of sustainable development;ESD is an Imp...The basic characteristics of China ESD program is:The dual attribute of the definition of ESD;A new interpretation of the subject-oriented education theory from the perspective of sustainable development;ESD is an Important Content of strengthening morality education;the"whole?school"model has become the norm;an international cooperation and exchange platform has been actively built.展开更多
Although the cell membrane and cytoskeleton play essential roles in cellular morphogenesis,the interaction between the membrane and cytoskeleton is poorly understood.Cotton fibers are extremely elongated single cells,...Although the cell membrane and cytoskeleton play essential roles in cellular morphogenesis,the interaction between the membrane and cytoskeleton is poorly understood.Cotton fibers are extremely elongated single cells,which makes them an ideal model for studying cell development.Here,we used the sphingolipid biosynthesis inhibitor,fumonisin B1(FB1),and found that it effectively suppressed the myeloblastosis(MYB)transcription factor GhMYB86,thereby negatively affecting fiber elongation.A direct target of GhMYB86 is GhTUB7,which encodes the tubulin protein,the major component of the microtubule cytoskeleton.Interestingly,both the overexpression of GhMYB86 and GhTUB7 caused an ectopic microtubule arrangement at the fiber tips,and then leading to shortened fibers.Moreover,we found that GhMBE2 interacted with GhMYB86 and that FB1 and reactive oxygen species induced its transport into the nucleus,thereby enhancing the promotion of GhTUB7 by GhMYB86.Overall,we established a GhMBE2-GhMYB86-GhTUB7 regulation module for fiber elongation and revealed that membrane sphingolipids affect fiber elongation by altering microtubule arrangement.展开更多
Aldehyde dehydrogenase 2(ALDH2)is a key enzyme of alcohol metabolism and it is involved in the cellular mechanism of alcohol liver disease.ALDH2 gene mutations exist in about 8%of the world’s population,with the inci...Aldehyde dehydrogenase 2(ALDH2)is a key enzyme of alcohol metabolism and it is involved in the cellular mechanism of alcohol liver disease.ALDH2 gene mutations exist in about 8%of the world’s population,with the incidence reaching 45%in East Asia.The mutations will result in impairment of enzyme activity and accumulation of acetaldehyde,facilitating the progression of other liver diseases,including non-alcoholic fatty liver diseases,viral hepatitis and hepatocellular carcinoma,through adduct formation and inflammatory responses.In this review,we seek to summarize recent research progress on the correlation between ALDH2 gene polymorphism and multiple liver diseases,with an attempt to provide clues for better understanding of the disease mechanism and for strategy making.展开更多
文摘Heuristic optimization methods provide a robust and efficient approach to solving complex optimization problems.This paper presents a hybrid optimization technique combining two heuristic optimization methods,artificial immune system（AIS） and particle swarm optimization（PSO）,together in searching for the global optima of nonlinear functions.The proposed algorithm,namely hybrid anti-prematuration optimization method,contains four significant operators,i.e.swarm operator,cloning operator,suppression operator,and receptor editing operator.The swarm operator is inspired by the particle swarm intelligence,and the clone operator,suppression operator,and receptor editing operator are gleaned by the artificial immune system.The simulation results of three representative nonlinear test functions demonstrate the superiority of the hybrid optimization algorithm over the conventional methods with regard to both the solution quality and convergence rate.It is also employed to cope with a real-world optimization problem.
文摘The basic characteristics of China ESD program is:The dual attribute of the definition of ESD;A new interpretation of the subject-oriented education theory from the perspective of sustainable development;ESD is an Important Content of strengthening morality education;the"whole?school"model has become the norm;an international cooperation and exchange platform has been actively built.
基金funded by the National Natural Science Foundation of China(31571722 and 31971984)the Genetically Modified Organisms Breeding Major Project of China(No.2018ZX0800921B)Fundamental Research Funds for the Central Universities(SWU‐XDJH202315).
文摘Although the cell membrane and cytoskeleton play essential roles in cellular morphogenesis,the interaction between the membrane and cytoskeleton is poorly understood.Cotton fibers are extremely elongated single cells,which makes them an ideal model for studying cell development.Here,we used the sphingolipid biosynthesis inhibitor,fumonisin B1(FB1),and found that it effectively suppressed the myeloblastosis(MYB)transcription factor GhMYB86,thereby negatively affecting fiber elongation.A direct target of GhMYB86 is GhTUB7,which encodes the tubulin protein,the major component of the microtubule cytoskeleton.Interestingly,both the overexpression of GhMYB86 and GhTUB7 caused an ectopic microtubule arrangement at the fiber tips,and then leading to shortened fibers.Moreover,we found that GhMBE2 interacted with GhMYB86 and that FB1 and reactive oxygen species induced its transport into the nucleus,thereby enhancing the promotion of GhTUB7 by GhMYB86.Overall,we established a GhMBE2-GhMYB86-GhTUB7 regulation module for fiber elongation and revealed that membrane sphingolipids affect fiber elongation by altering microtubule arrangement.
基金supported by the National Natural Science Foundation of China(NSFC),Grant numbers 81600467 and 81670527.
文摘Aldehyde dehydrogenase 2(ALDH2)is a key enzyme of alcohol metabolism and it is involved in the cellular mechanism of alcohol liver disease.ALDH2 gene mutations exist in about 8%of the world’s population,with the incidence reaching 45%in East Asia.The mutations will result in impairment of enzyme activity and accumulation of acetaldehyde,facilitating the progression of other liver diseases,including non-alcoholic fatty liver diseases,viral hepatitis and hepatocellular carcinoma,through adduct formation and inflammatory responses.In this review,we seek to summarize recent research progress on the correlation between ALDH2 gene polymorphism and multiple liver diseases,with an attempt to provide clues for better understanding of the disease mechanism and for strategy making.
