Aiming at the problem of poor system dynamic performance caused by low parameter matching in the coordinated control of Stirling engine and linear generator in the starting stage control of free piston Stirling linear...Aiming at the problem of poor system dynamic performance caused by low parameter matching in the coordinated control of Stirling engine and linear generator in the starting stage control of free piston Stirling linear generator system,a joint control method of free piston Stirling permanent magnet synchronous linear generator system based on field orientation control is proposed,based on the theoretical derivation of the mathematical model of the system and the principle of controller parameters setting,the simulation experiments of the system starting stage under several Stirling engine working conditions are carried out under simulation.The experimental results show that the stability and rapidity of the system are improved,and the dynamic response speed of generator parameters under different working conditions is accelerated,what fully verifies the correctness and effectiveness of the method.It provides an effective way to improve the control performance of the system and stabilize the power generation operation.展开更多
Obesity and its associated complications are highly related to a current public health crisis around the world.A growing body of evidence has indicated that G-protein coupled bile acid(BA) receptor TGR5(also known as ...Obesity and its associated complications are highly related to a current public health crisis around the world.A growing body of evidence has indicated that G-protein coupled bile acid(BA) receptor TGR5(also known as Gpbar-1) is a potential drug target to treat obesity and associated metabolic disorders.We have identified notoginsenoside Ftl(Ftl) from Panax notoginseng as an agonist of TGR5 in vitro.However,the pharmacological effects of Ftl on diet-induced obese(DIO) mice and the underlying mechanisms are still elusive.Here we show that Ftl(100 mg/100 diet) increased adipose lipolysis,promoted fat browning in inguinal adipose tissue and induced glucagon-like peptide-1(GLP-1) secretion in the ileum of wild type but not Tgr5^(-/-) obese mice.In addition,Ftl elevated serum free and taurineconjugated bile acids(BAs) by antagonizing Fxr transcriptional activities in the ileum to activate Tgr5 in the adipose tissues.The metabolic benefits of Ftl were abolished in Cyp27 al^(-/-) mice which have much lower BA levels.These results identify Ftl as a single compound with opposite activities on two key BA receptors to alleviate high fat diet-induced obesity and insulin resistance in mice.展开更多
基金This work was supported in part by the National Natural Science Foundation of China under Grant 51767018,in part by the Scientific research project of Education Department of Gansu Province under Grant 2017A-012.
文摘Aiming at the problem of poor system dynamic performance caused by low parameter matching in the coordinated control of Stirling engine and linear generator in the starting stage control of free piston Stirling linear generator system,a joint control method of free piston Stirling permanent magnet synchronous linear generator system based on field orientation control is proposed,based on the theoretical derivation of the mathematical model of the system and the principle of controller parameters setting,the simulation experiments of the system starting stage under several Stirling engine working conditions are carried out under simulation.The experimental results show that the stability and rapidity of the system are improved,and the dynamic response speed of generator parameters under different working conditions is accelerated,what fully verifies the correctness and effectiveness of the method.It provides an effective way to improve the control performance of the system and stabilize the power generation operation.
基金financially sponsored by Shanghai Pujiang Program(17PJ1408800,China)the Natural Science Foundations of China to Lili Ding(81773961)+6 种基金Zhengtao Wang(81920108033)Yingbo Yang(81703682)financially supported by the National S&T Major Special Projects of China(No.2017ZX09309006)to Li YangInterdisciplinary Program of Shanghai Jiao Tong University to Qiaoling Yang(YG2019QNA03,China)partially supported by R01DK124627George Schaeffer fundJohn Hench fund(USA)to Wendong Huang。
文摘Obesity and its associated complications are highly related to a current public health crisis around the world.A growing body of evidence has indicated that G-protein coupled bile acid(BA) receptor TGR5(also known as Gpbar-1) is a potential drug target to treat obesity and associated metabolic disorders.We have identified notoginsenoside Ftl(Ftl) from Panax notoginseng as an agonist of TGR5 in vitro.However,the pharmacological effects of Ftl on diet-induced obese(DIO) mice and the underlying mechanisms are still elusive.Here we show that Ftl(100 mg/100 diet) increased adipose lipolysis,promoted fat browning in inguinal adipose tissue and induced glucagon-like peptide-1(GLP-1) secretion in the ileum of wild type but not Tgr5^(-/-) obese mice.In addition,Ftl elevated serum free and taurineconjugated bile acids(BAs) by antagonizing Fxr transcriptional activities in the ileum to activate Tgr5 in the adipose tissues.The metabolic benefits of Ftl were abolished in Cyp27 al^(-/-) mice which have much lower BA levels.These results identify Ftl as a single compound with opposite activities on two key BA receptors to alleviate high fat diet-induced obesity and insulin resistance in mice.
