BACKGROUND: Many international studies have shown that plasminogen activator inhibitor-1 (PAl-l) 4G/5G promoter polymorphism does not increase the risk for cerebral infarction. OBJECTIVE: Using PCR methodology and...BACKGROUND: Many international studies have shown that plasminogen activator inhibitor-1 (PAl-l) 4G/5G promoter polymorphism does not increase the risk for cerebral infarction. OBJECTIVE: Using PCR methodology and agarose electrophoresis to detect PAI-1 4G/5G promoter polymorphism in patients with recurrent cerebral infarction in the North Jiangsu Province of China, and to compare results with healthy subjects and patients with first-occurrence cerebral infarction in the same region. DESIGN, TIME AND SETTING: Non-randomized, concurrent, control trial. A total of 122 cerebral infarction patients were admitted to Xuzhou Medical College Hospital's Department of Neurology and Xuzhou Central Hospital's Department of Neurology between July 2003 and August 2006. PARTICIPANTS: The patients consisted of 63 males and 59 females, aged (62 ± 10) years. They were divided into first-occurrence (n = 58) and recurrence (n = 64) groups. In addition, 50 healthy subjects that underwent physical examination in the outpatient department, including 26 males and 24 females, aged (60 ±12) years, were selected as controls. METHODS AND MAIN OUTCOME MEASURES: PAl-1 4G/5G promoter polymorphism was detected and analyzed using PCR methodology and agarose electrophoresis. RESULTS: Significant differences were determined in terms of genotypic frequency and allele frequency of PAI-1 4G/5G promoter polymorphism, in patients with first-occurrence or recurrent cerebral infarction, when compared with healthy subjects (P 〈 0.05). There was, however, no significant difference between the first-occurrence and recurrence groups (P 〉 0.05). CONCLUSION: PAl- 1 4G/5G promoter polymorphism is genetic risk factor for cerebral infarction in China. However, it may be associated with recurrence of cerebral infarction in patients from the North Jiangsu Province of China.展开更多
Based on plasma kinetic theory, the instabilities of self-gravitation systems under perturbation with orbital angular momentum(OAM) are investigated, and the concept of twisted Jeans mode is introduced to describe the...Based on plasma kinetic theory, the instabilities of self-gravitation systems under perturbation with orbital angular momentum(OAM) are investigated, and the concept of twisted Jeans mode is introduced to describe the new phenomenon. The result shows that the growth rate of the Jeans instability is enhanced with the OAM parameter increased, while the critical wave number is consistent with the classical Jeans critical value. It is expected that the present results would give more insight into the evolution and dynamics of a self-gravitational system.展开更多
基金the Xuzhou Social Development Foundation of Jiangsu Province, No. 2006046
文摘BACKGROUND: Many international studies have shown that plasminogen activator inhibitor-1 (PAl-l) 4G/5G promoter polymorphism does not increase the risk for cerebral infarction. OBJECTIVE: Using PCR methodology and agarose electrophoresis to detect PAI-1 4G/5G promoter polymorphism in patients with recurrent cerebral infarction in the North Jiangsu Province of China, and to compare results with healthy subjects and patients with first-occurrence cerebral infarction in the same region. DESIGN, TIME AND SETTING: Non-randomized, concurrent, control trial. A total of 122 cerebral infarction patients were admitted to Xuzhou Medical College Hospital's Department of Neurology and Xuzhou Central Hospital's Department of Neurology between July 2003 and August 2006. PARTICIPANTS: The patients consisted of 63 males and 59 females, aged (62 ± 10) years. They were divided into first-occurrence (n = 58) and recurrence (n = 64) groups. In addition, 50 healthy subjects that underwent physical examination in the outpatient department, including 26 males and 24 females, aged (60 ±12) years, were selected as controls. METHODS AND MAIN OUTCOME MEASURES: PAl-1 4G/5G promoter polymorphism was detected and analyzed using PCR methodology and agarose electrophoresis. RESULTS: Significant differences were determined in terms of genotypic frequency and allele frequency of PAI-1 4G/5G promoter polymorphism, in patients with first-occurrence or recurrent cerebral infarction, when compared with healthy subjects (P 〈 0.05). There was, however, no significant difference between the first-occurrence and recurrence groups (P 〉 0.05). CONCLUSION: PAl- 1 4G/5G promoter polymorphism is genetic risk factor for cerebral infarction in China. However, it may be associated with recurrence of cerebral infarction in patients from the North Jiangsu Province of China.
基金supported by the National Natural Science Foundation of China (Grant Nos.11763006 and 11863004)the fund from the Jiangxi Provincial Key Laboratory of Fusion and Information Control (Grant No.20171BCD40005)the Project of Scientific and Technological Innovation Base of Jiangxi Province (Grant No.20203CCD46008)。
文摘Based on plasma kinetic theory, the instabilities of self-gravitation systems under perturbation with orbital angular momentum(OAM) are investigated, and the concept of twisted Jeans mode is introduced to describe the new phenomenon. The result shows that the growth rate of the Jeans instability is enhanced with the OAM parameter increased, while the critical wave number is consistent with the classical Jeans critical value. It is expected that the present results would give more insight into the evolution and dynamics of a self-gravitational system.