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角膜电刺激对糖尿病大鼠前部缺血性视神经病变模型的影响 被引量:1
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作者 程蓓 王启常 唐罗生 《中华眼视光学与视觉科学杂志》 CAS CSCD 2019年第9期689-697,共9页
目的:观察并评估角膜电刺激对糖尿病大鼠前部缺血性视神经病变(AION)模型的影响。方法:实验研究。健康雄性Sparague-Dawley大鼠40只,随机分组后抽出8只作为正常大鼠组。余下32只先予以链脲佐菌素腹腔注射建立糖尿病大鼠模型,将造模成功... 目的:观察并评估角膜电刺激对糖尿病大鼠前部缺血性视神经病变(AION)模型的影响。方法:实验研究。健康雄性Sparague-Dawley大鼠40只,随机分组后抽出8只作为正常大鼠组。余下32只先予以链脲佐菌素腹腔注射建立糖尿病大鼠模型,将造模成功的大鼠随机抽出8只作为糖尿病组,余下24只糖尿病大鼠采用孟加拉玫瑰红联合532nm激光方法建立AION大鼠模型。将24只造模成功的AION大鼠随机分成3组,每组8只,分别为AION模型组,不予任何处理;电刺激组,予以角膜电刺激(刺激参数为:电流1mA,频率20Hz,波宽1ms/phase,刺激时间1h,隔日1次,刺激2周);假电刺激组,电极安放位置与电刺激组相同,仅不接通电源。2周后5组大鼠进行眼底照相、光学相干断层扫描和视觉诱发电位,然后处死,行视网膜及视神经冰冻切片,苏木精伊红染色观察。数据采用单因素方差分析和LSD-t检验进行分析。结果:正常大鼠组视盘上半部视网膜厚度为(211±13)μm,糖尿病大鼠组为(206±16)μm,AION模型组为(240±54)μm,假电刺激组为(216±11)μm,电刺激组为(198±4)μm,5组视盘上半部视网膜厚度差异有统计学意义(F=2.854,P=0.038)。其中AION模型组视盘上半部视网膜厚度高于正常组、糖尿病组、电刺激组,差异均有统计学意义(P<0.05);正常组与糖尿病组差异无统计学意义,AION模型组与假电刺激组未见明显差异。视觉诱发电位示AION模型组N1潜伏期较电刺激组延长,差异有统计学意义(t=4.1,P<0.001);AION模型组P1潜伏期较正常组、糖尿病组、假电刺激组、电刺激组延长,差异均有统计学意义(t=4.1、2.5、2.6、3.2,P<0.05);电刺激组N1-P1波幅大于假电刺激组,差异有统计学意义(t=4.0,P<0.001)。结论:角膜电刺激能促进糖尿病大鼠前部缺血性视神经病变模型肿胀的视盘变薄,加速视盘水肿的消退,同时在一定程度上改善视功能。 展开更多
关键词 角膜电刺激 糖尿病大鼠 前部缺血性视神经病变 光学相干断层扫描
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Promotional effect of silica on the combustion of nano-sized aluminum powder in carbon dioxide 被引量:1
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作者 Baozhong ZHU Jinghui wang +3 位作者 qichang wang Yunlan SUN Weiqi CHEN Jiquan wang 《Chinese Journal of Aeronautics》 SCIE EI CAS CSCD 2022年第4期245-252,共8页
This paper presents how the combustion performance of nano-sized aluminum(nAl)powder in carbon dioxide are affected by silica. The ignition and combustion performance of nAl powder with silica addition were studied by... This paper presents how the combustion performance of nano-sized aluminum(nAl)powder in carbon dioxide are affected by silica. The ignition and combustion performance of nAl powder with silica addition were studied by a high-temperature tube furnace. An s-type thermocouple and a high-speed motion acquisition instrument were performed to evaluate the ignition temperature, maximum combustion temperature, maximum change of rate of temperature, and combustion propagation speed. The combustion efficiency and combustion products were measured and analyzed by a gas-volumetric method and an X-ray diffraction. The results show that silica added into nAl powder can enhance its maximum combustion temperature and maximum change of rate of temperature, while its ignition temperature increases slightly. The nAl powders with addition of 6.00 wt.% and 12.00 wt.% silica present high combustion propagation speeds, especially for the latter, it has high combustion efficiency. The effect mechanism of silica on the combustion of nAl powder in carbon dioxide was discussed. 展开更多
关键词 COMBUSTION MECHANISM Nano-sized aluminum powder Promotional effect SILICA
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